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  1. Article ; Online: Burnout Rates Among General Orthopedic Surgeons and Subspecialists: A Pilot Study.

    Nugent, Robert E / Gaston, Tara E / Markowitz, Michael P / Cheesman, Quincy T / Herbst, Kristen A / Radack, Tyler M / Parekh, Selene G / Daniel, Joseph N

    Orthopedics

    2022  Volume 45, Issue 6, Page(s) 333–339

    Abstract: Burnout among physicians is a syndrome of emotional exhaustion, de-personalization, and reduced sense of personal accomplishment that can negatively affect personal relationships, physician well-being, and patient outcomes. Although burnout rates of up ... ...

    Abstract Burnout among physicians is a syndrome of emotional exhaustion, de-personalization, and reduced sense of personal accomplishment that can negatively affect personal relationships, physician well-being, and patient outcomes. Although burnout rates of up to 50% to 60% among orthopedic surgeons have been reported, no studies have evaluated burnout among orthopedic generalists and subspecialists. The primary goal of this study was to examine the prevalence of burnout among orthopedic disciplines. We conducted a multicenter study from March 2019 through December 2019 involving 149 orthopedists. An abbreviated Maslach Burnout Inventory-Human Services Survey was used to measure burnout. Demographic information, personal characteristics, professional characteristics, family life and spousal support, and depression were also assessed. The mean rate of burnout among all respondents was 62%, whereas 16.77% screened positive for depression. Subspecialties with the highest rates of burnout were oncology (100%), sports medicine (68%), and trauma (63%). Similarly, trauma (50.00%), oncology (40.00%), and general orthopedics (20.00%) had the highest positive depression screening rates. In contrast, shoulder and elbow (50%), pediatric (52%), and foot and ankle (54%) specialists had the lowest rates of burnout, whereas shoulder and elbow (0.00%), spine (0.00%), and sports medicine (6.50%) specialists had the lowest rates of positive depression screening. Older age, higher debt load, and oncology subspecialty were associated with increased burnout risk. This study sought to determine burnout rates within each orthopedic discipline, with a secondary aim of disclosing contributing factors. Trauma and oncology had the highest rates of burnout and positive depression screening. Because this study represents a small orthopedic cohort, larger studies are needed to appropriately manage burnout in the future. [
    MeSH term(s) Humans ; Child ; Orthopedic Surgeons ; Pilot Projects ; Burnout, Professional/epidemiology ; Burnout, Professional/diagnosis ; Burnout, Professional/psychology ; Orthopedics ; Surgeons
    Language English
    Publishing date 2022-09-13
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 424447-3
    ISSN 1938-2367 ; 0147-7447
    ISSN (online) 1938-2367
    ISSN 0147-7447
    DOI 10.3928/01477447-20220907-06
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  2. Article ; Online: Refractory very early-onset inflammatory bowel disease associated with cytosolic isoleucyl-tRNA synthetase deficiency: A case report.

    Fagbemi, Andrew / Newman, William G / Tangye, Stuart G / Hughes, Stephen M / Cheesman, Edmund / Arkwright, Peter D

    World journal of gastroenterology

    2020  Volume 26, Issue 15, Page(s) 1841–1846

    Abstract: ... Genome Sequencing revealed a novel pathogenic missense variant (c.290A > G) in the cytosolic isoleucyl-tRNA ...

    Abstract Background: Aminoacyl tRNA synthetases/ligases (ARSs) are highly conserved enzymes involved in attaching amino acids to tRNA promoting protein synthesis. Although deficiencies of ARSs localized to the mitochondria classically present with neuropathology, the clinical features of cytosolic ARS deficiencies are more variable. They have previously been associated with neonatal hepatitis, but never with early-onset inflammatory bowel disease.
    Case summary: A nine-year-old Bangladeshi boy presented with neonatal liver failure and deranged clotting, transaminitis and cholestasis. His parents were first cousins. Two older brothers and a sister were well. The patient suffered from loose stools from early infancy which became more troublesome and persistent from five years old with ten bloody motions a day. Repeated endoscopies showed persistent pancolitis, which was refractory to mesalazine, corticosteroids, azathioprine, sirolimus and anti-TNF (adalimumab) therapy, but has improved recently with subcutaneous methotrexate.Whole Genome Sequencing revealed a novel pathogenic missense variant (c.290A > G) in the cytosolic isoleucyl-tRNA synthetase gene, leading to an amino acid substitution (p.Asp97Gly). Pathogenic variants in other genes associated with inflammatory bowel disease (IBD) (
    Conclusion: This case report provides evidence that recessive mutations in cytosolic isoleucyl-tRNA synthetase are a novel monogenic cause of IBD, which should be considered, particularly in infants and children with a history of neonatal hepatitis and very early-onset IBD poorly responsive to treatment.
    MeSH term(s) Age of Onset ; Biopsy ; Child ; Colon/pathology ; Drug Resistance/genetics ; Humans ; Inflammatory Bowel Diseases/diagnosis ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/genetics ; Inflammatory Bowel Diseases/pathology ; Intestinal Mucosa/pathology ; Isoleucine-tRNA Ligase/deficiency ; Isoleucine-tRNA Ligase/genetics ; Male ; Mutation
    Chemical Substances Isoleucine-tRNA Ligase (EC 6.1.1.5)
    Language English
    Publishing date 2020-04-14
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v26.i15.1841
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  3. Article ; Online: How to estimate heritability: a guide for genetic epidemiologists.

