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  1. Article ; Online: High altitude exposure during pregnancy enhances the vulnerability of fetal heart dysfunction to ischemic stress: Epigenetic mechanisms.

    Shao, Xuesi M

    International journal of cardiology

    2018  Volume 274, Page(s) 59–60

    MeSH term(s) Altitude ; Altitude Sickness ; Female ; Fetal Heart ; Heart Diseases ; Humans ; Hypoxia ; Pregnancy ; Reperfusion Injury
    Language English
    Publishing date 2018-09-15
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2018.09.053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1673: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Last Word on Viewpoint: pH Buffer capacity and pharmacokinetics: two remaining questions.

    Shao, Xuesi M / Friedman, Theodore C

    Journal of applied physiology (Bethesda, Md. : 1985)

    2020  Volume 128, Issue 4, Page(s) 1063–1064

    MeSH term(s) Buffers ; Electronic Nicotine Delivery Systems ; Hydrogen-Ion Concentration ; Nicotine
    Chemical Substances Buffers ; Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2020-04-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00165.2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.249: Show issues Location:
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  3. Article ; Online: Severe Acute Toxicity of Inhaled Nicotine and e-Cigarettes: Seizures and Cardiac Arrhythmia.

    Shao, Xuesi M / Fang, Zhuang T

    Chest

    2020  Volume 157, Issue 3, Page(s) 506–508

    MeSH term(s) Administration, Inhalation ; Amygdala/metabolism ; Animals ; Arrhythmias, Cardiac/chemically induced ; Arrhythmias, Cardiac/metabolism ; Autonomic Fibers, Preganglionic/metabolism ; Electronic Nicotine Delivery Systems ; Humans ; Medulla Oblongata/metabolism ; Nicotine/poisoning ; Nicotinic Agonists/poisoning ; Receptors, Nicotinic/metabolism ; Respiratory Center/metabolism ; Respiratory Insufficiency/chemically induced ; Respiratory Insufficiency/metabolism ; Seizures/chemically induced ; Seizures/metabolism ; Vaping ; alpha7 Nicotinic Acetylcholine Receptor
    Chemical Substances Nicotinic Agonists ; Receptors, Nicotinic ; alpha7 Nicotinic Acetylcholine Receptor ; nicotinic acetylcholine receptor alpha4 subunit ; Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2020-03-07
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2019.10.008
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    Ui III Zs.45: Show issues Location:
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    Zs.MO 349: Show issues

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  4. Article ; Online: Pod-mod vs. conventional e-cigarettes: nicotine chemistry, pH, and health effects.

    Shao, Xuesi M / Friedman, Theodore C

    Journal of applied physiology (Bethesda, Md. : 1985)

    2019  Volume 128, Issue 4, Page(s) 1056–1058

    MeSH term(s) Electronic Nicotine Delivery Systems ; Hydrogen-Ion Concentration ; Nicotine ; Tobacco Products ; Vaping/adverse effects
    Chemical Substances Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2019-12-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00717.2019
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.249: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Prenatal Nicotine Exposure Raises Male Blood Pressure via FTO-Mediated NOX2/ROS Signaling.

    Liu, Bailin / Xia, Liang / Li, Yong / Jiang, Siyi / Yu, Wansu / Zhang, Lubo / Shao, Xuesi M / Xu, Zhice / Xiao, Daliao

    Hypertension (Dallas, Tex. : 1979)

    2023  Volume 81, Issue 2, Page(s) 240–251

    Abstract: Background: Cigarette smoking/nicotine exposure in pregnancy shows an increased risk of hypertension in offspring, but the mechanisms are unclear. This study tested the hypothesis that m6A RNA hypomethylation epigenetically regulates vascular NOX (NADPH ...

