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  1. Book ; Online ; E-Book: Exosomes

    Edelstein, Lawrence R. / Smythies, John R. / Quesenberry, Peter J. / Noble, Denis

    a clinical compendium

    2020  

    Author's details edited by Lawrence Edelstein, John Smythies, Peter Quesenberry, Denis Noble
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xxvii, 519 Seiten), Illustrationen
    Publisher AP, Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020336315
    ISBN 978-0-12-816054-1 ; 9780128160534 ; 0-12-816054-3 ; 0128160535
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Non-Hodgkin lymphoma

    Quesenberry, Peter J. / Castillo, Jorge J.

    prognostic factors and targets

    (Cancer drug discovery and development)

    2013  

    Author's details Peter J. Quesenberry ; Jorge J. Castillo ed
    Series title Cancer drug discovery and development
    Keywords Lymphomas--Research ; Carcinogenesis--Animal models
    Language English
    Size VI, 304 S. : Ill., graph. Darst., 24 cm
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017547832
    ISBN 978-1-4614-5850-0 ; 9781461458517 ; 1-4614-5850-1 ; 146145851X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 5240 order for loan Magazin

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  3. Book: Stem cell biology and gene therapy

    Quesenberry, Peter J.

    1998  

    Author's details ed. by Peter J. Quesenberry
    Keywords Gene Therapy ; Hematopoietic Stemm Cells / therapeutic use ; Blutstammzelle ; Gentherapie ; Arzneistoffträger
    Subject Arzneimittel ; Arzneimittelträger ; Arzneimittelcarrier ; Drug Carrier ; Arzneiträger ; Arzneistoffträgersystem ; Hämatopoetische Stammzelle ; Blutstammzellen ; Somatische Gentherapie
    Language English
    Size XIII, 566 S. : Ill., graph. Darst.
    Publisher Wiley-Liss
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Includes index
    HBZ-ID HT009416109
    ISBN 0-471-14656-0 ; 978-0-471-14656-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1998 A 8434 order for loan Magazin

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  4. Article ; Online: The universal stem cell.

    Quesenberry, Peter J / Wen, Sicheng / Goldberg, Laura R / Dooner, Mark S

    Leukemia

    2022  Volume 36, Issue 12, Page(s) 2784–2792

    Abstract: Current dogma is that there exists a hematopoietic pluripotent stem cell, resident in the marrow, which is quiescent, but with tremendous proliferative and differentiative potential. Furthermore, the hematopoietic system is essentially hierarchical with ... ...

    Abstract Current dogma is that there exists a hematopoietic pluripotent stem cell, resident in the marrow, which is quiescent, but with tremendous proliferative and differentiative potential. Furthermore, the hematopoietic system is essentially hierarchical with progressive differentiation from the pluripotent stem cells to different classes of hematopoietic cells. However, results summarized here indicate that the marrow pluripotent hematopoietic stem cell is actively cycling and thus continually changing phenotype. As it progresses through cell cycle differentiation potential changes as illustrated by sequential changes in surface expression of B220 and GR-1 epitopes. Further data indicated that the potential of purified hematopoietic stem cells extends to multiple other non-hematopoietic cells. It appears that marrow stem cells will give rise to epithelial pulmonary cells at certain points in cell cycle. Thus, it appears that the marrow "hematopoietic" stem cell is also a stem cell for other non-hematopoietic tissues. These observations give rise to the concept of a universal stem cell. The marrow stem cell is not limited to hematopoiesis and its differentiation potential continually changes as it transits cell cycle. Thus, there is a universal stem cell in the marrow which alters its differentiation potential as it progresses through cell cycle. This potential is expressed when it resides in tissues compatible with its differentiation potential, at a particular point in cell cycle transit, or when it interacts with vesicles from that tissue.
    MeSH term(s) Bone Marrow Cells ; Hematopoietic Stem Cells/metabolism ; Hematopoiesis ; Cell Differentiation ; Cell Cycle
    Language English
    Publishing date 2022-10-28
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/s41375-022-01715-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2295: Show issues Location:
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  5. Article ; Online: Polarization of neutrophil granules - A characteristic of inflammatory states.

