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  1. Book ; Online ; E-Book: Control of breathing during sleep

    Rowley, James A. / Badr, M. Safwan / Chowdhuri, Susmita

    from bench to bedside

    2022  

    Author's details edited by Susmita Chowdhuri, M. Safwan Badr, James A. Rowley
    Keywords Respiration ; Sleep apnea syndromes
    Subject code 616.209
    Language English
    Size 1 online resource (282 pages)
    Publisher CRC Press
    Publishing place Boca Raton, Florida
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-00-300063-0 ; 1-003-00063-0 ; 1-000-57327-3 ; 0-367-55625-1 ; 978-1-00-300063-1 ; 978-1-003-00063-1 ; 978-1-000-57327-5 ; 978-0-367-55625-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Will Intranasal Leptin Mitigate Opioid-induced Sleep-disordered Breathing?

    Prasad, Bharati / Chowdhuri, Susmita

    American journal of respiratory cell and molecular biology

    2020  Volume 63, Issue 4, Page(s) 410–412

    MeSH term(s) Administration, Intranasal ; Animals ; Leptin ; Mice ; Mice, Obese ; Sleep Apnea Syndromes
    Chemical Substances Leptin
    Language English
    Publishing date 2020-08-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2020-0318ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Prevalence of central sleep apnea among veterans and response rate to continuous positive airway pressure therapy.

    Ibrahim, Nesrine Adly / Sankari, Abdulghani / Aldwaikat, Ahmad / Pandya, Nishtha / Chowdhuri, Susmita / Salloum, Anan / Martin, Jennifer L / Zeineddine, Salam / Badr, M Safwan

    Sleep advances : a journal of the Sleep Research Society

    2024  Volume 5, Issue 1, Page(s) zpae011

    Abstract: Study objectives: Sleep-disordered breathing (SDB) is common in the Veteran population. In this retrospective study, we investigated the prevalence of comorbid central and obstructive SDB and the response rate to PAP among Veterans.: Methods: ... ...

    Abstract Study objectives: Sleep-disordered breathing (SDB) is common in the Veteran population. In this retrospective study, we investigated the prevalence of comorbid central and obstructive SDB and the response rate to PAP among Veterans.
    Methods: Veterans were screened from a single VA medical center who had polysomnography (PSG) study from 2017 to 2021 to ascertain the presence, severity, and type of SDB by measuring the apnea-hypopnea index (AHI) and central apnea index (CAI). Patients were excluded if they did not have complete studies (diagnostic and PAP titration studies). The inclusion criteria for these analyses were central sleep apnea (CSA) defined as AHI ≥ 10 events/hour and CAI ≥ 5 events/hour. Diagnostic "CSA only" was defined as AHI ≥ 10 events/hour and CAI ≥ 50% of AHI. "OSA only" was defined if AHI ≥ 10 events/hour and CAI < 5 events/hour. Comorbid central and obstructive sleep apnea (COSA) was defined if AHI ≥ 10 events/hour and CAI > 5 events/hour but < 50% of AHI. The responsiveness to PAP therapy was determined based on the CAI < 5 events/hour on the titration study.
    Results: A total of 90 patients met the inclusion criteria and from those 64 Veterans were found to have COSA (71%), 18 (20%) were CSA only, and 8 (9%) were OSA only. A total of 22 (24.4%) Veterans diagnosed with CSA or COSA were responsive to PAP therapy. Sixty days after treatment initiation, both responsive and nonresponsive groups had significant decreases in AHI and CAI (
    Conclusions: Comorbid central and obstructive SDB is common among Veterans. The response to PAP therapy is suboptimal but improves over time.
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ISSN 2632-5012
    ISSN (online) 2632-5012
    DOI 10.1093/sleepadvances/zpae011
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  4. Article ; Online: Leukocytes: A Potential Link between Obstructive Sleep Apnea and Cardiovascular Disease?

    Rowley, James A / Chowdhuri, Susmita

    Annals of the American Thoracic Society

    2018  Volume 15, Issue 8, Page(s) 918–919

    MeSH term(s) Atherosclerosis ; Cardiovascular Diseases ; Humans ; Leukocytes ; Sleep Apnea, Obstructive
    Language English
    Publishing date 2018-08-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.201805-360ED
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    Zs.A 5828: Show issues Location:
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  5. Article ; Online: Oxygen Therapy in Sleep-Disordered Breathing.

