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Article ; Online: Effects of Hyperosmolality on Hypothalamic Astrocytic Area, mRNA Expression and Glutamate Balance In Vitro.

Souza, M M / Vechiato, F M V / Debarba, L K / Leao, R M / Dias, M V S / Pereira, A A / Cruz, J C / Elias, L L K / Antunes-Rodrigues, J / Ruginsk, S G

Neuroscience

2020 Volume 442, Page(s) 286–295

Abstract: During prolonged dehydration, body fluid homeostasis is challenged by extracellular fluid (ECF) hyperosmolality, which induce important functional changes in the hypothalamus, in parallel with other effector responses, such as the activation of the local ...

Abstract	During prolonged dehydration, body fluid homeostasis is challenged by extracellular fluid (ECF) hyperosmolality, which induce important functional changes in the hypothalamus, in parallel with other effector responses, such as the activation of the local renin-angiotensin system (RAS). Therefore, in the present study we investigated the role of sodium-driven ECF hyperosmolality on glial fibrillary acid protein (GFAP) immunoreactivity and protein expression, membrane capacitance, mRNA expression of RAS components and glutamate balance in cultured hypothalamic astrocytes. Our data show that hypothalamic astrocytes respond to increased hyperosmolality with a similar decrease in GFAP expression and membrane capacitance, indicative of reduced cellular area. Hyperosmolality also downregulates the transcript levels of angiotensinogen and both angiotensin-converting enzymes, whereas upregulates type 1a angiotensin II receptor mRNA. Incubation with hypertonic solution also decreases the immunoreactivity to the membrane glutamate/aspartate transporter (GLAST) as well as tritiated-aspartate uptake by astrocytes. This latter effect is completely restored to basal levels when astrocytes previously exposed to hypertonicity are incubated under isotonic conditions. Together with a direct effect on two important local signaling systems (glutamate and RAS), these synaptic rearrangements driven by astrocytes may accomplish for a coordinated increase in the excitatory drive onto the hypothalamic neurosecretory system, ultimately culminating with increased AVP release in response to hyperosmolality.
MeSH term(s)	Astrocytes/metabolism ; Cells, Cultured ; Excitatory Amino Acid Transporter 2/metabolism ; Glial Fibrillary Acidic Protein/metabolism ; Glutamic Acid ; Hypothalamus/metabolism ; RNA, Messenger
Chemical Substances	Excitatory Amino Acid Transporter 2 ; Glial Fibrillary Acidic Protein ; RNA, Messenger ; Glutamic Acid (3KX376GY7L)
Language	English
Publishing date	2020-06-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	196739-3
ISSN	1873-7544 ; 0306-4522
ISSN (online)	1873-7544
ISSN	0306-4522
DOI	10.1016/j.neuroscience.2020.06.029
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Zs.A 1215: Show issues

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Article ; Online: The endocannabinoid system and the neuroendocrine control of hydromineral balance.

Ruginsk, S G / Vechiato, F M V / Elias, L L K / Antunes-Rodrigues, J

Journal of neuroendocrinology

2014 Volume 26, Issue 6, Page(s) 370–376

Abstract: Endocannabinoids (ECBs) are ubiquitous lipophilic agents, and this characteristic is consistent with the wide range of homeostatic functions attributed to the ECB system. There is an increasing number of studies showing that the ECB system affects ... ...

