LIVIVO - Search results -

Search results

Result 1 - 10 of total 806

Search options

Article ; Online: Evaluation of the efficacy and safety of an integrated telerehabilitation platform for home-based cardiac REHABilitation in patients with heart failure (E-REHAB): protocol for a randomised controlled trial.

2023 Volume 13, Issue 8, Page(s) e073846

Abstract: ... analysis: The E-REHAB trial aims to evaluate the efficacy and safety of RH-01 for home-based CR compared ...

Abstract	Introduction: Cardiac rehabilitation (CR) is strongly recommended as a medical treatment to improve the prognosis and quality of life of patients with heart failure (HF); however, participation rates in CR are low compared with other evidence-based treatments. One reason for this is the geographical distance between patients' homes and hospitals. To address this issue, we developed an integrated telerehabilitation platform, RH-01, for home-based CR. We hypothesised that using the RH-01 platform for home-based CR would demonstrate non-inferiority compared with traditional centre-based CR. Methods and analysis: The E-REHAB trial aims to evaluate the efficacy and safety of RH-01 for home-based CR compared with traditional centre-based CR for patients with HF. This clinical trial will be conducted under a prospective, randomised, controlled and non-inferiority design with a primary focus on HF patients. Further, to assess the generalisability of the results in HF to other cardiovascular disease (CVD), the study will also include patients with other CVDs. The trial will enrol 108 patients with HF and 20 patients with other CVD. Eligible HF patients will be randomly assigned to either traditional centre-based CR or home-based CR in a 1:1 fashion. Patients with other CVDs will not be randomised, as safety assessment will be the primary focus. The intervention group will receive a 12-week programme conducted two or three times per week consisting of a remotely supervised home-based CR programme using RH-01, while the control group will receive a traditional centre-based CR programme. The primary endpoint of this trial is change in 6 min walk distance. Ethics and dissemination: The conduct of the study has been approved by an institutional review board at each participating site, and all patients will provide written informed consent before entry. The report of the study will be disseminated via scientific fora, including peer-reviewed publications and presentations at conferences. Trial registration number: jRCT:2052200064.
MeSH term(s)	Humans ; Cardiac Rehabilitation ; Telerehabilitation ; Prospective Studies ; Quality of Life ; Heart Failure ; Cardiovascular Diseases ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2023-08-24
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-073846
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Determination of optimal concentration of vitamin E in polyethylene liners for producing minimal biological response to prosthetic wear debris.

Matsumae, Gen / Kida, Hiroaki / Takahashi, Daisuke / Shimizu, Tomohiro / Ebata, Taku / Yokota, Shunichi / Alhasan, Hend / Aly, Mahmoud Khamis / Yutani, Tomoyo / Uetsuki, Keita / Terkawi, Mohamad Alaa / Iwasaki, Norimasa

Journal of biomedical materials research. Part B, Applied biomaterials

2022 Volume 110, Issue 7, Page(s) 1587–1593

Abstract: The introduction of vitamin E-blended ultra-high molecular weight polyethylene (VE-UHMWPE) for use ... with different concentrations of vitamin E of 0.1, 0.3, 0.5, and 1% and evaluated their biological reaction ... vitamin E concentration is the most appropriate concentration for use in prosthetic components ...

