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  1. Article ; Online: Radiotherapy Versus Inguinofemoral Lymphadenectomy as Treatment for Vulvar Cancer Patients With Micrometastases in the Sentinel Node: Results of GROINSS-V II.

    Oonk, Maaike H M / Slomovitz, Brian / Baldwin, Peter J W / van Doorn, Helena C / van der Velden, Jacobus / de Hullu, Joanne A / Gaarenstroom, Katja N / Slangen, Brigitte F M / Vergote, Ignace / Brännström, Mats / van Dorst, Eleonora B L / van Driel, Willemien J / Hermans, Ralph H / Nunns, David / Widschwendter, Martin / Nugent, David / Holland, Cathrine M / Sharma, Aarti / DiSilvestro, Paul A /
    Mannel, Robert / Boll, Dorry / Cibula, David / Covens, Al / Provencher, Diane / Runnebaum, Ingo B / Luesley, David / Ellis, Patricia / Duncan, Timothy J / Tjiong, Ming Y / Cruickshank, Derek J / Kjølhede, Preben / Levenback, Charles F / Bouda, Jiri / Kieser, Katharina E / Palle, Connie / Spirtos, Nicola M / O'Malley, David M / Leitao, Mario M / Geller, Melissa A / Dhar, Kalyan / Asher, Viren / Tamussino, Karl / Tobias, Daniel H / Borgfeldt, Christer / Lea, Jayanthi S / Bailey, Jo / Lood, Margareta / Eyjolfsdottir, Brynhildur / Attard-Montalto, Stephen / Tewari, Krishnansu S / Manchanda, Ranjit / Jensen, Pernille T / Persson, Par / Van Le, Linda / Putter, Hein / de Bock, Geertruida H / Monk, Bradley J / Creutzberg, Carien L / van der Zee, Ate G J

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2021  Volume 39, Issue 32, Page(s) 3623–3632

    Abstract: Purpose: The Groningen International Study on Sentinel nodes in Vulvar cancer (GROINSS-V)-II ... in vulvar cancer patients with a metastatic sentinel node (SN).: Methods: GROINSS-V-II was a prospective ...

    Abstract Purpose: The Groningen International Study on Sentinel nodes in Vulvar cancer (GROINSS-V)-II investigated whether inguinofemoral radiotherapy is a safe alternative to inguinofemoral lymphadenectomy (IFL) in vulvar cancer patients with a metastatic sentinel node (SN).
    Methods: GROINSS-V-II was a prospective multicenter phase-II single-arm treatment trial, including patients with early-stage vulvar cancer (diameter < 4 cm) without signs of lymph node involvement at imaging, who had primary surgical treatment (local excision with SN biopsy). Where the SN was involved (metastasis of any size), inguinofemoral radiotherapy was given (50 Gy). The primary end point was isolated groin recurrence rate at 24 months. Stopping rules were defined for the occurrence of groin recurrences.
    Results: From December 2005 until October 2016, 1,535 eligible patients were registered. The SN showed metastasis in 322 (21.0%) patients. In June 2010, with 91 SN-positive patients included, the stopping rule was activated because the isolated groin recurrence rate in this group went above our predefined threshold. Among 10 patients with an isolated groin recurrence, nine had SN metastases > 2 mm and/or extracapsular spread. The protocol was amended so that those with SN macrometastases (> 2 mm) underwent standard of care (IFL), whereas patients with SN micrometastases (≤ 2 mm) continued to receive inguinofemoral radiotherapy. Among 160 patients with SN micrometastases, 126 received inguinofemoral radiotherapy, with an ipsilateral isolated groin recurrence rate at 2 years of 1.6%. Among 162 patients with SN macrometastases, the isolated groin recurrence rate at 2 years was 22% in those who underwent radiotherapy, and 6.9% in those who underwent IFL (
    Conclusion: Inguinofemoral radiotherapy is a safe alternative for IFL in patients with SN micrometastases, with minimal morbidity. For patients with SN macrometastasis, radiotherapy with a total dose of 50 Gy resulted in more isolated groin recurrences compared with IFL.
    MeSH term(s) Aged ; Female ; Humans ; Lymph Node Excision/adverse effects ; Lymph Node Excision/mortality ; Lymphatic Metastasis ; Middle Aged ; Neoplasm Micrometastasis ; Neoplasm Staging ; Prospective Studies ; Radiation Dosage ; Sentinel Lymph Node/pathology ; Sentinel Lymph Node/radiation effects ; Sentinel Lymph Node/surgery ; Time Factors ; Treatment Outcome ; Vulvar Neoplasms/mortality ; Vulvar Neoplasms/pathology ; Vulvar Neoplasms/therapy
    Language English
    Publishing date 2021-08-25
    Publishing country United States
    Document type Clinical Trial, Phase II ; Comparative Study ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't ; Webcast
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.21.00006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1847: Show issues Location:
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  2. Article ; Online: Prognostic significance of cathepsin V (CTSV/CTSL2) in breast ductal carcinoma in situ.