    Barry, Ciarrah-Jane S / Walker, Venexia M / Cheesman, Rosa / Davey Smith, George / Morris, Tim T / Davies, Neil M

    International journal of epidemiology

    2022  Volume 52, Issue 2, Page(s) 624–632

    Abstract: Traditionally, heritability has been estimated using family-based methods such as twin studies. Advancements in molecular genomics have facilitated the development of methods that use large samples of (unrelated or related) genotyped individuals. Here, ... ...

    Abstract Traditionally, heritability has been estimated using family-based methods such as twin studies. Advancements in molecular genomics have facilitated the development of methods that use large samples of (unrelated or related) genotyped individuals. Here, we provide an overview of common methods applied in genetic epidemiology to estimate heritability, i.e. the proportion of phenotypic variation explained by genetic variation. We provide a guide to key genetic concepts required to understand heritability estimation methods from family-based designs (twin and family studies), genomic designs based on unrelated individuals [linkage disequilibrium score regression, genomic relatedness restricted maximum-likelihood (GREML) estimation] and family-based genomic designs (sibling regression, GREML-kinship, trio-genome-wide complex trait analysis, maternal-genome-wide complex trait analysis, relatedness disequilibrium regression). We describe how heritability is estimated for each method and the assumptions underlying its estimation, and discuss the implications when these assumptions are not met. We further discuss the benefits and limitations of estimating heritability within samples of unrelated individuals compared with samples of related individuals. Overall, this article is intended to help the reader determine the circumstances when each method would be appropriate and why.
    MeSH term(s) Humans ; Epidemiologists ; Genotype ; Twins ; Quantitative Trait Loci ; Genome, Human ; Polymorphism, Single Nucleotide ; Genome-Wide Association Study ; Models, Genetic ; Phenotype
    Language English
    Publishing date 2022-11-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 187909-1
    ISSN 1464-3685 ; 0300-5771
    ISSN (online) 1464-3685
    ISSN 0300-5771
    DOI 10.1093/ije/dyac224
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  4. Article ; Online: Can a virtual microbiology simulation be as effective as the traditional Wetlab for pharmacy student education?

    Baumann-Birkbeck, L / Anoopkumar-Dukie, S / Khan, S A / Cheesman, M J / O'Donoghue, M / Grant, G D

    BMC medical education

    2021  Volume 21, Issue 1, Page(s) 583

    Abstract: Background: Pharmacy practice education requires the development of proficiencies and an understanding of clinical microbiology. Learning in this area could be delivered using practical laboratory exercises, or potentially, simulation-based education. ... ...