Abstract	The introduction of vitamin E-blended ultra-high molecular weight polyethylene (VE-UHMWPE) for use in prosthetic components of hip implants has resulted in the production of implants that have excellent mechanical properties and substantially less adverse cellular responses. Given the importance of a biological response to wear in the survival of a prosthesis, we generated wear debris from UHMWPE that had been prepared with different concentrations of vitamin E of 0.1, 0.3, 0.5, and 1% and evaluated their biological reaction in vitro and in vivo. All types of VE-UHMWPE debris promoted a significantly lower expression of Tnf-α in murine peritoneal macrophages than that induced by conventional UHMWPE debris. However, levels of Tnf-α were not significantly different among the macrophages that were stimulated with VE-UHMWPE wear at the concentrations tested. The ability of wear debris to induce inflammatory osteolysis was assessed in a mouse calvarial osteolysis model. The expressions of Tnf-α, Il-6, and Rankl in granulomatous tissue formed around the wear debris were significantly reduced in mice that had been implanted with 0.3%VE-UHMWPE debris as compared to the corresponding values for mice that had been implanted with UHMWPE debris. Consistent with this finding, 0.3%VE-UHMWPE debris showed the lowest osteolytic activity, as evidenced by the reduced bone resorption area, the degree of infiltration of inflammatory cells and the TRAP staining area. Our results suggested that a 0.3% vitamin E concentration is the most appropriate concentration for use in prosthetic components with a reduced adverse cellular response for prolonging the life-span of the implant.
MeSH term(s)	Animals ; Disease Models, Animal ; Mice ; Osteolysis/metabolism ; Polyethylene/adverse effects ; Polyethylenes/pharmacology ; Prosthesis Failure ; Skull/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Vitamin E/pharmacology
Chemical Substances	Polyethylenes ; Tumor Necrosis Factor-alpha ; Vitamin E (1406-18-4) ; Polyethylene (9002-88-4)
Language	English
Publishing date	2022-02-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2099992-6
ISSN	1552-4981 ; 1552-4973 ; 0021-9304
ISSN (online)	1552-4981
ISSN	1552-4973 ; 0021-9304
DOI	10.1002/jbm.b.35019
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6196: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Diverse effects of prostaglandin E₂ on vascular contractility.

Kida, Taiki / Sawada, Kei / Kobayashi, Koji / Hori, Masatoshi / Ozaki, Hiroshi / Murata, Takahisa

Heart and vessels

2013 Volume 29, Issue 3, Page(s) 390–395

Abstract: Prostaglandin E₂ (PGE₂) is a major prostanoid produced under inflammatory situations. There have ...

Abstract	Prostaglandin E₂ (PGE₂) is a major prostanoid produced under inflammatory situations. There have been controversial reports showing contractile or relaxant effect of PGE₂ on vascular tone in various types of blood vessels. Thus, it is still elusive whether and how PGE₂ modulates vascular tone. We here assessed the effects of PGE₂ on vascular contractility using different types of vasculatures isolated form rat. In endothelium-denuded aortas and mesenteric arteries, PGE₂ (1 nM-10 μM) concentration-dependently enhanced the contraction elicited by K(+) (35.4 mM) or norepinephrine (10 nM). In pulmonary arteries, PGE₂ did not alter the both-induced contraction. Tail arteries were relaxed by a low dose of PGE₂ (1-100 nM), but this response shifted to contraction by the higher dose of PGE₂ (300 nM-10 μM). There are four types of PGE₂ receptors EP1-4. RT-PCR showed that aortas and mesenteric arteries abundantly expressed EP3, while tail arteries abundantly expressed EP4. We next revealed that selective EP3 agonism enhanced the contraction in mesenteric arteries, whereas EP4 agonism induced relaxation in tail arteries. Taken together, PGE₂ causes different contractile responses depending on the type of vascular bed. This phenomenon may be due to the difference in expression pattern and activity of EP receptors.
MeSH term(s)	Animals ; Aorta/drug effects ; Aorta/metabolism ; Dinoprostone/pharmacology ; Dose-Response Relationship, Drug ; Male ; Mesenteric Arteries/drug effects ; Mesenteric Arteries/metabolism ; Muscle, Smooth, Vascular/drug effects ; Muscle, Smooth, Vascular/metabolism ; Pulmonary Artery/drug effects ; Pulmonary Artery/metabolism ; RNA, Messenger/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Prostaglandin E/agonists ; Receptors, Prostaglandin E/genetics ; Receptors, Prostaglandin E/metabolism ; Tail/blood supply ; Vasoconstriction/drug effects ; Vasoconstrictor Agents/pharmacology ; Vasodilation/drug effects ; Vasodilator Agents/pharmacology
Chemical Substances	RNA, Messenger ; Receptors, Prostaglandin E ; Vasoconstrictor Agents ; Vasodilator Agents ; Dinoprostone (K7Q1JQR04M)
Language	English
Publishing date	2013-06-09
Publishing country	Japan
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	89678-0
ISSN	1615-2573 ; 0910-8327 ; 0935-736X
ISSN (online)	1615-2573
ISSN	0910-8327 ; 0935-736X
DOI	10.1007/s00380-013-0374-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2049: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: The 19q12 bladder cancer GWAS signal: association with cyclin E function and aggressive disease.

