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  1. Article ; Online: Erratum to "A scoping review on the effects of Varroa mite (Varroa destructor) on global honey bee decline" [Sci. Total Environ. 906 (2024) 167492].

    Warner, Summer / Pokhrel, Lok R / Akula, Shaw M / Ubah, Chukwudi S / Richards, Stephanie L / Jensen, Heidi / Kearney, Gregory D

    The Science of the total environment

    2024  , Page(s) 172820

    Language English
    Publishing date 2024-04-26
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.172820
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 949: Show issues Location:
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  2. Article ; Online: Flu or a Bug?

    Akula, Shaw M.

    Essays on Life, Science and Society

    Abstract: Of late, apart from the four calendar seasons, there is yet another season referred to as the “flu season.” During this time of the year, we routinely hear the phrase “the flu is going around.” I was surprised last week when I heard my 6-year-old son ... ...

    Abstract Of late, apart from the four calendar seasons, there is yet another season referred to as the “flu season.” During this time of the year, we routinely hear the phrase “the flu is going around.” I was surprised last week when I heard my 6-year-old son mention to me that there is some bug going around in his class and that his best friend was sick. I asked him to define the bug and he said it causes stuffy nose. The word “bug” is used so callously by adults that it has been registered wrongly in the minds of the little ones.
    Keywords covid19
    Publisher PMC
    Document type Article ; Online
    DOI 10.1007/978-3-030-28775-7_3
    Database COVID19

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  3. Article ; Online: Cellular miR-150-5p may have a crucial role to play in the biology of SARS-CoV-2 infection by regulating nsp10 gene

    Akula, Shaw M. / Bolin, Paul / Cook, Paul P.

    RNA Biology. 2022 Dec. 31, v. 19, no. 1 p.1-11

    2022  

    Abstract: The role for circulating miRNAs as biomarkers of the COVID-19 disease remains uncertain. We analysed the circulating miRNA profile in twelve COVID-19 patients with moderate-severe disease. This analysis was conducted by performing next generation ... ...

    Abstract The role for circulating miRNAs as biomarkers of the COVID-19 disease remains uncertain. We analysed the circulating miRNA profile in twelve COVID-19 patients with moderate-severe disease. This analysis was conducted by performing next generation sequencing (NGS) followed by real-time polymerase chain reaction (RT-qPCR). Compared with healthy controls, we detected significant changes in the circulating miRNA profile of COVID-19 patients. The miRNAs that were significantly altered in all the COVID-19 patients were miR-150-5p, miR-375, miR-122-5p, miR-494-3p, miR-3197, miR-4690-5p, miR-1915-3p, and miR-3652. Infection assays performed using miRNA mimics in HEK-293 T cells determined miR-150-5p to have a crucial role in SARS-CoV-2 infection and this was based on the following data: (i) miR-150-5p mimic lowered in vitro SARS-CoV-2 infection; (ii) miR-150-5p inhibitor reversed the effects of miR-150-5p mimic on SARS-CoV-2 infection of cells; and (iii) a novel miRNA recognition element (MRE) was identified in the coding strand of SARS-CoV-2 nsp10, the expression of which could be inhibited by miR-150-5p mimic. Our findings identified crucial miRNA footprints in COVID-19 patients with moderate-severe disease. A combination of co-transfection and Western blotting experiments also determined the ability of miR-150-5p to inhibit SARS-CoV-2 infection via directly interacting with MRE in the coding strand of nsp10. Our investigation showed that a sharp decline in the miR-150-5p plasma levels in COVID-19 patients may support enhanced SARS-CoV-2 infection. Furthermore, this study provides insight into one possible mechanism by which COVID-19-induced changes to miR-150-5p levels may promote SARS-CoV-2 infection via modulating nsp10 expression.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; biomarkers ; genes ; microRNA ; quantitative polymerase chain reaction ; COVID-19 ; SARS-CoV-2 ; miR-150-5p ; nsp10 ; plasma ; circulating biomarkers
    Language English
    Dates of publication 2022-1231
    Size p. 1-11.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2159587-2
    ISSN 1555-8584
    ISSN 1555-8584
    DOI 10.1080/15476286.2021.2010959
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Antibacterial efficacy, mode of action, and safety of a novel nano-antibiotic against antibiotic-resistant Escherichia coli strains.

