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  1. Article ; Online: Formal synthesis of the ACE inhibitor benazepril x HCl via an asymmetric aza-Michael reaction.

    Yu, Luo-Ting / Huang, Ji-Ling / Chang, Ching-Yao / Yang, Teng-Kuei

    Molecules (Basel, Switzerland)

    2006  Volume 11, Issue 8, Page(s) 641–648

    Abstract: ... Our synthesis employed an asymmetric aza-Michael addition of L-homophenylalanine ethyl ester (LHPE, 1) to 4-(2 ... leading to benazepril x HCl (4). ...

    Abstract A formal enantioselective synthesis of benazepril.HCl (4), an anti- hypertensive drug, is reported. Our synthesis employed an asymmetric aza-Michael addition of L-homophenylalanine ethyl ester (LHPE, 1) to 4-(2-nitrophenyl)-4-oxo- but-2-enoic acid methyl ester (6) as the key step to prepare (2S,3'S)-2-(2-oxo-2,3,4,5- tetrahydro-1H-benzo[b]azepin-3-ylamino)-4-phenylbutyric acid ethyl ester (8), which is the key intermediate leading to benazepril x HCl (4).
    MeSH term(s) Angiotensin-Converting Enzyme Inhibitors/chemical synthesis ; Angiotensin-Converting Enzyme Inhibitors/chemistry ; Benzazepines/chemical synthesis ; Benzazepines/chemistry ; Models, Chemical ; Solvents/chemistry
    Chemical Substances Angiotensin-Converting Enzyme Inhibitors ; Benzazepines ; Solvents ; benazepril (UDM7Q7QWP8)
    Language English
    Publishing date 2006-08-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/11080641
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  2. Book ; Online: Tackling Multiple Tasks with One Single Learning Framework

    Yang, Michael X.

    2022  

    Abstract: ... from Xuewen Yang to Michael X. Yang. So I started using this name now ...

    Abstract Deep Multi-Task Learning (DMTL) has been widely studied in the machine learning community and applied to a broad range of real-world applications. Searching for the optimal knowledge sharing in DMTL is more challenging for sequential learning problems, as the task relationship will change in the temporal dimension. In this paper, we propose a flexible and efficient framework called HierarchicalTemporal Activation Network (HTAN) to simultaneously explore the optimal sharing of the neural network hierarchy (hierarchical axis) and the time-variant task relationship (temporal axis). HTAN learns a set of time-variant activation functions to encode the task relation. A functional regularization implemented by a modulated SPDNet and adversarial learning is further proposed to enhance the DMTL performance. Comprehensive experiments on several challenging applications demonstrate that our HTAN-SPD framework outperforms SOTA methods significantly in sequential DMTL.

    Comment: In submission to NeuroIPS. I changed my name from Xuewen Yang to Michael X. Yang. So I started using this name now
    Keywords Computer Science - Machine Learning
    Subject code 006
    Publishing date 2022-05-29
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Improving Speed of Cerebrospinal Fluid Collection Safely During Lumbar Punctures.

    Yang, Michael X / Ault, Mark J

    Annals of emergency medicine

    2020  Volume 77, Issue 1, Page(s) 129–130

    MeSH term(s) Cerebrospinal Fluid ; Humans ; Patient Safety ; Quality Improvement ; Spinal Puncture/adverse effects ; Spinal Puncture/instrumentation ; Spinal Puncture/methods ; Time Factors
    Language English
    Publishing date 2020-12-21
    Publishing country United States
    Document type Letter
    ZDB-ID 603080-4
    ISSN 1097-6760 ; 0196-0644
    ISSN (online) 1097-6760
    ISSN 0196-0644
    DOI 10.1016/j.annemergmed.2020.07.001
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    Zs.A 1344: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Central Venous Catheter Insertion in the Prone Position-A Last Resort in Critically Ill COVID-19 Patients.

    Yang, Michael X / Ng, Philip K

    Journal of intensive care medicine

    2020  Volume 36, Issue 3, Page(s) 373–375

    Abstract: Background: In the setting of the COVID pandemic, many patients falling ill with acute respiratory distress syndrome eventually require prone positioning for gas exchange. Traditionally, central venous catheters are inserted with patient in the supine ... ...

