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  1. Article ; Online: sigma-Bishomoconjugation (sigma-Bishomoaromaticity) in 4C/3(2)e Cations-Scope and Limitations This project has been supported by the Deutsche Forschungsgemeinschaft, the Fonds der Chemischen Industrie, and BASF AG. We thank A. Kurscheidt and M. Lutterbeck for technical assistance, Dr. D. Hunkler and Dr. J. Wörth for NMR and MS measurements, and Prof. Dr. T. Bally for access to his (60)Co-gamma-irradiation equipment.

    Prinzbach, Horst / Reinbold, Jens / Bertau, Martin / Voss, Torsten / Martin, Hans-Dieter / Mayer, Bernhard / Heinze, Jürgen / Neschchadin, Dmytro / Gescheidt, Georg / Prakash, G. K. Surya / Olah, George A.

    Angewandte Chemie (International ed. in English)

    2001  Volume 40, Issue 5, Page(s) 911–914

    Language English
    Publishing date 2001-03-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Mentales Training

    Mayer, Jan / Hermann, Hans-Dieter

    Grundlagen und Anwendung in Sport, Rehabilitation, Arbeit und Wirtschaft

    2015  

    Author's details Jan Mayer, Hans-Dieter Hermann
    Keywords Persönlichkeitsentwicklung ; Sportwissenschaft ; Vorstellungskraft ; Leistungsfähigkeit ; Imagination ; Sportpsychologie ; Trainer ; Selbstmanagement ; Mentaltraining ; Leistungssteigerung ; Rehabilitation ; Motivation ; Mentales Coaching ; Coaching ; Motivationsförderung ; Reha ; Neurophysiologie ; Mentales Training
    Subject Mentaltraining
    Language German
    Size XI, 249 Seiten, Illustrationen
    Edition 3., korrigierte und aktualisierte Auflage
    Publisher Springer
    Publishing place Berlin ; Heidelberg
    Publishing country Germany
    Document type Book
    HBZ-ID HT018685641
    ISBN 978-3-662-46819-7 ; 978-3-662-46818-0 ; 3-662-46818-2 ; 3-662-46819-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 3215 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: NSCl(2)(-): Thiazyl Dichloride-An Aza Analogue of Thionyl Dichloride A.S. thanks Prof. Dr. T. M. Klapötke (LMU München) for his generous support and Prof. Dr. R. D. Harcourt (Melbourne University) for many helpful discussions. We thank Prof. Dr. W. Schnick and S. Schmidt (LMU München) for carrying out the powder diffraction experiments, Dr. K. Karaghiosoff and Dr. J. Senker (MAS) for carrying out the NMR experiments.

    Keßenich, Elmar / Kopp, Felix / Mayer, Peter / Schulz, Axel

    Angewandte Chemie (International ed. in English)

    2001  Volume 40, Issue 10, Page(s) 1904–1907

    Language English
    Publishing date 2001-05-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Role of diet and its effects on the gut microbiome in the pathophysiology of mental disorders.

    Horn, J / Mayer, D E / Chen, S / Mayer, E A

    Translational psychiatry

    2022  Volume 12, Issue 1, Page(s) 164

    Abstract: There is emerging evidence that diet has a major modulatory influence on brain-gut-microbiome (BGM) interactions with important implications for brain health, and for several brain disorders. The BGM system is made up of neuroendocrine, neural, and ... ...

