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  1. Article: Centrality of G6PD in COVID-19: The Biochemical Rationale and Clinical Implications.

    Buinitskaya, Yuliya / Gurinovich, Roman / Wlodaver, Clifford G / Kastsiuchenka, Siarhei

    Frontiers in medicine

    2020  Volume 7, Page(s) 584112

    Abstract: Introduction: ...

    Abstract Introduction:
    Keywords covid19
    Language English
    Publishing date 2020-10-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2020.584112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Centrality of G6PD in COVID-19

    Buinitskaya, Yuliya / Gurinovich, Roman / Wlodaver, Clifford G. / Kastsiuchenka, Siarhei

    Frontiers in Medicine

    The Biochemical Rationale and Clinical Implications

    2020  Volume 7

    Keywords covid19
    Publisher Frontiers Media SA
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2020.584112
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Centrality of G6PD in COVID-19

    Yuliya Buinitskaya / Roman Gurinovich / Clifford G. Wlodaver / Siarhei Kastsiuchenka

    Frontiers in Medicine, Vol

    The Biochemical Rationale and Clinical Implications

    2020  Volume 7

    Abstract: Introduction: COVID-19 is a novel and devastating disease. Its manifestations vary from asymptomatic to lethal. Moreover, mortality rates differ based on underlying health conditions and ethnicity. We investigated the biochemical rationale behind these ... ...

    Abstract Introduction: COVID-19 is a novel and devastating disease. Its manifestations vary from asymptomatic to lethal. Moreover, mortality rates differ based on underlying health conditions and ethnicity. We investigated the biochemical rationale behind these observations using machine reasoning by the sci.AI system (https://sci.ai/). Facts were extracted and linked from publications available in nlm.nih.gov and Europe PMC to form the dataset which was validated by medical experts.Results: Based on the analysis of experimental and clinical data, we synthesized detailed biochemical pathways of COVID-19 pathogenesis which were used to explain epidemiological and clinical observations. Clinical manifestations and biomarkers are highlighted to monitor the course of COVID-19 and navigate treatment. As depicted in the Graphical Abstract, SARS-CoV-2 triggers a pro-oxidant (PO) response leading to the production of reactive oxygen species (ROS) as a normal innate defense. However, SARS-CoV-2's unique interference with the antioxidant (AO) system, through suppression of nitric oxide (NO) production in the renin- angiotensin-aldosterone system (RAAS), leads to an excessive inflammatory PO response. The excessive PO response becomes critical in cohorts with a compromised AO system such as patients with glucose-6-phosphate dehydrogenase deficiency (G6PDd) where NO and glutathione (GSH) mechanisms are impaired. G6PDd develops in patients with metabolic syndrome. It is mediated by aldosterone (Ald) which also increases specifically in COVID-19.Conclusion: G6PD is essential for an adequate immune response. Both G6PDd and SARS-CoV-2 compromise the AO system through the same pathways rendering G6PDd the Achilles' heel for COVID-19. Thus, the evolutionary antimalarial advantage of the G6PDd cohort can be a disadvantage against SARS-CoV-2.
    Keywords COVID-19 ; glucose-6-phosphate dehydrogenase (G6PD) ; reactive oxygen species ; nitric oxide - NO ; glutathione ; aldosterone (Ald) ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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