Abstract	Endocannabinoids (ECBs) are ubiquitous lipophilic agents, and this characteristic is consistent with the wide range of homeostatic functions attributed to the ECB system. There is an increasing number of studies showing that the ECB system affects neurotransmission within the hypothalamic neurohypophyseal system. We provide an overview of the primary roles of ECBs in the modulation of neuroendocrine function and, specifically, in the control of hydromineral homeostasis. Accordingly, the general aspects of ECB-mediated signalling, as well as the specific contributions of the central component of the ECB system to the integration of behavioural and endocrine responses that control body fluid homeostasis, are discussed.
MeSH term(s)	Animals ; Endocannabinoids/physiology ; Humans ; Minerals/metabolism ; Neurosecretory Systems/physiology ; Receptor, Cannabinoid, CB1/drug effects ; Receptors, Cannabinoid/physiology ; Water-Electrolyte Balance/physiology
Chemical Substances	Endocannabinoids ; Minerals ; Receptor, Cannabinoid, CB1 ; Receptors, Cannabinoid
Language	English
Publishing date	2014-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1007517-3
ISSN	1365-2826 ; 0953-8194
ISSN (online)	1365-2826
ISSN	0953-8194
DOI	10.1111/jne.12158
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Zs.A 2634: Show issues

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Article ; Online: The type-1 cannabinoid receptor modulates the hydroelectrolytic balance independently of the energy homeostasis during salt load.

Vechiato, F M V / Rivas, P M S / Ruginsk, S G / Borges, B C / Elias, L L K / Antunes-Rodrigues, J

Hormones and behavior

2016 Volume 78, Page(s) 43–51

Abstract: Hydroelectrolytic imbalances, such as saline load (SL), trigger behavioral and neuroendocrine responses, such as thirst, hypophagia, vasopressin (AVP) and oxytocin (OT) release and hypothalamus–pituitary–adrenal (HPA) axis activation. To investigate the ... ...

Abstract	Hydroelectrolytic imbalances, such as saline load (SL), trigger behavioral and neuroendocrine responses, such as thirst, hypophagia, vasopressin (AVP) and oxytocin (OT) release and hypothalamus–pituitary–adrenal (HPA) axis activation. To investigate the participation of the type-1 cannabinoid receptor (CB1R) in these homeostatic mechanisms,male adult Wistar rats were subjected to SL (0.3MNaCl) for four days. SL induced not only increases in the water intake and plasma levels of AVP, OT and corticosterone, as previously described, but also increases in CB1R expression in the lamina terminalis, which integrates sensory afferents, aswell as in the hypothalamus, the main integrative and effector area controlling hydroelectrolytic homeostasis. A more detailed analysis revealed that CB1R-positive terminals are in close apposition with not only axons but also dendrites and secretory granules of magnocellular neurons, particularly vasopressinergic cells. In satiated and euhydrated animals, the intracerebroventricular administration of the CB1R selective agonist ACEA (0.1 μg/5 μL) promoted hyperphagia, but this treatment did not reverse the hyperosmolality-induced hypophagia in the SL group. Furthermore, ACEA pretreatment potentiated water intake in the SL animals during rehydration as well as enhanced the corticosterone release and prevented the increase in AVP and OT secretion induced by SL. The same parameters were not changed by ACEA in the animals whose daily food intake was matched to that of the SL group (Pair-Fed). These data indicate that CB1Rs modulate the hydroelectrolytic balance independently of the food intake during sustained hyperosmolality and hypovolemia.
MeSH term(s)	Animals ; Eating/drug effects ; Endocannabinoids/pharmacology ; Energy Metabolism/drug effects ; Energy Metabolism/physiology ; Homeostasis/drug effects ; Homeostasis/physiology ; Hypothalamo-Hypophyseal System/drug effects ; Hypothalamo-Hypophyseal System/metabolism ; Hypothalamus/drug effects ; Hypothalamus/metabolism ; Hypovolemia/metabolism ; Male ; Neurons/drug effects ; Neurons/enzymology ; Neurons/metabolism ; Pituitary-Adrenal System/drug effects ; Pituitary-Adrenal System/metabolism ; Rats ; Rats, Wistar ; Receptor, Cannabinoid, CB1/agonists ; Receptor, Cannabinoid, CB1/physiology ; Sodium Chloride, Dietary/pharmacology ; Water-Electrolyte Balance/drug effects
Chemical Substances	Cnr1 protein, rat ; Endocannabinoids ; Receptor, Cannabinoid, CB1 ; Sodium Chloride, Dietary ; arachidonoyl-2 chloroethanolamine
Language	English
Publishing date	2016-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	214409-8
ISSN	1095-6867 ; 0018-506X
ISSN (online)	1095-6867
ISSN	0018-506X
DOI	10.1016/j.yhbeh.2015.10.011
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Zs.A 693: Show issues

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Article: Glial Cells Are Involved in ANG-II-Induced Vasopressin Release and Sodium Intake in Awake Rats.

