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Article ; Online: Home Medical Care for Heart Failure.

Yumino, Dai

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

2016 Volume 136, Issue 8, Page(s) 1133–1136

Abstract: As heart failure progresses to the end stage, it becomes more difficult to maintain the same level of quality of life using the established therapy for the heart failure patients. We believe that an innovative home medical care for heart failure therapy ... ...

Abstract	As heart failure progresses to the end stage, it becomes more difficult to maintain the same level of quality of life using the established therapy for the heart failure patients. We believe that an innovative home medical care for heart failure therapy that focuses on the individual's quality of daily living and early intervention is necessary. The roles of home medical care include: early discharge to home as opposed to long hospitalization; the prevention of re-hospitalization; the provision of good care; treatment of any exacerbations; and options available at the end of the patient's life at home. Being able to provide all of the above will allow heart failure patients to live at their home. Home medical care for heart failure requires collaborative teamwork among multiple institutions and medical professionals. Among this collaborative group, the role of pharmacists is critical. Since many of the elderly with heart failure are taking multiple medications, it is important to evaluate the compliance and to intervene for improvement. Pharmacists visiting the patient's home will be able to check the patient's living environment, to evaluate medication compliance, to reconsider the necessary medications for the specific patient, and to consult physicians. Pharmacists can also explain clearly to patients and their family members any changes in medical therapy, as the conditions for an end-stage heart failure patient may change drastically in a short time. By achieving all of the above, it may be possible to prevent re-hospitalization and to help maintain the quality of life for heart failure patients.
MeSH term(s)	Aged ; Heart Failure/therapy ; Home Care Services ; Humans ; Interdisciplinary Communication ; Intersectoral Collaboration ; Male ; Medication Adherence ; Palliative Care ; Patient Care Team ; Patient Education as Topic ; Pharmaceutical Services ; Pharmacists ; Professional Role ; Quality of Life
Language	Japanese
Publishing date	2016
Publishing country	Japan
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	200514-1
ISSN	1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
ISSN (online)	1347-5231
ISSN	0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
DOI	10.1248/yakushi.15-00271-5
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Article ; Online: A mutually communicable external system resource in remote monitoring for cardiovascular implantable electronic devices.

Hasumi, Eriko / Fujiu, Katsuhito / Nakamura, Kentaro / Yumino, Dai / Nishii, Nobuhiro / Imai, Yasushi / Shoda, Morio / Komuro, Issei

Pacing and clinical electrophysiology : PACE

2023 Volume 47, Issue 1, Page(s) 127–130

Abstract: Background: Using third-party resources to manage remote monitoring (RM) data from implantable cardiac electronic devices (CIEDs) can assist in device clinic workflows. However, each hospital-acquired data is not used for further analysis as big data.!## ...

Abstract	Background: Using third-party resources to manage remote monitoring (RM) data from implantable cardiac electronic devices (CIEDs) can assist in device clinic workflows. However, each hospital-acquired data is not used for further analysis as big data. Methods and results: We developed a real-time and automatically centralized system of CIED information from multiple hospitals. If the extensive data-based analysis suggests individual problems, it can be returned to each hospital. To show its feasibility, we prospectively analyzed data from six hospitals. For example, unexpected abnormal battery levels were easily illustrated without recall information. Conclusions: The centralized RM system could be a new platform that promotes the utilization of device data as big data, and that information could be used for each patient's practice.
MeSH term(s)	Humans ; Pacemaker, Artificial ; Defibrillators, Implantable ; Remote Sensing Technology/methods ; Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/therapy ; Monitoring, Physiologic/methods
Language	English
Publishing date	2023-12-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	424437-0
ISSN	1540-8159 ; 0147-8389
ISSN (online)	1540-8159
ISSN	0147-8389
DOI	10.1111/pace.14882
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Zs.A 1466: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Uremic Toxins and Atrial Fibrillation: Mechanisms and Therapeutic Implications.