    Abstract Background: Pharmacy practice education requires the development of proficiencies and an understanding of clinical microbiology. Learning in this area could be delivered using practical laboratory exercises, or potentially, simulation-based education. Simulation has previously successfully enhanced learning in health professional education. The current global climate due to COVID-19 has further highlighted the important role of technology-enhanced learning in delivering outcomes that meet the requisite learning objectives of a course. The aim of the present study was to compare the impact of a commercially available virtual microbiology simulation (VUMIE™) with a traditional wet laboratory (wetlab) on learner knowledge, skills and confidence in a second-year integrated pharmacotherapeutics course for Bachelor of Pharmacy students.
    Methods: A randomised, crossover study was employed to determine whether the simulation intervention (VUMIE™) improves learning outcomes (knowledge, skills and confidence) of pharmacy students, when compared to a traditional wetlab intervention. Each student completed three 1-2 h length sessions, for both the wetlab and VUMIE™ interventions (6 sessions total). Data was collected using surveys deployed at baseline (pre-interventions), post-intervention 1 or 2 (VUMIE™ or wetlab) and endpoint (post-interventions 1 and 2). Statistical analysis was conducted using SPSS Statistics 25 and Instat™ software.
    Results: Response rates were approximately 50% at initial survey and approximately 25% at endpoint survey. VUMIE™ produced higher post-intervention knowledge scores for the multiple-choice questions compared to the wetlab, however, the highest score was achieved at endpoint. Both interventions produced statistically significant differences for mean scores compared to baseline (pre-VUMIE™ and wetlab) across the domains of knowledge, skills and confidence. VUMIE™ produced higher post-intervention mean scores for knowledge, skills and confidence compared to post-intervention mean scores for the wetlab, however there was no statistical significance between the mean score for the two interventions, thus the VUMIE™ activity produced learning outcomes comparable to the wetlab activity.
    Conclusion: These findings suggest VUMIE™ provides similar effects on students' knowledge, skills, and confidence as a wetlab. The simulation's implementation was not cost-prohibitive, provided students with a physically and psychologically safe learning environment, and the benefit of being able to repeat activities, supporting deliberate practice.
    MeSH term(s) COVID-19 ; Cross-Over Studies ; Education, Pharmacy ; Humans ; Pharmacy ; SARS-CoV-2 ; Students, Pharmacy
    Language English
    Publishing date 2021-11-17
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2044473-4
    ISSN 1472-6920 ; 1472-6920
    ISSN (online) 1472-6920
    ISSN 1472-6920
    DOI 10.1186/s12909-021-03000-3
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  5. Article: Genetic contributions of noncognitive skills to academic development.

    Malanchini, Margherita / Allegrini, Andrea G / Nivard, Michel G / Biroli, Pietro / Rimfeld, Kaili / Cheesman, Rosa / von Stumm, Sophie / Demange, Perline A / van Bergen, Elsje / Grotzinger, Andrew D / Raffington, Laurel / De la Fuente, Javier / Pingault, Jean-Baptiste / Harden, K Paige / Tucker-Drob, Elliot M / Plomin, Robert

    Research square

    2023  

    Abstract: Noncognitive skills such as motivation and self-regulation, predict academic achievement beyond cognitive skills. However, the role of genetic and environmental factors and of their interplay in these developmental associations remains unclear. We ... ...

    Abstract Noncognitive skills such as motivation and self-regulation, predict academic achievement beyond cognitive skills. However, the role of genetic and environmental factors and of their interplay in these developmental associations remains unclear. We provide a comprehensive account of how cognitive and noncognitive skills contribute to academic achievement from ages 7 to 16 in a sample of >10,000 children from England and Wales. Results indicated that noncognitive skills become increasingly predictive of academic achievement across development. Triangulating genetic methods, including twin analyses and polygenic scores (PGS), we found that the contribution of noncognitive genetics to academic achievement becomes stronger over development. The PGS for noncognitive skills predicted academic achievement developmentally, with prediction nearly doubling by age 16, pointing to gene-environment correlation (rGE). Within-family analyses indicated both passive and active/evocative rGE processes driven by noncognitive genetics. By studying genetic effects through a developmental lens, we provide novel insights into the role of noncognitive skills in academic development.
    Language English
    Publishing date 2023-04-07
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-2775994/v1
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  6. Article: Genetic contributions of noncognitive skills to academic development.

    Malanchini, Margherita / Allegrini, Andrea G / Nivard, Michel G / Biroli, Pietro / Rimfeld, Kaili / Cheesman, Rosa / von Stumm, Sophie / Demange, Perline A / van Bergen, Elsje / Grotzinger, Andrew D / Raffington, Laurel / De la Fuente, Javier / Pingault, Jean-Baptiste / Harden, K Paige / Tucker-Drob, Elliot M / Plomin, Robert

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Noncognitive skills such as motivation and self-regulation, are partly heritable and predict academic achievement beyond cognitive skills. However, how the relationship between noncognitive skills and academic achievement changes over development is ... ...

    Abstract Noncognitive skills such as motivation and self-regulation, are partly heritable and predict academic achievement beyond cognitive skills. However, how the relationship between noncognitive skills and academic achievement changes over development is unclear. The current study examined how cognitive and noncognitive skills contribute to academic achievement from ages 7 to 16 in a sample of over 10,000 children from England and Wales. Noncognitive skills were increasingly predictive of academic achievement across development. Twin and polygenic scores analyses found that the contribution of noncognitive genetics to academic achievement became stronger over the school years. Results from within-family analyses indicated that associations with noncognitive genetics could not simply be attributed to confounding by environmental differences between nuclear families and are consistent with a possible role for evocative/active gene-environment correlations. By studying genetic effects through a developmental lens, we provide novel insights into the role of noncognitive skills in academic development.
    Language English
    Publishing date 2023-10-26
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.03.535380
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  7. Article ; Online: Reliable Pain Relief But Variable Return to Play After Arthroscopic Elbow Debridement in Baseball Players.