Flôr, Atalia F L / de Brito Alves, José L / França-Silva, Maria S / Balarini, Camille M / Elias, Lucila L K / Ruginsk, Silvia G / Antunes-Rodrigues, José / Braga, Valdir A / Cruz, Josiane C

Frontiers in physiology

2018 Volume 9, Page(s) 430

Abstract: It is known that circulating angiotensin II (ANG-II) acts on the circumventricular organs (CVOs), which partially lack a normal blood-brain barrier, to stimulate pressor responses, vasopressin (AVP), and oxytocin (OT) secretion, as well as sodium and ... ...

Abstract	It is known that circulating angiotensin II (ANG-II) acts on the circumventricular organs (CVOs), which partially lack a normal blood-brain barrier, to stimulate pressor responses, vasopressin (AVP), and oxytocin (OT) secretion, as well as sodium and water intake. Although ANG-II type 1 receptors (AT1
Language	English
Publishing date	2018-05-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2018.00430
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Article ; Online: Cannabinoid CB1 receptor mediates glucocorticoid effects on hormone secretion induced by volume and osmotic changes.

Ruginsk, S G / Uchoa, E T / Elias, L L K / Antunes-Rodrigues, J

Clinical and experimental pharmacology & physiology

2012 Volume 39, Issue 2, Page(s) 151–154

Abstract: ... or not in 1 hour by dexamethasone (1 mg/Kg, i.p.). Extracellular volume expansion (EVE, 2 mL/100 g ...

Abstract	The present study provides the first in vivo evidence that the cannabinoid CB(1) receptor mediates the effects of dexamethasone on hormone release induced by changes in circulating volume and osmolality. Male adult rats were administered with the CB(1) receptor antagonist rimonabant (10 mg/Kg, p.o.), followed or not in 1 hour by dexamethasone (1 mg/Kg, i.p.). Extracellular volume expansion (EVE, 2 mL/100 g of body weight, i.v.) was performed 2 hours after dexamethasone or vehicle treatment using either isotonic (I-EVE, 0.15 mol/L) or hypertonic (H-EVE, 0.30 mol/L) NaCl solution. Five minutes after EVE, animals were decapitated and trunk blood was collected for all plasma measurements. Rimonabant potentiated oxytocin (OT) secretion induced by H-EVE and completely reversed the inhibitory effects of dexamethasone in response to the same stimulus. These data suggest that glucocorticoid modulation of OT release is mediated by the CB(1) receptor. Although dexamethasone did not affect vasopressin (AVP) secretion induced by H-EVE, the administration of rimonabant potentiated AVP release in response to the same stimulus, supporting the hypothesis that the CB(1) receptor regulates AVP secretion independently of glucocorticoid-mediated signalling. Dexamethasone alone did not affect atrial natriuretic peptide (ANP) release stimulated by I-EVE or H-EVE. However, pretreatment with rimonabant potentiated ANP secretion induced by H-EVE, suggesting a possible role for the CB(1) receptor in the control of peripheral factors that modulate cardiovascular function. Rimonabant also reversed the inhibitory effects of dexamethasone on H-EVE-induced corticosterone secretion, reinforcing the hypothesis that the CB(1) receptor may be involved in the negative feedback exerted by glucocorticoids on the activity of the hypothalamic-pituitary-adrenal axis. Collectively, the results of the present study indicate that the CB(1) receptor modulates neurohypophyseal hormone secretion and systemic factors, such as corticosterone and ANP, thus participating in homeostatic responses to altered extracellular volume and plasma tonicity.
MeSH term(s)	Animals ; Atrial Natriuretic Factor/blood ; Atrial Natriuretic Factor/secretion ; Blood Volume ; Extracellular Fluid/drug effects ; Extracellular Fluid/physiology ; Glucocorticoids/physiology ; Male ; Osmolar Concentration ; Osmosis ; Oxytocin/blood ; Oxytocin/secretion ; Piperidines/pharmacology ; Pyrazoles/pharmacology ; Rats ; Rats, Wistar ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; Receptor, Cannabinoid, CB1/physiology ; Vasopressins/blood ; Vasopressins/secretion
Chemical Substances	Glucocorticoids ; Piperidines ; Pyrazoles ; Receptor, Cannabinoid, CB1 ; Vasopressins (11000-17-2) ; Oxytocin (50-56-6) ; Atrial Natriuretic Factor (85637-73-6) ; rimonabant (RML78EN3XE)
Language	English
Publishing date	2012-02
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	189277-0
ISSN	1440-1681 ; 0305-1870 ; 0143-9294
ISSN (online)	1440-1681
ISSN	0305-1870 ; 0143-9294
DOI	10.1111/j.1440-1681.2011.05658.x
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Zs.A 990: Show issues

