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Article ; Online: A reduction method for anterior opening displacement in thoracolumbarvertebral fractures with diffuse idiopathic skeletal hyperostosis using the skull clamp-assisted position.

Kobayashi, Hiroshi / Watanabe, Kazuyuki / Kobayashi, Yoshihiro / Kato, Kinshi / Nikaido, Takuya / Otani, Koji / Yabuki, Shoji / Konno, Shin-Ichi / Matsumoto, Yoshihiro

Fukushima journal of medical science

2024 Volume 70, Issue 2, Page(s) 87–92

Abstract: Diffuse idiopathic skeletal hyperostosis (DISH) frequently occurs in the spine, resulting in unstable fractures. Treating thoracolumbar fractures in patients with DISH is often difficult because the anterior opening of the vertebral body is exacerbated ... ...

Abstract	Diffuse idiopathic skeletal hyperostosis (DISH) frequently occurs in the spine, resulting in unstable fractures. Treating thoracolumbar fractures in patients with DISH is often difficult because the anterior opening of the vertebral body is exacerbated by dislocation in the prone position, making reduction difficult. In this study, we introduced a novel skull clamp-assisted positioning (SAP) technique. The patient is placed in a supine position with a skull clamp used in cervical spine surgery before surgery to prevent the progression of dislocation and to restore the patient's position. Using this method, the mean difference in local kyphosis angle improved from -2.9 (±8.4)° preoperatively to 10.9 (±7.7)° postoperatively. Furthermore, posterior displacement decreased from a preoperative mean of 5.5 (±4.3) mm to 0.3 (±0.7) mm postoperatively. Complications such as neurological sequelae, implant fracture, and surgical site infection were not observed through one year of postoperative follow-up. SAP may decrease invasiveness and complications. Longer-term studies and larger sample sizes are needed to establish long-term efficacy and benefits.
MeSH term(s)	Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Hyperostosis, Diffuse Idiopathic Skeletal/complications ; Hyperostosis, Diffuse Idiopathic Skeletal/surgery ; Lumbar Vertebrae/injuries ; Lumbar Vertebrae/surgery ; Patient Positioning/methods ; Skull/surgery ; Spinal Fractures/surgery ; Spinal Fractures/etiology ; Thoracic Vertebrae/injuries ; Thoracic Vertebrae/surgery
Language	English
Publishing date	2024-03-20
Publishing country	Japan
Document type	Journal Article
ZDB-ID	958255-1
ISSN	2185-4610 ; 0016-2590
ISSN (online)	2185-4610
ISSN	0016-2590
DOI	10.5387/fms.23-00014
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Article ; Online: A systematic review and meta-analysis of macrolides in the management of adult patients with asthma.

Ohnishi, Hiroshi / Otani, Toshihito / Kanemitsu, Yoshihiro / Nagano, Tatsuya / Hara, Johsuke / Eitoku, Masamitsu

Allergology international : official journal of the Japanese Society of Allergology

2024

Abstract: Background: The efficacy of macrolides in the management of asthma has been studied but remains controversial. We conducted a systematic review and meta-analysis of macrolides in the management of adult patients with asthma.: Methods: Randomized ... ...

Abstract	Background: The efficacy of macrolides in the management of asthma has been studied but remains controversial. We conducted a systematic review and meta-analysis of macrolides in the management of adult patients with asthma. Methods: Randomized controlled trials of macrolides used in adult patients with asthma were searched for in MEDLINE, EMBASE, PsycINFO, Cochrane Library, CINAHL, and Igaku Chuo Zasshi databases to evaluate the efficacy and safety of macrolides. Results: Seventeen reports with macrolide treatment durations ranging from 6 to 48 weeks were included. Macrolides did not reduce exacerbations requiring hospitalization, severe exacerbations, or rescue use of short-acting beta-2 agonist inhalers; improve lung function; decrease peripheral blood or sputum neutrophil counts; or decrease fractional exhaled nitric oxide compared to placebo. Macrolides statistically improved asthma control and quality of life but by less than the minimal clinically important difference. Peripheral blood eosinophil counts as well as serum and sputum eosinophilic cationic protein concentrations were significantly decreased with macrolides compared to placebo. The improvement of asthma symptoms and airway hyperresponsiveness varied by study. The safety profile of macrolides was comparable to that of placebo. Conclusions: Although macrolides have some useful clinical aspects, there is not sufficient evidence to recommend their use in the management of adult patients with asthma.
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1336498-4
ISSN	1440-1592 ; 1323-8930
ISSN (online)	1440-1592
ISSN	1323-8930
DOI	10.1016/j.alit.2024.01.002
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Article: [A Case of Interstitial Pneumonia Induced by Immune Checkpoint Inhibitors for Gastric Cancer During the COVID- 19 Pandemic].

Yasuda, Koji / Naito, Masaki / Kawakami, Koki / Kishimoto, Ayana / Narita, Kimimasa / Moriwaki, Yoshihiro / Otani, Jun

Gan to kagaku ryoho. Cancer & chemotherapy

2024 Volume 51, Issue 4, Page(s) 466–469

Abstract: Background: The novel coronavirus disease(corona virus disease 2019: COVID-19)has calmed down worldwide, and the severity of the disease is decreasing. On the other hand, due to the emergence of strain mutations, the number of infected people shows a ... ...

Abstract	Background: The novel coronavirus disease(corona virus disease 2019: COVID-19)has calmed down worldwide, and the severity of the disease is decreasing. On the other hand, due to the emergence of strain mutations, the number of infected people shows a wavy course. I have experienced a case of gastric cancer that underwent chemotherapy including an immune checkpoint inhibitors(ICI) early after COVID-19, so I will report it including a discussion. Case: A 71-year-old man. The patient visited our hospital with a chief complaint of stomach discomfort, and gastrointestinal endoscopy revealed advanced gastric cancer accompanied by narrowing of the gastric lumen. The histopathological examination showed a poorly differentiated adenocarcinoma. A CT scan of the chest and abdomen showed thickening of the entire gastric wall, indicating the presence of enlarged adjacent lymph nodes and infiltration into adjacent organs. No other obvious distant metastases were observed. Staging laparoscopy was performed, it revealed infiltration of the posterior wall of the stomach into the celiac artery and anterior surface of the pancreas. We determined that curative resection would be difficult. As a result of planning chemotherapy for locally advanced gastric cancer, the patient contracted COVID-19 due to a hospital- acquired infection. The patient's COVID-19 infection was managed with supportive care alone without severe complications, and they recovered within the course of treatment. Two weeks after the onset of the infection, chemotherapy(FOLFOX+ Nivo)was initiated. The patient completed up to 9 courses of chemotherapy, and the treatment response was determined to be stable disease(SD). Due to a tendency of stenosis in the gastric lumen, the possibility of future dilation procedures was considered. As a result, the patient underwent second-line chemotherapy with a combination of wPTX+RAM. After completing 1 course of treatment, the patient developed drug-induced interstitial pneumonia, which was managed with intensive care and steroid pulse therapy, resulting in improvement. There was progression of gastric lumen stenosis, and an endoscopic dilation procedure/stent placement was performed. Subsequently, there was a rapid increase in malignant ascites and a decline in activities of daily living(ADL), leading to palliative care. Unfortunately, the patient succumbed to cancer-related complications 10 months after the diagnosis. Discussion: In this case, the serial antibody titers of COVID-19 also indicated the sustained effectiveness of the multi-drug combination chemotherapy. The treatment course suggests a suspicion of drug-induced interstitial pneumonia due to PTX/RAM, but the long-term imaging follow-up implies that ICI may be the cause. When using ICI, COVID-19 infection alone may pose a potential risk factor.
MeSH term(s)	Humans ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/pathology ; COVID-19/complications ; Aged ; Male ; Lung Diseases, Interstitial/chemically induced ; Immune Checkpoint Inhibitors/adverse effects ; Immune Checkpoint Inhibitors/therapeutic use ; Pandemics ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Adenocarcinoma/drug therapy
Chemical Substances	Immune Checkpoint Inhibitors
Language	Japanese
Publishing date	2024-04-01
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article ; Online: Time Course of Asymptomatic Stenosis in Multiple Lumbar Spinal Stenosis-Five-Year Results of Selective Decompression of Symptomatic Levels.

Watanabe, Kazuyuki / Otani, Koji / Nikaido, Takuya / Kato, Kinshi / Kobayashi, Hiroshi / Yabuki, Shoji / Konno, Shin-Ichi / Matsumoto, Yoshihiro

Medicina (Kaunas, Lithuania)

2024 Volume 60, Issue 4

Abstract: ... ...

Abstract	Background
MeSH term(s)	Humans ; Spinal Stenosis/surgery ; Spinal Stenosis/complications ; Spinal Stenosis/diagnostic imaging ; Male ; Decompression, Surgical/methods ; Female ; Lumbar Vertebrae/surgery ; Lumbar Vertebrae/diagnostic imaging ; Aged ; Middle Aged ; Magnetic Resonance Imaging/methods ; Time Factors ; Treatment Outcome ; Retrospective Studies ; Aged, 80 and over
Language	English
Publishing date	2024-04-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina60040636
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Article ; Online: Midline invasion predicts poor prognosis in diffuse hemispheric glioma, H3 G34-mutant: an individual participant data review.

Kegoya, Yasuhito / Otani, Yoshihiro / Inoue, Yohei / Mizuta, Ryo / Higaki, Fumiyo / Washio, Kana / Koizumi, Shinichiro / Kurozumi, Kazuhiko / Ishida, Joji / Fujii, Kentaro / Yamamoto, Norio / Tanaka, Yoshihiro / Date, Isao

Journal of neuro-oncology

2024 Volume 167, Issue 1, Page(s) 201–210

Abstract: Introduction: Diffuse hemispheric glioma, H3 G34-mutant (DHGs), is a newly categorized tumor in pediatric-type diffuse high-grade gliomas, World Health Organization grade 4, with a poor prognosis. Although prognostic factors associated with genetic ... ...

Abstract	Introduction: Diffuse hemispheric glioma, H3 G34-mutant (DHGs), is a newly categorized tumor in pediatric-type diffuse high-grade gliomas, World Health Organization grade 4, with a poor prognosis. Although prognostic factors associated with genetic abnormalities have been reported, few reports have examined the clinical presentation of DHGs, especially from the viewpoint of imaging findings. In this study, we investigated the relationship between clinical factors, including imaging findings, and prognosis in patients with DHGs. Methods: We searched Medline through the PubMed database using two search terms: "G34" and "glioma", between 1 April 2012 and 1 July 2023. We retrieved articles that described imaging findings and overall survival (OS), and added one DHG case from our institution. We defined midline invasion (MI) as invasion to the contralateral cerebrum, brainstem, corpus callosum, thalamus, and basal ganglia on magnetic resonance imaging. The primary outcome was 12-month survival, estimated using Kaplan-Meier curves and logistic regression. Results: A total of 96 patients were included in this study. The median age was 22 years, and the proportion of male patients was 48.4%. Lesions were most frequently located in the frontal lobe (52.6%). MI was positive in 39.6% of all patients. The median OS was 14.4 months. Univariate logistic regression analysis revealed that OS was significantly worse in the MI-positive group compared with the MI-negative group. Multivariate logistic regression analysis revealed that MI was an independent prognostic factor in DHGs. Conclusions: In this study, MI-positive cases had a worse prognosis compared with MI-negative cases. Previous presentations: No portion of this study has been presented or published previously.
MeSH term(s)	Humans ; Male ; Child ; Young Adult ; Adult ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Histones/genetics ; Mutation ; Glioma/diagnostic imaging ; Glioma/genetics ; Prognosis
Chemical Substances	Histones
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	604875-4
ISSN	1573-7373 ; 0167-594X
ISSN (online)	1573-7373
ISSN	0167-594X
DOI	10.1007/s11060-024-04587-5
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Zs.A 1825: Show issues

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Article ; Online: Combination therapy with hydrogen peroxide and irradiation promotes an abscopal effect in mouse models.

Kemmotsu, Naoya / Zhu, Li / Nagasaki, Joji / Otani, Yoshihiro / Ueda, Youki / Dansako, Hiromichi / Fang, Yue / Date, Isao / Togashi, Yosuke

Cancer science

2023 Volume 114, Issue 10, Page(s) 3848–3856

Abstract: Hydrogen peroxide ( ... ...

Abstract	Hydrogen peroxide (H
Language	English
Publishing date	2023-07-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2115647-5
ISSN	1349-7006 ; 1349-7006
ISSN (online)	1349-7006
ISSN	1349-7006
DOI	10.1111/cas.15911
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Article ; Online: Radiographic knee osteoarthritis severity has no impact on fall risk: the locomotive syndrome and health outcomes in the aizu cohort study (LOHAS): a cross-sectional study.

Sonobe, Tatsuru / Otani, Koji / Sekiguchi, Miho / Otoshi, Kenichi / Nikaido, Takuya / Sato, Mari / Konno, Shinichi / Matsumoto, Yoshihiro

BMC musculoskeletal disorders

2024 Volume 25, Issue 1, Page(s) 298

Abstract: Background: To investigate factors that have an impact on the risk of falls and determine whether radiographic knee osteoarthritis (KOA) is a factor involved in falls independent of knee pain, psychological factors, and physical function.: Methods: A ...

Abstract	Background: To investigate factors that have an impact on the risk of falls and determine whether radiographic knee osteoarthritis (KOA) is a factor involved in falls independent of knee pain, psychological factors, and physical function. Methods: A cross-sectional analysis was conducted on 1083 subjects for the 2009 Locomotive Syndrome and Health Outcomes in the Aizu Cohort Study (LOHAS). A logistic regression analysis was performed to examine the relationship between radiographic KOA and fall history. Results: Fall history was significantly associated with the severity of knee pain. Compared to subjects with no knee pain, the odds ratio (OR) was 1.53 times higher in the subjects with mild knee pain (95% confidence interval [CI]: 1.04-2.25), 1.69 times higher in those with moderate knee pain (95%CI: 1.03-2.79), and 2.98 times higher in those with severe knee pain (95%CI: 1.67-5.30). In subjects with depression, the OR was 1.91 (95%CI: 1.25-2.92), and in those with decreased mobility, the OR was 1.70 (95%CI: 1.08-2.69). Age, gender, knee crepitus, BMI, OLST, and sleeping pill use were not significantly associated with fall risk. In a multivariate analysis, radiographic KOA severity was not significantly associated with fall risk (OR 0.81, 95%CI 0.44-1.50 in mild OA; OR 1.10, 95%CI 0.57-2.14 in severe OA). Conclusion: Knee pain, decreased mobility, and depression, but not the radiographic KOA severity, were significantly associated with a fall risk. Regardless of the individual's radiographic KOA severity, the risk of falls may be reduced by treating his/her knee pain, mobility problems, and/or psychological factors.
MeSH term(s)	Humans ; Male ; Female ; Osteoarthritis, Knee/diagnostic imaging ; Osteoarthritis, Knee/epidemiology ; Osteoarthritis, Knee/complications ; Cohort Studies ; Cross-Sectional Studies ; Knee Joint/diagnostic imaging ; Pain ; Syndrome ; Outcome Assessment, Health Care
Language	English
Publishing date	2024-04-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2041355-5
ISSN	1471-2474 ; 1471-2474
ISSN (online)	1471-2474
ISSN	1471-2474
DOI	10.1186/s12891-024-07421-1
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Article ; Online: Utility of genome-wide DNA methylation profiling for pediatric-type diffuse gliomas.

Otani, Yoshihiro / Satomi, Kaishi / Suruga, Yasuki / Ishida, Joji / Fujii, Kentaro / Ichimura, Koichi / Date, Isao

Brain tumor pathology

2023 Volume 40, Issue 2, Page(s) 56–65

Abstract: Despite the current progress of treatment, pediatric-type diffuse glioma is one of the most lethal primary malignant tumors in the central nervous system (CNS). Since pediatric-type CNS tumors are rare disease entities and highly heterogeneous, the ... ...

Abstract	Despite the current progress of treatment, pediatric-type diffuse glioma is one of the most lethal primary malignant tumors in the central nervous system (CNS). Since pediatric-type CNS tumors are rare disease entities and highly heterogeneous, the diagnosis is challenging. An accurate diagnosis is essential for the choice of optimal treatment, which leads to precision oncology and improvement of the patient's outcome. Genome-wide DNA methylation profiling recently emerged as one of the most important tools for the diagnosis of CNS tumors, and the utility of this novel assay has been reported in both pediatric and adult patients. In the current World Health Organization classification published in 2021, several new entities are recognized in pediatric-type diffuse gliomas, some of which require methylation profiling. In this review, we investigated the utility of genome-wide DNA methylation profiling in pediatric-type diffuse glioma, as well as issues in the clinical application of this assay. Furthermore, the combination of genome-wide DNA methylation profiling and other comprehensive genomic assays, which may improve diagnostic accuracy and detection of the actionable target, will be discussed.
MeSH term(s)	Adult ; Humans ; Child ; Brain Neoplasms/diagnosis ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; DNA Methylation/genetics ; Precision Medicine ; Glioma/diagnosis ; Glioma/genetics ; Glioma/pathology ; Central Nervous System Neoplasms/genetics
Language	English
Publishing date	2023-04-01
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	1193775-0
ISSN	1861-387X ; 1433-7398 ; 0914-8108
ISSN (online)	1861-387X
ISSN	1433-7398 ; 0914-8108
DOI	10.1007/s10014-023-00457-6
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Zs.A 4555: Show issues

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Article: [Gene Therapy and Viral Therapy for Malignant Glioma].

Kurozumi, Kazuhiko / Koizumi, Shinichiro / Otani, Yoshihiro

No shinkei geka. Neurological surgery

2021 Volume 49, Issue 3, Page(s) 608–616

Abstract: Malignant gliomas have a poor prognosis despite advances in surgical procedures, radiotherapy, and the emergence of new treatments have improved outcomes. One of these new treatments is gene therapy, which has been developed as a new therapeutic strategy. ...

Abstract	Malignant gliomas have a poor prognosis despite advances in surgical procedures, radiotherapy, and the emergence of new treatments have improved outcomes. One of these new treatments is gene therapy, which has been developed as a new therapeutic strategy. Recently, new methods and approaches have been developed. Gene therapy involves the introduction of genes or cells into a glioma, or the human body, to treat gliomas; various genes such as cancer-suppressing genes, immunomodulation cytokine-related genes, and suicide genes are used in this treatment. Viral therapy is a treatment that oncolytic viral replicates in tumor cells to destroy tumors. Various viral genes can also be used as therapeutic genes. Currently, the most well-studied and accumulated viruses are adenoviruses and HSV-1. Various clinical trials have been conducted using gene therapy and viral therapy, some of which are scheduled to be approved in the near future. Gene therapy and viral therapy have dramatically improved and have developed progressively since their first clinical use.
MeSH term(s)	Brain Neoplasms/genetics ; Brain Neoplasms/therapy ; Genetic Therapy ; Glioma/genetics ; Glioma/therapy ; Humans ; Oncolytic Virotherapy
Language	Japanese
Publishing date	2021-06-06
Publishing country	Japan
Document type	Journal Article
ZDB-ID	197053-7
ISSN	1882-1251 ; 0301-2603
ISSN (online)	1882-1251
ISSN	0301-2603
DOI	10.11477/mf.1436204434
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Article ; Online: Implications of immune cells in oncolytic herpes simplex virotherapy for glioma.

Otani, Yoshihiro / Yoo, Ji Young / Shimizu, Toshihiko / Kurozumi, Kazuhiko / Date, Isao / Kaur, Balveen

Brain tumor pathology

2022 Volume 39, Issue 2, Page(s) 57–64

Abstract: Despite current progress in treatment, glioblastoma (GBM) remains a lethal primary malignant tumor of the central nervous system. Although immunotherapy has recently achieved remarkable survival effectiveness in multiple malignancies, none of the immune ... ...

Abstract	Despite current progress in treatment, glioblastoma (GBM) remains a lethal primary malignant tumor of the central nervous system. Although immunotherapy has recently achieved remarkable survival effectiveness in multiple malignancies, none of the immune checkpoint inhibitors (ICIs) for GBM have shown anti-tumor efficacy in clinical trials. GBM has a characteristic immunosuppressive tumor microenvironment (TME) that results in the failure of ICIs. Oncolytic herpes simplex virotherapy (oHSV) is the most advanced United States Food and Drug Administration-approved virotherapy for advanced metastatic melanoma patients. Recently, another oHSV, Delytact
MeSH term(s)	Glioblastoma/therapy ; Glioma/therapy ; Herpes Simplex/therapy ; Humans ; Oncolytic Virotherapy/methods ; Simplexvirus/genetics ; Tumor Microenvironment
Language	English
Publishing date	2022-04-06
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	1193775-0
ISSN	1861-387X ; 1433-7398 ; 0914-8108
ISSN (online)	1861-387X
ISSN	1433-7398 ; 0914-8108
DOI	10.1007/s10014-022-00431-8
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