Yamagami, Fumi / Tajiri, Kazuko / Yumino, Dai / Ieda, Masaki

Toxins

2019 Volume 11, Issue 10

Abstract: Atrial fibrillation (AF) is the most prevalent arrhythmia in the general population. There is a close association between chronic kidney disease (CKD) and AF. In recent years, attention has been focused on the relationship between AF and uremic toxins, ... ...

Abstract	Atrial fibrillation (AF) is the most prevalent arrhythmia in the general population. There is a close association between chronic kidney disease (CKD) and AF. In recent years, attention has been focused on the relationship between AF and uremic toxins, including indoxyl sulfate (IS). Several animal studies have shown that IS promotes the development and progression of AF. IS has been shown to cause fibrosis and inflammation in the myocardium and exacerbate AF by causing oxidative stress and reducing antioxidative defense. Administration of AST-120, an absorbent of uremic toxins, decreases uremic toxin-induced AF in rodents. We have recently reported that patients with a higher serum IS level exhibit a higher rate of AF recurrence after catheter ablation, with serum IS being a significant predictor of AF recurrence. In this review, we discuss the possible mechanisms behind the AF-promoting effects of uremic toxins and summarize the reported clinical studies of uremic toxin-induced AF.
MeSH term(s)	Animals ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/etiology ; Atrial Fibrillation/physiopathology ; Carbon/therapeutic use ; Humans ; Indican/therapeutic use ; Oxides/therapeutic use ; Renal Insufficiency, Chronic/complications ; Toxins, Biological ; Uremia
Chemical Substances	Oxides ; Toxins, Biological ; Carbon (7440-44-0) ; AST 120 (90597-58-3) ; Indican (N187WK1Y1J)
Language	English
Publishing date	2019-10-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518395-3
ISSN	2072-6651 ; 2072-6651
ISSN (online)	2072-6651
ISSN	2072-6651
DOI	10.3390/toxins11100597
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Article ; Online: Uremic Toxins and Atrial Fibrillation

Fumi Yamagami / Kazuko Tajiri / Dai Yumino / Masaki Ieda

Toxins, Vol 11, Iss 10, p

Mechanisms and Therapeutic Implications

2019 Volume 597

Abstract	Atrial fibrillation (AF) is the most prevalent arrhythmia in the general population. There is a close association between chronic kidney disease (CKD) and AF. In recent years, attention has been focused on the relationship between AF and uremic toxins, including indoxyl sulfate (IS). Several animal studies have shown that IS promotes the development and progression of AF. IS has been shown to cause fibrosis and inflammation in the myocardium and exacerbate AF by causing oxidative stress and reducing antioxidative defense. Administration of AST-120, an absorbent of uremic toxins, decreases uremic toxin-induced AF in rodents. We have recently reported that patients with a higher serum IS level exhibit a higher rate of AF recurrence after catheter ablation, with serum IS being a significant predictor of AF recurrence. In this review, we discuss the possible mechanisms behind the AF-promoting effects of uremic toxins and summarize the reported clinical studies of uremic toxin-induced AF.
Keywords	atrial fibrillation ; uremic toxin ; indoxyl sulfate ; chronic kidney disease ; Medicine ; R
Language	English
Publishing date	2019-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Long-Term Prognostic Role of the Diagnostic Criteria for Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia.

Kikuchi, Noriko / Yumino, Dai / Shiga, Tsuyoshi / Suzuki, Atsushi / Hagiwara, Nobuhisa

JACC. Clinical electrophysiology

2016 Volume 2, Issue 1, Page(s) 107–115

Abstract: Objectives: The aim of this study was to evaluate the long-term prognostic role of the 2010 task force criteria (TFC)-based scoring in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D).: Background: Categories of the ... ...