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Article ; Online: Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring.

Silva, Marcia S / Lúcio-Oliveira, Fabiana / Mecawi, Andre Souza / Almeida, Lucas F / Ruginsk, Silvia G / Greenwood, Michael P / Greenwood, Mingkwan / Vivas, Laura / Elias, Lucila L K / Murphy, David / Antunes-Rodrigues, José

Physiological reports

2017 Volume 5, Issue 6

Abstract: Excessive sodium ( ... ...

Abstract	Excessive sodium (Na
MeSH term(s)	Animals ; Behavior, Animal/drug effects ; Corticosterone/blood ; Drinking/drug effects ; Female ; Kidney/drug effects ; Kidney/metabolism ; Lactation/physiology ; Male ; Oxytocin/blood ; Pregnancy ; Prenatal Exposure Delayed Effects/metabolism ; Rats ; Rats, Wistar ; Sodium Chloride/pharmacology ; Urination/drug effects ; Urination/physiology ; Water Deprivation/physiology ; Water-Electrolyte Balance/drug effects
Chemical Substances	Sodium Chloride (451W47IQ8X) ; Oxytocin (50-56-6) ; Corticosterone (W980KJ009P)
Language	English
Publishing date	2017-03-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2724325-4
ISSN	2051-817X ; 2051-817X
ISSN (online)	2051-817X
ISSN	2051-817X
DOI	10.14814/phy2.13210
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Article ; Online: Chronic treatment with fluoxetine modulates vascular adrenergic responses by inhibition of pre- and post-synaptic mechanisms.

Pereira, Camila A / Rodrigues, Fernanda L / Ruginsk, Silvia G / Zanotto, Camila Z / Rodrigues, José A / Duarte, Diego A / Costa-Neto, Claudio M / Resstel, Leonardo B / Carneiro, Fernando S / Tostes, Rita C

European journal of pharmacology

2017 Volume 800, Page(s) 70–80

Abstract: Fluoxetine, a serotonin reuptake inhibitor (SSRI), has other effects in addition to blocking serotonin reuptake, including changes in the vasomotor tone. Whereas many studies focused on the acute effects of fluoxetine in the vasculature, its chronic ... ...