    Toss, Michael / Miligy, Islam / Gorringe, Kylie / Mittal, Karuna / Aneja, Ritu / Ellis, Ian / Green, Andrew / Rakha, Emad

    Journal of clinical pathology

    2019  Volume 73, Issue 2, Page(s) 76–82

    Abstract: Aims: Cathepsin V (CTSV/CTSL2) is a lysosomal cysteine proteinase and plays a role ...

    Abstract Aims: Cathepsin V (CTSV/CTSL2) is a lysosomal cysteine proteinase and plays a role in extracellular matrix degradation. It is associated with poor prognosis in invasive breast cancer (IBC), but its role in breast ductal carcinoma in situ (DCIS) remains unclear. In this study, we aimed to evaluate the prognostic significance of CTSV in DCIS.
    Methods: CTSV protein expression was immunohistochemically assessed in a well-characterised and annotated cohort of DCIS comprising pure DCIS (n=776) and DCIS coexisting with IBC (n=239). CTSV expression was analysed in tumour cells and surrounding stroma, including its association with clinicopathological parameters and outcome.
    Results: In pure DCIS, high CTSV expression was observed in 29% of epithelial tumour cells and 20% of surrounding stroma. High expression in both components was associated with features of poor prognosis including higher nuclear grade, hormone receptor negativity and HER2 positivity. In addition, stromal CTSV expression was associated with larger DCIS size, comedo-type necrosis and high proliferation index. DCIS associated with IBC showed higher CTSV expression than pure DCIS either within the epithelial tumour cells or surrounding stroma (p<0.0001 and p=0.001, respectively). In DCIS/IBC, CTSV expression was higher in the invasive component than DCIS component either in tumour cells or surrounding stroma (both p<0.0001). CTSV stromal expression was associated with invasive recurrence independent of other prognostic factors in patients treated with breast conserving surgery (HR=3.0, p=0.005).
    Conclusion: High expression of CTSV is associated with poor outcome in DCIS and is a potential marker to predict DCIS progression to invasive disease.
    MeSH term(s) Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Breast Neoplasms/enzymology ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Carcinoma, Intraductal, Noninfiltrating/enzymology ; Carcinoma, Intraductal, Noninfiltrating/pathology ; Cathepsins/analysis ; Cathepsins/genetics ; Cysteine Endopeptidases/analysis ; Cysteine Endopeptidases/genetics ; Disease Progression ; Female ; Humans ; Immunohistochemistry ; Middle Aged ; Prognosis ; Up-Regulation
    Chemical Substances Biomarkers, Tumor ; Cathepsins (EC 3.4.-) ; Cysteine Endopeptidases (EC 3.4.22.-) ; CTSV protein, human (EC 3.4.22.43)
    Language English
    Publishing date 2019-08-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 80261-x
    ISSN 1472-4146 ; 0021-9746
    ISSN (online) 1472-4146
    ISSN 0021-9746
    DOI 10.1136/jclinpath-2019-205939
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  3. Article: Optimal early active mobilisation protocol after extensor tendon repairs in zones V and VI: A systematic review of literature.

    Collocott, Shirley Jf / Kelly, Edel / Ellis, Richard F

    Hand therapy

    2017  Volume 23, Issue 1, Page(s) 3–18

    Abstract: Introduction: Early mobilisation protocols after repair of extensor tendons in zone V and VI ... active mobilisation protocols used after extensor tendon repair in zone V and VI. The purpose was ... mobilisation protocols after extensor tendon repair in zone V and VI. Databases searched were AMED, Embase ...

    Abstract Introduction: Early mobilisation protocols after repair of extensor tendons in zone V and VI provide better outcomes than immobilisation protocols. This systematic review investigated different early active mobilisation protocols used after extensor tendon repair in zone V and VI. The purpose was to determine whether any one early active mobilisation protocol provides superior results.
    Methods: An extensive literature search was conducted to identify articles investigating the outcomes of early active mobilisation protocols after extensor tendon repair in zone V and VI. Databases searched were AMED, Embase, Medline, Cochrane and CINAHL. Studies were included if they involved participants with extensor tendon repairs in zone V and VI in digits 2-5 and described a post-operative rehabilitation protocol which allowed early active metacarpophalangeal joint extension. Study designs included were randomised controlled trials, observational studies, cohort studies and case series. The Structured Effectiveness Quality Evaluation Scale was used to evaluate the methodological quality of the included studies.
    Results: Twelve articles met the inclusion criteria. Two types of early active mobilisation protocols were identified: controlled active motion protocols and relative motion extension splinting protocols. Articles describing relative motion extension splinting protocols were more recent but of lower methodological quality than those describing controlled active motion protocols. Participants treated with controlled active motion and relative motion extension splinting protocols had similar range of motion outcomes, but those in relative motion extension splinting groups returned to work earlier.
    Discussion: The evidence reviewed suggested that relative motion extension splinting protocols may allow an earlier return to function than controlled active motion protocols without a greater risk of complication.
    Language English
    Publishing date 2017-09-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2615398-1
    ISSN 1758-9991 ; 1758-9983
    ISSN (online) 1758-9991
    ISSN 1758-9983
    DOI 10.1177/1758998317729713
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Search for gluinos in events with an isolated lepton, jets and missing transverse momentum at [Formula: see text] = 13 Te V with the ATLAS detector.