Abstract	Objectives: The aim of this study was to evaluate the long-term prognostic role of the 2010 task force criteria (TFC)-based scoring in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D). Background: Categories of the 2010 TFC include the risk factors for cardiovascular mortality and sudden cardiac death in patients with ARVC/D. Methods: Ninety patients with ARVC/D who met the definitive diagnosis of the 2010 TFC were retrospectively studied. ARVC/D risk score was calculated as the sum of major (2 points) and minor (1 point) criteria in all 6 subdivided categories of the TFC and was divided into tertile groups of scores; group A (4 to 6 points), group B (7 to 9 points), and group C (10 to 12 points). The primary endpoints were major adverse cardiovascular events: cardiovascular death, heart failure hospitalization, and sustained ventricular tachycardia or ventricular fibrillation. Results: During the follow-up period of 10.2 ± 7.1 years, 19 patients died because of cardiovascular causes, 28 patients were admitted because of worsened heart failure, and 47 patients experienced sustained ventricular tachycardia or ventricular fibrillation. Patients in groups B and C were at increased risk for major adverse cardiovascular events compared with those in group A (hazard ratio [HR]: 4.80; 95% confidence interval [CI]: 1.87 to 12.33; p = 0.001; and HR: 6.15; 95% CI: 2.20 to 17.21; p = 0.001, respectively). Patients in groups B and C were at increased risk for sustained ventricular tachycardia or ventricular fibrillation compared with those in group A (HR: 6.64; 95% CI: 2.00 to 22.03; p = 0.002; and HR: 9.18; 95% CI: 2.60 to 32.40; p = 0.001, respectively). Conclusions: Our study suggests that risk scoring based on the 2010 TFC is useful to predict major adverse cardiovascular events in patients with ARVC/D.
Language	English
Publishing date	2016-02
Publishing country	United States
Document type	Journal Article
ISSN	2405-5018
ISSN (online)	2405-5018
DOI	10.1016/j.jacep.2015.09.009
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Article ; Online: Relationship of stroke volume to different patterns of Cheyne-Stokes respiration in heart failure.

Inami, Toru / Kasai, Takatoshi / Yumino, Dai / Perger, Elisa / Alshaer, Hisham / Hummel, Richard / Lyons, Owen D / Floras, John S / Bradley, T Douglas

Sleep

2019 Volume 42, Issue 4

Abstract: Study objectives: In patients with heart failure (HF) and reduced left ventricular ejection fraction (HFrEF), stroke volume (SV) falls during hyperpnea of Cheyne-Stokes respiration with central sleep apnea (CSR-CSA). We have identified two distinct ... ...

Abstract	Study objectives: In patients with heart failure (HF) and reduced left ventricular ejection fraction (HFrEF), stroke volume (SV) falls during hyperpnea of Cheyne-Stokes respiration with central sleep apnea (CSR-CSA). We have identified two distinct patterns of hyperpnea: positive, in which end-expiratory lung volume (EELV) remains at or above functional residual capacity (FRC), and negative, in which EELV falls below FRC. The increase in expiratory intrathoracic pressure generated by the latter should have effects on the heart analogous to external chest compression. To test the hypotheses that in HFrEF patients, CSR-CSA with the negative pattern has an auto-resuscitation effect such that compared with the positive pattern, it is associated with a smaller fall in SV and a smaller increase in cardiac workload (product of heart rate and systolic blood pressure). Methods: In 15 consecutive HFrEF patients with CSR-CSA during polysomnography, hemodynamic data derived from digital photoplethysmography during positive and negative hyperpneas were compared. Results: Compared to the positive, negative hyperpneas were accompanied by reductions in the maximum and mean relative fall in SV of 30% (p = 0.002) and 10% (p = 0.031), respectively, and by reductions in the degree of increases in heart rate and rate pressure product during hyperpnea of 46% (p < 0.001) and 13% (p = 0.007), respectively. Conclusions: Our findings suggest the novel concept that the negative pattern of CSR-CSA may constitute a form of auto-resuscitation that acts as a compensatory mechanism to maintain SV in patients with severe HF.
MeSH term(s)	Blood Pressure/physiology ; Cheyne-Stokes Respiration/physiopathology ; Female ; Heart/physiopathology ; Heart Failure/physiopathology ; Heart Rate/physiology ; Humans ; Male ; Middle Aged ; Photoplethysmography ; Polysomnography ; Sleep Apnea, Central/physiopathology ; Stroke Volume/physiology ; Ventricular Function, Left/physiology
Language	English
Publishing date	2019-04-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	424441-2
ISSN	1550-9109 ; 0161-8105
ISSN (online)	1550-9109
ISSN	0161-8105
DOI	10.1093/sleep/zsy262
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Zs.A 1475: Show issues

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Article ; Online: Quality Indicators in Patient Referral Documents for Heart Failure in Japan.