    Abstract Background: Cigarette smoking/nicotine exposure in pregnancy shows an increased risk of hypertension in offspring, but the mechanisms are unclear. This study tested the hypothesis that m6A RNA hypomethylation epigenetically regulates vascular NOX (NADPH oxidase) and reactive oxygen species production, contributing to the fetal programming of a hypertensive phenotype in nicotine-exposed offspring.
    Methods: Pregnant rats were exposed to episodic chronic intermittent nicotine aerosol (CINA) or saline aerosol control from gestational day 4 to day 21, and experiments were performed in 6-month-old adult offspring.
    Results: Antenatal CINA exposure augmented Ang II (angiotensin II)-stimulated blood pressure response in male, but not female offspring. Moreover, CINA increased vascular NOX2 expression and superoxide production exclusively in male offspring. Inhibition of NOX2 with gp91ds-tat, both ex vivo and in vivo, mitigated the CINA-induced elevation in superoxide production and blood pressure response. Notably, CINA enhanced the expression of vascular m6A demethylase FTO (fat mass and obesity-associated protein), while reducing the total vascular m6A abundance and specific m6A methylation of the NOX2 gene. Additionally, ex vivo inhibition of FTO with FB23-2 attenuated CINA-induced increases in vascular NOX2 expression. In vitro experiments using human umbilical vein endothelial cells demonstrated that nicotine dose-dependently upregulated FTO and NOX2 protein abundance, which were reversed by treatment with the FTO inhibitor FB23-2 or FTO knockdown using siRNAs.
    Conclusions: This study uncovers a new mechanism: m6A demethylase FTO-mediated epigenetic upregulation of vascular NOX2 signaling in CINA-induced hypertensive phenotype. This insight could lead to a therapeutic target for preventing and treating developmental hypertension programming.
    MeSH term(s) Pregnancy ; Rats ; Male ; Female ; Animals ; Humans ; Infant ; Nicotine/pharmacology ; Blood Pressure ; Reactive Oxygen Species/metabolism ; Superoxides ; Endothelial Cells/metabolism ; Hypertension ; NADPH Oxidases/genetics ; NADPH Oxidases/metabolism ; Aerosols/adverse effects ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO
    Chemical Substances Nicotine (6M3C89ZY6R) ; Reactive Oxygen Species ; Superoxides (11062-77-4) ; NADPH Oxidases (EC 1.6.3.-) ; Aerosols ; FTO protein, human (EC 1.14.11.33) ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO (EC 1.14.11.33)
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.123.21766
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Electronic Cigarette Use and the Risk of Cardiovascular Diseases.

    Espinoza-Derout, Jorge / Shao, Xuesi M / Lao, Candice J / Hasan, Kamrul M / Rivera, Juan Carlos / Jordan, Maria C / Echeverria, Valentina / Roos, Kenneth P / Sinha-Hikim, Amiya P / Friedman, Theodore C

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 879726

    Abstract: Electronic cigarettes or e-cigarettes are the most frequently used tobacco product among adolescents. Despite the widespread use of e-cigarettes and the known detrimental cardiac consequences of nicotine, the effects of e-cigarettes on the cardiovascular ...

    Abstract Electronic cigarettes or e-cigarettes are the most frequently used tobacco product among adolescents. Despite the widespread use of e-cigarettes and the known detrimental cardiac consequences of nicotine, the effects of e-cigarettes on the cardiovascular system are not well-known. Several
    Language English
    Publishing date 2022-04-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.879726
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  7. Article ; Online: The lipolysis inhibitor acipimox reverses the cardiac phenotype induced by electronic cigarettes.

    Espinoza-Derout, Jorge / Arambulo, Jose Mari Luis / Ramirez-Trillo, William / Rivera, Juan Carlos / Hasan, Kamrul M / Lao, Candice J / Jordan, Maria C / Shao, Xuesi M / Roos, Kenneth P / Sinha-Hikim, Amiya P / Friedman, Theodore C

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 18239

    Abstract: ... Analysis revealed that e-cigarette (2.4%)-treated mice had gene expression changes in the G2/M DNA damage ...

    Abstract Electronic cigarettes (e-cigarettes) are a prevalent alternative to conventional nicotine cigarettes among smokers and people who have never smoked. Increased concentrations of serum free fatty acids (FFAs) are crucial in generating lipotoxicity. We studied the effects of acipimox, an antilipolytic drug, on e-cigarette-induced cardiac dysfunction. C57BL/6J wild-type mice on high fat diet were treated with saline, e-cigarette with 2.4% nicotine [e-cigarette (2.4%)], and e-cigarette (2.4%) plus acipimox for 12 weeks. Fractional shortening and ejection fraction were diminished in mice exposed to e-cigarettes (2.4%) compared with saline and acipimox-treated mice. Mice exposed to e-cigarette (2.4%) had increased circulating levels of inflammatory cytokines and FFAs, which were diminished by acipimox. Gene Set Enrichment Analysis revealed that e-cigarette (2.4%)-treated mice had gene expression changes in the G2/M DNA damage checkpoint pathway that was normalized by acipimox. Accordingly, we showed that acipimox suppressed the nuclear localization of phospho-p53 induced by e-cigarette (2.4%). Additionally, e-cigarette (2.4%) increased the apurinic/apyrimidinic sites, a marker of oxidative DNA damage which was normalized by acipimox. Mice exposed to e-cigarette (2.4%) had increased cardiac Heme oxygenase 1 protein levels and 4-hydroxynonenal (4-HNE). These markers of oxidative stress were decreased by acipimox. Therefore, inhibiting lipolysis with acipimox normalizes the physiological changes induced by e-cigarettes and the associated increase in inflammatory cytokines, oxidative stress, and DNA damage.
    MeSH term(s) Humans ; Mice ; Animals ; Electronic Nicotine Delivery Systems ; Nicotine ; Lipolysis ; Mice, Inbred C57BL ; Phenotype ; Cytokines
    Chemical Substances Nicotine (6M3C89ZY6R) ; acipimox (K9AY9IR2SD) ; Cytokines
    Language English
    Publishing date 2023-10-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-44082-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Social Isolation Induces Neuroinflammation And Microglia Overactivation, While Dihydromyricetin Prevents And Improves Them.

