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Book ; Thesis: Magnetresonanztomographie (MRT) und Magnetresonanzangiographie (MRA) der hypothalamisch-hypophysären Region

Stemmler, Hans Joachim

1995

Author's details	vorgelegt von Hans Joachim Stemmler
Language	German
Size	173 S. : Ill., graph. Darst.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	München, Univ., Diss., 1995
HBZ-ID	HT006771000
Database	Catalogue ZB MED Medicine, Health

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Article: PTCY-Based Haploidentical Donor Transplantation versus HLA-Matched Related and Unrelated Donor Transplantations in Patients with Refractory or Relapsed Lymphoma-A Matched-Pair Analysis.

Haebe, Sarah / Fraccaroli, Alessia / Stauffer, Elena / Prevalsek, Dusan / Zoellner, Anna K / Drolle, Heidrun / Stemmler, Hans-Joachim / Dreyling, Martin / von Bergwelt-Baildon, Michael / Tischer, Johanna

Cancers

2023 Volume 15, Issue 21

Abstract: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has demonstrated its potential as a curative option for patients with r/r lymphoma. With the introduction of post-transplant cyclophosphamide-based (PTCY) graft-versus-host disease (GvHD) ... ...

Abstract	Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has demonstrated its potential as a curative option for patients with r/r lymphoma. With the introduction of post-transplant cyclophosphamide-based (PTCY) graft-versus-host disease (GvHD) prophylaxis, allo-HCT using haploidentical related donors (Haplo-HSCT) has emerged as a valuable alternative for patients without an available HLA-matched donor. In this study, we compared intermediate and long-term outcomes between Haplo-HSCT and HLA-matched related donor (MRD) and unrelated donor (URD) transplantations in 16 matched pairs using age, disease status, lymphoma classification and performance status as matching criteria. Of note, 88% of patients in each group presented with active disease at the time of conditioning. After a median follow-up of >10 years, 10-year overall and progression-free survival and non-relapse mortality incidence after Haplo-HSCT were 31%, 25% and 38%, respectively, and did not differ compared to the values observed in MRD-HSCT and URD-HSCT. A remarkable lower incidence of acute GvHD ≥ II and moderate and severe chronic GvHD was observed after Haplo-HSCT compared to MRD-HSCT (50%/50%,
Language	English
Publishing date	2023-10-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15215246
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Book ; Online ; Thesis: Einfluss der PEEP-Beatmung auf das Herzzeitvolumen

Sparrer, Jakob / Stemmler, Hans-Joachim

Evaluation einer neuen Methode (USCOM)

2013

Author's details	Jakob Sparrer. Betreuer: Hans-Joachim Stemmler
Language	German
Size	Online-Ressource
Publisher	Universitätsbibliothek der Ludwig-Maximilians-Universität
Publishing place	München
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	München, Ludwig-Maximilians-Universität, Diss., 2013
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Lung ultrasound predicts clinical course but not outcome in COVID-19 ICU patients: a retrospective single-center analysis.

Stecher, Stephanie-Susanne / Anton, Sofia / Fraccaroli, Alessia / Götschke, Jeremias / Stemmler, Hans Joachim / Barnikel, Michaela

BMC anesthesiology

2021 Volume 21, Issue 1, Page(s) 178

Abstract: Background: Point-of-care lung ultrasound (LU) is an established tool in the first assessment of patients with coronavirus disease (COVID-19). Purpose of this study was to evaluate the value of lung ultrasound in COVID-19 intensive care unit (ICU) ... ...

Abstract	Background: Point-of-care lung ultrasound (LU) is an established tool in the first assessment of patients with coronavirus disease (COVID-19). Purpose of this study was to evaluate the value of lung ultrasound in COVID-19 intensive care unit (ICU) patients in predicting clinical course and outcome. Methods: We analyzed lung ultrasound score (LUS) of all COVID-19 patients admitted from March 2020 to December 2020 to the Internal Intensive Care Unit, Ludwig-Maximilians-University (LMU) of Munich. LU was performed according to a standardized protocol at ICU admission and in case of clinical deterioration with the need for intubation. A normal lung scores 0 points, the worst LUS has 24 points. Patients were stratified in a low (0-12 points) and a high (13-24 points) lung ultrasound score group. Results: The study included 42 patients, 69% of them male. The most common comorbidities were hypertension (81%) and obesity (57%). The values of pH (7.42 ± 0.09 vs 7.35 ± 0.1; p = 0.047) and p Conclusions: LU can be a useful monitoring tool to predict clinical course but not outcome of COVID-19 ICU patients and can early recognize possible deteriorations.
MeSH term(s)	Aged ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/pathology ; Critical Care/methods ; Female ; Germany/epidemiology ; Humans ; Lung/diagnostic imaging ; Male ; Middle Aged ; Point-of-Care Testing ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; SARS-CoV-2 ; Ultrasonography/methods
Language	English
Publishing date	2021-06-28
Publishing country	England
Document type	Journal Article
ISSN	1471-2253
ISSN (online)	1471-2253
DOI	10.1186/s12871-021-01396-5
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Article ; Online: Intrathecal trastuzumab versus alternate routes of delivery for HER2-targeted therapies in patients with HER2+ breast cancer leptomeningeal metastases.