Fu, Yi-Ping / Kohaar, Indu / Moore, Lee E / Lenz, Petra / Figueroa, Jonine D / Tang, Wei / Porter-Gill, Patricia / Chatterjee, Nilanjan / Scott-Johnson, Alexandra / Garcia-Closas, Montserrat / Muchmore, Brian / Baris, Dalsu / Paquin, Ashley / Ylaya, Kris / Schwenn, Molly / Apolo, Andrea B / Karagas, Margaret R / Tarway, McAnthony / Johnson, Alison /

Mumy, Adam / Schned, Alan / Guedez, Liliana / Jones, Michael A / Kida, Masatoshi / Hosain, G M Monawar / Malats, Nuria / Kogevinas, Manolis / Tardon, Adonina / Serra, Consol / Carrato, Alfredo / Garcia-Closas, Reina / Lloreta, Josep / Wu, Xifeng / Purdue, Mark / Andriole, Gerald L / Grubb, Robert L / Black, Amanda / Landi, Maria T / Caporaso, Neil E / Vineis, Paolo / Siddiq, Afshan / Bueno-de-Mesquita, H Bas / Trichopoulos, Dimitrios / Ljungberg, Börje / Severi, Gianluca / Weiderpass, Elisabete / Krogh, Vittorio / Dorronsoro, Miren / Travis, Ruth C / Tjønneland, Anne / Brennan, Paul / Chang-Claude, Jenny / Riboli, Elio / Prescott, Jennifer / Chen, Constance / De Vivo, Immaculata / Govannucci, Edward / Hunter, David / Kraft, Peter / Lindstrom, Sara / Gapstur, Susan M / Jacobs, Eric J / Diver, W Ryan / Albanes, Demetrius / Weinstein, Stephanie J / Virtamo, Jarmo / Kooperberg, Charles / Hohensee, Chancellor / Rodabough, Rebecca J / Cortessis, Victoria K / Conti, David V / Gago-Dominguez, Manuela / Stern, Mariana C / Pike, Malcolm C / Van Den Berg, David / Yuan, Jian-Min / Haiman, Christopher A / Cussenot, Olivier / Cancel-Tassin, Geraldine / Roupret, Morgan / Comperat, Eva / Porru, Stefano / Carta, Angela / Pavanello, Sofia / Arici, Cecilia / Mastrangelo, Giuseppe / Grossman, H Barton / Wang, Zhaoming / Deng, Xiang / Chung, Charles C / Hutchinson, Amy / Burdette, Laurie / Wheeler, William / Fraumeni, Joseph / Chanock, Stephen J / Hewitt, Stephen M / Silverman, Debra T / Rothman, Nathaniel / Prokunina-Olsson, Ludmila

Cancer research

2014 Volume 74, Issue 20, Page(s) 5808–5818

Abstract: ... which encodes cyclin E, a cell-cycle protein. We performed genetic fine-mapping analysis of the CCNE1 region ... disease, with P = 0.0015 for case-only analysis. Cyclin E protein expression analyzed in 265 ... allele (P(trend) = 0.024). Overexpression of recombinant cyclin E in cell lines caused significant ...