    Aad, G / Abbott, B / Abdallah, J / Abdinov, O / Abeloos, B / Aben, R / Abolins, M / AbouZeid, O S / Abramowicz, H / Abreu, H / Abreu, R / Abulaiti, Y / Acharya, B S / Adamczyk, L / Adams, D L / Adelman, J / Adomeit, S / Adye, T / Affolder, A A /
    Agatonovic-Jovin, T / Agricola, J / Aguilar-Saavedra, J A / Ahlen, S P / Ahmadov, F / Aielli, G / Akerstedt, H / Åkesson, T P A / Akimov, A V / Alberghi, G L / Albert, J / Albrand, S / Verzini, M J Alconada / Aleksa, M / Aleksandrov, I N / Alexa, C / Alexander, G / Alexopoulos, T / Alhroob, M / Alimonti, G / Alison, J / Alkire, S P / Allbrooke, B M M / Allen, B W / Allport, P P / Aloisio, A / Alonso, A / Alonso, F / Alpigiani, C / Gonzalez, B Alvarez / Piqueras, D Álvarez / Alviggi, M G / Amadio, B T / Amako, K / Coutinho, Y Amaral / Amelung, C / Amidei, D / Santos, S P Amor Dos / Amorim, A / Amoroso, S / Amram, N / Amundsen, G / Anastopoulos, C / Ancu, L S / Andari, N / Andeen, T / Anders, C F / Anders, G / Anders, J K / Anderson, K J / Andreazza, A / Andrei, V / Angelidakis, S / Angelozzi, I / Anger, P / Angerami, A / Anghinolfi, F / Anisenkov, A V / Anjos, N / Annovi, A / Antonelli, M / Antonov, A / Antos, J / Anulli, F / Aoki, M / Bella, L Aperio / Arabidze, G / Arai, Y / Araque, J P / Arce, A T H / Arduh, F A / Arguin, J-F / Argyropoulos, S / Arik, M / Armbruster, A J / Armitage, L J / Arnaez, O / Arnold, H / Arratia, M / Arslan, O / Artamonov, A / Artoni, G / Artz, S / Asai, S / Asbah, N / Ashkenazi, A / Åsman, B / Asquith, L / Assamagan, K / Astalos, R / Atkinson, M / Atlay, N B / Augsten, K / Avolio, G / Axen, B / Ayoub, M K / Azuelos, G / Baak, M A / Baas, A E / Baca, M J / Bachacou, H / Bachas, K / Backes, M / Backhaus, M / Bagiacchi, P / Bagnaia, P / Bai, Y / Baines, J T / Baker, O K / Baldin, E M / Balek, P / Balestri, T / Balli, F / Balunas, W K / Banas, E / Banerjee, Sw / Bannoura, A A E / Barak, L / Barberio, E L / Barberis, D / Barbero, M / Barillari, T / Barklow, T / Barlow, N / Barnes, S L / Barnett, B M / Barnett, R M / Barnovska, Z / Baroncelli, A / Barone, G / Barr, A J / Navarro, L Barranco / Barreiro, F / da Costa, J Barreiro Guimarães / Bartoldus, R / Barton, A E / Bartos, P / Basalaev, A / Bassalat, A / Basye, A / Bates, R L / Batista, S J / Batley, J R / Battaglia, M / Bauce, M / Bauer, F / Bawa, H S / Beacham, J B / Beattie, M D / Beau, T / Beauchemin, P H / Bechtle, P / Beck, H P / Becker, K / Becker, M / Beckingham, M / Becot, C / Beddall, A J / Beddall, A / Bednyakov, V A / Bedognetti, M / Bee, C P / Beemster, L J / Beermann, T A / Begel, M / Behr, J K / Belanger-Champagne, C / Bell, A S / Bella, G / Bellagamba, L / Bellerive, A / Bellomo, M / Belotskiy, K / Beltramello, O / Belyaev, N L / Benary, O / Benchekroun, D / Bender, M / Bendtz, K / Benekos, N / Benhammou, Y / Noccioli, E Benhar / Benitez, J / Garcia, J A Benitez / Benjamin, D P / Bensinger, J R / Bentvelsen, S / Beresford, L / Beretta, M / Berge, D / Kuutmann, E Bergeaas / Berger, N / Berghaus, F / Beringer, J / Berlendis, S / Bernard, N R / Bernius, C / Bernlochner, F U / Berry, T / Berta, P / Bertella, C / Bertoli, G / Bertolucci, F / Bertram, I A / Bertsche, C / Bertsche, D / Besjes, G J / Bylund, O Bessidskaia / Bessner, M / Besson, N / Betancourt, C / Bethke, S / Bevan, A J / Bhimji, W / Bianchi, R M / Bianchini, L / Bianco, M / Biebel, O / Biedermann, D / Bielski, R / Biesuz, N V / Biglietti, M / De Mendizabal, J Bilbao / Bilokon, H / Bindi, M / Binet, S / Bingul, A / Bini, C / Biondi, S / Bjergaard, D M / Black, C W / Black, J E / Black, K M / Blackburn, D / Blair, R E / Blanchard, J-B / Blanco, J E / Blazek, T / Bloch, I / Blocker, C / Blum, W / Blumenschein, U / Blunier, S / Bobbink, G J / Bobrovnikov, V S / Bocchetta, S S / Bocci, A / Bock, C / Boehler, M / Boerner, D / Bogaerts, J A / Bogavac, D / Bogdanchikov, A G / Bohm, C / Boisvert, V / Bold, T / Boldea, V / Boldyrev, A S / Bomben, M / Bona, M / Boonekamp, M / Borisov, A / Borissov, G / Bortfeldt, J / Bortoletto, D / Bortolotto, V / Bos, K / Boscherini, D / Bosman, M / Sola, J D Bossio / Boudreau, J / Bouffard, J / Bouhova-Thacker, E V / Boumediene, D / Bourdarios, C / Bousson, N / Boutle, S K / Boveia, A / Boyd, J / Boyko, I R / Bracinik, J / Brandt, A / Brandt, G / Brandt, O / Bratzler, U / Brau, B / Brau, J E / Braun, H M / Madden, W D Breaden / Brendlinger, K / Brennan, A J / Brenner, L / Brenner, R / Bressler, S / Bristow, T M / Britton, D / Britzger, D / Brochu, F M / Brock, I / Brock, R / Brooijmans, G / Brooks, T / Brooks, W K / Brosamer, J / Brost, E / Broughton, J H / de Renstrom, P A Bruckman / Bruncko, D / Bruneliere, R / Bruni, A / Bruni, G / Brunt, B H / Bruschi, M / Bruscino, N / Bryant, P / Bryngemark, L / Buanes, T / Buat, Q / Buchholz, P / Buckley, A G / Budagov, I A / Buehrer, F / Bugge, M K / Bulekov, O / Bullock, D / Burckhart, H / Burdin, S / Burgard, C D / Burghgrave, B / Burka, K / Burke, S / Burmeister, I / Busato, E / Büscher, D / Büscher, V / Bussey, P / Butler, J M / Butt, A I / Buttar, C M / Butterworth, J M / Butti, P / Buttinger, W / Buzatu, A / Buzykaev, A R / Urbán, S Cabrera / Caforio, D / Cairo, V M / Cakir, O / Calace, N / Calafiura, P / Calandri, A / Calderini, G / Calfayan, P / Caloba, L P / Calvet, D / Calvet, S / Calvet, T P / Toro, R Camacho / Camarda, S / Camarri, P / Cameron, D / Armadans, R Caminal / Camincher, C / Campana, S / Campanelli, M / Campoverde, A / Canale, V / Canepa, A / Bret, M Cano / Cantero, J / Cantrill, R / Cao, T / Garrido, M D M Capeans / Caprini, I / Caprini, M / Capua, M / Caputo, R / Carbone, R M / Cardarelli, R / Cardillo, F / Carli, I / Carli, T / Carlino, G / Carminati, L / Caron, S / Carquin, E / Carrillo-Montoya, G D / Carter, J R / Carvalho, J / Casadei, D / Casado, M P / Casolino, M / Casper, D W / Castaneda-Miranda, E / Castelli, A / Gimenez, V Castillo / Castro, N F / Catinaccio, A / Catmore, J R / Cattai, A / Caudron, J / Cavaliere, V / Cavalli, D / Cavalli-Sforza, M / Cavasinni, V / Ceradini, F / Alberich, L Cerda / Cerio, B C / Cerqueira, A S / Cerri, A / Cerrito, L / Cerutti, F / Cerv, M / Cervelli, A / Cetin, S A / Chafaq, A / Chakraborty, D / Chan, S K / Chan, Y L / Chang, P / Chapman, J D / Charlton, D G / Chatterjee, A / Chau, C C / Barajas, C A Chavez / Che, S / Cheatham, S / Chegwidden, A / Chekanov, S / Chekulaev, S V / Chelkov, G A / Chelstowska, M A / Chen, C / Chen, H / Chen, K / Chen, S / Chen, X / Chen, Y / Cheng, H C / Cheng, H J / Cheng, Y / Cheplakov, A / Cheremushkina, E / Moursli, R Cherkaoui El / Chernyatin, V / Cheu, E / Chevalier, L / Chiarella, V / Chiarelli, G / Chiodini, G / Chisholm, A S / Chitan, A / Chizhov, M V / Choi, K / Chomont, A R / Chouridou, S / Chow, B K B / Christodoulou, V / Chromek-Burckhart, D / Chudoba, J / Chuinard, A J / Chwastowski, J J / Chytka, L / Ciapetti, G / Ciftci, A K / Cinca, D / Cindro, V / Cioara, I A / Ciocio, A / Cirotto, F / Citron, Z H / Ciubancan, M / Clark, A / Clark, B L / Clark, P J / Clarke, R N / Clement, C / Coadou, Y / Cobal, M / Coccaro, A / Cochran, J / Coffey, L / Colasurdo, L / Cole, B / Cole, S / Colijn, A P / Collot, J / Colombo, T / Compostella, G / Muiño, P Conde / Coniavitis, E / Connell, S H / Connelly, I A / Consorti, V / Constantinescu, S / Conta, C / Conti, G / Conventi, F / Cooke, M / Cooper, B D / Cooper-Sarkar, A M / Cornelissen, T / Corradi, M / Corriveau, F / Corso-Radu, A / Cortes-Gonzalez, A / Cortiana, G / Costa, G / Costa, M J / Costanzo, D / Cottin, G / Cowan, G / Cox, B E / Cranmer, K / Crawley, S J / Cree, G / Crépé-Renaudin, S / Crescioli, F / Cribbs, W