Abstract	Fluoxetine, a serotonin reuptake inhibitor (SSRI), has other effects in addition to blocking serotonin reuptake, including changes in the vasomotor tone. Whereas many studies focused on the acute effects of fluoxetine in the vasculature, its chronic effects are still limited. In the present study, we tested the hypothesis that chronic fluoxetine treatment modulates adrenergic vascular responses by interfering with post- and pre-synaptic mechanisms. Wistar rats were treated with vehicle (water) or chronic fluoxetine (10mg/kg/day) for 21 days. Blood pressure (BP) and heart rate were measured. Vascular reactivity was evaluated in perfused mesenteric arterial beds (MAB) and in mesenteric resistance arteries. Protein expression by western blot analysis or immunohistochemistry, β-arrestin recruitment by BRET and calcium influx by FLIPR assay. Fluoxetine treatment decreased phenylephrine (PE)-induced, but not electrical-field stimulation (EFS)-induced vasoconstriction. Fluoxetine-treated rats exhibited increased KCl-induced vasoconstriction, which was abolished by prazosin. Desipramine, an inhibitor of norepinephrine (NA) reuptake, increased EFS-induced vasoconstrictor response in vehicle-treated, but not in fluoxetine-treated rats. Chronic treatment did not alter vascular expression of α
MeSH term(s)	Animals ; Arterial Pressure/drug effects ; Calcium/metabolism ; Electric Stimulation ; Fluoxetine/pharmacology ; Heart Rate/drug effects ; Intracellular Space/drug effects ; Intracellular Space/metabolism ; Male ; Norepinephrine Plasma Membrane Transport Proteins/metabolism ; Potassium Chloride/pharmacology ; Rats ; Rats, Wistar ; Receptors, Adrenergic, alpha-1/metabolism ; Serotonin Uptake Inhibitors/pharmacology ; Signal Transduction/drug effects ; Sympathetic Nervous System/drug effects ; Sympathetic Nervous System/physiology ; Synapses/drug effects ; Time Factors ; Vasoconstriction/drug effects ; beta-Arrestins/metabolism
Chemical Substances	Norepinephrine Plasma Membrane Transport Proteins ; Receptors, Adrenergic, alpha-1 ; Serotonin Uptake Inhibitors ; beta-Arrestins ; Fluoxetine (01K63SUP8D) ; Potassium Chloride (660YQ98I10) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2017-04-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2017.02.029
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Zs.A 522: Show issues

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Article ; Online: CB(1) modulation of hormone secretion, neuronal activation and mRNA expression following extracellular volume expansion.

Ruginsk, S G / Uchoa, E T / Elias, L L K / Antunes-Rodrigues, J

Experimental neurology

2010 Volume 224, Issue 1, Page(s) 114–122

Abstract: The endocannabinoid system includes important signaling molecules that are involved in several homeostatic and neuroendocrine functions. In the present study, we evaluated the effects of the type 1 cannabinoid (CB(1)) receptor antagonist, rimonabant (10 ... ...