    Mantripragada, Kalyan C / Quesenberry, Peter J

    Blood cells, molecules & diseases

    2017  Volume 69, Page(s) 74

    MeSH term(s) Cytoplasmic Granules/metabolism ; Cytoplasmic Granules/pathology ; Humans ; Inflammation/metabolism ; Inflammation/pathology ; Neutrophils/metabolism ; Neutrophils/pathology
    Language English
    Publishing date 2017-09-25
    Publishing country United States
    Document type Letter
    ZDB-ID 1237083-6
    ISSN 1096-0961 ; 1079-9796
    ISSN (online) 1096-0961
    ISSN 1079-9796
    DOI 10.1016/j.bcmd.2017.09.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1138: Show issues Location:
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  6. Book ; Conference proceedings: Hematopoietic growth factors

    Quesenberry, Peter J.

    molecular biology to clinical applications of rG-CSF ; proceedings of a satellite symposium of the Sixth International Congress of Mucosal Immunology, Tokyo, July 22, 1990

    (International congress series ; 971)

    1991  

    Institution Symposium Hematopoietic Growth Factors, With Emphasis on RG-CSF: From Molecular and Cellular Biology to Clinical Applications of the Factors
    Event/congress International Congress on Mucosal Immunology (6, 1990, Tokio)
    Author's details [Symposium Hematopoietic Growth Factors, with Emphasis on RG-CSF: From Molecular and Cellular Biology to Clinical Applications of the Factors]. Ed.: Peter J. Quesenberry
    Series title International congress series ; 971
    Collection
    Keywords Hematopoietic Cell Growth Factors / congresses ; Koloniestimulierender Faktor
    Subject CSF ; Colony-stimulating factor
    Language English
    Size XIII, 173 S. : Ill., graph. Darst.
    Publisher Excerpta Medica
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT003960809
    ISBN 0-444-81462-0 ; 978-0-444-81462-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ua VI Zs 294/a -971- verfügbar in Königswinter Königswinter

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  7. Article: A Unique Neuropsychiatric Syndrome in Variant Hereditary Coproporphyria: Case Report and Review of the Literature.

    Baumgartner, Alex / Quesenberry, Peter J

    Journal of hematology

    2017  Volume 6, Issue 1, Page(s) 21–24

    Abstract: Hereditary coproporphyria (HCP) is the third most common of the acute porphyrias, after acute intermittent porphyria and variegate porphyria. It is caused by decreased activity of the sixth step in the heme biosynthetic pathway. Here we present a case of ...

    Abstract Hereditary coproporphyria (HCP) is the third most common of the acute porphyrias, after acute intermittent porphyria and variegate porphyria. It is caused by decreased activity of the sixth step in the heme biosynthetic pathway. Here we present a case of a woman with HCP who has experienced a wide variety of symptoms over several years. Most interesting among these is a unique neuropsychiatric syndrome marked by severe confusion, disorientation, and abnormal behavior. The literature is reviewed regarding the pathophysiology and management of neuropsychiatric manifestations of porphyria. As many other diagnoses are often considered before the diagnosis of porphyria is made, clinicians should keep in mind the highly variable neurological and psychiatric symptoms of porphyria.
    Language English
    Publishing date 2017-03-21
    Publishing country Canada
    Document type Case Reports
    ZDB-ID 2662519-2
    ISSN 1927-1220 ; 1927-1212
    ISSN (online) 1927-1220
    ISSN 1927-1212
    DOI 10.14740/jh315w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Differentiation Epitopes Define Hematopoietic Stem Cells and Change with Cell Cycle Passage.