A / Ortuzar, M Crispin / Cristinziani, M / Croft, V / Crosetti, G / Donszelmann, T Cuhadar / Cummings, J / Curatolo, M / Cúth, J / Cuthbert, C / Czirr, H / Czodrowski, P / D'Auria, S / D'Onofrio, M / De Sousa, M J Da Cunha Sargedas / Via, C Da / Dabrowski, W / Dai, T / Dale, O / Dallaire, F / Dallapiccola, C / Dam, M / Dandoy, J R / Dang, N P / Daniells, A C / Dann, N S / Danninger, M / Hoffmann, M Dano / Dao, V / Darbo, G / Darmora, S / Dassoulas, J / Dattagupta, A / Davey, W / David, C / Davidek, T / Davies, M / Davison, P / Davygora, Y / Dawe, E / Dawson, I / Daya-Ishmukhametova, R K / De, K / de Asmundis, R / De Benedetti, A / De Castro, S / De Cecco, S / De Groot, N / de Jong, P / De la Torre, H / De Lorenzi, F / De Pedis, D / De Salvo, A / De Sanctis, U / De Santo, A / De Regie, J B De Vivie / Dearnaley, W J / Debbe, R / Debenedetti, C / Dedovich, D V / Deigaard, I / Del Peso, J / Del Prete, T / Delgove, D / Deliot, F / Delitzsch, C M / Deliyergiyev, M / Dell'Acqua, A / Dell'Asta, L / Dell'Orso, M / Della Pietra, M / Della Volpe, D / Delmastro, M / Delsart, P A / Deluca, C / DeMarco, D A / Demers, S / Demichev, M / Demilly, A / Denisov, S P / Denysiuk, D / Derendarz, D / Derkaoui, J E / Derue, F / Dervan, P / Desch, K / Deterre, C / Dette, K / Deviveiros, P O / Dewhurst, A / Dhaliwal, S / Di Ciaccio, A / Di Ciaccio, L / Di Clemente, W K / Di Donato, C / Di Girolamo, A / Di Girolamo, B / Di Micco, B / Di Nardo, R / Di Simone, A / Di Sipio, R / Di Valentino, D / Diaconu, C / Diamond, M / Dias, F A / Diaz, M A / Diehl, E B / Dietrich, J / Diglio, S / Dimitrievska, A / Dingfelder, J / Dita, P / Dita, S / Dittus, F / Djama, F / Djobava, T / Djuvsland, J I / do Vale, M A B / Dobos, D / Dobre, M / Doglioni, C / Dohmae, T / Dolejsi, J / Dolezal, Z / Dolgoshein, B A / Donadelli, M / Donati, S / Dondero, P / Donini, J / Dopke, J / Doria, A / Dova, M T / Doyle, A T / Drechsler, E / Dris, M / Du, Y / Duarte-Campderros, J / Duchovni, E / Duckeck, G / Ducu, O A / Duda, D / Dudarev, A / Duflot, L / Duguid, L / Dührssen, M / Dunford, M / Yildiz, H Duran / Düren, M / Durglishvili, A / Duschinger, D / Dutta, B / Dyndal, M / Eckardt, C / Ecker, K M / Edgar, R C / Edson, W / Edwards, N C / Eifert, T / Eigen, G / Einsweiler, K / Ekelof, T / Kacimi, M El / Ellajosyula, V / Ellert, M / Elles, S / Ellinghaus, F / Elliot, A A / Ellis, N / Elmsheuser, J / Elsing, M / Emeliyanov, D / Enari, Y / Endner, O C / Endo, M / Ennis, J S / Erdmann, J / Ereditato, A / Ernis, G / Ernst, J / Ernst, M / Errede, S / Ertel, E / Escalier, M / Esch, H / Escobar, C / Esposito, B / Etienvre, A I / Etzion, E / Evans, H / Ezhilov, A / Fabbri, F / Fabbri, L / Facini, G / Fakhrutdinov, R M / Falciano, S / Falla, R J / Faltova, J / Fang, Y / Fanti, M / Farbin, A / Farilla, A / Farina, C / Farooque, T / Farrell, S / Farrington, S M / Farthouat, P / Fassi, F / Fassnacht, P / Fassouliotis, D / Giannelli, M Faucci / Favareto, A / Fawcett, W J / Fayard, L / Fedin, O L / Fedorko, W / Feigl, S / Feligioni, L / Feng, C / Feng, E J / Feng, H / Fenyuk, A B / Feremenga, L / Martinez, P Fernandez / Perez, S Fernandez / Ferrando, J / Ferrari, A / Ferrari, P / Ferrari, R / de Lima, D E Ferreira / Ferrer, A / Ferrere, D / Ferretti, C / Parodi, A Ferretto / Fiedler, F / Filipčič, A / Filipuzzi, M / Filthaut, F / Fincke-Keeler, M / Finelli, K D / Fiolhais, M C N / Fiorini, L / Firan, A / Fischer, A / Fischer, C / Fischer, J / Fisher, W C / Flaschel, N / Fleck, I / Fleischmann, P / Fletcher, G T / Fletcher, G / Fletcher, R R M / Flick, T / Floderus, A / Castillo, L R Flores / Flowerdew, M J / Forcolin, G T / Formica, A / Forti, A / Foster, A G / Fournier, D / 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    The European physical journal. C, Particles and fields