Abstract	The endocannabinoid system includes important signaling molecules that are involved in several homeostatic and neuroendocrine functions. In the present study, we evaluated the effects of the type 1 cannabinoid (CB(1)) receptor antagonist, rimonabant (10 mg/kg, p.o.), on hormone secretion, neuronal activation and mRNA expression in the hypothalamus following isotonic (I-) or hypertonic (H-) extracellular volume expansion (EVE). The total nitrate content in the PVN and SON was also assessed under the same experimental conditions. Our results showed that OT and AVP plasma concentrations were increased in response to H-EVE, while decreased AVP levels were found following I-EVE. Accordingly, both I- and H-EVE stimulated oxytocinergic neuronal activation, as evidenced by the increased number of c-Fos/OT double labeled neurons in the hypothalamus. The vasopressinergic cells of the PVN and SON, however, were only activated in response to H-EVE. Furthermore, increased amounts of both AVP and OT mRNAs were found in the hypothalamus following EVE. Pretreatment with rimonabant significantly potentiated hormone secretion and also vasopressinergic and oxytocinergic neuronal activation induced by EVE, although decreased AVP and OT mRNA expression was found in the hypothalami of rimonabant pretreated groups. In addition, the nitrate content in the PVN and SON was not altered in response to EVE or rimonabant pretreatment. Taken together, these results suggest that the CB(1) receptor may modulate several events that contribute to the development of appropriate responses to increased fluid volume and osmolality.
MeSH term(s)	Analysis of Variance ; Animals ; Arginine Vasopressin/metabolism ; Catheters, Indwelling ; Extracellular Fluid/metabolism ; Hypothalamus/chemistry ; Hypothalamus/drug effects ; Hypothalamus/metabolism ; Immunoassay ; Immunohistochemistry ; Male ; Neurons/drug effects ; Neurons/metabolism ; Nitrates/analysis ; Oxytocin/metabolism ; Piperidines/pharmacology ; Proto-Oncogene Proteins c-fos/metabolism ; Pyrazoles/pharmacology ; RNA, Messenger/metabolism ; Rats ; Rats, Wistar ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; Receptor, Cannabinoid, CB1/metabolism ; Reverse Transcriptase Polymerase Chain Reaction
Chemical Substances	Nitrates ; Piperidines ; Proto-Oncogene Proteins c-fos ; Pyrazoles ; RNA, Messenger ; Receptor, Cannabinoid, CB1 ; Arginine Vasopressin (113-79-1) ; Oxytocin (50-56-6) ; rimonabant (RML78EN3XE)
Language	English
Publishing date	2010-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	207148-4
ISSN	1090-2430 ; 0014-4886
ISSN (online)	1090-2430
ISSN	0014-4886
DOI	10.1016/j.expneurol.2010.03.001
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Zs.A 184: Show issues

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Article ; Online: Hypothalamic cocaine- and amphetamine-regulated transcript and corticotrophin releasing factor neurons are stimulated by extracellular volume and osmotic changes.

Ruginsk, S G / Uchoa, E T / Elias, L L K / Antunes-Rodrigues, J / Llewellyn-Smith, I J

Neuroscience

2011 Volume 186, Page(s) 57–64

Abstract: Several studies suggest that hypothalamic cocaine- and amphetamine-regulated transcript (CART) may interact with the hypothalamic-pituitary-adrenal (HPA) axis in the control of neuroendocrine function and may also participate in cardiovascular regulation. ...

Abstract	Several studies suggest that hypothalamic cocaine- and amphetamine-regulated transcript (CART) may interact with the hypothalamic-pituitary-adrenal (HPA) axis in the control of neuroendocrine function and may also participate in cardiovascular regulation. Therefore, this study aimed to evaluate, in experimental models of isotonic (I-EVE) and hypertonic (H-EVE) extracellular volume expansion and water deprivation (WD), the activation of CART- and corticotrophin releasing factor (CRF)-immunoreactive neurons, as well as the relative expression of CART and CRF mRNAs in the paraventricular (PVN) and supraoptic (SON) nuclei of the hypothalamus. Both H-EVE (0.30M NaCl, 2mL/100g of body weight, in 1 minute) and 24 hours of WD significantly increased plasma sodium concentrations, producing, respectively, either an increase or a decrease in extracellular volume. I-EVE (0.15M NaCl, 2mL/100g of body weight, in 1 minute) evoked a significant increase in the circulating volume accompanied by unaltered plasma concentrations of sodium. CART-expressing neurons of both magnocellular and parvocellular hypothalamic divisions were activated to produce Fos in response to H-EVE but not in response to I-EVE. Furthermore, increased expression of CART mRNA was found in the PVN of H-EVE but not I-EVE rats. These data show for the first time that EVE not only activates hypothalamic CRF neurons but also increases CRF mRNA expression in the PVN. In contrast, WD increases the number of CART-immunoreactive neurons activated to produce Fos in the PVN and SON but does not change the number of neurons double labeled for Fos and CRF or expression of CRF mRNA in the PVN. These findings provided new insights into the participation of CART in diverse processes within the PVN and SON, including its possible involvement in activation of the HPA axis and cardiovascular regulation in response to changes in extracellular volume and osmolality.
MeSH term(s)	Animals ; Corticotropin-Releasing Hormone/genetics ; Corticotropin-Releasing Hormone/metabolism ; Down-Regulation/physiology ; Extracellular Fluid/metabolism ; Extracellular Fluid/physiology ; Hypothalamus/blood supply ; Hypothalamus/cytology ; Hypothalamus/metabolism ; Male ; Nerve Tissue Proteins/physiology ; Neurons/cytology ; Neurons/metabolism ; Osmolar Concentration ; Rats ; Rats, Sprague-Dawley ; Supraoptic Nucleus/blood supply ; Supraoptic Nucleus/cytology ; Supraoptic Nucleus/metabolism ; Up-Regulation/physiology ; Water-Electrolyte Balance/physiology
Chemical Substances	Nerve Tissue Proteins ; cocaine- and amphetamine-regulated transcript protein ; Corticotropin-Releasing Hormone (9015-71-8)
Language	English
Publishing date	2011-07-14
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	196739-3
ISSN	1873-7544 ; 0306-4522
ISSN (online)	1873-7544
ISSN	0306-4522
DOI	10.1016/j.neuroscience.2011.04.047
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Zs.A 1215: Show issues