    Goldberg, Laura R / Dooner, Mark S / Papa, Elaine / Pereira, Mandy / Del Tatto, Michael / Cheng, Yan / Wen, Sicheng / Quesenberry, Peter J

    Stem cell reviews and reports

    2022  Volume 18, Issue 7, Page(s) 2351–2364

    Abstract: Hematopoietic stem cells express differentiation markers B220 and Gr1 and are proliferative. We have shown that the expression of these entities changes with cell cycle passage. Overall, we conclude that primitive hematopoietic stem cells alter their ... ...

    Abstract Hematopoietic stem cells express differentiation markers B220 and Gr1 and are proliferative. We have shown that the expression of these entities changes with cell cycle passage. Overall, we conclude that primitive hematopoietic stem cells alter their differentiation potential with cell cycle progression. Murine derived long-term hematopoietic stem cells (LT-HSC) are cycling and thus always changing phenotype. Here we show that over one half of marrow LT-HSC are in the population expressing differentiation epitopes and that B220 and Gr-1 positive populations are replete with LT-HSC after a single FACS separation but if subjected to a second separation these cells no longer contain LT-HSC. However, with second separated cells there is a population appearing that is B220 negative and replete with cycling c-Kit, Sca-1 CD150 positive LT-HSC. There is a 3-4 h interval between the first and second B220 or GR-1 FACS separation during which the stem cells continue to cycle. Thus, the LT-HSC have lost B220 or GR-1 expression as the cells progress through cell cycle, although they have maintained the c-kit, Sca-1 and CD150 stem cells markers over this time interval. These data indicate that cycling stem cells express differentiation epitopes and alter their differentiation potential with cell cycle passage.
    MeSH term(s) Animals ; Antigens, Differentiation ; Cell Cycle ; Cell Differentiation/genetics ; Epitopes ; Hematopoietic Stem Cells ; Mice
    Chemical Substances Antigens, Differentiation ; Epitopes
    Language English
    Publishing date 2022-05-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2495577-2
    ISSN 2629-3277 ; 1558-6804 ; 1550-8943
    ISSN (online) 2629-3277 ; 1558-6804
    ISSN 1550-8943
    DOI 10.1007/s12015-022-10374-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6198: Show issues Location:
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  9. Article: Perspectives on the Potential Therapeutic Uses of Vesicles.

    Camussi, Giovanni / Quesenberry, Peter J

    Exosomes and microvesicles

    2015  Volume 1, Issue 6

    Abstract: The role of extracellular vesicles as an important mediator of cell-to-cell communication has been well established by many studies that have shown their capability for exchanging proteins, bioactive lipids and nucleic acids. Extracellular vesicles have ... ...

    Abstract The role of extracellular vesicles as an important mediator of cell-to-cell communication has been well established by many studies that have shown their capability for exchanging proteins, bioactive lipids and nucleic acids. Extracellular vesicles have been implicated in several physiological and pathological processes according to the cell of origin. Identification of the innate properties of extracellular vesicles derived from stem cells and from immune cells has led to the possibility of their exploitation in regenerative medicine and immune therapies. As extracellular vesicles are able to cross biological barriers, express surface receptors and contain defined cargoes able to target specific cells/tissues, they may represent a biocompatible and effective tool for drug delivery. Herein, we review and discuss the perspectives related to the therapeutic opportunities of extracellular vesicles.
    Language English
    Publishing date 2015-05-13
    Publishing country Croatia
    Document type Journal Article
    ZDB-ID 2802657-3
    ISSN 1848-9214
    ISSN 1848-9214
    DOI 10.5772/57393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Doublet spherocytes.

    Mantripragada, Kalyan / Quesenberry, Peter J

    Blood

    2014  Volume 124, Issue 1, Page(s) 12

    MeSH term(s) Anemia, Hemolytic, Autoimmune/pathology ; Anemia, Hemolytic, Autoimmune/physiopathology ; Female ; Humans ; Middle Aged ; Spherocytes/pathology ; Thrombocytopenia/pathology ; Thrombocytopenia/physiopathology
    Language English
    Publishing date 2014-08-10
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2014-01-549675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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