Kinugasa, Yoshiharu / Saitoh, Masakazu / Ikegame, Toshimi / Ikarashi, Aoi / Kadota, Kazushige / Kamiya, Kentaro / Kohsaka, Shun / Mizuno, Atsushi / Miyajima, Isao / Nakane, Eisaku / Nei, Azusa / Shibata, Tatsuhiro / Yokoyama, Hiroyuki / Yumikura, Sei / Yumino, Dai / Watanabe, Noboru / Isobe, Mitsuaki

International heart journal

2022 Volume 63, Issue 2, Page(s) 278–285

Abstract: This study examined quality indicators (QIs) for heart failure (HF) in patients' referral documents (PRDs).We conducted a nationwide questionnaire survey to identify information that general practitioners (GPs) would like hospital cardiologists (HCs) to ... ...

Abstract	This study examined quality indicators (QIs) for heart failure (HF) in patients' referral documents (PRDs).We conducted a nationwide questionnaire survey to identify information that general practitioners (GPs) would like hospital cardiologists (HCs) to include in PRDs and that HCs actually include in PRDs. The percentage of GPs that desired each item included in PRDs was converted into a deviation score, and items with a deviation score of ≥ 50 were defined as QIs. We rated the quality of PRDs provided by HCs based on QI assessment.We received 281 responses from HCs and 145 responses from GPs. The following were identified as QIs: 1) HF cause; 2) B-type natriuretic peptide (BNP) or N-terminal pro-BNP concentration; 3) left ventricular ejection fraction or echocardiography; 4) body weight; 5) education of patients and their families on HF; 6) physical function, and 7) functions of daily living. Based on QI assessment, only 21.7% of HCs included all seven items in their PRDs. HCs specializing in HF and institutions with many full-time HCs were independently associated with including the seven items in PRDs.The quality of PRDs for HF varies among physicians and hospitals, and standardization is needed based on QI assessment.
MeSH term(s)	Heart Failure/diagnosis ; Heart Failure/therapy ; Humans ; Japan ; Quality Indicators, Health Care ; Referral and Consultation ; Stroke Volume ; Ventricular Function, Left
Language	English
Publishing date	2022-03-15
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2187806-7
ISSN	1349-3299 ; 1349-2365
ISSN (online)	1349-3299
ISSN	1349-2365
DOI	10.1536/ihj.21-617
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Article: Sleep apnea and the heart: diagnosis and treatment.

Yumino, Dai / Kasanuki, Hiroshi

Reviews in cardiovascular medicine

2008 Volume 9, Issue 3, Page(s) 159–167

Abstract: Although sleep apnea is closely associated with cardiovascular disease, it remains underdiagnosed and undertreated. Obstructive sleep apnea elicits a cascade of harmful cardiovascular stimuli, and central sleep apnea is a prognostic factor for heart ... ...

Abstract	Although sleep apnea is closely associated with cardiovascular disease, it remains underdiagnosed and undertreated. Obstructive sleep apnea elicits a cascade of harmful cardiovascular stimuli, and central sleep apnea is a prognostic factor for heart failure and may exert adverse effects on outcomes. The adverse effects of obstructive sleep apnea can promote the development of atherosclerosis and have also been implicated in the pathogenesis of cardiovascular disease. Sleep apnea characterized by variables of the autonomic nervous system may have a direct association with arrhythmia. Polysomnography with electroencephalography is the gold standard for assessing sleep apnea. Alternative methods of screening for OSA have recently become available. Continuous positive airway pressure for obstructive sleep apnea reduces cardiac risk and cardiovascular disease mortality. Targeting sleep apnea in the primary and/or secondary prevention of cardiovascular disease may lead to better outcomes.
MeSH term(s)	Cardiovascular Agents/therapeutic use ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/therapy ; Continuous Positive Airway Pressure ; Electroencephalography ; Heart Failure/etiology ; Heart Failure/prevention & control ; Humans ; Polysomnography ; Sleep Apnea Syndromes/complications ; Sleep Apnea Syndromes/diagnosis ; Sleep Apnea Syndromes/therapy ; Sleep Apnea, Central/complications ; Sleep Apnea, Central/diagnosis ; Sleep Apnea, Central/therapy ; Treatment Outcome
Chemical Substances	Cardiovascular Agents
Language	English
Publishing date	2008
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2108910-3
ISSN	1530-6550
ISSN	1530-6550
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Zs.A 6410: Show issues