Lazaratos, Anna-Maria / Maritan, Sarah M / Quaiattini, Andrea / Darlix, Amelie / Ratosa, Ivica / Ferraro, Emanuela / Griguolo, Gaia / Guarneri, Valentina / Pellerino, Alessia / Hofer, Silvia / Jacot, William / Stemmler, Hans-Joachim / van den Broek, Marcel P H / Dobnikar, Nika / Panet, Francois / Lahijanian, Zubin / Morikawa, Aki / Seidman, Andrew D / Soffietti, Riccardo /

Panasci, Lawrence / Petrecca, Kevin / Rose, April A N / Bouganim, Nathaniel / Dankner, Matthew

Breast (Edinburgh, Scotland)

2023 Volume 69, Page(s) 451–468

Abstract: Background: Patients with HER2+ breast cancer (BC) frequently develop leptomeningeal metastases (LM). While HER2-targeted therapies have demonstrated efficacy in the neoadjuvant, adjuvant, and metastatic settings, including for parenchymal brain ... ...

Abstract	Background: Patients with HER2+ breast cancer (BC) frequently develop leptomeningeal metastases (LM). While HER2-targeted therapies have demonstrated efficacy in the neoadjuvant, adjuvant, and metastatic settings, including for parenchymal brain metastases, their efficacy for patients with LM has not been studied in a randomized controlled trial. However, several single-armed prospective studies, case series and case reports have studied oral, intravenous, or intrathecally administered HER2-targeted therapy regimens for patients with HER2+ BC LM. Methods: We conducted a systematic review and meta-analysis of individual patient data to evaluate the efficacy of HER2-targeted therapies in HER2+ BC LM in accordance with PRISMA guidelines. Targeted therapies evaluated were trastuzumab (intrathecal or intravenous), pertuzumab, lapatinib, neratinib, tucatinib, trastuzumab-emtansine and trastuzumab-deruxtecan. The primary endpoint was overall survival (OS), with CNS-specific progression-free survival (PFS) as a secondary endpoint. Results: 7780 abstracts were screened, identifying 45 publications with 208 patients, corresponding to 275 lines of HER2-targeted therapy for BC LM which met inclusion criteria. In univariable and multivariable analyses, we observed no significant difference in OS and CNS-specific PFS between intrathecal trastuzumab compared to oral or intravenous administration of HER2-targeted therapy. Anti-HER2 monoclonal antibody-based regimens did not demonstrate superiority over HER2 tyrosine kinase inhibitors. In a cohort of 15 patients, treatment with trastuzumab-deruxtecan was associated with prolonged OS compared to other HER2-targeted therapies and compared to trastuzumab-emtansine. Conclusions: The results of this meta-analysis, comprising the limited data available, suggest that intrathecal administration of HER2-targeted therapy for patients with HER2+ BC LM confers no additional benefit over oral and/or IV treatment regimens. Although the number of patients receiving trastuzumab deruxtecan in this cohort is small, this novel agent offers promise for this patient population and requires further investigation in prospective studies.
MeSH term(s)	Female ; Humans ; Ado-Trastuzumab Emtansine/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Prospective Studies ; Randomized Controlled Trials as Topic ; Receptor, ErbB-2/antagonists & inhibitors ; Trastuzumab/administration & dosage ; Trastuzumab/therapeutic use ; Meningeal Neoplasms/secondary
Chemical Substances	Ado-Trastuzumab Emtansine (SE2KH7T06F) ; Receptor, ErbB-2 (EC 2.7.10.1) ; Trastuzumab (P188ANX8CK)
Language	English
Publishing date	2023-05-01
Publishing country	Netherlands
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	1143210-x
ISSN	1532-3080 ; 0960-9776
ISSN (online)	1532-3080
ISSN	0960-9776
DOI	10.1016/j.breast.2023.04.008
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Zs.A 3620: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 588: Show issues

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Article ; Online: sCD25 as an independent adverse prognostic factor in adult patients with HLH: results of a multicenter retrospective study.

