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Article ; Online: Evaluation of nine active components of Lu-Jiao Fang in normal and hypertrophic rat myocardia via LC-MS/MS.

Ma, Jing-Ya / Shi, Xiao-Li / Liu, Li / Xu, Guang-Lin / Zhang, Jian-Wei

2020 Volume 34, Issue 5, Page(s) e4814

Abstract: Lu-Jiao Fang (LJF), a traditional Chinese medicine prescription, can improve the cardiac function ...

Abstract	Lu-Jiao Fang (LJF), a traditional Chinese medicine prescription, can improve the cardiac function of chronic heart failure (CHF) patients; however, knowledge about the cardiac distribution of LJF, especially in CHF animal models, is rather limited. This work aimed to explore the cardiac distribution of LJF in pressure overload-induced CHF rats at the last gavage administration of LJF after 30 weeks of treatment. LC-MS/MS methods for analyzing nine active components (i.e. loganin, hesperidin, epimedin C, icariin, psoralen, isopsoralen, baohuoside I, morroniside and specnuezhenide) of LJF in cardiac tissue samples were established, and the components were then analyzed in left ventricular wall (LVW) and right ventricular wall (RVW) in parallel at same time point postdose for three dose groups. The results showed that most analytical component levels in LVW (hypertrophic myocardium) were only 39-74% of those in RVW (normal myocardium); however, psoralen and isopsoralen levels in LVW were equal to or even greater than the levels in RVW, suggesting that the hypertrophic myocardium tissue affinity of psoralen and isopsoralen might overcome the negative effect of decreased blood flow on distribution. This study indicated that the pathological state may influence drug distribution, and the efficacy of psoralen and isopsoralen for improving CHF deserves further investigation.
MeSH term(s)	Animals ; Cardiomyopathy, Hypertrophic/drug therapy ; Chromatography, High Pressure Liquid/methods ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/chemistry ; Heart/drug effects ; Heart Failure/drug therapy ; Humans ; Male ; Rats ; Rats, Wistar ; Tandem Mass Spectrometry/methods
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2020-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	632848-9
ISSN	1099-0801 ; 0269-3879
ISSN (online)	1099-0801
ISSN	0269-3879
DOI	10.1002/bmc.4814
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: The water extract of "Jiao Mei Gu" attenuates the lipopolysaccharide-induced inflammatory response via inhibiting NF-κB activity in mice.

Luo, Li / Zhang, Wei / Zhang, Zaiqi / Zhu, Junyu / Li, Wei / Yi, Yuhao / Yang, Xue / Ma, Wei / Liang, Huaping

Journal of ethnopharmacology

2020 Volume 259, Page(s) 112882

Abstract: Ethnopharmacological relevance: Jiao Mei Gu (JMG), Cayratia albifolia C.L.Li, is a type of Dong ...

