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  1. Article ; Online: MECHANISMS IN ENDOCRINOLOGY: The gut-brain axis: regulating energy balance independent of food intake.

    Nogueiras, Ruben

    European journal of endocrinology

    2021  Volume 185, Issue 3, Page(s) R75–R91

    Abstract: Obesity is a global pandemic with a large health and economic burden worldwide. Bodyweight is regulated by the ability of the CNS, and especially the hypothalamus, to orchestrate the function of peripheral organs that play a key role in metabolism. Gut ... ...

    Abstract Obesity is a global pandemic with a large health and economic burden worldwide. Bodyweight is regulated by the ability of the CNS, and especially the hypothalamus, to orchestrate the function of peripheral organs that play a key role in metabolism. Gut hormones play a fundamental role in the regulation of energy balance, as they modulate not only feeding behavior but also energy expenditure and nutrient partitioning. This review examines the recent discoveries about hormones produced in the stomach and gut, which have been reported to regulate food intake and energy expenditure in preclinical models. Some of these hormones act on the hypothalamus to modulate thermogenesis and adiposity in a food intake-independent fashion. Finally, the association of these gut hormones to eating, energy expenditure, and weight loss after bariatric surgery in humans is discussed.
    MeSH term(s) Adipose Tissue/metabolism ; Animals ; Brain/metabolism ; Eating ; Energy Metabolism ; Gastric Mucosa/metabolism ; Gastrointestinal Hormones/metabolism ; Gastrointestinal Tract/metabolism ; Humans ; Hypothalamus/metabolism ; Obesity/metabolism
    Chemical Substances Gastrointestinal Hormones
    Language English
    Publishing date 2021-08-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1183856-5
    ISSN 1479-683X ; 0804-4643
    ISSN (online) 1479-683X
    ISSN 0804-4643
    DOI 10.1530/EJE-21-0277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Food odour recognition adjusts systemic metabolism to nutrient availability.

    Prevot, Vincent / Nogueiras, Ruben

    Nature reviews. Endocrinology

    2023  Volume 19, Issue 3, Page(s) 130–131

    MeSH term(s) Humans ; Odorants ; Nutrients
    Language English
    Publishing date 2023-01-05
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/s41574-022-00801-4
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  3. Article ; Online: Author Correction: Seeing through the fog: a neuroendocrine explanation for post-COVID cognitive deficits.

    Rasika, S / Nogueiras, Ruben / Schwaninger, Markus / Prevot, Vincent

    Nature reviews. Endocrinology

    2024  Volume 20, Issue 4, Page(s) 252

    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/s41574-024-00961-5
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  4. Article ; Online: Ghrelin.

    López, Miguel / Nogueiras, Ruben

    Current biology : CB

    2023  Volume 33, Issue 21, Page(s) R1133–R1135

    Abstract: López and Nogueiras introduce the peptide ghrelin and its physiological functions, including ...

    Abstract López and Nogueiras introduce the peptide ghrelin and its physiological functions, including its roles in stimulating appetite and growth hormone release.
    MeSH term(s) Ghrelin ; Growth Hormone ; Appetite/physiology
    Chemical Substances Ghrelin ; Growth Hormone (9002-72-6)
    Language English
    Publishing date 2023-11-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2023.09.009
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  5. Article ; Online: Seeing through the fog: a neuroendocrine explanation for post-COVID cognitive deficits.

    Rasika, S / Nogueiras, Ruben / Schwaninger, Markus / Prevot, Vincent

    Nature reviews. Endocrinology

    2024  Volume 20, Issue 4, Page(s) 189–190

    MeSH term(s) Humans ; Animals ; COVID-19 ; Cognitive Dysfunction/etiology ; Service Animals ; Cognition
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/s41574-024-00955-3
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  6. Article ; Online: Human defensin 5-based compounds: a new approach to fight obesity?

    Claret, Marc / Nogueiras, Ruben

    Gut

    2022  Volume 72, Issue 4, Page(s) 610–611

    MeSH term(s) Humans ; Defensins
    Chemical Substances Defensins
    Language English
    Publishing date 2022-08-12
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2022-328158
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  7. Article ; Online: Sun exposure stimulates appetite in males.

    Dieguez, Carlos / Nogueiras, Ruben

    Nature metabolism

    2022  Volume 4, Issue 7, Page(s) 796–797

    MeSH term(s) Appetite ; Humans ; Male ; Sunlight
    Language English
    Publishing date 2022-07-11
    Publishing country Germany
    Document type Journal Article ; Comment
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-022-00592-y
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  8. Article: Dual and Triple Incretin-Based Co-agonists: Novel Therapeutics for Obesity and Diabetes.