Wimmer, Thomas / Mattes, Raphael / Stemmler, Hans-Joachim / Hauck, Fabian / Schulze-Koops, Hendrik / Stecher, Stephanie-Susanne / Starck, Michael / Wendtner, Clemens-Martin / Bojko, Peter / Hentrich, Marcus / Nickel, Katharina E / Götze, Katharina S / Bassermann, Florian / von Bergwelt-Baildon, Michael / Spiekermann, Karsten

Blood advances

2022 Volume 7, Issue 5, Page(s) 832–844

Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a rare but often fatal hyperinflammatory syndrome caused by an inborn or acquired error of immunity. In adults, the underlying immunodeficiency generally arises alongside severe infections, malignancies, ... ...

Abstract	Hemophagocytic lymphohistiocytosis (HLH) is a rare but often fatal hyperinflammatory syndrome caused by an inborn or acquired error of immunity. In adults, the underlying immunodeficiency generally arises alongside severe infections, malignancies, autoimmune diseases, and immunosuppressive treatment. To analyze risk factors and outcome in adults, we conducted a multicenter retrospective study. A total of 62 adult (age ≥18 years) patients met at least one of the following inclusion criteria: (1) ≥5 of 8 HLH-2004 criteria, (2) HScore ≥ 200 plus 4 HLH-2004 criteria, or (3) mutation compatible with an HLH diagnosis. Most patients (65%) were male, and the median age at diagnosis was 53.5 years (range, 19-81 years). All patients were assigned to 4 etiologic subgroups based on their most likely HLH trigger. The survival probability of the 4 etiologic subgroups differed significantly (P = .004, log-rank test), with patients with an underlying malignancy having the worst clinical outcome (1-year survival probability of 21%). The parameters older age, malignant trigger, elevated serum levels of aspartate transferase, creatinine, international normalized ratio, lactate dehydrogenase, sCD25, and a low albumin level and platelet count at treatment initiation were significantly (P < .1) associated with worse overall survival in the univariate Cox regression model. In multivariate analysis, sCD25 remained the only significant prognostic factor (P = .005). Our results suggest that sCD25 could be a useful marker for the prognosis of patients with HLH that might help to stratify therapeutic interventions.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; Lymphohistiocytosis, Hemophagocytic/diagnosis ; Lymphohistiocytosis, Hemophagocytic/etiology ; Neoplasms/complications ; Prognosis ; Retrospective Studies ; Risk Factors
Chemical Substances	IL2RA protein, human
Language	English
Publishing date	2022-08-16
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2022007953
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Zs.A 7153: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Clinicopathologic Findings in Fatal Neurotoxicity After Adoptive Immunotherapy With CD19-Directed CAR T-Cells.

Karschnia, Philipp / Strübing, Felix / Teske, Nico / Blumenberg, Viktoria / Bücklein, Veit L / Schmidt, Christian / Schöberl, Florian / Dimitriadis, Konstantinos / Forbrig, Robert / Stemmler, Hans-Joachim / Tonn, Joerg-Christian / von Bergwelt-Baildon, Michael / Subklewe, Marion / von Baumgarten, Louisa

HemaSphere

2021 Volume 5, Issue 3, Page(s) e533

Language	English
Publishing date	2021-02-10
Publishing country	United States
Document type	Case Reports
ISSN	2572-9241
ISSN (online)	2572-9241
DOI	10.1097/HS9.0000000000000533
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Article ; Online: Update 2021: COVID-19 aus Sicht der Intensivmedizin.

Stecher, Stephanie-Susanne / Stemmler, Hans Joachim / Eichenauer, Dennis A / Kochanek, Matthias / Shimabukuro-Vornhagen, Alexander / von Bergwelt-Baildon, Michael / Böll, Boris

Deutsche medizinische Wochenschrift (1946)

2021 Volume 146, Issue 13-14, Page(s) 908–910

Abstract: COVID-19 continues to challenge health-care systems and ICUs around the globe more than one year into the pandemic and in spite of all advances in diagnosis and treatment of the disease caused by the novel SARS-CoV-2. Many open questions remain ... ...