    Al Omran, Alzahra J / Shao, Amy S / Watanabe, Saki / Zhang, Zeyu / Zhang, Jifeng / Xue, Chen / Watanabe, Junji / Davies, Daryl L / Shao, Xuesi M / Liang, Jing

    Research square

    2021  

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-10-01
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-923871/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Dihydromyricetin improves social isolation-induced cognitive impairments and astrocytic changes in mice.

    Watanabe, Saki / Omran, Alzahra Al / Shao, Amy S / Xue, Chen / Zhang, Zeyu / Zhang, Jifeng / Davies, Daryl L / Shao, Xuesi M / Watanabe, Junji / Liang, Jing

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 5899

    Abstract: Social isolation induces stress, anxiety, and mild cognitive impairment that could progress towards irreversible brain damage. A probable player in the mechanism of social isolation-induced anxiety is astrocytes, specialized glial cells that support ... ...

    Abstract Social isolation induces stress, anxiety, and mild cognitive impairment that could progress towards irreversible brain damage. A probable player in the mechanism of social isolation-induced anxiety is astrocytes, specialized glial cells that support proper brain function. Using a social isolation mouse model, we observed worsened cognitive and memory abilities with reductions of Object Recognition Index (ORI) in novel object recognition test and Recognition Index (RI) in novel context recognition test. Social isolation also increased astrocyte density, reduced astrocyte size with shorter branches, and reduced morphological complexity in the hippocampus. Dihydromyricetin, a flavonoid that we previously demonstrated to have anxiolytic properties, improved memory/cognition and restored astrocyte plasticity in these mice. Our study indicates astrocytic involvement in social isolation-induced cognitive impairment as well as anxiety and suggest dihydromyricetin as an early-stage intervention against anxiety, cognitive impairment, and potential permanent brain damage.
    MeSH term(s) Animals ; Astrocytes ; Cognitive Dysfunction/drug therapy ; Cognitive Dysfunction/etiology ; Flavonols/pharmacology ; Flavonols/therapeutic use ; Hippocampus ; Mice ; Social Isolation/psychology
    Chemical Substances Flavonols ; dihydromyricetin (KD8QND6427)
    Language English
    Publishing date 2022-04-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-09814-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Modulation of Hippocampal GABAergic Neurotransmission and Gephyrin Levels by Dihydromyricetin Improves Anxiety.

    Silva, Joshua / Shao, Amy S / Shen, Yi / Davies, Daryl L / Olsen, Richard W / Holschneider, Daniel P / Shao, Xuesi M / Liang, Jing

    Frontiers in pharmacology

    2020  Volume 11, Page(s) 1008

    Abstract: Anxiety disorders are the most common mental illness in the U.S. and are estimated to consume one-third of the country's mental health spending. Although anxiolytic therapies are available, many patients exhibit treatment-resistance, relapse, or ... ...

    Abstract Anxiety disorders are the most common mental illness in the U.S. and are estimated to consume one-third of the country's mental health spending. Although anxiolytic therapies are available, many patients exhibit treatment-resistance, relapse, or substantial side effects. An urgent need exists to explore the underlying mechanisms of chronic anxiety and to develop alternative therapies. Presently, we identified dihydromyricetin (DHM), a flavonoid that has anxiolytic properties in a mouse model of isolation-induced anxiety. Socially isolated mice demonstrated increased anxiety levels and reduced exploratory behavior measured by elevated plus-maze and open-field tests. Socially isolated mice showed impaired GABAergic neurotransmission, including reduction in GABA
    Language English
    Publishing date 2020-07-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.01008
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