    Zeineddine, Salam / Rowley, James A / Chowdhuri, Susmita

    Chest

    2021  Volume 160, Issue 2, Page(s) 701–717

    Abstract: Sleep-disordered breathing (SDB) is highly prevalent in adults and leads to significant cardiovascular and neurologic sequelae. Intermittent hypoxia during sleep is a direct consequence of SDB. Administration of nocturnal supplemental oxygen (NSO) has ... ...

    Abstract Sleep-disordered breathing (SDB) is highly prevalent in adults and leads to significant cardiovascular and neurologic sequelae. Intermittent hypoxia during sleep is a direct consequence of SDB. Administration of nocturnal supplemental oxygen (NSO) has been used as a therapeutic alternative to positive airway pressure (PAP) in SDB. NSO significantly improves oxygen saturation in OSA but is inferior to PAP in terms of reducing apnea severity and may prolong the duration of obstructive apneas. The effect of NSO on daytime sleepiness remains unclear, but NSO may improve physical function-related quality of life in OSA. Its effects on BP reduction remain inconclusive. The effects of NSO vs PAP in OSA with comorbid COPD (overlap syndrome) are unknown. NSO is effective in reducing central sleep apnea related to congestive heart failure; however, its impact on mortality and cardiovascular clinical outcomes are being investigated in an ongoing clinical trial. In conclusion, studies are inconclusive or limited regarding clinical outcomes with oxygen therapy compared with sham or PAP therapy in patients with OSA and overlap syndrome. Oxygen does mitigate central sleep apnea. This review examines the crucial knowledge gaps and suggests future research priorities to clarify the effects of optimal dose and duration of NSO, alone or in combination with PAP, on cardiovascular, sleep, and cognitive outcomes.
    MeSH term(s) Cognition ; Continuous Positive Airway Pressure ; Humans ; Oxygen Inhalation Therapy ; Oxygen Saturation ; Sleep Apnea Syndromes/therapy ; Sleep Quality
    Language English
    Publishing date 2021-02-19
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.02.017
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  6. Article ; Online: Sleep Disordered Breathing Caused by Chronic Opioid Use: Diverse Manifestations and Their Management.

    Chowdhuri, Susmita / Javaheri, Shahrokh

    Sleep medicine clinics

    2017  Volume 12, Issue 4, Page(s) 573–586

    Abstract: Opioid-induced sleep disordered breathing presents a therapeutic predicament with the increasing incidence of prescription opioid use for noncancer chronic pain in the United States. Central sleep apnea with a Biot or cluster breathing pattern is ... ...

    Abstract Opioid-induced sleep disordered breathing presents a therapeutic predicament with the increasing incidence of prescription opioid use for noncancer chronic pain in the United States. Central sleep apnea with a Biot or cluster breathing pattern is characteristic of polysomnography studies; however, long-term clinical outcomes and the impact of therapy remain unknown. Novel ampakine-based therapies are being investigated. Randomized controlled trials with therapies that target the underlying pathophysiologic mechanisms of opioid-induced sleep disordered breathing are required.
    MeSH term(s) Analgesics, Opioid/adverse effects ; Humans ; Positive-Pressure Respiration/methods ; Sleep Apnea Syndromes/chemically induced ; Sleep Apnea Syndromes/therapy
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2017-12
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1556-4088
    ISSN (online) 1556-4088
    DOI 10.1016/j.jsmc.2017.07.007
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  7. Article ; Online: The Veterans Administration and Department of Defense clinical practice guidelines for the diagnosis and management of sleep disorders: what does this mean for the practice of sleep medicine?

    Martin, Jennifer L / Mysliwiec, Vincent / Chowdhuri, Susmita / Ulmer, Christi S

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2020  Volume 16, Issue 8, Page(s) 1377–1381

    Abstract: None: In 2017 the Veterans Administration (VA) and Department of Defense (DOD) launched development of clinical practice guidelines (CPGs) for the diagnosis and treatment of sleep disorders, with the goal of informing and improving patient care. The ... ...