Abstract	Ethnopharmacological relevance: Jiao Mei Gu (JMG), Cayratia albifolia C.L.Li, is a type of Dong plant widely growing in Dong autonomous counties, Hunan province, China. As a type of traditional herbal medicine, the root of JMG plant has been used to treat inflammatory-related diseases such as arthritis because of its prominent anti-inflammatory effects in Dong medicine. Aim of the study: This work investigated the anti-inflammatory effects and mechanisms of the water extract from the root of JMG on lipopolysaccharide (LPS)-induced inflammatory models. Methods: Endotoxemia was induced in C57BL/6 mice by intraperitoneal injection of LPS (20 mg/kg), meanwhile intraperitoneal administration of safe doses of JMG. The survival curve of mice was determined. Serum inflammatory cytokines were detected by the Bio-Plex Mouse Cytokine 23-Plex Panel Kit and enzyme-linked immunosorbent assay (ELISA) at 6 h after drug treatment. Hematoxylin-eosin (HE) staining of important organs was completed at 24 h after treatment. The mechanism of inflammatory action was investigated in vitro on LPS-stimulated macrophages. Macrophage inflammation was then induced using 10 μg/mL LPS. The anti-inflammatory effect of JMG was investigated by the quantitative polymerase chain reaction (qPCR) and ELISA. The anti-inflammatory mechanism was determined using western blotting, the electrophoretic mobility shift assay, and immunocytochemistry. Finally, the antimicrobial activity of JMG was verified by survival experiments in vivo and by bacterial culture experiments in vitro. Results: A 200 mg/kg water extract of JMG was safe for mice and had a significant protective effect on LPS-induced sepsis. Organ damage of heart, liver, lung and kidney was also significantly reduced at 24 h in the JMG group, when compared with the LPS group. The serum MIP-1α (CCL-3), MIP-1β (CCL-4), IL-1β, and TNFα cytokines were significantly decreased at 6 h in the JMG group, when compared with the LPS group. In a similar manner, 0.2μg/ml JMG significantly reduced mRNA and protein levels of MIP-1α (CCL-3), MIP-1β (CCL-4), IL-1β, and TNFα in LPS-stimulated macrophage. JMG treatment inhibited the phosphorylation of NF-κB p65 and reduced nuclear transduction, thus reducing transcriptional activity. At the same time, we showed that JMG had no protective effect on Escherichia coli-induced sepsis, as well as no antimicrobial activity. Conclusions: Our results showed that a water-soluble extract of JMG inhibited LPS-induced inflammation via attenuating the NF-κB signaling pathway, which provides an important rationale for the treatment of inflammation-related diseases.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Cytokines/blood ; Cytokines/metabolism ; Drugs, Chinese Herbal/pharmacology ; Endotoxemia/chemically induced ; Endotoxemia/drug therapy ; Escherichia coli ; I-kappa B Proteins/metabolism ; Lipopolysaccharides/pharmacology ; Macrophages/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Signal Transduction/drug effects ; Transcription Factor RelA/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Anti-Inflammatory Agents ; Cytokines ; Drugs, Chinese Herbal ; I-kappa B Proteins ; Lipopolysaccharides ; NF-kappa B ; Transcription Factor RelA ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2020-04-20
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2020.112882
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1494: Show issues

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Article ; Online: Identification of components and metabolites in plasma of type 2 diabetic rat after oral administration of Jiao-Tai-Wan using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.

Li, Zhihui / Chen, Jianhua / Gao, Xing / Zhang, Ting / Zheng, Wei / Wei, Guijie / Huang, Yunfang / Qi, Jing / Zhang, Yujie / Ma, Pengkai

Journal of separation science

2020 Volume 43, Issue 13, Page(s) 2690–2707

Abstract: Jiao-Tai-Wan, which is composed of Coptis Rhizoma and Cinnamon Cortex, has been recently used ... potential bioactive components of Jiao-Tai-Wan, we identified its multiple prototypes and metabolites ... cinnamic acid after oral administration of Jiao-Tai-Wan. The prototypes from Jiao-Tai-Wan were extensively ...

Abstract	Jiao-Tai-Wan, which is composed of Coptis Rhizoma and Cinnamon Cortex, has been recently used to treat type 2 diabetes. Owing to lack of data on its prototypes and metabolites, elucidation of the pharmacological and clinically safe levels of this formula has been significantly hindered. To screen more potential bioactive components of Jiao-Tai-Wan, we identified its multiple prototypes and metabolites in the plasma of type 2 diabetic rats by ultra high performance liquid chromatography/quadrupole-time-of-flight mass spectrometry. A total of 47 compounds were identified in the plasma of type 2 diabetic rats, including 22 prototypes and 25 metabolites, with alkaloids constituting the majority of the absorbed prototype components. In addition, this is the first study to detect vanillic acid, gallic acid, chlorogenic acid, protocatechuic acid, 2-hydroxycinnamic acid, 3-hydroxycinnamic acid, 4-hydroxycinnamic acid, and 2-methoxy cinnamic acid after oral administration of Jiao-Tai-Wan. The prototypes from Jiao-Tai-Wan were extensively metabolized by demethylation, hydroxylation, and reduction in phase Ⅰ metabolic reactions and by methylation or conjugation of glucuronide or sulfate in phase Ⅱ reactions. This is the first systematic study on the components and metabolic profiles of Jiao-Tai-Wan in vivo. This study provides a useful chemical basis for further pharmacological research and clinical application of Jiao-Tai-Wan.
MeSH term(s)	Administration, Oral ; Animals ; Chromatography, High Pressure Liquid ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/metabolism ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/analysis ; Glucose Tolerance Test ; Male ; Mass Spectrometry ; Rats ; Rats, Sprague-Dawley ; Time Factors
Chemical Substances	Drugs, Chinese Herbal ; jiao tai wan
Language	English
Publishing date	2020-05-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.201901040
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Lun heng jiao du jian shi

Ma, Zonghuo

(Xin bian zhu zi ji cheng xu bian)

