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  1. Article ; Online: A catalytic career: Studies spanning glutamine synthetase, phospholipase C, peroxiredoxin, and the intracellular messenger role of hydrogen peroxide.

    Rhee, Sue Goo

    The Journal of biological chemistry

    2019  Volume 294, Issue 13, Page(s) 5169–5180

    Abstract: I learned biochemistry from P. Boon Chock and Earl Stadtman while working on the regulation ... ...

    Abstract I learned biochemistry from P. Boon Chock and Earl Stadtman while working on the regulation of
    MeSH term(s) Animals ; Circadian Clocks ; Epidermal Growth Factor/metabolism ; Escherichia coli/enzymology ; Escherichia coli/metabolism ; Glutamate-Ammonia Ligase/metabolism ; Humans ; Hydrogen Peroxide/metabolism ; Peroxiredoxins/metabolism ; Signal Transduction ; Type C Phospholipases/metabolism
    Chemical Substances Epidermal Growth Factor (62229-50-9) ; Hydrogen Peroxide (BBX060AN9V) ; Peroxiredoxins (EC 1.11.1.15) ; Type C Phospholipases (EC 3.1.4.-) ; Glutamate-Ammonia Ligase (EC 6.3.1.2)
    Language English
    Publishing date 2019-03-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.X119.007975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Multiple functions of 2-Cys peroxiredoxins, I and II, and their regulations via post-translational modifications.

    Rhee, Sue Goo / Woo, Hyun Ae

    Free radical biology & medicine

    2020  Volume 152, Page(s) 107–115

    Abstract: Peroxiredoxins (Prxs) are an unusual family of thiol-specific peroxidases that possess a binding site for ... ...

    Abstract Peroxiredoxins (Prxs) are an unusual family of thiol-specific peroxidases that possess a binding site for H
    MeSH term(s) Animals ; Cysteine/metabolism ; Hydrogen Peroxide/metabolism ; Oxidation-Reduction ; Peroxiredoxins/genetics ; Peroxiredoxins/metabolism ; Protein Processing, Post-Translational
    Chemical Substances Hydrogen Peroxide (BBX060AN9V) ; Peroxiredoxins (EC 1.11.1.15) ; Cysteine (K848JZ4886)
    Language English
    Publishing date 2020-03-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2020.02.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Control of the signaling role of PtdIns(4)P at the plasma membrane through H

    Jo, Su In / Kim, Suree / Lim, Jung Mi / Rhee, Sue Goo / Jeong, Bo-Gyeong / Cha, Sun-Shin / Chang, Jae-Byum / Kang, Dongmin

    Redox biology

    2024  Volume 71, Page(s) 103097

    Abstract: Phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5) ... ...

    Abstract Phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P
    MeSH term(s) Phosphatidylinositols ; Hydrogen Peroxide/metabolism ; Phosphatidylinositol 4,5-Diphosphate/metabolism ; Phosphoric Monoester Hydrolases/metabolism ; Cell Membrane/metabolism ; Signal Transduction ; Endocytosis ; Nerve Tissue Proteins
    Chemical Substances Phosphatidylinositols ; synaptojanin (EC 3.1.3.-) ; Hydrogen Peroxide (BBX060AN9V) ; Phosphatidylinositol 4,5-Diphosphate ; Phosphoric Monoester Hydrolases (EC 3.1.3.2) ; Nerve Tissue Proteins
    Language English
    Publishing date 2024-02-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2024.103097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Overview on Peroxiredoxin.

    Rhee, Sue Goo

    Molecules and cells

    2016  Volume 39, Issue 1, Page(s) 1–5

    Abstract: ... of oxidation by peroxides (Hall et al., 2011; Rhee et al., 2012). Peroxides oxidize the CP-SH to cysteine ...

