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  1. Article ; Online: m

    Zhang, Yingyu / Zhang, Wanwei / Zhao, Jingyao / Ito, Takamasa / Jin, Jiacheng / Aparicio, Alexis O / Zhou, Junsong / Guichard, Vincent / Fang, Yinshan / Que, Jianwen / Urban, Joseph F / Hanna, Jacob H / Ghosh, Sankar / Wu, Xuebing / Ding, Lei / Basu, Uttiya / Huang, Yuefeng

    Nature immunology

    2023  Volume 24, Issue 8, Page(s) 1256–1264

    Abstract: Innate lymphoid cells (ILCs) can quickly switch from a quiescent state to an active state and rapidly produce effector molecules that provide critical early immune protection. How the post-transcriptional machinery processes different stimuli and ... ...

    Abstract Innate lymphoid cells (ILCs) can quickly switch from a quiescent state to an active state and rapidly produce effector molecules that provide critical early immune protection. How the post-transcriptional machinery processes different stimuli and initiates robust gene expression in ILCs is poorly understood. Here, we show that deletion of the N
    MeSH term(s) Cytokines/metabolism ; Homeostasis ; Immunity, Innate/genetics ; Immunity, Innate/immunology ; Lymphocytes/immunology ; RNA/metabolism ; Animals ; Mice
    Chemical Substances Cytokines ; RNA (63231-63-0) ; Gata3 protein, mouse ; Mettl3 protein, mouse (EC 2.1.1.-)
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-023-01548-4
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  2. Article ; Online: Systematic Study on Zirconium Chelidamates: From a Molecular Complex to a M-HOF and a MOF.

    Poschmann, Mirjam P M / Alan, Özge / Ito, Sho / Näther, Christian / Friedrichs, Gernot / Stock, Norbert

    Inorganic chemistry

    2023  Volume 62, Issue 31, Page(s) 12252–12259

    Abstract: We report the synthesis and in-depth characterization of three zirconium chelidamates, a molecular complex ( ... ...

    Abstract We report the synthesis and in-depth characterization of three zirconium chelidamates, a molecular complex (H
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c01079
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  3. Article ; Online: Electron Affinities of Ligated Icosahedral M

    Ito, Shun / Tasaka, Yuriko / Nakamura, Katsunosuke / Fujiwara, Yuki / Hirata, Keisuke / Koyasu, Kiichirou / Tsukuda, Tatsuya

    The journal of physical chemistry letters

    2022  Volume 13, Issue 22, Page(s) 5049–5055

    Abstract: The electron binding energies of the ligand-protected gold/silver-based cluster anions, [ ... ...

    Abstract The electron binding energies of the ligand-protected gold/silver-based cluster anions, [Au
    Language English
    Publishing date 2022-06-02
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.2c01284
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  4. Article ; Online: Supervalence Bonding in Bi-icosahedral Cores of [M

    Ito, Emi / Ito, Shun / Takano, Shinjiro / Nakamura, Toshikazu / Tsukuda, Tatsuya

    JACS Au

    2022  Volume 2, Issue 11, Page(s) 2627–2634

    Abstract: ... ...

    Abstract Au
    Language English
    Publishing date 2022-11-04
    Publishing country United States
    Document type Journal Article
    ISSN 2691-3704
    ISSN (online) 2691-3704
    DOI 10.1021/jacsau.2c00519
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  5. Article ; Online: Comparison of 0.1 M Stable CsCl and 1 M NH

    Koshikawa, Masami K / Watanabe, Mirai / Tamaoki, Masanori / Ito, Shoko / Takamatsu, Takejiro / Murata, Tomoyoshi / Saito, Takashi / Hayashi, Seiji

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

    2018  Volume 35, Issue 2, Page(s) 153–158

    Abstract: To evaluate the mobility and bioavailability ... ...

    Abstract To evaluate the mobility and bioavailability of
    MeSH term(s) Cesium/chemistry ; Cesium Radioisotopes/analysis ; Cesium Radioisotopes/isolation & purification ; Chemical Fractionation/methods ; Chlorides/chemistry ; Indicators and Reagents/chemistry ; Minerals/chemistry ; Nitrates/chemistry ; Soil/chemistry
    Chemical Substances Cesium Radioisotopes ; Chlorides ; Indicators and Reagents ; Minerals ; Nitrates ; Soil ; Cesium (1KSV9V4Y4I) ; Cesium-137 (4T2E65IAR7) ; cesium chloride (GNR9HML8BA) ; ammonium nitrate (T8YA51M7Y6)
    Language English
    Publishing date 2018-09-21
    Publishing country Japan
    Document type Comparative Study ; Journal Article
    ZDB-ID 1483376-1
    ISSN 1348-2246 ; 0910-6340
    ISSN (online) 1348-2246
    ISSN 0910-6340
    DOI 10.2116/analsci.18P325
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  6. Article ; Online: Syntheses, structures, and magnetic properties of a series of Mn-M-Mn trinuclear complexes with different spin configurations.

    Shiga, Takuya / Ito, Honami / Mihara, Nozomi / Nihei, Masayuki

    Dalton transactions (Cambridge, England : 2003)

    2022  Volume 51, Issue 2, Page(s) 562–569

    Abstract: A series of trinuclear complexes, [ ... ...

    Abstract A series of trinuclear complexes, [MnII2Y
    Language English
    Publishing date 2022-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d1dt03030b
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  7. Article ; Online: Negative correlation between organ heteroplasmy, particularly hepatic heteroplasmy, and age at death revealed by post-mortem studies of m.3243A > G cases.

    Yagi, Kunimasa / Okazaki, Satoko / Ohbatake, Azusa / Nakaya, Masako / Liu, Jianhui / Arite, Eiko / Miyamoto, Yukiko / Ito, Naoko / Nakano, Kaoru / Yamaaki, Naoto / Honoki, Hisae / Fujisaka, Shiho / Chujo, Daisuke / Tsunoda, Shin-Ichiro / Yanagimoto, Kunio / Nozue, Tsuyoshi / Yamada, Masayo / Ooe, Kotaro / Araki, Tsutomu /
    Nakashima, Akikatsu / Azami, Yasushi / Sodemoto, Yukio / Tadokoro, Kenichi / Nagano, Makoto / Noguchi, Tohru / Nohara, Atushi / Origasa, Hideki / Niida, Yo / Tada, Hayato

    Molecular genetics and metabolism

    2023  Volume 140, Issue 3, Page(s) 107691

    Abstract: Mitochondrial DNA m.3243A > G mutation causes mitochondrial encephalopathy, lactic acidosis, and ... associations between m.3243A > G organ heteroplasmy and clinical phenotypes, including the age at death ... to juvenile-onset (any m.3243A > G-related symptoms appeared before 20) and stroke-like episodes. Multiple ...

    Abstract Mitochondrial DNA m.3243A > G mutation causes mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) and its associated multi-organ disorders, including diabetes. To clarify associations between m.3243A > G organ heteroplasmy and clinical phenotypes, including the age at death, we combined genetic and pathological examinations from seven unreported and 36 literature cases of autopsied subjects. Clinical characteristics of subjects were as follows: male, 13; female, 28; unknown, 2; the age at death, 36.9 ± 20.2 [4-82] years; BMI, 16.0 ± 2.9 [13.0-22.3]; diabetes, N = 21 (49%), diabetes onset age 38.6 ± 14.2 years; deafness, N = 27 (63%); stroke-like episodes (StLEp), N = 25 (58%); congestive heart failure (CHF), N = 15 (35%); CHF onset age, 51.3 ± 14.5 years. Causes of death (N = 32) were as follows: cardiac, N = 13 (41%); infection, N = 8 (25%); StLEp, N = 4 (13%); gastrointestinal, N = 4 (13%); renal, N = 2 (6%); hepatic, N = 1 (2%). High and low heteroplasmies were confirmed in non-regenerative and regenerative organs, respectively. Heteroplasmy of the liver, spleen, leukocytes, and kidney for all subjects was significantly associated with the age at death. Furthermore, the age at death was related to juvenile-onset (any m.3243A > G-related symptoms appeared before 20) and stroke-like episodes. Multiple linear regression analysis with the age at death as an objective variable showed the significant contribution of liver heteroplasty and juvenile-onset to the age at death. m.3243A > G organ heteroplasmy levels, particularly hepatic heteroplasmy, are significantly associated with the age at death in deceased cases.
    MeSH term(s) Humans ; Male ; Female ; Adult ; Middle Aged ; Aged ; Child, Preschool ; Child ; Adolescent ; Young Adult ; Aged, 80 and over ; Heteroplasmy ; DNA, Mitochondrial/genetics ; Mutation ; Diabetes Mellitus ; Stroke/complications ; Liver/pathology ; MELAS Syndrome/genetics
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2023-08-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1418518-0
    ISSN 1096-7206 ; 1096-7192
    ISSN (online) 1096-7206
    ISSN 1096-7192
    DOI 10.1016/j.ymgme.2023.107691
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    Zs.A 617: Show issues Location:
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  8. Article: Genetic Characterization of CTX-M-2-Producing

    Tsuka, Takeshi / Ozaki, Hiroichi / Saito, Daisuke / Murase, Toshiyuki / Okamoto, Yoshiharu / Azuma, Kazuo / Osaki, Tomohiro / Ito, Norihiko / Murahata, Yusuke / Imagawa, Tomohiro

    Frontiers in veterinary science

    2021  Volume 8, Page(s) 659222

    Abstract: CTX-M-2-producing ...

    Abstract CTX-M-2-producing
    Language English
    Publishing date 2021-05-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2021.659222
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  9. Article ; Online: 5-HT and α-m-5-HT attenuate excitatory synaptic transmissions onto the lateral amygdala principal neurons via presynaptic 5-HT

    Yamamoto, Ryo / Ito, Tetsufumi / Furuyama, Takafumi / Ono, Munenori / Kato, Nobuo

    Biochemical and biophysical research communications

    2022  Volume 624, Page(s) 28–34

    Abstract: ... We confirmed that 5-HT and α-m-5-HT, a broad 5-HT ...

    Abstract Accumulating evidence suggests that the serotonergic (5-HT) system in the amygdala has significant effects on affective states. Dysregulation of the 5-HT system in the basolateral amygdaloid complex causes affective disorders. To search for therapeutic targets, subtype specification of 5-HT receptors is crucial. The present study was undertaken to identify the 5-HT receptor subtype responsible for the 5-HT-mediated suppression of excitatory transmission to principal neurons (PNs) in the lateral amygdala (LA). Whole-cell recordings were performed to record excitatory post synaptic currents (EPSCs) in acute rat brain slices. We confirmed that 5-HT and α-m-5-HT, a broad 5-HT
    MeSH term(s) Amygdala ; Animals ; Excitatory Postsynaptic Potentials ; Neurons ; Rats ; Receptor, Serotonin, 5-HT1B ; Serotonin/pharmacology ; Serotonin/physiology ; Synaptic Transmission
    Chemical Substances Receptor, Serotonin, 5-HT1B ; Serotonin (333DO1RDJY)
    Language English
    Publishing date 2022-07-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2022.07.076
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  10. Article ; Online: Discovery of anti-cell migration activity of an anti-HIV heterocyclic compound by identification of its binding protein hnRNP M.

    Kamo, Masahiro / Ito, Miu / Toma, Tsugumasa / Gotoh, Haruna / Shimozono, Rie / Nakagawa, Riko / Koga, Ryoko / Monde, Kazuaki / Tateishi, Hiroshi / Misumi, Shogo / Otsuka, Masami / Fujita, Mikako

    Bioorganic chemistry

    2021  Volume 107, Page(s) 104627

    Abstract: ... successfully identified heterogenous nuclear ribonucleoprotein M (hnRNP M) as a BMMP-binding protein ... This protein was found not to be accountable for the anti-HIV activity of BMMP. As hnRNP M has been reported ... showed that BMMP suppressed the expression of CD44 mRNA via the regulation of hnRNP M. Furthermore, six ...

    Abstract One compound sometimes shows two biological functions, becoming important aspect of recent drug discovery. This study began with an attempt to confirm the previously reported molecular mechanism of the anti-human immunodeficiency virus (HIV) heterocyclic compound BMMP [2-(benzothiazol-2-ylmethylthio)-4-methylpyrimidine], i.e., induction of abnormal uncoating of the viral core at the post-entry step. Our mechanistic study gave results consistent with this mechanism. We further attempted to find out the molecular target of BMMP by a pulldown approach using previously synthesized biotinylated BMMP (Biotin-BMMP) and successfully identified heterogenous nuclear ribonucleoprotein M (hnRNP M) as a BMMP-binding protein. This protein was found not to be accountable for the anti-HIV activity of BMMP. As hnRNP M has been reported to promote cancer metastasis, we tested this mechanism and found that BMMP suppressed migration of the human lung carcinoma cell line A549 stimulated with transforming growth factor-β (TGF-β). Mechanistic study showed that BMMP suppressed the expression of CD44 mRNA via the regulation of hnRNP M. Furthermore, six new derivatives of BMMP were synthesized, and the patterns of their activities against HIV-1 and cell migration were not uniform, suggesting that the anti-HIV mechanism and the anti-cell migration mechanism of BMMP are independent. Taken together, the anti-cell migration activity of the anti-HIV heterocyclic compound BMMP was newly discovered by identification of its binding protein hnRNP M using a chemical biology approach.
    MeSH term(s) Anti-HIV Agents/chemistry ; Anti-HIV Agents/metabolism ; Anti-HIV Agents/pharmacology ; Cell Line ; Cell Movement/drug effects ; Down-Regulation/drug effects ; Drug Evaluation, Preclinical ; Heterocyclic Compounds/chemistry ; Heterocyclic Compounds/metabolism ; Heterocyclic Compounds/pharmacology ; Heterogeneous-Nuclear Ribonucleoprotein Group M/antagonists & inhibitors ; Heterogeneous-Nuclear Ribonucleoprotein Group M/genetics ; Heterogeneous-Nuclear Ribonucleoprotein Group M/metabolism ; Humans ; Hyaluronan Receptors/genetics ; Hyaluronan Receptors/metabolism ; Protein Binding ; Pyrimidines/chemistry ; Pyrimidines/metabolism ; Pyrimidines/pharmacology ; RNA Interference ; RNA, Small Interfering/chemistry ; RNA, Small Interfering/metabolism
    Chemical Substances Anti-HIV Agents ; Heterocyclic Compounds ; Heterogeneous-Nuclear Ribonucleoprotein Group M ; Hyaluronan Receptors ; Pyrimidines ; RNA, Small Interfering
    Language English
    Publishing date 2021-01-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2021.104627
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