Title translation	Update 2021: COVID-19 from the perspective of intensive care.
Abstract	COVID-19 continues to challenge health-care systems and ICUs around the globe more than one year into the pandemic and in spite of all advances in diagnosis and treatment of the disease caused by the novel SARS-CoV-2. Many open questions remain concerning optimal medical therapy, respiratory management and resource allocation, particuly in times of limited available health care personell. In the following short article, we summarized current knowlegde on management of COVID-19 in the ICU.
MeSH term(s)	COVID-19/therapy ; Critical Care ; Humans ; Intensive Care Units/standards ; Intensive Care Units/trends
Language	German
Publishing date	2021-07-13
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	200446-x
ISSN	1439-4413 ; 0012-0472
ISSN (online)	1439-4413
ISSN	0012-0472
DOI	10.1055/a-1449-4995
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Ua VI Zs.60: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: Central nervous system metastases in HER-2-overexpressing metastatic breast cancer: a treatment challenge.

Stemmler, Hans-Joachim / Heinemann, Volker

The oncologist

2008 Volume 13, Issue 7, Page(s) 739–750

Abstract: With improvements in diagnostic and therapeutic options and a corresponding improvement in survival, central nervous system (CNS) metastasis is becoming a more frequent diagnosis in breast cancer patients. It can be assumed that up to 30% of metastatic ... ...

Abstract	With improvements in diagnostic and therapeutic options and a corresponding improvement in survival, central nervous system (CNS) metastasis is becoming a more frequent diagnosis in breast cancer patients. It can be assumed that up to 30% of metastatic breast cancer (MBC) patients may experience CNS metastasis during the course of their disease. Moreover, it has been reported that patients with human epidermal growth factor receptor (HER)-2-overexpressing MBC are at a higher risk for CNS involvement. Whereas locoregional treatment modalities such as surgery, radiosurgery, and whole-brain radiotherapy still must be considered as the treatment of first choice, the armamentarium of systemic treatment modalities has been expanded by the introduction of small molecules such as the tyrosine kinase inhibitors. Rather than analyzing the risk factors for the development of CNS metastasis and reviewing the standard diagnostic and therapeutic approaches in patients with CNS involvement, this review focuses specifically on systemic treatment modalities in patients suffering from CNS metastasis from HER-2-overexpressing MBC.
MeSH term(s)	Adult ; Antibodies, Monoclonal/therapeutic use ; Blood-Brain Barrier ; Brain/surgery ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Central Nervous System Neoplasms/secondary ; Central Nervous System Neoplasms/therapy ; Chemotherapy, Adjuvant ; Female ; Humans ; Immunologic Factors/therapeutic use ; Radiotherapy, Adjuvant ; Randomized Controlled Trials as Topic ; Receptor, ErbB-2/metabolism
Chemical Substances	Antibodies, Monoclonal ; Immunologic Factors ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2008-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1409038-7
ISSN	1083-7159
ISSN	1083-7159
DOI	10.1634/theoncologist.2008-0052
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Zs.A 4845: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: The Feasibility of Percutaneous Dilatational Tracheostomy in Immunosuppressed ICU Patients with or without Thrombocytopenia.

Angelberger, Marianne / Barnikel, Michaela / Fraccaroli, Alessia / Tischer, Johanna / Antón, Sofía / Pawlikowski, Alexandra / Op den Winkel, Mark / Stemmler, Hans Joachim / Stecher, Stephanie-Susanne

Critical care research and practice

2022 Volume 2022, Page(s) 5356413

Abstract: Background: Percutaneous dilatational tracheostomy (PDT) has become the preferred method in several intensive care units (ICUs), but data on PDT performed in immunosuppressed and thrombocytopenic patients are scarce. This study aimed to analyze the ... ...

Abstract	Background: Percutaneous dilatational tracheostomy (PDT) has become the preferred method in several intensive care units (ICUs), but data on PDT performed in immunosuppressed and thrombocytopenic patients are scarce. This study aimed to analyze the feasibility of PDT in immunosuppressed and thrombocytopenic patients compared to conventional open surgical tracheostomy (OST). Methods: We retrospectively analyzed the charts of patients who underwent PDT or OST between May 2017 and November 2020. Our outcomes were stoma site infections and bleeding complications. Results: 63 patients underwent PDT, and 21 patients underwent OST. Distribution of gender ratio, age, SAPS II, time of ventilation before tracheostomy, and preexisting hematooncological diseases was comparable between the two groups. After allogeneic stem cell transplantation (alloSCT), patients were more likely to undergo PDT than OST ( Conclusion: PDT is a feasible and safe procedure in a predominantly immunosuppressed and thrombocytopenic patient cohort without an increased risk for stoma site infections or bleeding complications.
Language	English
Publishing date	2022-05-26
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2573849-5
ISSN	2090-1313 ; 2090-1305
ISSN (online)	2090-1313
ISSN	2090-1305
DOI	10.1155/2022/5356413
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