    Stenson, James F / Cheesman, Quincy T / Kirsch, Jacob M / Antonacci, Christopher L / Alberta, Frank G / Austin, Luke S

    Arthroscopy, sports medicine, and rehabilitation

    2021  Volume 3, Issue 5, Page(s) e1295–e1299

    Abstract: Purpose: We sought to determine the rate of return to play (RTP) in baseball players following arthroscopic elbow debridement for the management of the symptomatic elbow.: Methods: A retrospective case series with prospectively collected data via ... ...

    Abstract Purpose: We sought to determine the rate of return to play (RTP) in baseball players following arthroscopic elbow debridement for the management of the symptomatic elbow.
    Methods: A retrospective case series with prospectively collected data via questionnaire was conducted on all baseball players who underwent an arthroscopic elbow debridement, from July, 15, 2004 to November 1, 2017. A postoperative questionnaire was released at an average 7.25 year follow-up. Data collected included age, gender, laterality, preoperative diagnosis, range of motion, duration and characterization of symptoms, visual analog scale (VAS) pain score, complications, level of play, and RTP.
    Results: Follow-up data were available on 18 baseball players. Average age was 19.7 years (range 16-24). Seventeen were pitchers, and 1 was a catcher. Level of play included 12 collegiate athletes, 2 high school athletes, 2 recreational athletes, 1 minor league athletes, and 1 major league athlete. Rate of RTP was 61% (11/18) with 6 returning to a greater level and 5 to an equal level. The length of time to RTP following surgery was most commonly within 6-8 months (44.4%, 8/18). Mean VAS pain score improved from 6.9 to 0.75 (
    Conclusions: Pain can reliably be relieved following arthroscopic elbow debridement in baseball players. Although patient satisfaction may be high, patients do not always return to their previous level of play. Patients must be counseled on the risk of limited postoperative athletic capacity before the time of surgery.
    Level of evidence: Level IV, therapeutic case series.
    Language English
    Publishing date 2021-07-16
    Publishing country United States
    Document type Journal Article
    ISSN 2666-061X
    ISSN (online) 2666-061X
    DOI 10.1016/j.asmr.2021.05.010
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  8. Article ; Online: Midterm outcomes and survivorship of arthroscopic elbow debridement: a comparison of posttraumatic versus primary degenerative osteoarthritis.

    DeBernardis, Dennis A / Santoro, Adam J / Minissale, Nicholas J / Kirsch, Jacob M / Cheesman, Quincy T / Alberta, Frank G / Austin, Luke S

    JSES international

    2021  Volume 6, Issue 1, Page(s) 175–181

    Abstract: Background: Arthroscopic debridement is an effective means of surgical management of both degenerative osteoarthritis (DOA) and posttraumatic arthritis (PTA) of the elbow. However, the difference in the efficacy and longevity of this procedure when ... ...

    Abstract Background: Arthroscopic debridement is an effective means of surgical management of both degenerative osteoarthritis (DOA) and posttraumatic arthritis (PTA) of the elbow. However, the difference in the efficacy and longevity of this procedure when performed for these two distinct pathologies remains in question. The purpose of this study was to identify and compare the midterm outcomes and survivorship of arthroscopic debridement of elbow PTA and DOA.
    Methods: A retrospective analysis of patients undergoing arthroscopic debridement of DOA and PTA of the elbow was performed. A questionnaire containing the Oxford Elbow Score, as well as questions regarding the incidence of reoperation, additional nonoperative intervention, complications, pain, and satisfaction, was given at 5 years, minimum, after surgery. The midterm survivorship of arthroscopic debridement free of reoperation for any reason, as well as the remaining outcome measurements obtained via the questionnaire and in-office evaluation, was compared between PTA and DOA cohorts.
    Results: Eighty patients (DOA = 36, PTA = 44) were included in this study for analysis. All 36 patients with DOA were noted to be male. Follow-up time at the date of questionnaire response was 7.9 years (range, 5.6-11.8) in the DOA cohort and 8.6 years (range, 5.7-12.7) in the PTA cohort. Reoperation rates of 5.6% and 11.4% were identified in the DOA and PTA cohorts, respectively. No statistical difference was noted in reoperation rate, survivorship, or any measured patient-reported outcomes between cohorts at the final follow-up visit. Both cohorts demonstrated a significant improvement in Visual Analog Scale pain scores (
    Conclusion: Arthroscopic debridement is an equally efficacious treatment option for DOA and PTA of the elbow. Patients with either pathology can expect satisfactory elbow function and an improvement in pain with little chance of reoperation at the midterm of the follow-up duration.
    Language English
    Publishing date 2021-09-29
    Publishing country United States
    Document type Journal Article
    ISSN 2666-6383
    ISSN (online) 2666-6383
    DOI 10.1016/j.jseint.2021.07.018
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  9. Article: Initial multicenter experience using a novel articulating through-the-scope traction device for endoscopic submucosal dissection.