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Article ; Online: Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis.

Antunes-Rodrigues, J / Ruginsk, S G / Mecawi, A S / Margatho, L O / Cruz, J C / Vilhena-Franco, T / Reis, W L / Ventura, R R / Reis, L C / Vivas, L M / Elias, L L K

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

2013 Volume 46, Issue 4, Page(s) 327–338

Abstract: Several forebrain and brainstem neurochemical circuitries interact with peripheral neural and humoral signals to collaboratively maintain both the volume and osmolality of extracellular fluids. Although much progress has been made over the past decades ... ...

Abstract	Several forebrain and brainstem neurochemical circuitries interact with peripheral neural and humoral signals to collaboratively maintain both the volume and osmolality of extracellular fluids. Although much progress has been made over the past decades in the understanding of complex mechanisms underlying neuroendocrine control of hydromineral homeostasis, several issues still remain to be clarified. The use of techniques such as molecular biology, neuronal tracing, electrophysiology, immunohistochemistry, and microinfusions has significantly improved our ability to identify neuronal phenotypes and their signals, including those related to neuron-glia interactions. Accordingly, neurons have been shown to produce and release a large number of chemical mediators (neurotransmitters, neurohormones and neuromodulators) into the interstitial space, which include not only classic neurotransmitters, such as acetylcholine, amines (noradrenaline, serotonin) and amino acids (glutamate, GABA), but also gaseous (nitric oxide, carbon monoxide and hydrogen sulfide) and lipid-derived (endocannabinoids) mediators. This efferent response, initiated within the neuronal environment, recruits several peripheral effectors, such as hormones (glucocorticoids, angiotensin II, estrogen), which in turn modulate central nervous system responsiveness to systemic challenges. Therefore, in this review, we shall evaluate in an integrated manner the physiological control of body fluid homeostasis from the molecular aspects to the systemic and integrated responses.
MeSH term(s)	Animals ; Body Fluids/physiology ; Brain Mapping ; Homeostasis/physiology ; Humans ; Neural Pathways/physiology ; Neurosecretion/physiology ; Neurotransmitter Agents/physiology ; Osmolar Concentration ; Signal Transduction/physiology
Chemical Substances	Neurotransmitter Agents
Language	English
Publishing date	2013-04-12
Publishing country	Brazil
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	786234-9
ISSN	1414-431X ; 0100-879X
ISSN (online)	1414-431X
ISSN	0100-879X
DOI	10.1590/1414-431X20132788
Database	MEDical Literature Analysis and Retrieval System OnLINE

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