LIVIVO - Search results -

Search results

Result 1 - 10 of total 1255

Search options

Article ; Online: Fentanyl overdose: Temporal effects and prognostic factors in SKH1 mice.

Newman, Mackenzie / Lynch, Cayla / Connery, Heather / Goldsmith, William / Nurkiewicz, Timothy / Raylman, Raymond / Boyd, Jonathan

Basic & clinical pharmacology & toxicology

2024 Volume 134, Issue 4, Page(s) 460–471

Abstract: Fentanyl exposure and overdose are growing concerns in public health and occupational safety. This study aimed to establish parameters of fentanyl lethality in SKH1 mice for future overdose research. Lethality was determined using the up-down procedure, ... ...

Abstract	Fentanyl exposure and overdose are growing concerns in public health and occupational safety. This study aimed to establish parameters of fentanyl lethality in SKH1 mice for future overdose research. Lethality was determined using the up-down procedure, with subjects monitored post-administration using pulse oximetry (5 min) and then whole-body plethysmography (40 min). Following the determination of subcutaneous dose-response, [18F]Fluorodeoxyglucose positron emission tomography (
MeSH term(s)	Humans ; Animals ; Mice ; Fluorodeoxyglucose F18/therapeutic use ; Prognosis ; Fentanyl/toxicity ; Positron-Emission Tomography ; Drug Overdose/drug therapy ; Analgesics, Opioid/therapeutic use
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Fentanyl (UF599785JZ) ; Analgesics, Opioid
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2134679-3
ISSN	1742-7843 ; 1742-7835
ISSN (online)	1742-7843
ISSN	1742-7835
DOI	10.1111/bcpt.13984
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uf I Zs.144: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Carotid wave analysis in young adults with a history of adolescent anorexia nervosa: a case control study.

Springall, Gabriella A C / Goldsmith, Greta / Zannino, Diana / Cheong, Jeanie / Mynard, Jonathan P / Yeo, Michele / Cheung, Michael M H

Journal of eating disorders

2024 Volume 12, Issue 1, Page(s) 21

Abstract: Background: Anorexia nervosa (AN) is associated with abnormalities that may increase the risk of future cardiovascular disease. This study assessed the cardiovascular health of individuals who recovered from AN during adolescence by conducting wave ... ...

Abstract	Background: Anorexia nervosa (AN) is associated with abnormalities that may increase the risk of future cardiovascular disease. This study assessed the cardiovascular health of individuals who recovered from AN during adolescence by conducting wave power analysis. Methods: Former AN patients discharged from the Royal Children's and Monash Children's Hospitals (N = 17) in Melbourne, Australia underwent ultrasound imaging of the right carotid artery. Wave power analysis was conducted to assess biomechanical interactions of the cardiovascular system. Patient measures were compared to healthy controls (N = 51). Results: Eighty-eight percent of the former AN patients and controls were female, aged approximately 25 years, with a healthy body mass index. Mean carotid flow and pulsatility index were not different between groups. Carotid arterial strain and distensibility were lower, and the wave speed and beta stiffness index higher in the former AN patients. Characteristic impedance was not different nor were the forward and backward wave amplitudes. However, wave reflection indices (ratios of backward-to-forward compression wave area, and wave-related effect on pressure and hydraulic power) were 12-18% lower in the former AN patients (p < 0.05). Conclusions: Increased carotid artery stiffness and reduced wave reflection are evident in young adults who recovered from adolescent AN. This may relate to an adaptive process that helps to maintain or restore flow and characteristic impedance despite increased vessel stiffness, with this warranting future investigation.
Language	English
Publishing date	2024-02-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2699357-0
ISSN	2050-2974
ISSN	2050-2974
DOI	10.1186/s40337-023-00963-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Primary MRSA Myositis Mimicking Septic Arthritis.

Abu-Abaa, Mohammad / Pulikeyil, Amy / Arshad, Hassaan / Goldsmith, Daniel

Case reports in critical care

2023 Volume 2023, Page(s) 5623876

Abstract: As the incidence of bacterial myositis and pyomyositis in the United States is rising, we aim to highlight the presentation of bacterial myositis which is known as a great imitator in tropical regions. This is a case report of a 61-year-old female ... ...