    Abstract There is emerging evidence that diet has a major modulatory influence on brain-gut-microbiome (BGM) interactions with important implications for brain health, and for several brain disorders. The BGM system is made up of neuroendocrine, neural, and immune communication channels which establish a network of bidirectional interactions between the brain, the gut and its microbiome. Diet not only plays a crucial role in shaping the gut microbiome, but it can modulate structure and function of the brain through these communication channels. In this review, we summarize the evidence available from preclinical and clinical studies on the influence of dietary habits and interventions on a selected group of psychiatric and neurologic disorders including depression, cognitive decline, Parkinson's disease, autism spectrum disorder and epilepsy. We will particularly address the role of diet-induced microbiome changes which have been implicated in these effects, and some of which are shared between different brain disorders. While the majority of these findings have been demonstrated in preclinical and in cross-sectional, epidemiological studies, to date there is insufficient evidence from mechanistic human studies to make conclusions about causality between a specific diet and microbially mediated brain function. Many of the dietary benefits on microbiome and brain health have been attributed to anti-inflammatory effects mediated by the microbial metabolites of dietary fiber and polyphenols. The new attention given to dietary factors in brain disorders has the potential to improve treatment outcomes with currently available pharmacological and non-pharmacological therapies.
    MeSH term(s) Autism Spectrum Disorder ; Brain ; Brain Diseases ; Cross-Sectional Studies ; Diet ; Epilepsy ; Gastrointestinal Microbiome ; Humans ; Mental Disorders
    Language English
    Publishing date 2022-04-20
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2609311-X
    ISSN 2158-3188 ; 2158-3188
    ISSN (online) 2158-3188
    ISSN 2158-3188
    DOI 10.1038/s41398-022-01922-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Artificial intelligence and machine learning in clinical pharmacological research.

    Mayer, Benjamin / Kringel, Dario / Lötsch, Jörn

    Expert review of clinical pharmacology

    2024  Volume 17, Issue 1, Page(s) 79–91

    Abstract: Background: Clinical pharmacology research has always involved computational analysis. With the abundance of drug-related data available, the integration of artificial intelligence (AI) and machine learning (ML) methods has emerged as a promising way to ...

    Abstract Background: Clinical pharmacology research has always involved computational analysis. With the abundance of drug-related data available, the integration of artificial intelligence (AI) and machine learning (ML) methods has emerged as a promising way to enhance clinical pharmacology research.
    Methods: Based on an accepted definition of clinical pharmacology as a field of research dealing with all aspects of drug-human interactions, the analysis included publications from institutes specializing in clinical pharmacology. Research topics and the most used machine learning methods in clinical pharmacology were retrieved from the PubMed database and summarized.
    Results: ML was identified in 674 publications attributed to clinical pharmacology research, with a significant increase in publication activity over the last decade. Notable research topics addressed by ML/AI included Covid-19-related clinical pharmacology research, clinical neuropharmacology, drug safety and risk assessment, clinical pharmacology related to cancer research, and antimicrobial and antiviral research unrelated to Covid-19. In terms of ML methods, neural networks, random forests, and support vector machines were frequently mentioned in the abstracts of the retrieved papers.
    Conclusions: ML, and AI in general, is increasingly being used in various research areas within clinical pharmacology. This report presents specific examples of applications and highlights the most used ML methods.
    MeSH term(s) Humans ; Artificial Intelligence ; Machine Learning ; COVID-19 ; Pharmacology, Clinical
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article
    ISSN 1751-2441
    ISSN (online) 1751-2441
    DOI 10.1080/17512433.2023.2294005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Proposed reductions in limits on added sugar and alcohol for the new dietary guidelines: our perspective.

    Mayer-Davis, Elizabeth J / Naimi, Timothy S / Mattes, Richard D

    The American journal of clinical nutrition

    2023  Volume 114, Issue 2, Page(s) 405–406

    MeSH term(s) Diet ; Dietary Sugars ; Humans ; Sugars
    Chemical Substances Dietary Sugars ; Sugars
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 280048-2
    ISSN 1938-3207 ; 0002-9165
    ISSN (online) 1938-3207
    ISSN 0002-9165
    DOI 10.1093/ajcn/nqab092
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Potential of dietary polyphenols for protection from age-related decline and neurodegeneration: a role for gut microbiota?