    Ubah, Chukwudi S / Pokhrel, Lok R / Williams, Jordan E / Akula, Shaw M / Richards, Stephanie L / Kearney, Gregory D / Williams, Andre

    The Science of the total environment

    2024  Volume 925, Page(s) 171675

    Abstract: Globally rising antibiotic-resistant (AR) and multi-drug resistant (MDR) bacterial infections are of public health concern due to treatment failure with current antibiotics. Enterobacteria, particularly Escherichia coli, cause infections of surgical ... ...

    Abstract Globally rising antibiotic-resistant (AR) and multi-drug resistant (MDR) bacterial infections are of public health concern due to treatment failure with current antibiotics. Enterobacteria, particularly Escherichia coli, cause infections of surgical wound, bloodstream, and urinary tract, including pneumonia and sepsis. Herein, we tested in vitro antibacterial efficacy, mode of action (MoA), and safety of novel amino-functionalized silver nanoparticles (NH
    MeSH term(s) Humans ; Anti-Bacterial Agents/toxicity ; Escherichia coli ; Silver/toxicity ; Metal Nanoparticles/toxicity ; Bacterial Infections ; Bacteria ; Ampicillin/pharmacology ; Kanamycin/pharmacology ; Microbial Sensitivity Tests
    Chemical Substances Anti-Bacterial Agents ; Silver (3M4G523W1G) ; Ampicillin (7C782967RD) ; Kanamycin (59-01-8)
    Language English
    Publishing date 2024-03-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.171675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 949: Show issues Location:
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  5. Article ; Online: Five nanometer size highly positive silver nanoparticles are bactericidal targeting cell wall and adherent fimbriae expression.

    Pokhrel, Lok R / Jacobs, Zachary L / Dikin, Dmitriy / Akula, Shaw M

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 6729

    Abstract: To tackle growing antibiotic resistance (AR) and hospital-acquired infections (HAIs), novel antimicrobials are warranted that are effective against HAIs and safer for human use. We hypothesize that small 5 nm size positively charged nanoparticles could ... ...

    Abstract To tackle growing antibiotic resistance (AR) and hospital-acquired infections (HAIs), novel antimicrobials are warranted that are effective against HAIs and safer for human use. We hypothesize that small 5 nm size positively charged nanoparticles could specifically target bacterial cell wall and adherent fimbriae expression, serving as the next generation antibacterial agent. Herein we show highly positively charged, 5 nm amino-functionalized silver nanoparticles (NH
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Cell Wall ; Citric Acid/pharmacology ; Dihydrotachysterol/pharmacology ; Escherichia coli ; Humans ; Ions/pharmacology ; Metal Nanoparticles ; Silver/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Ions ; Citric Acid (2968PHW8QP) ; Silver (3M4G523W1G) ; Dihydrotachysterol (R5LM3H112R)
    Language English
    Publishing date 2022-04-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-10778-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cellular miR-150-5p may have a crucial role to play in the biology of SARS-CoV-2 infection by regulating

    Akula, Shaw M / Bolin, Paul / Cook, Paul P

    RNA biology

    2021  Volume 19, Issue 1, Page(s) 1–11

    Abstract: The role for circulating miRNAs as biomarkers of the COVID-19 disease remains uncertain. We analysed the circulating miRNA profile in twelve COVID-19 patients with moderate-severe disease. This analysis was conducted by performing next generation ... ...