Abstract	As the incidence of bacterial myositis and pyomyositis in the United States is rising, we aim to highlight the presentation of bacterial myositis which is known as a great imitator in tropical regions. This is a case report of a 61-year-old female patient with poorly controlled diabetes who presented initially with lateral hip pain and tenderness. This was initially believed to be septic arthritis and warranted arthrocentesis. What makes this case interesting is that what was believed to be a primary community-acquired MRSA myositis, which progressed to a life-threatening septic shock, happened in a nontropical area (Northeastern USA) and in a patient with no underlying recent muscle injury. This case serves to remind clinicians that infectious myositis is gaining more incidence in nontropical regions and can masquerade as septic arthritis, requiring a high index of suspicion. Normal muscle enzymes like CK and aldolase do not rule out myositis.
Language	English
Publishing date	2023-02-28
Publishing country	United States
Document type	Case Reports
ZDB-ID	2927720-6
ISSN	2090-6439 ; 2090-6420
ISSN (online)	2090-6439
ISSN	2090-6420
DOI	10.1155/2023/5623876
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Exploring the thermal behaviour of the solvated structures of nifedipine.

Jones, Eleanor C L / Goldsmith, Kate E / Ward, Martin R / Bimbo, Luis M / Oswald, Iain D H

Acta crystallographica Section B, Structural science, crystal engineering and materials

2023 Volume 79, Issue Pt 2, Page(s) 164–175

Abstract: Understanding the solvation and desolvation of pharmaceutical materials is an important part of materials discovery and development. In situ structural data are vital to understand the changes to crystal form that may occur in the system. In this study, ... ...

Abstract	Understanding the solvation and desolvation of pharmaceutical materials is an important part of materials discovery and development. In situ structural data are vital to understand the changes to crystal form that may occur in the system. In this study, the isolation and characterization of seven solvates of the L-type calcium channel antagonist, nifedipine, is described using variable-temperature powder X-ray diffraction so that the structural evolution as a function of temperature can be followed. The solvates reported herein can be split into those that are structurally similar to the previously reported dimethyl sulfoxide (DMSO) and dioxane solvates and those that have a novel packing arrangement. Of particular note is the solvate with tetrahydrofuran (THF) which has a hydrogen-bonding motif between the nifedipine molecules very similar to that of metastable β-nifedipine. In addition to variable-temperature X-ray diffraction, the stability of the solid forms was assessed using differential scanning calorimetry and thermogravimetric analysis and indicates that in all cases desolvation results in the thermodynamically stable α-polymorph of nifedipine even with the THF solvate. From the diffraction data the pathway of desolvation during heating of the DMF solvate showed conversion to another likely 1:1 polymorph before desolvation to α-nifedipine. The desolvation of this material indicated a two-stage process; first the initial loss of 90% of the solvent before the last 10% is lost on melting. The methanol solvate shows interesting negative thermal expansion on heating, which is rarely reported in organic materials, but this behaviour can be linked back to the winerack-type hydrogen-bonding pattern of the nifedipine molecules.
Language	English
Publishing date	2023-03-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2020841-8
ISSN	2052-5206 ; 1600-5740 ; 1600-8650 ; 2052-5192
ISSN (online)	2052-5206 ; 1600-5740 ; 1600-8650
ISSN	2052-5192
DOI	10.1107/S2052520623001282
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Observed Profiles of Infant Temperament: Stability, Heritability, and Associations With Parenting.

Planalp, Elizabeth M / Goldsmith, H Hill

Child development

2019 Volume 91, Issue 3, Page(s) e563–e580

Abstract: Profiles of infant temperament were derived from 990 infants at 6 and 12 months of age using observed measures from the Laboratory Temperament Assessment Battery. Mothers and fathers completed questionnaires measuring parent affect and stress. Four ... ...