    Abstract Peroxiredoxins (Prxs) are a very large and highly conserved family of peroxidases that reduce peroxides, with a conserved cysteine residue, designated the "peroxidatic" Cys (CP) serving as the site of oxidation by peroxides (Hall et al., 2011; Rhee et al., 2012). Peroxides oxidize the CP-SH to cysteine sulfenic acid (CP-SOH), which then reacts with another cysteine residue, named the "resolving" Cys (CR) to form a disulfide that is subsequently reduced by an appropriate electron donor to complete a catalytic cycle. This overview summarizes the status of studies on Prxs and relates the following 10 minireviews.
    MeSH term(s) Animals ; Catalytic Domain ; Conserved Sequence ; Cysteine/metabolism ; Humans ; Oxidation-Reduction ; Peroxides/metabolism ; Peroxiredoxins/chemistry ; Peroxiredoxins/metabolism
    Chemical Substances Peroxides ; Peroxiredoxins (EC 1.11.1.15) ; Cysteine (K848JZ4886)
    Language English
    Publishing date 2016-02-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1148964-9
    ISSN 0219-1032 ; 1016-8478
    ISSN (online) 0219-1032
    ISSN 1016-8478
    DOI 10.14348/molcells.2016.2368
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mitochondrial H

    Rhee, Sue Goo / Kil, In Sup

    Free radical biology & medicine

    2016  Volume 100, Page(s) 73–80

    Abstract: Mitochondria produce hydrogen peroxide ( ... ...

    Abstract Mitochondria produce hydrogen peroxide (H
    Language English
    Publishing date 2016-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2016.10.011
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  6. Article ; Online: Mitochondrial H

    Rhee, Sue Goo / Kil, In Sup

    Free radical biology & medicine

    2016  Volume 99, Page(s) 120–127

    Abstract: Mitochondria produce hydrogen peroxide ( ... ...

    Abstract Mitochondria produce hydrogen peroxide (H
    Language English
    Publishing date 2016-08-04
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2016.07.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Maturation of Mitochondrially Targeted Prx V Involves a Second Cleavage by Mitochondrial Intermediate Peptidase That Is Sensitive to Inhibition by H

    Sim, Juhyun / Park, Jiyoung / Woo, Hyun Ae / Rhee, Sue Goo

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 3

    Abstract: Prx V mRNA contains two in-frame AUG codons, producing a long (L-Prx V) and short form of Prx V (S-Prx V), and mouse L-Prx V is expressed as a precursor protein containing a 49-amino acid N-terminal mitochondria targeting sequence. Here, we show that the ...

    Abstract Prx V mRNA contains two in-frame AUG codons, producing a long (L-Prx V) and short form of Prx V (S-Prx V), and mouse L-Prx V is expressed as a precursor protein containing a 49-amino acid N-terminal mitochondria targeting sequence. Here, we show that the N-terminal 41-residue sequence of L-Prx V is cleaved by mitochondrial processing peptidase (MPP) in the mitochondrial matrix to produce an intermediate Prx V (I-Prx V) with a destabilizing phenylalanine at its N-terminus, and further, that the next 8-residue sequence is cleaved by mitochondrial intermediate peptidase (MIP) to convert I-Prx V to a stabilized mature form that is identical to S-Prx V. Further, we show that when mitochondrial H
    Language English
    Publishing date 2021-02-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10030346
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  8. Article: Mitochondrial Peroxiredoxin III Protects against Non-Alcoholic Fatty Liver Disease Caused by a Methionine-Choline Deficient Diet.

    Park, Jiyoung / Kim, Nam Hee / Yi, Ho Jin / Rhee, Sue Goo / Woo, Hyun Ae

    Antioxidants (Basel, Switzerland)

    2022  Volume 12, Issue 1

    Abstract: Non-alcoholic fatty liver disease (NAFLD) is emerging as the most common chronic liver disease worldwide. In addition, NAFLD may increase the risk of cardiovascular and liver-related diseases, and displays features of metabolic syndrome. In NAFLD, ... ...