    Abstract None: In 2017 the Veterans Administration (VA) and Department of Defense (DOD) launched development of clinical practice guidelines (CPGs) for the diagnosis and treatment of sleep disorders, with the goal of informing and improving patient care. The guideline development process followed GRADE methodology, considering studies and systematic reviews published over the 10-year period prior to guideline development. A total of 41 recommendations were made,18 related to the diagnosis and treatment of obstructive sleep apnea (OSA) and 23 regarding chronic insomnia disorder. In contrast to other published guidelines, the VA DoD CPGs provide a comprehensive approach to diagnosis and management of the two most common sleep disorders, including a discussion of the sequencing of diagnostic approaches and treatment options. Regarding OSA, strong recommendations were made for follow-up evaluation after non-diagnostic home sleep apnea tests, positive airway pressure therapy as first-line treatment, and the incorporation of supportive, educational and behavioral interventions for patients at high risk for PAP therapy non-adherence due to comorbid conditions. Strong recommendations were also made for the use of cognitive-behavioral therapy for insomnia and against the use of kava (an herbal supplement) in the treatment of chronic insomnia disorder. These guidelines, while intended to directly inform care within VA and DOD, are broadly relevant to the practice of sleep medicine. The majority of scientific evidence was based on studies of non-military, non-veteran populations. The CPG is a major milestone for the VA and DOD in recognizing the importance of evidence-based treatments for sleep disorders in military personnel and veterans.
    MeSH term(s) Humans ; Military Personnel ; Sleep ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/therapy ; United States ; United States Department of Veterans Affairs ; Veterans
    Language English
    Publishing date 2020-08-17
    Publishing country United States
    Document type Journal Article ; Practice Guideline ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.8486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6590: Show issues Location:
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  8. Article ; Online: Tetraplegia is associated with increased hypoxic ventilatory response during nonrapid eye movement sleep.

    Vaughan, Sarah / Sankari, Abdulghani / Carroll, Sean / Eshraghi, Mehdi / Obiakor, Harold / Yarandi, Hossein / Chowdhuri, Susmita / Salloum, Anan / Badr, M Safwan

    Physiological reports

    2022  Volume 10, Issue 17, Page(s) e15455

    Abstract: People with cervical spinal cord injury (SCI) are likely to experience chronic intermittent hypoxia while sleeping. The physiological effects of intermittent hypoxia on the respiratory system during spontaneous sleep in individuals with chronic cervical ... ...

    Abstract People with cervical spinal cord injury (SCI) are likely to experience chronic intermittent hypoxia while sleeping. The physiological effects of intermittent hypoxia on the respiratory system during spontaneous sleep in individuals with chronic cervical SCI are unknown. We hypothesized that individuals with cervical SCI would demonstrate higher short- and long-term ventilatory responses to acute intermittent hypoxia (AIH) exposure than individuals with thoracic SCI during sleep. Twenty participants (10 with cervical SCI [9 male] and 10 with thoracic SCI [6 male]) underwent an AIH and sham protocol during sleep. During the AIH protocol, each participant experienced 15 episodes of isocapnic hypoxia using mixed gases of 100% nitrogen (N
    MeSH term(s) Eye Movements ; Humans ; Hypoxia ; Male ; Quadriplegia ; Sleep/physiology ; Spinal Cord Injuries/complications
    Language English
    Publishing date 2022-09-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.15455
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Control of Ventilation in Health and Disease.

    Chowdhuri, Susmita / Badr, M Safwan

    Chest

    2016  Volume 151, Issue 4, Page(s) 917–929

    Abstract: Control of ventilation occurs at different levels of the respiratory system through a negative feedback system that allows precise regulation of levels of arterial carbon dioxide and oxygen. Mechanisms for ventilatory instability leading to sleep- ... ...

    Abstract Control of ventilation occurs at different levels of the respiratory system through a negative feedback system that allows precise regulation of levels of arterial carbon dioxide and oxygen. Mechanisms for ventilatory instability leading to sleep-disordered breathing include changes in the genesis of respiratory rhythm and chemoresponsiveness to hypoxia and hypercapnia, cerebrovascular reactivity, abnormal chest wall and airway reflexes, and sleep state oscillations. One can potentially stabilize breathing during sleep and treat sleep-disordered breathing by identifying one or more of these pathophysiological mechanisms. This review describes the current concepts in ventilatory control that pertain to breathing instability during wakefulness and sleep, delineates potential avenues for alternative therapies to stabilize breathing during sleep, and proposes recommendations for future research.
    MeSH term(s) Humans ; Hypercapnia/physiopathology ; Hypoxia/physiopathology ; Pulmonary Ventilation/physiology ; Sleep Apnea Syndromes/physiopathology ; Sleep Apnea Syndromes/prevention & control ; Wakefulness/physiology
    Language English
    Publishing date 2016-12-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2016.12.002
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  10. Article ; Online: Who Needs Oxygen with Positive Airway Pressure Therapy?

    Chowdhuri, Susmita / Sankari, Abdulghani / Rowley, James A

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2017  Volume 13, Issue 1, Page(s) 7–8

    MeSH term(s) Continuous Positive Airway Pressure ; Humans ; Oxygen ; Oxygen Inhalation Therapy ; Respiratory System
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2017-01-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.6372
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