    Abstract The role for circulating miRNAs as biomarkers of the COVID-19 disease remains uncertain. We analysed the circulating miRNA profile in twelve COVID-19 patients with moderate-severe disease. This analysis was conducted by performing next generation sequencing (NGS) followed by
    MeSH term(s) Animals ; COVID-19/genetics ; COVID-19/metabolism ; Cell Line, Tumor ; Chlorocebus aethiops ; Gene Expression Regulation, Viral ; HEK293 Cells ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism ; Vero Cells ; Viral Regulatory and Accessory Proteins/biosynthesis ; Viral Regulatory and Accessory Proteins/genetics
    Chemical Substances MIRN150 microRNA, human ; MicroRNAs ; NSP10 protein, SARS-CoV-2 ; Viral Regulatory and Accessory Proteins
    Language English
    Publishing date 2021-12-31
    Publishing country United States
    Document type Journal Article ; Video-Audio Media
    ISSN 1555-8584
    ISSN (online) 1555-8584
    DOI 10.1080/15476286.2021.2010959
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Emerging Role of Kinin B1 Receptor in Persistent Neuroinflammation and Neuropsychiatric Symptoms in Mice Following Recovery from SARS-CoV-2 Infection.

    Sriramula, Srinivas / Theobald, Drew / Parekh, Rohan Umesh / Akula, Shaw M / O'Rourke, Dorcas P / Eells, Jeffrey B

    Cells

    2023  Volume 12, Issue 16

    Abstract: Evidence suggests that patients with long COVID can experience neuropsychiatric, neurologic, and cognitive symptoms. However, these clinical data are mostly associational studies complicated by confounding variables, thus the mechanisms responsible for ... ...

    Abstract Evidence suggests that patients with long COVID can experience neuropsychiatric, neurologic, and cognitive symptoms. However, these clinical data are mostly associational studies complicated by confounding variables, thus the mechanisms responsible for persistent symptoms are unknown. Here we establish an animal model of long-lasting effects on the brain by eliciting mild disease in K18-hACE2 mice. Male and female K18-hACE2 mice were infected with 4 × 10
    MeSH term(s) Female ; Male ; Animals ; Humans ; Mice ; COVID-19/complications ; Post-Acute COVID-19 Syndrome ; SARS-CoV-2 ; Neuroinflammatory Diseases ; Kinins
    Chemical Substances K-18 conjugate ; Kinins
    Language English
    Publishing date 2023-08-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12162107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Where are we with understanding of COVID-19?

    Akula, Shaw M / McCubrey, James A

    Advances in biological regulation

    2020  Volume 78, Page(s) 100738

    Abstract: Coronavirus disease 2019 caused by SARS-CoV-2 originated from China and spread across every corner of the world. The scientific interest on COVID-19 increased after WHO declared it a pandemic in the early February of 2020. In fact, this pandemic has had ... ...

    Abstract Coronavirus disease 2019 caused by SARS-CoV-2 originated from China and spread across every corner of the world. The scientific interest on COVID-19 increased after WHO declared it a pandemic in the early February of 2020. In fact, this pandemic has had a worldwide impact on economy, health, and lifestyle like no other in the last 100 years. SARS-CoV-2 belongs to Coronaviridae family and causes the deadliest clinical manifestations when compared to other viruses in the family. COVID-19 is an emerging zoonotic disease that has resulted in over 383,000 deaths around the world. Scientists are scrambling for ideas to develop treatment and prevention strategies to thwart the disease condition. In this review, we have attempted to summarize the latest information on the virus, disease, prevention, and treatment strategies. The future looks promising.
    MeSH term(s) Animals ; Betacoronavirus/genetics ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Humans ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Zoonoses/drug therapy ; Zoonoses/epidemiology ; Zoonoses/transmission ; Zoonoses/virology
    Keywords covid19
    Language English
    Publishing date 2020-06-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2667413-0
    ISSN 2212-4934 ; 2212-4926
    ISSN (online) 2212-4934
    ISSN 2212-4926
    DOI 10.1016/j.jbior.2020.100738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Foreword for the special issue advances in COVID-19: Biology and clinic.