    Abstract Non-alcoholic fatty liver disease (NAFLD) is emerging as the most common chronic liver disease worldwide. In addition, NAFLD may increase the risk of cardiovascular and liver-related diseases, and displays features of metabolic syndrome. In NAFLD, oxidative stress is primarily caused by excessive free fatty acids. The oxidation of fatty acids is usually caused by β-oxidation of mitochondria under normal conditions, resulting in the production of energy. However, when the inflow of fatty acids in NAFLD becomes excessive, the β-oxidation of mitochondria becomes saturated and the oxidation process increases at sites including peroxisomes and microsomes, thereby increasing production of reactive oxygen species (ROS). Thus, hepatic mitochondrial ROS play an important role in the pathogenesis of NAFLD. Eliminating mitochondrial ROS may improve NAFLD, but the underlying mechanism remains unclear. We examined the effect of mitochondrial ROS on NAFLD by focusing on peroxiredoxin (Prx), an antioxidant protein that can remove hydrogen peroxide. The protective effect and pathological phenomenon of mitochondrial peroxiredoxin in methionine-choline deficient diet (MCD)-induced liver injury was assessed in a mouse model of NAFLD. In these mice, mitochondrial peroxiredoxin deficiency significantly increased hepatic steatosis and fibrosis. In addition, ablation of Prx III enhances susceptibility to MCD diet-induced oxidative stress and exacerbates NAFLD progression by promoting inflammation. The binding assay results also showed that Prx III-deficient mice had more severe liver damage than Prx III-abundant mice in MCD diet liver injury models. The present data suggest that mitochondrial peroxiredoxin III could be a therapeutic target for preventing and suppressing diet-induced NAFLD.
    Language English
    Publishing date 2022-12-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12010009
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  9. Article ; Online: Reflections on the days of phospholipase C.

    Rhee, Sue Goo

    Advances in biological regulation

    2013  Volume 53, Issue 3, Page(s) 223–231

    MeSH term(s) Animals ; Bacteria/enzymology ; Bacteria/genetics ; Biochemistry/history ; History, 20th Century ; History, 21st Century ; Humans ; Mammals/genetics ; Mammals/metabolism ; Type C Phospholipases/genetics ; Type C Phospholipases/metabolism
    Chemical Substances Type C Phospholipases (EC 3.1.4.-)
    Language English
    Publishing date 2013-09
    Publishing country England
    Document type Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2667413-0
    ISSN 2212-4934 ; 2212-4926
    ISSN (online) 2212-4934
    ISSN 2212-4926
    DOI 10.1016/j.jbior.2013.08.004
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  10. Article ; Online: Multiple Functions and Regulation of Mammalian Peroxiredoxins.

    Rhee, Sue Goo / Kil, In Sup

    Annual review of biochemistry

    2017  Volume 86, Page(s) 749–775

    Abstract: Peroxiredoxins (Prxs) constitute a major family of peroxidases, with mammalian cells expressing six Prx isoforms (PrxI to PrxVI). Cells produce hydrogen peroxide ( ... ...

    Abstract Peroxiredoxins (Prxs) constitute a major family of peroxidases, with mammalian cells expressing six Prx isoforms (PrxI to PrxVI). Cells produce hydrogen peroxide (H
    MeSH term(s) Animals ; Catalytic Domain ; Centrosome/metabolism ; Centrosome/ultrastructure ; Circadian Rhythm/genetics ; Gene Expression Regulation ; Humans ; Hydrogen Peroxide/metabolism ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Mitochondria/metabolism ; Mitochondria/ultrastructure ; Mitosis ; Oxidation-Reduction ; Peroxiredoxins/genetics ; Peroxiredoxins/metabolism ; Phosphorylation ; Signal Transduction
    Chemical Substances Isoenzymes ; Hydrogen Peroxide (BBX060AN9V) ; Peroxiredoxins (EC 1.11.1.15)
    Language English
    Publishing date 2017-06-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207924-0
    ISSN 1545-4509 ; 0066-4154
    ISSN (online) 1545-4509
    ISSN 0066-4154
    DOI 10.1146/annurev-biochem-060815-014431
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