Abstract	A genome-wide association study (GWAS) of bladder cancer identified a genetic marker rs8102137 within the 19q12 region as a novel susceptibility variant. This marker is located upstream of the CCNE1 gene, which encodes cyclin E, a cell-cycle protein. We performed genetic fine-mapping analysis of the CCNE1 region using data from two bladder cancer GWAS (5,942 cases and 10,857 controls). We found that the original GWAS marker rs8102137 represents a group of 47 linked SNPs (with r(2) ≥ 0.7) associated with increased bladder cancer risk. From this group, we selected a functional promoter variant rs7257330, which showed strong allele-specific binding of nuclear proteins in several cell lines. In both GWASs, rs7257330 was associated only with aggressive bladder cancer, with a combined per-allele OR = 1.18 [95% confidence interval (CI), 1.09-1.27, P = 4.67 × 10(-5)] versus OR = 1.01 (95% CI, 0.93-1.10, P = 0.79) for nonaggressive disease, with P = 0.0015 for case-only analysis. Cyclin E protein expression analyzed in 265 bladder tumors was increased in aggressive tumors (P = 0.013) and, independently, with each rs7257330-A risk allele (P(trend) = 0.024). Overexpression of recombinant cyclin E in cell lines caused significant acceleration of cell cycle. In conclusion, we defined the 19q12 signal as the first GWAS signal specific for aggressive bladder cancer. Molecular mechanisms of this genetic association may be related to cyclin E overexpression and alteration of cell cycle in carriers of CCNE1 risk variants. In combination with established bladder cancer risk factors and other somatic and germline genetic markers, the CCNE1 variants could be useful for inclusion into bladder cancer risk prediction models.
MeSH term(s)	Case-Control Studies ; Chromosomes, Human, Pair 19/genetics ; Cyclin E/genetics ; Cyclin E/metabolism ; Gene Expression ; Gene Frequency ; Genome-Wide Association Study ; Haplotypes ; HeLa Cells ; Humans ; Oncogene Proteins/genetics ; Oncogene Proteins/metabolism ; Polymorphism, Single Nucleotide ; Urinary Bladder/metabolism ; Urinary Bladder/pathology ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/pathology
Chemical Substances	CCNE1 protein, human ; Cyclin E ; Oncogene Proteins
Language	English
Publishing date	2014-10-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-14-1531
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.135/5: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Apolipoprotein E and progression of chronic kidney disease.

Kida, Yujiro

JAMA

2006 Volume 295, Issue 1, Page(s) 35; author reply 35–6

MeSH term(s)	Angiotensin II/antagonists & inhibitors ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Antihypertensive Agents/therapeutic use ; Apolipoproteins E/genetics ; Chronic Disease ; Disease Progression ; Humans ; Kidney Diseases/genetics ; Kidney Diseases/physiopathology ; Risk Factors
Chemical Substances	Angiotensin-Converting Enzyme Inhibitors ; Antihypertensive Agents ; Apolipoproteins E ; Angiotensin II (11128-99-7)
Language	English
Publishing date	2006-01-04
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.295.1.35-a
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.88: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Book ; Thesis: Tumor-Nekrose-Faktor-alpha- und Lymphotoxin-alpha-Genpolymorphismen und ihre Assoziation mit letalen Infektionen bei akuter lymphoblastischer Leukämie im Kindesalter

Kida, Ekaterini

eine Fall-Kontroll-Studie

2009

Author's details	vorgelegt von Ekaterini Kida
Language	German
Size	56, [10] Bl., Ill., graph. Darst., 30 cm
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Hannover, Med. Hochsch., Diss., 2009
HBZ-ID	HT016459746
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2010 E 2370	order for loan	Magazin

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: SU-E-J-33: Geometric Agreement Check for Imaging System with Radiation Beam by KV and MV-CBCT.

Saotome, N / Kida, S / Haga, A / Masutani, Y / Ohtomo, K / Nakagawa, K

Medical physics

2012 Volume 39, Issue 6Part6, Page(s) 3659

Abstract: Purpose: The verification method of the geometry agreement between a light field and/or a laser coordinate and treatment beam should be easy and quick. In this presentation, we propose a novel QA method by using both kV- and MV-CBCT for kV-IGRT system. ... ...