    Abstract Background: In the setting of the COVID pandemic, many patients falling ill with acute respiratory distress syndrome eventually require prone positioning for gas exchange. Traditionally, central venous catheters are inserted with patient in the supine or Trendelenburg position. However, when a patient cannot tolerate supine position and the need for central venous access is urgent, catheter placement may be considered with the patient in the prone position.
    Case summary: A 69-year-old male with rapidly declining respiratory status secondary to COVID pneumonia quickly developed acute respiratory distress syndrome, was rapidly intubated, and then placed in the prone position. Patient could not tolerate the supine position even briefly and required a central venous catheter insertion for continuous renal replacement therapy. We kept the patient in the prone position and successfully inserted a central venous catheter in such position with real-time ultrasound guidance and using micropuncture technique.
    Conclusion: In the setting of the COVID pandemic, many cases of acute respiratory distress syndrome require patients to be prone in order to improve gas exchange. In the most severe situations, these patients would not be able to tolerate rotating back to the supine position but would still require central venous catheter insertion urgently. We demonstrated feasibility of central venous catheter insertion in the prone position in these severely ill patients.
    MeSH term(s) Aged ; COVID-19/therapy ; Catheterization, Central Venous/methods ; Humans ; Intubation, Intratracheal ; Male ; Patient Positioning/methods ; Prone Position ; Punctures ; Respiratory Distress Syndrome/therapy ; SARS-CoV-2 ; Ultrasonography, Interventional/methods
    Keywords covid19
    Language English
    Publishing date 2020-09-16
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 632828-3
    ISSN 1525-1489 ; 0885-0666
    ISSN (online) 1525-1489
    ISSN 0885-0666
    DOI 10.1177/0885066620959649
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    Zs.A 2158: Show issues Location:
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  5. Article ; Online: Multispectral Large-Panel X-ray Imaging Enabled by Stacked Metal Halide Scintillators.

    Ran, Peng / Yang, Lurong / Jiang, Tingming / Xu, Xuehui / Hui, Juan / Su, Yirong / Kuang, Cuifang / Liu, Xu / Yang, Yang Michael

    Advanced materials (Deerfield Beach, Fla.)

    2022  Volume 34, Issue 42, Page(s) e2205458

    Abstract: Conventional energy-integration black-white X-ray imaging lacks the spectral information of X ... ray photons. Although X-ray spectra (energy) can be distinguished by the photon-counting technique typically ... with CdZnTe detectors, it is very challenging to be applied to large-area flat-panel X-ray imaging (FPXI ...

    Abstract Conventional energy-integration black-white X-ray imaging lacks the spectral information of X-ray photons. Although X-ray spectra (energy) can be distinguished by the photon-counting technique typically with CdZnTe detectors, it is very challenging to be applied to large-area flat-panel X-ray imaging (FPXI). Herein, multilayer stacked scintillators of different X-ray absorption capabilities and scintillation spectra are designed; in this scenario, the X-ray energy can be discriminated by detecting the emission spectra of each scintillator; therefore, multispectral X-ray imaging can be easily obtained by color or multispectral visible-light camera in a single shot of X-rays. To verify this idea, stacked multilayer scintillators based on several emerging metal halides are fabricated in a cost-effective and scalable solution process, and proof-of-concept multispectral (or multi-energy) FPXI are experimentally demonstrated. The dual-energy X-ray image of a "bone-muscle" model clearly shows the details that are invisible in conventional energy-integration FPXI. By stacking four layers of specifically designed multilayer scintillators with appropriate thicknesses, a prototype FPXI with four energy channels is realized, proving its extendibility to multispectral or even hyperspectral X-ray imaging. This study provides a facile and effective strategy to realize multispectral large-area flat-panel X-ray imaging.
    Language English
    Publishing date 2022-09-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202205458
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  6. Article ; Online: In Situ Fabrication of Cs

    Hu, Xudong / Yan, Peng / Ran, Peng / Lu, Linpeng / Leng, Jing / Yang, Yang Michael / Li, Xiaoming

    The journal of physical chemistry letters

    2022  Volume 13, Issue 13, Page(s) 2862–2870

    Abstract: ... ...

    Abstract Cs
    MeSH term(s) Diagnostic Imaging ; Iodides ; Nanoparticles ; Thallium ; X-Rays
    Chemical Substances Iodides ; Thallium (AD84R52XLF)
    Language English
    Publishing date 2022-03-24
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.2c00456
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  7. Article ; Online: A Paralyzing Vacation: Surfer's Myelopathy.

    Yang, Michael X / Ault, Mark J

    The American journal of medicine

    2019  Volume 132, Issue 11, Page(s) 1289–1291

    MeSH term(s) Athletic Injuries/diagnostic imaging ; Athletic Injuries/drug therapy ; Diagnosis, Differential ; Female ; Humans ; Magnetic Resonance Imaging ; Risk Factors ; Spinal Cord Diseases/diagnostic imaging ; Spinal Cord Diseases/drug therapy ; Steroids/therapeutic use ; Water Sports/injuries ; Young Adult
    Chemical Substances Steroids
    Language English
    Publishing date 2019-04-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2019.03.041
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    Ua VI Zs.289: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Intestinal Spirochetosis Masquerading as Inflammatory Bowel Disease.