    McCubrey, James A / Akula, Shaw M / Payrastre, Bernard

    Advances in biological regulation

    2020  Volume 77, Page(s) 100744

    MeSH term(s) Anticoagulants/therapeutic use ; Antiviral Agents/therapeutic use ; Betacoronavirus/pathogenicity ; COVID-19 ; Comorbidity ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Cytokine Release Syndrome/diagnosis ; Cytokine Release Syndrome/drug therapy ; Cytokine Release Syndrome/epidemiology ; Cytokine Release Syndrome/mortality ; Disseminated Intravascular Coagulation/diagnosis ; Disseminated Intravascular Coagulation/drug therapy ; Disseminated Intravascular Coagulation/epidemiology ; Disseminated Intravascular Coagulation/mortality ; Humans ; Lung/blood supply ; Lung/drug effects ; Lung/pathology ; Lung/virology ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/drug therapy ; Pulmonary Embolism/epidemiology ; Pulmonary Embolism/mortality ; Respiratory Insufficiency/diagnosis ; Respiratory Insufficiency/drug therapy ; Respiratory Insufficiency/epidemiology ; Respiratory Insufficiency/mortality ; SARS-CoV-2 ; Survival Analysis ; Trace Elements/therapeutic use ; Vitamins/therapeutic use
    Chemical Substances Anticoagulants ; Antiviral Agents ; Trace Elements ; Vitamins
    Keywords covid19
    Language English
    Publishing date 2020-07-09
    Publishing country England
    Document type Editorial
    ZDB-ID 2667413-0
    ISSN 2212-4934 ; 2212-4926
    ISSN (online) 2212-4934
    ISSN 2212-4926
    DOI 10.1016/j.jbior.2020.100744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Where are we with understanding of COVID-19?

    Akula, Shaw M / McCubrey, James A

    Advances in biological regulation

    2020  Volume 77, Page(s) 100745

    Abstract: Coronavirus disease 2019 caused by SARS-CoV-2 originated from China and spread across every corner of the world. The scientific interest on COVID-19 increased after WHO declared it a pandemic in the early February of 2020. In fact, this pandemic has had ... ...

    Abstract Coronavirus disease 2019 caused by SARS-CoV-2 originated from China and spread across every corner of the world. The scientific interest on COVID-19 increased after WHO declared it a pandemic in the early February of 2020. In fact, this pandemic has had a worldwide impact on economy, health, and lifestyle like no other in the last 100 years. SARS-CoV-2 belongs to Coronaviridae family and causes the deadliest clinical manifestations when compared to other viruses in the family. COVID-19 is an emerging zoonotic disease that has resulted in over 383,000 deaths around the world. Scientists are scrambling for ideas to develop treatment and prevention strategies to thwart the disease condition. In this review, we have attempted to summarize the latest information on the virus, disease, prevention, and treatment strategies. The future looks promising.
    MeSH term(s) Antiviral Agents/therapeutic use ; Ataxia/diagnosis ; Ataxia/physiopathology ; Ataxia/virology ; Betacoronavirus/pathogenicity ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/therapy ; COVID-19/transmission ; Communicable Disease Control/methods ; Communicable Disease Control/organization & administration ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/therapy ; Coronavirus Infections/transmission ; Humans ; Hydroxychloroquine/therapeutic use ; Nausea/diagnosis ; Nausea/physiopathology ; Nausea/virology ; Pandemics/prevention & control ; Personal Protective Equipment/supply & distribution ; Physical Distancing ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/therapy ; Pneumonia, Viral/transmission ; Quarantine/methods ; Quarantine/organization & administration ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index ; Vomiting/diagnosis ; Vomiting/physiopathology ; Vomiting/virology
    Chemical Substances Antiviral Agents ; Hydroxychloroquine (4QWG6N8QKH)
    Keywords covid19
    Language English
    Publishing date 2020-07-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2667413-0
    ISSN 2212-4934 ; 2212-4926
    ISSN (online) 2212-4934
    ISSN 2212-4926
    DOI 10.1016/j.jbior.2020.100745
    Database MEDical Literature Analysis and Retrieval System OnLINE

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