    Gutgesell, Robert M / Nogueiras, Rubén / Tschöp, Matthias H / Müller, Timo D

    Diabetes therapy : research, treatment and education of diabetes and related disorders

    2024  

    Abstract: The discovery of long-acting incretin receptor agonists represents a major stride forward in tackling the dual epidemic of obesity and diabetes. Here we outline the evolution of incretin-based pharmacotherapy, from exendin-4 to the discovery of the multi- ...

    Abstract The discovery of long-acting incretin receptor agonists represents a major stride forward in tackling the dual epidemic of obesity and diabetes. Here we outline the evolution of incretin-based pharmacotherapy, from exendin-4 to the discovery of the multi-incretin hormone receptor agonists that look set to be our next step toward curing diabetes and obesity. We discuss the multiagonists currently in clinical trials and the improvement in efficacy each new generation of these drugs bring. The success of these agents in preclinical models and clinical trials suggests a promising future for multiagonists in the treatment of metabolic diseases, with the most recent glucose-dependent insulinotropic peptide receptor:glucagon-like peptide 1 receptor:glucagon receptor (GIPR:GLP-1R:GCGR) triagonists rivaling the efficacy of bariatric surgery. However, further research is needed to fully understand how these therapies exert their effect on body weight and in the last section we cover open questions about the potential mechanisms of multiagonist drugs, and the understanding of how gut-brain communication can be leveraged to achieve sustained body weight loss without adverse effects.
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2566702-6
    ISSN 1869-6961 ; 1869-6953
    ISSN (online) 1869-6961
    ISSN 1869-6953
    DOI 10.1007/s13300-024-01566-x
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  9. Article ; Online: Expanding the roles of the renin-angiotensin system: Drug-induced liver injury.

    Nogueiras, Ruben / Aspichueta, Patricia

    Journal of hepatology

    2022  Volume 78, Issue 3, Page(s) 457–459

    MeSH term(s) Humans ; Renin-Angiotensin System ; Renin ; Kidney/metabolism ; Chemical and Drug Induced Liver Injury/metabolism ; Liver/metabolism
    Chemical Substances Renin (EC 3.4.23.15)
    Language English
    Publishing date 2022-12-30
    Publishing country Netherlands
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2022.12.016
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    Zs.A 2027: Show issues Location:
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  10. Article ; Online: Gut hormone co-agonists for the treatment of obesity: from bench to bedside.

    Nogueiras, Ruben / Nauck, Michael A / Tschöp, Matthias H

    Nature metabolism

    2023  Volume 5, Issue 6, Page(s) 933–944

    Abstract: The discovery and development of so-called gut hormone co-agonists as a new class of drugs for the treatment of diabetes and obesity is considered a transformative breakthrough in the field. Combining action profiles of multiple gastrointestinal hormones ...

    Abstract The discovery and development of so-called gut hormone co-agonists as a new class of drugs for the treatment of diabetes and obesity is considered a transformative breakthrough in the field. Combining action profiles of multiple gastrointestinal hormones within a single molecule, these novel therapeutics achieve synergistic metabolic benefits. The first such compound, reported in 2009, was based on balanced co-agonism at glucagon and glucagon-like peptide-1 (GLP-1) receptors. Today, several classes of gut hormone co-agonists are in development and advancing through clinical trials, including dual GLP-1-glucose-dependent insulinotropic polypeptide (GIP) co-agonists (first described in 2013), and triple GIP-GLP-1-glucagon co-agonists (initially designed in 2015). The GLP-1-GIP co-agonist tirzepatide was approved in 2022 by the US Food and Drug Administration for the treatment of type 2 diabetes, providing superior HbA1c reductions compared to basal insulin or selective GLP-1 receptor agonists. Tirzepatide also achieved unprecedented weight loss of up to 22.5%-similar to results achieved with some types of bariatric surgery-in non-diabetic individuals with obesity. In this Perspective, we summarize the discovery, development, mechanisms of action and clinical efficacy of the different types of gut hormone co-agonists, and discuss potential challenges, limitations and future developments.
    MeSH term(s) United States ; Humans ; Glucagon ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Gastrointestinal Hormones/therapeutic use ; Glucagon-Like Peptide 1/therapeutic use ; Glucagon-Like Peptide 1/metabolism ; Obesity/metabolism
    Chemical Substances Glucagon (9007-92-5) ; Gastrointestinal Hormones ; Glucagon-Like Peptide 1 (89750-14-1)
    Language English
    Publishing date 2023-06-12
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-023-00812-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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