2010

Author's details	Ma zong huo zhu
Series title	Xin bian zhu zi ji cheng xu bian
Language	Chinese
Size	420 p, 20 cm
Edition	Di 1 ban
Publisher	Zhong hua shu ju
Publishing place	Bei jing
Document type	Book
Note	Hier auch später erschienene, unveränderte Nachdrucke
ISBN	9787101068122 ; 710106812X
Database	Former special subject collection: coastal and deep sea fishing

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Book ; Audio / Video: Wo jiao liu yue jin

Ma, Liwen

Lost and found

2007

Author's details	[Regie: Ma Liwen]
Language	Chinese
Size	1 DVD (Region 6), 87 Min
Publishing place	China
Document type	Book ; Audio / Video
Note	Audiosprachen: Chinesisch ; Untertitel: Chinesisch (Kurzzeichen)
Database	Former special subject collection: coastal and deep sea fishing

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Book: Dui wai han yu jiao xue shi fan jiao an

Zhang, Hesheng / Ma, Yanhua

2009

Author's details	Zhang Hesheng & Ma Yanhua = Teaching Plan Models for CLT / Zhang Hesheng & Ma Yanhua
Language	Chinese ; English
Size	2, 302 S.
Publisher	Beijing Normal University Publishing Group
Publishing place	Beijing
Document type	Book
ISBN	9787303098286 ; 7303098283
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Simultaneous determination of six coptis alkaloids in urine and feces by LC-MS/MS and its application to excretion kinetics and the compatibility mechanism of Jiao-Tai-Wan in insomniac rats.

Chen, Ning / Guo, Chang-E / Chen, Hongying / Chen, Jianhua / Bi, Xinning / Li, Hongpin / Zhu, Hongyu / Ma, Pengkai / Zhang, Yujie / Lin, Hongying

Biomedical chromatography : BMC

2018 Volume 32, Issue 8, Page(s) e4248

Abstract: Jiao-Tai-Wan (JTW) is a well-known traditional Chinese medicine prescription composed of Rhizoma ...

Abstract	Jiao-Tai-Wan (JTW) is a well-known traditional Chinese medicine prescription composed of Rhizoma Coptidis (RC) and Cortex Cinnamon (10:1, g/g). It has been used to treat insomnia in China for centuries. This study investigates the excretion properties of coptis alkaloids from RC and JTW in normal and insomniac rats, and it examines the compatibility mechanism for this prescription. A new liquid chromatography-tandem mass spectrometry method was developed for the simultaneous determination of six alkaloids - berberine, epiberberine, coptisine, jatrorrhizine, palmatine and magnoflorine - in rat urine and feces. The normal and model rats were orally treated with RC and JTW powder at a dosage containing 3.0 g kg
MeSH term(s)	Alkaloids/analysis ; Alkaloids/chemistry ; Alkaloids/pharmacokinetics ; Animals ; Chromatography, Liquid/methods ; Coptis/chemistry ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacokinetics ; Feces/chemistry ; Linear Models ; Male ; Rats ; Rats, Sprague-Dawley ; Reproducibility of Results ; Sensitivity and Specificity ; Sleep Initiation and Maintenance Disorders/metabolism ; Tandem Mass Spectrometry/methods
Chemical Substances	Alkaloids ; Drugs, Chinese Herbal ; jiao tai wan
Language	English
Publishing date	2018-08
Publishing country	England
Document type	Journal Article
ZDB-ID	632848-9
ISSN	1099-0801 ; 0269-3879
ISSN (online)	1099-0801
ISSN	0269-3879
DOI	10.1002/bmc.4248
Database	MEDical Literature Analysis and Retrieval System OnLINE

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In stock of ZB MED Cologne/Königswinter

Zs.A 2166: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Identification of components and metabolites in plasma of type 2 diabetic rat after oral administration of Jiao‐Tai‐Wan using ultra‐performance liquid chromatography/quadrupole time‐of‐flight mass spectrometry

Li, Zhihui / Chen, Jianhua / Gao, Xing / Zhang, Ting / Zheng, Wei / Wei, Guijie / Huang, Yunfang / Qi, Jing / Zhang, Yujie / Ma, Pengkai

Journal of separation science. 2020 July, v. 43, no. 13

2020

Abstract: Jiao‐Tai‐Wan, which is composed of Coptis Rhizoma and Cinnamon Cortex, has been recently used ... potential bioactive components of Jiao‐Tai‐Wan, we identified its multiple prototypes and metabolites ... cinnamic acid after oral administration of Jiao‐Tai‐Wan. The prototypes from Jiao‐Tai‐Wan were extensively ...