Abstract	Purpose: The verification method of the geometry agreement between a light field and/or a laser coordinate and treatment beam should be easy and quick. In this presentation, we propose a novel QA method by using both kV- and MV-CBCT for kV-IGRT system. This method confirms the temporal unchanging the agreement of geometry in the kV-IGRT system with the treatment beam geometry. Methods: 1) MV-flexmap: Sequential MV-projection images were acquired during gantry rotation by iViewGT (Elekta) and MV-CBCT was reconstructed by in-house software with a flexmap correction. The flexmap is displacement of gantry and detector panel related with gantry sag. The geometric change affects the deranging reconstructed image. To evaluate how much displacement of EPID panel and gantry was detectable, the images of 8mm diameter ball-bearing (BB) located at the radiation isocenter were reconstructed with improper Flexmap.2) A comparison between the kV-CBCT and the MV-CBCT: The kV-CBCT was provided by X-ray Volume image (XVI) system (Elekta). To confirm the agreement for the geometry between kV-IGRT system and treatment beam, the kV-CBCTs of BB are compared with that of MV-CBCTs. Results: The flexmaps were modified to (b)1mm / (c)3mm shifted to the rotation direction and (d)3mm to the rotation axis. The MV-CBCT were reconstructed with the correct flexmap and with incorrect flexmap (b), (c) and (d).ã€€The geometric confirmation for MV-CBCT was done by comparison of the width and center of the BB on the MV-CBCT. The discrepancy of center between kV-CBCT and MV-CBCT was less than 1mm. Conclusions: Less than 1mm of the geometrical changing to rotation direction for MV-detector panel could be recognized by reconstructed images of BB. Using kV- and MV-CBCT enable us to perform the simple comparison for geometrical non-idealities between the kV-IGRT system and the treatment beam. Dr. K. Nakagawa received research grant from Elekta.
Language	English
Publishing date	2012-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	188780-4
ISSN	2473-4209 ; 0094-2405
ISSN (online)	2473-4209
ISSN	0094-2405
DOI	10.1118/1.4734866
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1210: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: SU-E-J-203: Determination of PTV Margin for Lung Tumor Using In-Treatment 4D CBCT.

Haga, A / Nakagawa, K / Yamashita, H / Takahashi, W / Sakumi, A / Masutani, Y / Kida, S / Saotome, N / Itoh, S / Shiraki, T / Ohtomo, K

Medical physics

2012 Volume 39, Issue 6Part9, Page(s) 3699

Abstract: Purpose: To determine a planning target volume (PTV) margin for lung cancer patients using a four-dimensional cone-beam CT (4D CBCT) acquired during volumetric modulated arc therapy (VMAT) treatment.: Methods: A VMAT plan for lung cancer patients was ...

Abstract	Purpose: To determine a planning target volume (PTV) margin for lung cancer patients using a four-dimensional cone-beam CT (4D CBCT) acquired during volumetric modulated arc therapy (VMAT) treatment. Methods: A VMAT plan for lung cancer patients was created by Pinnacle v9.0 (Philips) treatment planning system (TPS), where the gross target volume (GTVs) in each breathing phase was delineated by using 4D-planning CT scan (TOSHIBA and ANZAI). The VMAT treatment was performed with a stereotactic body frame after the registration using Elekta X-ray volume imaging (XVI) unit. Simultaneous cone-beam projection images were acquired for 3 or 4 fractions of 10 patients. The in-treatment 4D CBCT was reconstructed by dividing into four breathing phase bins. A total of 38 in-treatment 4D-CBCT sets were exported to Pinnacle TPS. The isocenter of in-treatment 4D CBCT was matched with that of 4D-planning CT. The tumor motion during treatment was manually tracked on in-treatment 4D CBCT, and the center-of-mass (COM) location of the tumor was estimated. Analyzing the tumor regions observed by in-treatment 4D CBCT, a PTV margin in our system was derived. Results: The average difference in COM location of the tumor was less than 1mm for all directions, while the standard deviations (SD's) were about 1.3mm, 1.6mm, and 2.1mm for the lateral, the vertical, and the longitudinal directions, respectively. The large discrepancy more than 3mm was observed for one patient. The required PTV margin was about 3-4mm for the lateral and the vertical directions, whereas it was about 5mm for the longitudinal direction. Conclusions: The uncertainties of the tumor motion caused by respiration were observed by in-treatment 4D CBCT images. It was feasible to determine the PTV margin from 4D volume images. K. Nakagawa receives research funding from Elekta.
Language	English
Publishing date	2012-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	188780-4
ISSN	2473-4209 ; 0094-2405
ISSN (online)	2473-4209
ISSN	0094-2405
DOI	10.1118/1.4735043
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1210: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Cyclodextrin host as a supramolecular catalyst in nonpolar solvents: stereoselective synthesis of (E)-3-alkylideneoxindoles