    Ross, F C / Mayer, D E / Horn, J / Cryan, J F / Del Rio, D / Randolph, E / Gill, C I R / Gupta, A / Ross, R P / Stanton, C / Mayer, E A

    Nutritional neuroscience

    2024  , Page(s) 1–19

    Abstract: Many epidemiological studies have shown the beneficial effects of a largely plant-based diet, and the strong association between the consumption of a Mediterranean-type diet with healthy aging including a lower risk of cognitive decline. The ... ...

    Abstract Many epidemiological studies have shown the beneficial effects of a largely plant-based diet, and the strong association between the consumption of a Mediterranean-type diet with healthy aging including a lower risk of cognitive decline. The Mediterranean diet is characterized by a high intake of olive oil, fruits and vegetables and is rich in dietary fiber and polyphenols - both of which have been postulated to act as important mediators of these benefits. Polyphenols are large molecules produced by plants to protect them from environmental threats and injury. When ingested by humans, as little as 5% of these molecules are absorbed in the small intestine with the majority metabolized by the gut microbiota into absorbable simple phenolic compounds. Flavan-3-ols, a type of flavonoid, contained in grapes, berries, pome fruits, tea, and cocoa have been associated with many beneficial effects on several risk factors for cardiovascular disease, cognitive function and brain regions involved in memory formation. Both preclinical and clinical studies suggest that these brain and heart benefits can be attributed to endothelial vascular effects and anti-inflammatory properties among others. More recently the gut microbiota has emerged as a potential modulator of the aging brain and intriguingly polyphenols have been shown to alter microbiota composition and be metabolized by different microbial species. However, there is a need for well controlled studies in large populations to identify predictors of response, particularly given the vast inter-individual variation of human gut microbiota.
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1447449-9
    ISSN 1476-8305 ; 1028-415X
    ISSN (online) 1476-8305
    ISSN 1028-415X
    DOI 10.1080/1028415X.2023.2298098
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    In stock of ZB MED Bonn / Germany

    Z 7024: Show issues

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  8. Article: Emission Ghost Imaging: reconstruction with data augmentation.

    Coakley, K J / Chen-Mayer, H H / Ravel, B / Josell, D / Klimov, N N / Hussey, D S / Robinson, S M

    Physical review. A

    2024  Volume 109, Issue 2

    Abstract: Ghost Imaging enables 2D reconstruction of an object even though particles transmitted or emitted by the object of interest are detected with a single pixel detector without spatial resolution. This is possible because for the particular implementation ... ...

    Abstract Ghost Imaging enables 2D reconstruction of an object even though particles transmitted or emitted by the object of interest are detected with a single pixel detector without spatial resolution. This is possible because for the particular implementation of ghost imaging presented here, the incident beam is spatially modulated with a non-configurable attenuating mask whose orientation is varied (e.g. via transverse displacement or rotation) in the course of the ghost imaging experiment. Each orientation yields a distinct spatial pattern in the attenuated beam. In many cases, ghost imaging reconstructions can be dramatically improved by factoring the measurement matrix which consists of measured attenuated incident radiation for each of many orientations of the mask at each pixel to be reconstructed as the product of an orthonormal matrix
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209769-2
    ISSN 2469-9926 ; 0556-2791 ; 1050-2947
    ISSN 2469-9926 ; 0556-2791 ; 1050-2947
    DOI 10.1103/PhysRevA.109.023501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cortico-spinal modularity in the parieto-frontal system: A new perspective on action control.

    Bufacchi, R J / Battaglia-Mayer, A / Iannetti, G D / Caminiti, R

    Progress in neurobiology

    2023  Volume 231, Page(s) 102537

    Abstract: Classical neurophysiology suggests that the motor cortex (MI) has a unique role in action control. In contrast, this review presents evidence for multiple parieto-frontal spinal command modules that can bypass MI. Five observations support this modular ... ...