    2016  Volume 76, Issue 10, Page(s) 565

    Abstract: ... to masses of approximately 1.6 Te V depending on the mass spectrum of the simplified model, thus surpassing ...

    Abstract The results of a search for gluinos in final states with an isolated electron or muon, multiple jets and large missing transverse momentum using proton-proton collision data at a centre-of-mass energy of [Formula: see text] are presented. The dataset used was recorded in 2015 by the ATLAS experiment at the Large Hadron Collider and corresponds to an integrated luminosity of 3.2 fb[Formula: see text]. Six signal selections are defined that best exploit the signal characteristics. The data agree with the Standard Model background expectation in all six signal selections, and the largest deviation is a 2.1 standard deviation excess. The results are interpreted in a simplified model where pair-produced gluinos decay via the lightest chargino to the lightest neutralino. In this model, gluinos are excluded up to masses of approximately 1.6 Te V depending on the mass spectrum of the simplified model, thus surpassing the limits of previous searches.
    Language English
    Publishing date 2016-10-21
    Publishing country France
    Document type Journal Article
    ZDB-ID 1459069-4
    ISSN 1434-6052 ; 1434-6044
    ISSN (online) 1434-6052
    ISSN 1434-6044
    DOI 10.1140/epjc/s10052-016-4397-x
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  5. Article ; Online: A randomized clinical trial comparing early active motion programs: Earlier hand function, TAM, and orthotic satisfaction with a relative motion extension program for zones V and VI extensor tendon repairs.

    Collocott, Shirley J F / Kelly, Edel / Foster, Michael / Myhr, Heidi / Wang, Amy / Ellis, Richard F

    Journal of hand therapy : official journal of the American Society of Hand Therapists

    2019  Volume 33, Issue 1, Page(s) 13–24

    Abstract: ... mobilization programs are used after zones V and VI extensor tendon repairs; two programs used are relative ... with zones V-VI extensor tendon repairs were randomized into either a CAM or RME program. The Sollerman Hand ... earlier recovery of hand function and motion when compared to a CAM program following repair of zones V ...

    Abstract Study design: Randomized clinical trial with parallel groups.
    Introduction: Early active mobilization programs are used after zones V and VI extensor tendon repairs; two programs used are relative motion extension (RME) orthosis and controlled active motion (CAM). Although no comparative studies exist, use of the RME orthosis has been reported to support earlier hand function.
    Purpose of the study: This randomized clinical trial investigated whether patients managed with an RME program would recover hand function earlier postoperatively than those managed with a CAM program.
    Methods: Forty-two participants with zones V-VI extensor tendon repairs were randomized into either a CAM or RME program. The Sollerman Hand Function Test (SHFT) was the primary outcome measure of hand function. Days to return to work, QuickDASH (Disabilities of Arm, Shoulder and Hand) questionnaire, total active motion (TAM), grip strength, and patient satisfaction were the secondary measures of outcome.
    Results: The RME group demonstrated better results at four weeks for the SHFT score (P = .0073; 95% CI: -10.9, -1.8), QuickDASH score (P = .05; 95% CI: -0.05, 19.5), and TAM (P = .008; 95% CI: -65.4, -10.6). Days to return to work were similar between groups (P = .77; 95% CI: -28.1, 36.1). RME participants were more satisfied with the orthosis (P < .0001; 95% CI: 3.5, 8.4). No tendon ruptures occurred.
    Discussion: Participants managed using an RME program, and RME finger orthosis demonstrated significantly better early hand function, TAM, and orthosis satisfaction than those managed by the CAM program using a static wrist-hand-finger orthosis. This is likely due to the less restrictive design of the RME orthosis.
    Conclusions: The RME program supports safe earlier recovery of hand function and motion when compared to a CAM program following repair of zones V and VI extensor tendons.
    MeSH term(s) Adult ; Exercise Therapy/methods ; Female ; Hand Injuries/physiopathology ; Hand Injuries/rehabilitation ; Hand Injuries/surgery ; Hand Strength ; Humans ; Male ; Middle Aged ; Orthotic Devices ; Patient Satisfaction ; Range of Motion, Articular/physiology ; Recovery of Function ; Tendon Injuries/physiopathology ; Tendon Injuries/rehabilitation ; Tendon Injuries/surgery ; Time Factors ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2019-03-21
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 639284-2
    ISSN 1545-004X ; 0894-1130
    ISSN (online) 1545-004X
    ISSN 0894-1130
    DOI 10.1016/j.jht.2018.10.003
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  6. Article ; Online: (η4-Cyclooctatetraene)(η8-cyclooctatetraene)iodidotantalum(V)