    Vipani, Aarshi / Yang, Michael X

    The American journal of medicine

    2019  Volume 132, Issue 8, Page(s) e654–e655

    MeSH term(s) Adult ; Anemia/complications ; Anemia/etiology ; Anti-Bacterial Agents/therapeutic use ; Brachyspira/drug effects ; Brachyspira/pathogenicity ; Delayed Diagnosis ; Diagnosis, Differential ; Gastrointestinal Hemorrhage/etiology ; HIV Infections/diagnosis ; Humans ; Inflammatory Bowel Diseases/diagnosis ; Male ; Metronidazole/therapeutic use ; Spirochaetales Infections/complications ; Spirochaetales Infections/diagnosis
    Chemical Substances Anti-Bacterial Agents ; Metronidazole (140QMO216E)
    Language English
    Publishing date 2019-04-01
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2019.03.013
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  9. Article ; Online: Neural correlates of chocolate brand preference: A functional MRI study.

    Peiris, Senal / Tobia, Michael J / Smith, Andrew / Grun, Emily / Elyan, Rommy / Eslinger, Paul J / Yang, Qing X / Karunanayaka, Prasanna

    Journal of neuroimaging : official journal of the American Society of Neuroimaging

    2024  

    Abstract: Background and purpose: Preferences can be developed for, or against, specific brands and services. Using two functional magnetic resonance imaging (fMRI) experiments, this study investigated two dissociable aspects of reward processing, craving and ... ...

    Abstract Background and purpose: Preferences can be developed for, or against, specific brands and services. Using two functional magnetic resonance imaging (fMRI) experiments, this study investigated two dissociable aspects of reward processing, craving and liking, in chocolate lovers. The goal was to further delineate the neural basis supporting branding effects using familiar chocolate (FC) and unfamiliar chocolate (UC) brand images.
    Methods: In the first experiment, subjects rated their subjective craving and liking on a scale of 1-5 (weak-strong) for each FC and UC image. In the second experiment, they performed a choice task between FC and UC images.
    Results: Both the craving and liking ratings were significantly greater for FC and were differentially correlated with choice behavior. Craving ratings predicted greater preference for UC, and liking ratings predicted greater preference for FC. A contrast of neural activity for UC versus FC choice trials revealed significantly greater activation for UC choices in the bilateral inferior frontal gyrus and right caudate head. Response times for the FC images were faster than UC images; fMRI activity in the ventromedial prefrontal cortex was significantly correlated with response times during FC trials, but not UC trials. These correlations were significantly different from each other at the group level.
    Conclusions: The choices for branded chocolate products are driven by higher subjective reward ratings and lower neural processing demands.
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1071724-9
    ISSN 1552-6569 ; 1051-2284
    ISSN (online) 1552-6569
    ISSN 1051-2284
    DOI 10.1111/jon.13203
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    Zs.A 3211: Show issues Location:
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  10. Article ; Online: hnRNPA1 SUMOylation promotes cold hypersensitivity in chronic inflammatory pain by stabilizing TRPA1 mRNA.

    Zhang, Qiao / Weng, Weiji / Gu, Xiaokun / Xiang, Jinhua / Yang, Yang / Zhu, Michael X / Gu, Weidong / He, Zhenzhou / Li, Yong

    Cell reports

    2023  Volume 42, Issue 11, Page(s) 113401

    Abstract: TRPA1 is pivotal in cold hypersensitivity, but its regulatory mechanisms in inflammatory cold hyperalgesia remain poorly understood. We show here that the upregulation of SUMO1-conjugated protein levels in a complete Freund's adjuvant (CFA)-induced ... ...

    Abstract TRPA1 is pivotal in cold hypersensitivity, but its regulatory mechanisms in inflammatory cold hyperalgesia remain poorly understood. We show here that the upregulation of SUMO1-conjugated protein levels in a complete Freund's adjuvant (CFA)-induced inflammatory pain model enhances TRPA1 mRNA stability, ultimately leading to increased expression levels. We further demonstrate that hnRNPA1 binds to TRPA1 mRNA, and its SUMOylation, upregulated in CFA-induced inflammatory pain, contributes to stabilizing TRPA1 mRNA by accumulating hnRNPA1 in the cytoplasm. Moreover, we find that wild-type hnRNPA1 viral infection in dorsal root ganglia neurons, and not infection with the SUMOylation-deficient hnRNPA1 mutant, can rescue the reduced ability of hnRNPA1-knockdown mice to develop inflammatory cold pain hypersensitivity. These results suggest that hnRNPA1 is a regulator of TRPA1 mRNA stability, the capability of which is enhanced upon SUMO1 conjugation at lysine 3 in response to peripheral inflammation, and the increased expression of TRPA1 in turn underlies the development of chronic inflammatory cold pain hypersensitivity.
    MeSH term(s) Animals ; Mice ; Chronic Pain/metabolism ; Freund's Adjuvant ; Ganglia, Spinal/metabolism ; Hyperalgesia/metabolism ; Inflammation/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Sumoylation ; TRPA1 Cation Channel/genetics ; TRPA1 Cation Channel/metabolism
    Chemical Substances Freund's Adjuvant (9007-81-2) ; RNA, Messenger ; TRPA1 Cation Channel ; Trpa1 protein, mouse ; Hnrnpa1 protein, mouse
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.113401
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