    Abstract Classical neurophysiology suggests that the motor cortex (MI) has a unique role in action control. In contrast, this review presents evidence for multiple parieto-frontal spinal command modules that can bypass MI. Five observations support this modular perspective: (i) the statistics of cortical connectivity demonstrate functionally-related clusters of cortical areas, defining functional modules in the premotor, cingulate, and parietal cortices; (ii) different corticospinal pathways originate from the above areas, each with a distinct range of conduction velocities; (iii) the activation time of each module varies depending on task, and different modules can be activated simultaneously; (iv) a modular architecture with direct motor output is faster and less metabolically expensive than an architecture that relies on MI, given the slow connections between MI and other cortical areas; (v) lesions of the areas composing parieto-frontal modules have different effects from lesions of MI. Here we provide examples of six cortico-spinal modules and functions they subserve: module 1) arm reaching, tool use and object construction; module 2) spatial navigation and locomotion; module 3) grasping and observation of hand and mouth actions; module 4) action initiation, motor sequences, time encoding; module 5) conditional motor association and learning, action plan switching and action inhibition; module 6) planning defensive actions. These modules can serve as a library of tools to be recombined when faced with novel tasks, and MI might serve as a recombinatory hub. In conclusion, the availability of locally-stored information and multiple outflow paths supports the physiological plausibility of the proposed modular perspective.
    MeSH term(s) Humans ; Parietal Lobe/physiology ; Hand ; Cognition
    Language English
    Publishing date 2023-10-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 185535-9
    ISSN 1873-5118 ; 0301-0082
    ISSN (online) 1873-5118
    ISSN 0301-0082
    DOI 10.1016/j.pneurobio.2023.102537
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    In stock of ZB MED Cologne/Königswinter

    Se 205: Show issues Location:
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  10. Article: Health promotion for the unemployed: the evaluation of the JOBS Program Germany from the trainers' perspective.

    Jahn, Heiko J / Mayer, Dennis / Hollederer, Alfons

    Archives of public health = Archives belges de sante publique

    2023  Volume 81, Issue 1, Page(s) 199

    Abstract: Background: The JOBS Program Germany is a labor market integrative and health promotion intervention for unemployed people. This study examines JOBS Program Germany trainers' view of (1) the theoretical concept of the JOBS Program, (2) its practical ... ...

    Abstract Background: The JOBS Program Germany is a labor market integrative and health promotion intervention for unemployed people. This study examines JOBS Program Germany trainers' view of (1) the theoretical concept of the JOBS Program, (2) its practical implementation in Germany on-site, (3) its acceptance by participants, and (4) the training effects. The study aimed at identifying potential for adaption allowing adjustments to improve the practical implementation and the training effectiveness.
    Methods: JOBS Program Germany trainers (two for each training) were interviewed via voluntary survey (computer-assisted web interviews) after each training.
    Results: Fourteen JOBS Program trainings have been conducted and all trainers responded resulting in 28 interviews. 78.5% and 85.7% of the respondents were rather or very satisfied with the theoretical contents and its practical implementation, respectively. Almost all trainers (96.4-100.0%) were satisfied with the on-site coordination, the cooperation with the organizer's employees, the room equipment, the training room size, and the environmental conditions in the training rooms. In 89.3% of all responses the trainers rated the last training a success. However, the trainers also provided valuable suggestions for further improvement in Germany. This concerns the revision of the training manual, the adjustment of the trainer training and the preparation of participants.
    Conclusion: Besides the trainers' positive view on the different dimensions of the training content and implementation, their suggestions can help ensure that many unemployed people in Germany could benefit from a continued regular implementation of the JOBS Program Germany in the future.
    Trial registration: German Clinical Trials Register (DRKS), DRKS00022388. Registered on 20 July, 2020.
    Language English
    Publishing date 2023-11-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1117688-x
    ISSN 2049-3258 ; 0778-7367 ; 0003-9578
    ISSN (online) 2049-3258
    ISSN 0778-7367 ; 0003-9578
    DOI 10.1186/s13690-023-01203-2
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