Abstract	Jiao‐Tai‐Wan, which is composed of Coptis Rhizoma and Cinnamon Cortex, has been recently used to treat type 2 diabetes. Owing to lack of data on its prototypes and metabolites, elucidation of the pharmacological and clinically safe levels of this formula has been significantly hindered. To screen more potential bioactive components of Jiao‐Tai‐Wan, we identified its multiple prototypes and metabolites in the plasma of type 2 diabetic rats by ultra high performance liquid chromatography/quadrupole‐time‐of‐flight mass spectrometry. A total of 47 compounds were identified in the plasma of type 2 diabetic rats, including 22 prototypes and 25 metabolites, with alkaloids constituting the majority of the absorbed prototype components. In addition, this is the first study to detect vanillic acid, gallic acid, chlorogenic acid, protocatechuic acid, 2‐hydroxycinnamic acid, 3‐hydroxycinnamic acid, 4‐hydroxycinnamic acid, and 2‐methoxy cinnamic acid after oral administration of Jiao‐Tai‐Wan. The prototypes from Jiao‐Tai‐Wan were extensively metabolized by demethylation, hydroxylation, and reduction in phase Ⅰ metabolic reactions and by methylation or conjugation of glucuronide or sulfate in phase Ⅱ reactions. This is the first systematic study on the components and metabolic profiles of Jiao‐Tai‐Wan in vivo. This study provides a useful chemical basis for further pharmacological research and clinical application of Jiao‐Tai‐Wan.
Keywords	Coptis ; chlorogenic acid ; cinnamic acid ; cinnamon ; cortex ; demethylation ; gallic acid ; hydroxylation ; liquids ; mass spectrometry ; metabolites ; methylation ; noninsulin-dependent diabetes mellitus ; oral administration ; p-coumaric acid ; protocatechuic acid ; prototypes ; rats ; rhizomes ; separation ; sulfates ; ultra-performance liquid chromatography ; vanillic acid
Language	English
Dates of publication	2020-07
Size	p. 2690-2707.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	NAL-AP-2-clean ; JOURNAL ARTICLE
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.201901040
Database	NAL-Catalogue (AGRICOLA)

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Book: Zhong wai wen hua jiao liu shi

Ma, Shude / Zhou, Siyuan

(Wen hua shu xi ; 文化书系)

2000

Abstract: Ben shu shi wei wai guo liu xue sheng zhong guo yu yan wen hua zhuan ye jiao xue zhi xu bian xie de ... jie shao le zi qin han shi zhi jin zhong guo yu wai guo jin xing wen hua jiao liu de li shi ...

Title variant	Umschlagt.: Zhongwai wenhua jiaoliushi ; Zhongwai wenhua jiaoliushi
Author's details	Zhou si yuan zhu bian; chen qing, song shang zhai, zhang yan feng fu zhu bian; ma shu de bian zhu
Series title	Wen hua shu xi 文化书系
Abstract	Ben shu shi wei wai guo liu xue sheng zhong guo yu yan wen hua zhuan ye jiao xue zhi xu bian xie de, jie shao le zi qin han shi zhi jin zhong guo yu wai guo jin xing wen hua jiao liu de li shi
Keywords	China
Language	Chinese
Size	v, 331 p, ill, 20 cm
Edition	Di 1 ban
Publisher	Bei jing yu yan wen hua da xue chu ban she
Publishing place	Bei jing
Document type	Book
Note	Hier auch später erschienene, unveränderte Nachdrucke ; Includes bibliographical references (p. 329-330)
ISBN	7561908849 ; 9787561908846
Database	Former special subject collection: coastal and deep sea fishing

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Book: Duo wei shi jiao xia de ying guo cha wen hua yan jiu

Ma, Xiaoli

A study of british tea culture from a multi-dimentional perspective

(Bo shi wen cong, wen hua xi lie = culture and literature)

2010

Author's details	Ma Xiaoli zhu
Series title	Bo shi wen cong, wen hua xi lie = culture and literature
Language	Chinese
Size	getr. Zählung, Ill.
Edition	Di 1 ban
Publisher	Zhejiang University Press
Publishing place	Hangzhou
Document type	Book
ISBN	9787308078641 ; 7308078647
Database	Former special subject collection: coastal and deep sea fishing

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