    Hayat, Maham / Schlachterman, Alexander / Schiavone, Grace / Mizrahi, Meir / Park, Jong Kyu / Kumbhari, Vivek / Cheesman, Antonio / Draganov, Peter V / Hasan, Muhammad Khalid / Yang, Dennis

    Endoscopy international open

    2023  Volume 11, Issue 8, Page(s) E778–E784

    Abstract: Background and study ... ...

    Abstract Background and study aims
    Language English
    Publishing date 2023-08-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2761052-4
    ISSN 2196-9736 ; 2364-3722
    ISSN (online) 2196-9736
    ISSN 2364-3722
    DOI 10.1055/a-2117-8444
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  10. Article ; Online: The fate of patients with large abdominal aortic aneurysms referred for consideration for elective repair.

    Dawkins, Claire / Hollingsworth, Andrew C / Milburn, Simon / Cheesman, Matthew / Danjoux, Gerard / Mofidi, Reza

    The Journal of cardiovascular surgery

    2020  Volume 62, Issue 1, Page(s) 35–41

    Abstract: Background: The premise of the Vascular Services Quality Improvement Programme (VSQIP) in management of patients with asymptomatic large abdominal aortic aneurysms (AAA) is reducing mortality from ruptured AAA in a sustainable way without introducing ... ...

    Abstract Background: The premise of the Vascular Services Quality Improvement Programme (VSQIP) in management of patients with asymptomatic large abdominal aortic aneurysms (AAA) is reducing mortality from ruptured AAA in a sustainable way without introducing excessive procedure related mortality. Inevitably a proportion of patients are deemed unfit for elective repair. The aim of this study was to report outcomes of patients who were referred with large asymptomatic AAAs including those turned down for elective repair and identify independent risk factors for being turned down for elective open or endovascular repair of AAA.
    Methods: Consecutive patients referred to a regional vascular center with a large AAA (greater than 55 mm) between 1
    Results: A total of 876 patients of whom 768 were men and 108 were women with a mean age of 74 years (SD: 7.2) and a diagnosis of a large asymptomatic AAA were assessed. One hundred and seventy-four patients (19.9%) were turned down for elective repair and 702 (80.1%) underwent repair [Open: 244(34.8%), EVAR: 458 (65.2%] with perioperative and 30 day mortality of 1.13% (8 patients). Median duration of follow-up was 1530 days (51 months), (inter quartile range: 1714 days). Patients who underwent repair had significantly higher survival rates compared with those who were turned down (P<0.0001). Risk factors for being turned down for elective AAA included anaerobic threshold <8 mL kg
    Conclusions: A significant cohort of patients with large asymptomatic AAA is turned down for elective AAA repair. These patients appear to have significantly lower survival rates than those who are treated. Information on patients turned down for elective AAA repair should be routinely reported.
    MeSH term(s) Aged ; Aged, 80 and over ; Aortic Aneurysm, Abdominal/diagnostic imaging ; Aortic Aneurysm, Abdominal/mortality ; Aortic Aneurysm, Abdominal/surgery ; Asymptomatic Diseases ; Clinical Decision-Making ; Elective Surgical Procedures ; Endovascular Procedures/adverse effects ; Endovascular Procedures/mortality ; Female ; Humans ; Male ; Patient Selection ; Postoperative Complications/mortality ; Referral and Consultation ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Surgical Clearance ; Time Factors ; Treatment Outcome ; Vascular Surgical Procedures/adverse effects ; Vascular Surgical Procedures/mortality
    Language English
    Publishing date 2020-07-16
    Publishing country Italy
    Document type Comparative Study ; Journal Article
    ZDB-ID 80143-4
    ISSN 1827-191X ; 0021-9509
    ISSN (online) 1827-191X
    ISSN 0021-9509
    DOI 10.23736/S0021-9509.20.11377-6
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