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Article: Central sleep apnea and Cheyne-Stokes respiration.

Yumino, Dai / Bradley, T Douglas

Proceedings of the American Thoracic Society

2008 Volume 5, Issue 2, Page(s) 226–236

Abstract: Cheyne-Stokes respiration with central sleep apnea (CSR-CSA) is a form of periodic breathing, commonly observed in patients with heart failure (HF), in which central apneas alternate with hyperpneas that have a waxing-waning pattern of tidal volume. ... ...

Abstract	Cheyne-Stokes respiration with central sleep apnea (CSR-CSA) is a form of periodic breathing, commonly observed in patients with heart failure (HF), in which central apneas alternate with hyperpneas that have a waxing-waning pattern of tidal volume. Uniform criteria by which to diagnose a clinically significant degree of CSR-CSA have yet to be established. CSR-CSA is caused by respiratory control system instability characterized by a tendency to hyperventilate. Central apnea occurs when Pa(CO(2)) falls below the threshold for apnea during sleep due to ventilatory overshoot. Patients with CSR-CSA are generally hypocapnic, with a Pa(CO(2)) closer than normal to the apneic threshold such that even slight augmentation in ventilation drives Pa(CO(2)) below threshold and triggers apnea. Factors contributing to hyperventilation in HF include stimulation of pulmonary irritant receptors by pulmonary congestion, increased chemoreceptor sensitivity, reduced cerebrovascular blood flow, and recurrent arousals from sleep. Controversy remains as to whether CSR-CSA is simply a reflection of HF severity, or whether it exerts unique adverse effects on prognosis. The main adverse influence of CSR-CSA on cardiovascular function appears to be excessive sympathetic nervous system activity due to apnea-related hypoxia and arousals from sleep. A number of studies have examined the potential relationship between CSR-CSA and mortality in HF. Most reported that CSR-CSA was associated with an increased risk for mortality, but these studies were small. Further research is therefore needed to elucidate mechanisms which contribute to the pathogenesis of CSR-CSA, and to determine whether its treatment can reduce morbidity and mortality in patients with HF.
MeSH term(s)	Adult ; Cheyne-Stokes Respiration/diagnosis ; Cheyne-Stokes Respiration/etiology ; Cheyne-Stokes Respiration/physiopathology ; Heart Failure/complications ; Humans ; Polysomnography ; Risk Factors ; Sleep Apnea, Central/diagnosis ; Sleep Apnea, Central/etiology ; Sleep Apnea, Central/physiopathology
Language	English
Publishing date	2008-02-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2132421-9
ISSN	1943-5665 ; 1546-3222
ISSN (online)	1943-5665
ISSN	1546-3222
DOI	10.1513/pats.200708-129MG
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Article: Pathogenesis of atherosclerosis: is obstructive sleep apnea the new kid on the block?

Yumino, Dai / Bradley, T Douglas

American journal of respiratory and critical care medicine

2007 Volume 176, Issue 7, Page(s) 634–635

MeSH term(s)	Atherosclerosis/diagnosis ; Atherosclerosis/etiology ; Atherosclerosis/physiopathology ; Continuous Positive Airway Pressure ; Humans ; Risk Factors ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/physiopathology
Language	English
Publishing date	2007-10-01
Publishing country	United States
Document type	Comment ; Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	1180953-x
ISSN	1535-4970 ; 1073-449X ; 0003-0805
ISSN (online)	1535-4970
ISSN	1073-449X ; 0003-0805
DOI	10.1164/rccm.200706-926ED
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