    Pratik Verma / Victor J. Sussman / William W. Brennessel / John E. Ellis

    Acta Crystallographica Section E, Vol 70, Iss 7, Pp m245-m

    2014  Volume 246

    Abstract: The title complex, [Ta(η4-C8H8)(η8-C8H8)I], lies across a crystallographic mirror plane that includes the TaV atom and the iodide ligand. One cyclooctatetraene (cot) ring is η4-coordinating and is bisected by the mirror plane. The fold angle between the ... ...

    Abstract The title complex, [Ta(η4-C8H8)(η8-C8H8)I], lies across a crystallographic mirror plane that includes the TaV atom and the iodide ligand. One cyclooctatetraene (cot) ring is η4-coordinating and is bisected by the mirror plane. The fold angle between the plane of the coordinating butadiene portion and the middle plane of the ring is 27.4 (4)°. An additional minor fold angle of 9.3 (7)° exists between the final plane in the ring and the middle plane. The other cot ring is η8-coordinating and is also cut by the mirror plane. In this case, the ring is disordered over the mirror plane, and one position is modeled with appropriate restraints and constraints with respect to distances, angles and displacement parameters (the second position is generated by symmetry). This ring is nearly planar, with an r.m.s. deviation of only 0.05 Å when all eight C atoms are included in the calculation. Pairs of intermolecular η8-cot rings are parallel stacked and slightly off center, with a centroid–centroid distance of 3.652 Å. No other significant intermolecular interactions are observed. The compound is of interest as the first structurally characterized mixed halogen–cot complex of the group 5 metals and contains the longest terminal Ta—I distance [3.0107 (5) Å] reported to date.
    Keywords Chemistry ; QD1-999
    Subject code 512
    Language English
    Publishing date 2014-07-01T00:00:00Z
    Publisher International Union of Crystallography
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Reply to Francesco Montorsi, Alessandro Larcher, and Umberto Capitanio's Letter to the Editor re: Rohann J.M. Correa, Alexander V. Louie, Nicholas G. Zaorsky, et al. The Emerging Role of Stereotactic Ablative Radiotherapy for Primary Renal Cell Carcinoma: A Systematic Review and Meta-Analysis. Eur Urol Focus. 2019 Jun 24. pii: S2405-4569(19)30157-9. https://doi.org/10.1016/j.euf.2019.06.002. [Epub ahead of print].

    Correa, Rohann J M / Louie, Alexander V / Zaorsky, Nicholas G / Lehrer, Eric J / Ellis, Rodney / Ponsky, Lee / Kaplan, Irving / Mahadevan, Anand / Chu, William / Swaminath, Anand / Hannan, Raquibul / Onishi, Hiroshi / Teh, Bin S / Muacevic, Alexander / Lo, Simon S / Staehler, Michael / Siva, Shankar

    European urology focus

    2019  Volume 7, Issue 2, Page(s) 404–405

    MeSH term(s) Carcinoma, Renal Cell ; Humans ; Kidney Neoplasms ; Male ; Prostatic Neoplasms/surgery ; Radiosurgery
    Language English
    Publishing date 2019-11-01
    Publishing country Netherlands
    Document type Letter ; Comment
    ISSN 2405-4569
    ISSN (online) 2405-4569
    DOI 10.1016/j.euf.2019.10.004
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  8. Article: Arterial thrombosis in mice with factor V Leiden mutation.

    Sampram, Ellis S / Saad, Yasser / Ouriel, Kenneth

    Vascular

    2008  Volume 16, Issue 1, Page(s) 31–34

    Abstract: The factor V Leiden (FVL) mutation has been demonstrated to be associated with the development ...

    Abstract The factor V Leiden (FVL) mutation has been demonstrated to be associated with the development of venous thrombosis in humans. Whether such a propensity also exists in the arterial circulation remains controversial. In an effort to minimize the variability that clouds the clinical study of arterial thrombosis, we studied FVL-associated arterial thrombosis in an experimental model of homozygous, heterozygous, and wild-type mice. Heterozygous FVL mice were crossbred to C57BL/6J mice over several generations. The genotypes of the resulting three genotype groups (wild type, heterozygous FVL, and homozygous FVL) were blinded to the investigators. Arterial injury was produced with the injection of ferric chloride into an isolated segment of carotid artery. Arterial thrombosis was assessed with an ultrasonic flow probe and the time to occlusion (TTO) was recorded. The carotid artery occluded within 60 minutes of injury in 72 of the animals studied (97.3%). The carotid artery remained patent at 60 minutes in the remaining two animals, both of whom were subsequently found to be genotypically wild type. There was a statistically significant relationship between TTO and genotype (p = .002). TTO was greatest in the wild-type mice (p < .001 vs heterozygous, < .001 vs homozygous) and least in the homozygotes (p < .001 vs heterozygotes). Increased thrombogenicity is present in mice with the FVL mutation and is more prolonged in homozygotes than heterozygotes. These findings provide some corroboration to the clinical studies that suggest an increased risk of arterial events in patients with the FVL mutation.
    MeSH term(s) Animals ; Carotid Artery Injuries/complications ; Carotid Artery Thrombosis/etiology ; Carotid Artery Thrombosis/genetics ; Disease Models, Animal ; Factor V/genetics ; Genetic Predisposition to Disease ; Genotype ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mutation ; Thrombosis/genetics
    Chemical Substances factor V Leiden ; Factor V (9001-24-5)
    Language English
    Publishing date 2008-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2137151-9
    ISSN 1708-539X ; 1708-5381
    ISSN (online) 1708-539X
    ISSN 1708-5381
    DOI 10.2310/6670.2008.00007
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  9. Article: (η(4)-Cyclo-octa-tetra-ene)(η(8)-cyclo-octa-tetra-ene)iodido-tantalum(V).

    Verma, Pratik / Sussman, Victor J / Brennessel, William W / Ellis, John E

    Acta crystallographica. Section E, Structure reports online

    2014  Volume 70, Issue Pt 7, Page(s) m245–6

    Abstract: ... that includes the Ta(V) atom and the iodide ligand. One cyclo-octa-tetra-ene (cot) ring is η(4)-coordinating and ...

    Abstract The title complex, [Ta(η(4)-C8H8)(η(8)-C8H8)I], lies across a crystallographic mirror plane that includes the Ta(V) atom and the iodide ligand. One cyclo-octa-tetra-ene (cot) ring is η(4)-coordinating and is bis-ected by the mirror plane. The fold angle between the plane of the coordinating butadiene portion and the middle plane of the ring is 27.4 (4)°. An additional minor fold angle of 9.3 (7)° exists between the final plane in the ring and the middle plane. The other cot ring is η(8)-coordinating and is also cut by the mirror plane. In this case, the ring is disordered over the mirror plane, and one position is modeled with appropriate restraints and constraints with respect to distances, angles and displacement parameters (the second position is generated by symmetry). This ring is nearly planar, with an r.m.s. deviation of only 0.05 Å when all eight C atoms are included in the calculation. Pairs of inter-molecular η(8)-cot rings are parallel stacked and slightly off center, with a centroid-centroid distance of 3.652 Å. No other significant inter-molecular inter-actions are observed. The compound is of inter-est as the first structurally characterized mixed halogen-cot complex of the group 5 metals and contains the longest terminal Ta-I distance [3.0107 (5) Å] reported to date.
    Language English
    Publishing date 2014-06-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2041947-8
    ISSN 1600-5368
    ISSN 1600-5368
    DOI 10.1107/S1600536814012379
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  10. Article ; Online: Constrained-pairing mean-field theory. V. Triplet pairing formalism.

    Ellis, Jason K / Jiménez-Hoyos, Carlos A / Henderson, Thomas M / Tsuchimochi, Takashi / Scuseria, Gustavo E

    The Journal of chemical physics

    2011  Volume 135, Issue 3, Page(s) 34112

    Abstract: Describing strong (also known as static) correlation caused by degenerate or nearly degenerate orbitals near the Fermi level remains a theoretical challenge, particularly in molecular systems. Constrained-pairing mean-field theory has been quite ... ...

    Abstract Describing strong (also known as static) correlation caused by degenerate or nearly degenerate orbitals near the Fermi level remains a theoretical challenge, particularly in molecular systems. Constrained-pairing mean-field theory has been quite successful, capturing the effects of static correlation in bond formation and breaking in closed-shell molecular systems by using singlet electron entanglement to model static correlation at mean-field computational cost. This work extends the previous formalism to include triplet pairing. Additionally, a spin orbital extension of the "odd-electron" formalism is presented as a method for understanding electron entanglement in molecules.
    MeSH term(s) Chemical Hazard Release ; Hydrogen/chemistry ; Nitrogen/chemistry ; Quantum Theory
    Chemical Substances Hydrogen (7YNJ3PO35Z) ; Nitrogen (N762921K75)
    Language English
    Publishing date 2011-07-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/1.3610650
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