Asahara, Haruyasu / Kida, Toshiyuki / Hinoue, Tomoaki / Akashi, Mitsuru

Tetrahedron. 2013 Nov. 11, v. 69, no. 45

2013

Abstract: ... accelerated with enhanced E/Z selectivities in the presence of catalytic amounts of TIPS-β-CD. ...

Abstract	Heptakis(6-O-triisopropylsilyl)-β-cyclodextrin (TIPS-β-CD) effectively formed inclusion complexes with oxindole and its derivatives as guests in nonpolar solvents. Their inclusion complex formation was remarkably affected by the position and size of substituents on the oxindole ring of the guest. The Knoevenagel condensation reaction of these oxindoles with cinnamaldehyde to give 3-alkylideneoxindoles was accelerated with enhanced E/Z selectivities in the presence of catalytic amounts of TIPS-β-CD.
Keywords	catalysts ; chemical reactions ; chemical structure ; condensation ; cyclodextrins ; organic compounds ; solvents
Language	English
Dates of publication	2013-1111
Size	p. 9428-9433.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	204285-x
ISSN	1464-5416 ; 0040-4020 ; 0563-2064
ISSN (online)	1464-5416
ISSN	0040-4020 ; 0563-2064
DOI	10.1016/j.tet.2013.08.078
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.B 1076: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Regional differences in apolipoprotein E immunoreactivity in diffuse plaques in Alzheimer's disease brain.

Kida, E / Golabek, A A / Wisniewski, T / Wisniewski, K E

Neuroscience letters

1994 Volume 167, Issue 1-2, Page(s) 73–76

Abstract: Apolipoprotein E (Apo E) has been shown to be closely associated with beta amyloid ... in Alzheimer's disease (AD) brain. In the present study, we have found strong Apo E immunoreactivity in the amyloid cores ... of senile plaques (SP) in the various brain regions examined. However, Apo E immunoreactivity in diffuse plaques ...

Abstract	Apolipoprotein E (Apo E) has been shown to be closely associated with beta amyloid in Alzheimer's disease (AD) brain. In the present study, we have found strong Apo E immunoreactivity in the amyloid cores of senile plaques (SP) in the various brain regions examined. However, Apo E immunoreactivity in diffuse plaques varied distinctly and was strong within numerous cerebellar and cortical diffuse plaques, and absent or very weak within diffuse plaques in the striatum/thalamus. This distribution of Apo E immunoreactivity in SP correlates with the occurrence of small amounts of fibrillar amyloid in diffuse plaques that has been described in the cerebral and cerebellar cortex, but not in the basal ganglia. These results show that Apo E may be associated with sites of beta amyloid fibril formation in diffuse plaques in AD brain, but they also suggest that factors other than Apo E, probably local, may influence fibrillogenesis.
MeSH term(s)	Aged ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/metabolism ; Apolipoproteins E/metabolism ; Brain/metabolism ; Brain/pathology ; Humans ; Immunohistochemistry ; Middle Aged ; Tissue Distribution
Chemical Substances	Amyloid beta-Peptides ; Apolipoproteins E
Language	English
Publishing date	1994-02-14
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	194929-9
ISSN	1872-7972 ; 0304-3940
ISSN (online)	1872-7972
ISSN	0304-3940
DOI	10.1016/0304-3940(94)91030-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1166: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito