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  1. Article: Covid-19 in Iraq: Events and wisdom.

    Al-Kuraishy, Hayder M / Al-Gareeb, Ali I

    JPMA. The Journal of the Pakistan Medical Association

    2022  Volume 71Suppl 8, Issue 12, Page(s) S2–S3

    MeSH term(s) COVID-19 ; Humans ; Iraq ; Life Change Events ; SARS-CoV-2
    Language English
    Publishing date 2022-02-07
    Publishing country Pakistan
    Document type Editorial
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 845: Show issues Location:
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  2. Article ; Online: New insight on the possible role of statins in Vascular Parkinsonism: A need for presumptive therapy.

    Al-Kuraishy, Hayder M / Jabir, Majid S / Al-Gareeb, Ali I / Albuhadily, Ali K

    Ageing research reviews

    2024  Volume 95, Page(s) 102209

    Abstract: Vascular Parkinsonism (VP) is clinical term represents a progressive ischemic changes and subcortical lacunar infarct leading to Parkinsonism mainly in the lower limbs so called lower body Parkinsonism. The VP neuropathology is differed from that of PD ... ...

    Abstract Vascular Parkinsonism (VP) is clinical term represents a progressive ischemic changes and subcortical lacunar infarct leading to Parkinsonism mainly in the lower limbs so called lower body Parkinsonism. The VP neuropathology is differed from that of PD neuropathology which rarely associated with basal ganglion lesions. Dopamine transporters are normal in VP but are highly reduced in PD, and dopaminergic agonists had no effective role on VP. The neuropathological mechanisms of VP are related to vascular injury which induces the interruption of the neural connection between basal ganglion and cerebral cortex. Hyperlipidemia and other cardiometabolic risk factors augment VP risk and the related neuropathology. Targeting of these cardiometabolic disorders by lipid-lowering statins may be effective in the management of VP. Therefore, this mini-review aims to clarify the possible role of statins in the management of VP. Statins have neuroprotective effects against different neurodegenerative diseases by anti-inflammatory, antioxidant and antithrombotic effects with enhancement of endothelial function. In conclusion, statins can prevent and treat VP by inhibiting inflammatory and oxidative stress disorders, mitigating of white matter hyperintensities and improving of neuronal signaling pathways. Additional preclinical, clinical trials and prospective studies are warranted in this regard.
    MeSH term(s) Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Parkinson Disease, Secondary ; Parkinsonian Disorders/etiology ; Parkinsonian Disorders/pathology ; Vascular Diseases
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2024-01-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2024.102209
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5579: Show issues Location:
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  3. Article ; Online: New insights on the potential effect of orexin receptor antagonist suvorexant on Parkinson's disease symptoms.

    Al-Kuraishy, Hayder M / Al-Gareeb, Ali I / Alexiou, Athanasios / Papadakis, Marios / Saad, Hebatallah M / Batiha, Gaber El-Saber

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2024  Volume 45, Issue 5, Page(s) 2367–2368

    MeSH term(s) Humans ; Orexin Receptor Antagonists/pharmacology ; Orexin Receptor Antagonists/therapeutic use ; Parkinson Disease/drug therapy ; Azepines/pharmacology ; Azepines/therapeutic use ; Triazoles/pharmacology ; Triazoles/therapeutic use ; Sleep Initiation and Maintenance Disorders
    Chemical Substances Orexin Receptor Antagonists ; suvorexant (081L192FO9) ; Azepines ; Triazoles
    Language English
    Publishing date 2024-01-17
    Publishing country Italy
    Document type Letter
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-023-07261-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Hippo-YAP signaling and SARS-CoV-2 infection: a new mechanistic pathway.

    Al-Kuraishy, Hayder M / Al-Gareeb, Ali I / Saad, Hebatallah M / Batiha, Gaber El-Saber

    Cell stress & chaperones

    2023  Volume 28, Issue 2, Page(s) 121–123

    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Hippo Signaling Pathway ; Signal Transduction ; Cell Proliferation
    Language English
    Publishing date 2023-02-08
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1362749-1
    ISSN 1466-1268 ; 1355-8145
    ISSN (online) 1466-1268
    ISSN 1355-8145
    DOI 10.1007/s12192-023-01327-y
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    Zs.A 4797: Show issues Location:
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  5. Article ; Online: Crimean-Congo hemorrhagic fever in Iraq: Humanity before heroism.

    Al-Kuraishy, Hayder M / Al-Gareeb, Ali I / El-Bouseary, Maisra M / Batiha, Gaber El-Saber

    Wiener klinische Wochenschrift

    2023  Volume 135, Issue 21-22, Page(s) 637–638

    MeSH term(s) Humans ; Hemorrhagic Fever, Crimean/diagnosis ; Hemorrhagic Fever, Crimean/epidemiology ; Hemorrhagic Fever, Crimean/therapy ; Iraq ; Courage ; Hemorrhagic Fever Virus, Crimean-Congo
    Language English
    Publishing date 2023-06-13
    Publishing country Austria
    Document type Letter
    ZDB-ID 200462-8
    ISSN 1613-7671 ; 0043-5325 ; 0300-5178
    ISSN (online) 1613-7671
    ISSN 0043-5325 ; 0300-5178
    DOI 10.1007/s00508-023-02230-3
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    Zs.A 902: Show issues Location:
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  6. Article ; Online: The classical and non-classical axes of renin-angiotensin system in Parkinson disease: The bright and dark side of the moon.

    Al-Kuraishy, Hayder M / Al-Hamash, Sadiq M / Jabir, Majid S / Al-Gareeb, Ali I / Albuhadily, Ali K / Albukhaty, Salim / Sulaiman, Ghassan M

    Ageing research reviews

    2024  Volume 94, Page(s) 102200

    Abstract: Parkinson disease (PD) is a common brain neurodegenerative disease due to progressive degeneration of the dopaminergic neurons in the substantia nigra pars compacta (SNpc). Of note, the cardio-metabolic disorders such as hypertension are adversely affect ...

    Abstract Parkinson disease (PD) is a common brain neurodegenerative disease due to progressive degeneration of the dopaminergic neurons in the substantia nigra pars compacta (SNpc). Of note, the cardio-metabolic disorders such as hypertension are adversely affect PD neuropathology through exaggeration of renin-angiotensin system (RAS). The RAS affects the stability of dopaminergic neurons in the SNpc, and exaggeration of angiotensin II (AngII) is implicated in the development and progression of PD. RAS has two axes classical including angiotensin converting enzyme (ACE)/AngII/AT1R, and the non-classical axis which include ACE2/Ang1-7/Mas receptor, AngIII, AngIV, AT2R, and AT4R. It has been shown that brain RAS is differs from that of systemic RAS that produce specific neuronal effects. As well, there is an association between brain RAS and PD. Therefore, this review aims to revise from published articles the role of brain RAS in the pathogenesis of PD focusing on the non-classical pathway, and how targeting of this axis can modulate PD neuropathology.
    MeSH term(s) Humans ; Renin-Angiotensin System/physiology ; Parkinson Disease ; Neurodegenerative Diseases ; Angiotensin II/metabolism ; Hypertension ; Peptidyl-Dipeptidase A/metabolism
    Chemical Substances Angiotensin II (11128-99-7) ; Peptidyl-Dipeptidase A (EC 3.4.15.1)
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2024.102200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5579: Show issues Location:
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  7. Article ; Online: Long-term use of metformin and Alzheimer's disease: beneficial or detrimental effects.

    Al-Kuraishy, Hayder M / Al-Gareeb, Ali I / Saad, Hebatallah M / Batiha, Gaber El-Saber

    Inflammopharmacology

    2023  Volume 31, Issue 3, Page(s) 1107–1115

    Abstract: Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by extracellular deposition of amyloid beta (Aβ) leading to cognitive decline. Evidence from epidemiological studies has shown the association between type 2 diabetes ... ...

    Abstract Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by extracellular deposition of amyloid beta (Aβ) leading to cognitive decline. Evidence from epidemiological studies has shown the association between type 2 diabetes mellitus (T2DM) and the development of AD. T2DM and peripheral insulin resistance (IR) augment the risk of AD with the development of brain IR with inhibition of neuronal insulin receptors. These changes impair clearance of Aβ, increase secretion of Aβ
    MeSH term(s) Animals ; Humans ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Metformin/pharmacology ; Metformin/therapeutic use ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Neurodegenerative Diseases ; Prospective Studies ; Insulin/metabolism ; Insulin Resistance ; Brain/metabolism ; Disease Models, Animal
    Chemical Substances Amyloid beta-Peptides ; Metformin (9100L32L2N) ; Insulin
    Language English
    Publishing date 2023-02-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1080058-x
    ISSN 1568-5608 ; 0925-4692
    ISSN (online) 1568-5608
    ISSN 0925-4692
    DOI 10.1007/s10787-023-01163-7
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    Zs.A 3274: Show issues Location:
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  8. Article ; Online: Role of GABA pathway in motor and non-motor symptoms in Parkinson's disease: a bidirectional circuit.

    Alharbi, Bandar / Al-Kuraishy, Hayder M / Al-Gareeb, Ali I / Elekhnawy, Engy / Alharbi, Hind / Alexiou, Athanasios / Papadakis, Marios / Batiha, Gaber El-Saber

    European journal of medical research

    2024  Volume 29, Issue 1, Page(s) 205

    Abstract: Parkinson's disease (PD) is a progressive neurodegenerative disease as a result of the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The fundamental features of PD are motor and non-motor symptoms. PD symptoms develop ...

    Abstract Parkinson's disease (PD) is a progressive neurodegenerative disease as a result of the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The fundamental features of PD are motor and non-motor symptoms. PD symptoms develop due to the disruption of dopaminergic neurotransmitters and other neurotransmitters such as γ-aminobutyric acid (GABA). The potential role of GABA in PD neuropathology concerning the motor and non-motor symptoms of PD was not precisely discussed. Therefore, this review intended to illustrate the possible role of GABA in PD neuropathology regarding motor and non-motor symptoms. The GABA pathway is essential in regulating the inhibitory tone to prevent excessive stimulation of the cerebral cortex. Degeneration of dopaminergic neurons in PD is linked with reducing GABAergic neurotransmission. Decreasing GABA activity promotes mitochondrial dysfunction and oxidative stress, which are highly related to PD neuropathology. Hence, restoring GABA activity by GABA agonists may attenuate the progression of PD motor symptoms. Therefore, dysregulation of GABAergic neurons in the SNpc contributes to developing PD motor symptoms. Besides, PD non-motor symptoms are also related to the dysfunction of the GABAergic pathway, and amelioration of this pathway may reduce PD non-motor symptoms. In conclusion, the deregulation of the GABAergic pathway in PD might be intricate in developing motor and non-motor symptoms. Improving this pathway might be a novel, beneficial approach to control PD symptoms.
    MeSH term(s) Humans ; Parkinson Disease/metabolism ; Neurodegenerative Diseases ; gamma-Aminobutyric Acid/physiology ; Neurotransmitter Agents
    Chemical Substances gamma-Aminobutyric Acid (56-12-2) ; Neurotransmitter Agents
    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1329381-3
    ISSN 2047-783X ; 0949-2321
    ISSN (online) 2047-783X
    ISSN 0949-2321
    DOI 10.1186/s40001-024-01779-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4636: Show issues Location:
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  9. Article ; Online: Possible role of LCZ696 in atherosclerosis: new inroads and perspective.

    Al-Kuraishy, Hayder M / Al-Gareeb, Ali I / Elekhnawy, Engy / Batiha, Gaber El-Saber

    Molecular and cellular biochemistry

    2023  

    Abstract: LCZ696 blocks both angiotensin receptor type 1 (ATR1) and neprilysin (NEP), which are intricate in the degradation of natriuretic peptides (NPs) and other endogenous peptides. It has been shown NEP inhibitors and LCZ696 could be effectively in the ... ...

    Abstract LCZ696 blocks both angiotensin receptor type 1 (ATR1) and neprilysin (NEP), which are intricate in the degradation of natriuretic peptides (NPs) and other endogenous peptides. It has been shown NEP inhibitors and LCZ696 could be effectively in the management of atherosclerosis (AS). However, the underlying mechanism of LCZ696 in AS is needed to be clarified entirely. Hence, this review is directed to reconnoiter the mechanistic role of LCZ696 in AS. The anti-inflammatory role of LCZ696 is related to the inhibition of transforming growth factor beta (TGF-β)-activated kinase 1 (TAK) and nod-like receptor pyrin 3 receptor (NLRP3) inflammasome. Moreover, LCZ696, via inhibition of pro-inflammatory cytokines, oxidative stress, apoptosis and endothelial dysfunction can attenuate the development and progression of AS. In conclusion, LCZ696 could be effective in the management of AS through modulation of inflammatory and oxidative signaling. Preclinical and clinical studies are recommended in this regard.
    Language English
    Publishing date 2023-08-01
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 184833-1
    ISSN 1573-4919 ; 0300-8177
    ISSN (online) 1573-4919
    ISSN 0300-8177
    DOI 10.1007/s11010-023-04816-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 892: Show issues Location:
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  10. Article ; Online: The Potential Effect of Dapsone on the Inflammatory Reactions in Covid-19: Staggering view.

    Al-Kuraishy, Hayder M / Al-Gareeb, Ali I / Elekhnawy, Engy / Alexiou, Athanasios / Batiha, Gaber El-Saber

    Combinatorial chemistry & high throughput screening

    2023  

    Abstract: Severe SARS-CoV-2 infection is linked with an overstated immune response with the succeeding release of pro-inflammatory cytokines and progression of the cytokine storm. In addition, severe SARS-CoV-2 infection is associated with the development of ... ...

    Abstract Severe SARS-CoV-2 infection is linked with an overstated immune response with the succeeding release of pro-inflammatory cytokines and progression of the cytokine storm. In addition, severe SARS-CoV-2 infection is associated with the development of oxidative stress and coagulopathy. Dapsone (DPS) is a bacteriostatic antibiotic that has a potent anti-inflammatory effect. Thus, this mini-review aimed to elucidate the potential role of DPS in mitigating inflammatory disorders in Covid-19 patients. DPS inhibits neutrophil myeloperoxidase, inflammation, and neutrophil chemotaxis. Therefore, DPS could be effective against neutrophilia-induced complications in Covid-19. In addition, DPS could be effective in mitigating inflammatory and oxidative stress disorders by suppressing the expression of inflammatory signaling pathways and the generation of reactive oxygen species (ROS) correspondingly. In conclusion, DPS might be effective in the management of Covid-19 through the attenuation of inflammatory disorders. Therefore, preclinical and clinical studies are reasonable in this regard.
    Language English
    Publishing date 2023-03-31
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2064785-2
    ISSN 1875-5402 ; 1386-2073
    ISSN (online) 1875-5402
    ISSN 1386-2073
    DOI 10.2174/1386207326666230331121735
    Database MEDical Literature Analysis and Retrieval System OnLINE

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