Abstract	Profiles of infant temperament were derived from 990 infants at 6 and 12 months of age using observed measures from the Laboratory Temperament Assessment Battery. Mothers and fathers completed questionnaires measuring parent affect and stress. Four profiles emerged at each age (typical, low negative, withdrawn/inhibited, and positive/active or low reactive) using latent profile analysis. Temperament profiles show some evidence of stability and heritability, particularly for the withdrawn/inhibited group. In addition, profiles relate to parent affect and stress in different ways for mothers and fathers. Results highlight the utility of a person-centered approach to temperamental research and are discussed in relation to developmental patterns of infant temperament.
MeSH term(s)	Behavioral Research ; Child Development ; Emotions ; Fathers ; Female ; Humans ; Infant ; Male ; Mothers ; Parenting/psychology ; Psychology, Child ; Surveys and Questionnaires ; Temperament
Language	English
Publishing date	2019-07-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	215602-7
ISSN	1467-8624 ; 0009-3920
ISSN (online)	1467-8624
ISSN	0009-3920
DOI	10.1111/cdev.13277
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Um IV Zs.158: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: The interpretation of intracellular measurements of membrane potential, resistance, and coupling in cells of higher plants.

Goldsmith, T H / Goldsmith, M H

Planta

2014 Volume 143, Issue 3, Page(s) 267–274

Abstract: Results of microelectrode impalements of parenchymal cells of coleoptiles made in several different laboratories differ widely. The highest membrane potentials correlate with lower input resistance and the presence of intercellular coupling, whereas high ...

Abstract	Results of microelectrode impalements of parenchymal cells of coleoptiles made in several different laboratories differ widely. The highest membrane potentials correlate with lower input resistance and the presence of intercellular coupling, whereas high input resistance seems to be associated with an absence of measurable coupling and possibly lower membrane potentials. In this paper we demonstrate that these results are consistent with (1) a tonoplast resistance several times greater than the input resistance of the cytoplasmic compartment, and (2) the presence of variable amounts of shunting introduced by insertion of the microelectrode through the cell membranes. The general consequences of this hypothesis are developed quantitatively. If the ideas are applicable to other tissues of higher plants-and on this point the evidence is still insufficient to judgeboth the design of experiments and the interpretation of measurements made with microelectrodes will have to be reevaluated.
Language	English
Publishing date	2014-01-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	208909-9
ISSN	1432-2048 ; 0032-0935 ; 1866-2749
ISSN (online)	1432-2048
ISSN	0032-0935 ; 1866-2749
DOI	10.1007/BF00391997
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 46/303: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: Water and chloride as allosteric inhibitors in WNK kinase osmosensing.

Teixeira, Liliana R / Akella, Radha / Humphreys, John M / He, Haixia / Goldsmith, Elizabeth J

bioRxiv : the preprint server for biology

2023

Abstract: Previous observations showed that chloride and osmotic stress regulate the autophosphorylation and activity of the kinase domains of WNK1 and WNK3. Further, prior crystallography on the asymmetric dimeric of the unphosphorylated WNK1 kinase domain (WNK1/ ... ...

Abstract	Previous observations showed that chloride and osmotic stress regulate the autophosphorylation and activity of the kinase domains of WNK1 and WNK3. Further, prior crystallography on the asymmetric dimeric of the unphosphorylated WNK1 kinase domain (WNK1/S382A, WNK1/SA) revealed conserved waters in the active site. Here we show by crystallography that PEG400 applied to crystals of dimeric WNK1/SA grown in space group P1 induces de-dimerization with a change in space group to P2
Language	English
Publishing date	2023-08-31
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.08.29.555411
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: A path towards single molecule vibrational strong coupling in a Fabry-Pérot microcavity.

Koner, Arghadip / Du, Matthew / Pannir-Sivajothi, Sindhana / Goldsmith, Randall H / Yuen-Zhou, Joel

Chemical science

2023 Volume 14, Issue 28, Page(s) 7753–7761

Abstract: Interaction between light and molecular vibrations leads to hybrid light-matter states called vibrational polaritons. Even though many intriguing phenomena have been predicted for single-molecule vibrational strong coupling (VSC), several studies suggest ...

Abstract	Interaction between light and molecular vibrations leads to hybrid light-matter states called vibrational polaritons. Even though many intriguing phenomena have been predicted for single-molecule vibrational strong coupling (VSC), several studies suggest that these effects tend to be diminished in the many-molecule regime due to the presence of dark states. Achieving single or few-molecule vibrational polaritons has been constrained by the need for fabricating extremely small mode volume infrared cavities. In this theoretical work, we propose an alternative strategy to achieve single-molecule VSC in a cavity-enhanced Raman spectroscopy (CERS) setup, based on the physics of cavity optomechanics. We then present a scheme harnessing few-molecule VSC to thermodynamically couple two reactions, such that a spontaneous electron transfer can now fuel a thermodynamically uphill reaction that was non-spontaneous outside the cavity.
Language	English
Publishing date	2023-06-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d3sc01411h
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Link Prediction with Continuous-Time Classical and Quantum Walks.

Goldsmith, Mark / Saarinen, Harto / García-Pérez, Guillermo / Malmi, Joonas / Rossi, Matteo A C / Maniscalco, Sabrina

Entropy (Basel, Switzerland)

2023 Volume 25, Issue 5

Abstract: Protein-protein interaction (PPI) networks consist of the physical and/or functional interactions between the proteins of an organism, and they form the basis for the field of network medicine. Since the biophysical and high-throughput methods used to ... ...

Abstract	Protein-protein interaction (PPI) networks consist of the physical and/or functional interactions between the proteins of an organism, and they form the basis for the field of network medicine. Since the biophysical and high-throughput methods used to form PPI networks are expensive, time-consuming, and often contain inaccuracies, the resulting networks are usually incomplete. In order to infer missing interactions in these networks, we propose a novel class of link prediction methods based on continuous-time classical and quantum walks. In the case of quantum walks, we examine the usage of both the network adjacency and Laplacian matrices for specifying the walk dynamics. We define a score function based on the corresponding transition probabilities and perform tests on six real-world PPI datasets. Our results show that continuous-time classical random walks and quantum walks using the network adjacency matrix can successfully predict missing protein-protein interactions, with performance rivalling the state-of-the-art.
Language	English
Publishing date	2023-04-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e25050730
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: First clinical evaluation of the safety and efficacy of tarumase for the debridement of venous leg ulcers.

Fairlamb, David M / Szepeshazi, Kinga / Goldsmith, David / Danos, Peter / Lev-Tov, Hadar / Young, Nathan / Hanft, Jason / Zelen, Charles

International wound journal

2024 Volume 21, Issue 3, Page(s) e14805

Abstract: We report the first clinical evaluation of a new enzymatic wound debridement product containing tarumase in venous leg ulcer patients. As a first-in-human study, this was a prospective, open-label, multi-centre, dose escalation study across five dose ... ...

Abstract	We report the first clinical evaluation of a new enzymatic wound debridement product containing tarumase in venous leg ulcer patients. As a first-in-human study, this was a prospective, open-label, multi-centre, dose escalation study across five dose cohorts and involving a total of 43 patients treated three times weekly for up to 4 weeks (12 applications). The primary and secondary endpoints of the study were to assess the systemic safety, local tolerability, and early proof of concept both for wound debridement and healing. Results indicated that the tarumase enzyme was well tolerated when applied topically to wounds, with no indications of systemic absorption, no evidence of antibody generation, and no systemic effects on coagulation pathways. Locally, there was no evidence of pain on application, no local itching, no increases in erythema, oedema, exudate or bleeding and only a few treatment emergent adverse events were reported. As the concentration of tarumase was escalated, trends towards faster and improved effectiveness of wound debridement were observed, especially in patients with significant slough at baseline. Trends towards faster rates of healing were also noted based on observations of increased granulation tissue, increased linear healing and reduction in surface area over the 4-week treatment period.
MeSH term(s)	Humans ; Blood Coagulation ; Debridement ; Prospective Studies ; Varicose Ulcer/therapy ; Wound Healing
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	2170920-8
ISSN	1742-481X ; 1742-4801
ISSN (online)	1742-481X
ISSN	1742-4801
DOI	10.1111/iwj.14805
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6006: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito