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  1. Article ; Online: Different avenues for progress apply to drought tolerance, water use efficiency and yield in dry areas.

    Tardieu, Francois

    Current opinion in biotechnology

    2021  Volume 73, Page(s) 128–134

    Abstract: ... as synonyms. However, they correspond to markedly different suites of physiological mechanisms, based ...

    Abstract Drought tolerance, water use efficiency (WUE) and yield in dry areas are often considered as synonyms. However, they correspond to markedly different suites of physiological mechanisms, based on combinations of alleles constrained by evolution into consistent strategies. Improving (i) drought tolerance, sensu stricto, involves extreme conservative strategy with protection and repair mechanisms; (ii) WUE most often results in small plants but avenues exist with lower penalties for growth, that is, by reducing night transpiration; (iii) yield for drought prone areas involves both constititutive traits (e.g. phenology or plant architecture), favourable for most environmental scenarios, and adaptive physiological traits whose effects suited to a given scenario. Genetic improvement of the latter would requires identification of scenario-dependent combinations of alleles, involving phenomics, modelling and genomic prediction.
    MeSH term(s) Adaptation, Physiological/genetics ; Droughts ; Phenotype ; Water
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2021-08-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1052045-4
    ISSN 1879-0429 ; 0958-1669
    ISSN (online) 1879-0429
    ISSN 0958-1669
    DOI 10.1016/j.copbio.2021.07.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Different avenues for progress apply to drought tolerance, water use efficiency and yield in dry areas

    Tardieu, Francois

    Current opinion in biotechnology. 2022 Feb., v. 73

    2022  

    Abstract: ... as synonyms. However, they correspond to markedly different suites of physiological mechanisms, based ...

    Abstract Drought tolerance, water use efficiency (WUE) and yield in dry areas are often considered as synonyms. However, they correspond to markedly different suites of physiological mechanisms, based on combinations of alleles constrained by evolution into consistent strategies. Improving (i) drought tolerance, sensu stricto, involves extreme conservative strategy with protection and repair mechanisms; (ii) WUE most often results in small plants but avenues exist with lower penalties for growth, that is, by reducing night transpiration; (iii) yield for drought prone areas involves both constititutive traits (e.g. phenology or plant architecture), favourable for most environmental scenarios, and adaptive physiological traits whose effects suited to a given scenario. Genetic improvement of the latter would requires identification of scenario-dependent combinations of alleles, involving phenomics, modelling and genomic prediction.
    Keywords biotechnology ; drought ; drought tolerance ; evolution ; genetic improvement ; genomics ; phenology ; phenomics ; plant architecture ; prediction ; transpiration ; water use efficiency
    Language English
    Dates of publication 2022-02
    Size p. 128-134.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1052045-4
    ISSN 1879-0429 ; 0958-1669
    ISSN (online) 1879-0429
    ISSN 0958-1669
    DOI 10.1016/j.copbio.2021.07.019
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Brain development and the immune system: an introduction to inflammatory and infectious diseases of the child's brain.

    Marc, Tardieu

    Handbook of clinical neurology

    2013  Volume 112, Page(s) 1087–1089

    Abstract: A short overview of the specificities of immune response within the brain is given as an introduction to subsequent chapters on infectious and inflammatory diseases of the child's brain. The blood-brain barrier starts developing during vascular ... ...

    Abstract A short overview of the specificities of immune response within the brain is given as an introduction to subsequent chapters on infectious and inflammatory diseases of the child's brain. The blood-brain barrier starts developing during vascular proliferation of the developing brain during neurogenesis but maturation is not completed until several weeks after birth, and varies in different parts of the brain. The development of postcapillary venules in which cell recruitment occurs seems to be completed at birth. Brain macrophages are detected in brain tissue from the 8th to 12th week of gestation and then exert an important role during neuroblast selection and differentiation, as astrocytes and macrophages acquire the ability to secrete soluble substances. From the third trimester, the fetal brain is able to generate an inflammatory reaction and toll-like receptors can be detected on the surface of fetal neurons and glial cells. Innate immunity maturation occurs within weeks after birth. Although neonates lack preexisting immunological memory and have a small number of immune cells in peripheral lymphoid tissues, they are competent to develop a mature T-cell response, they have a strong CD8 cytotoxic function, and dendritic cells are fully competent.
    MeSH term(s) Blood-Brain Barrier ; Brain/growth & development ; Brain/immunology ; Brain Diseases/immunology ; Central Nervous System Infections/immunology ; Child ; Encephalitis/immunology ; Humans ; Immunity, Innate
    Language English
    Publishing date 2013
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 0072-9752
    ISSN 0072-9752
    DOI 10.1016/B978-0-444-52910-7.00026-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Predictors of multiple sclerosis in children and implications for early initiation of treatment.

    Tardieu, Marc

    The Lancet. Neurology

    2011  Volume 10, Issue 12, Page(s) 1039–1041

    MeSH term(s) Brain/pathology ; Demyelinating Diseases/diagnosis ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Multiple Sclerosis/diagnosis ; Nerve Fibers, Myelinated/pathology
    Language English
    Publishing date 2011-12
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 2079704-7
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(11)70248-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Teriflunomide in pediatric patients with relapsing multiple sclerosis: Open-label extension of TERIKIDS.

    Chitnis, Tanuja / Banwell, Brenda / Kappos, Ludwig / Arnold, Douglas L / Gücüyener, Kivilcim / Deiva, Kumaran / Saubadu, Stephane / Hu, Wenruo / Benamor, Myriam / Le-Halpere, Annaig / Truffinet, Philippe / Tardieu, Marc

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2024  , Page(s) 13524585241242050

    Abstract: Background: The double-blind TERIKIDS study demonstrated the efficacy and safety of teriflunomide.: Objective: To evaluate the efficacy, safety, and tolerability of continuous teriflunomide treatment in the TERIKIDS open-label extension.: Methods: ...

    Abstract Background: The double-blind TERIKIDS study demonstrated the efficacy and safety of teriflunomide.
    Objective: To evaluate the efficacy, safety, and tolerability of continuous teriflunomide treatment in the TERIKIDS open-label extension.
    Methods: In the double-blind period, children with relapsing MS were randomized to placebo or teriflunomide (14 mg adult-equivalent dose) for ⩽ 96 weeks. Participants received teriflunomide for ⩽ 192 weeks post-randomization in the open-label extension.
    Results: The mean age at screening was 14.6 years. For teriflunomide/teriflunomide versus placebo/teriflunomide, estimated clinical relapse risk was reduced by 38% (hazard ratio (HR) 0.62; 95% confidence interval (CI) 0.39-0.98;
    Conclusion: Teriflunomide reduced the long-term risk of focal inflammatory activity, with generally manageable tolerability and no new safety signals. Further evidence would strengthen clinical efficacy findings.ClinicalTrials.gov: NCT02201108.
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/13524585241242050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Anti-N-Methyl-D-aspartate receptor encephalitis: a new entity?

    Tardieu, Marc

    Developmental medicine and child neurology

    2010  Volume 52, Issue 5, Page(s) 410–411

    MeSH term(s) Autoantibodies/immunology ; Biomarkers/metabolism ; Child ; Encephalitis/diagnosis ; Encephalitis/immunology ; Humans ; Receptors, N-Methyl-D-Aspartate/immunology
    Chemical Substances Autoantibodies ; Biomarkers ; Receptors, N-Methyl-D-Aspartate
    Language English
    Publishing date 2010-05
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 80369-8
    ISSN 1469-8749 ; 0012-1622
    ISSN (online) 1469-8749
    ISSN 0012-1622
    DOI 10.1111/j.1469-8749.2009.03536.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Paediatric neurology: brain development at an interface between genetics, the environment, and the immune system.

    Tardieu, Marc

    The Lancet. Neurology

    2010  Volume 9, Issue 1, Page(s) 13–14

    MeSH term(s) Aging/genetics ; Aging/immunology ; Aging/physiology ; Brain/growth & development ; Brain/immunology ; Brain/physiopathology ; Brain Diseases/genetics ; Brain Diseases/immunology ; Brain Diseases/physiopathology ; Brain Neoplasms/genetics ; Brain Neoplasms/immunology ; Brain Neoplasms/physiopathology ; Central Nervous System Viral Diseases/genetics ; Central Nervous System Viral Diseases/immunology ; Central Nervous System Viral Diseases/physiopathology ; Child ; Child Development ; Environment ; Humans ; Neurology ; Pediatrics
    Language English
    Publishing date 2010-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2079704-7
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(09)70307-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The risk of very long-term brain dysfunction in treated adolescents with perinatally acquired HIV-1 infection.

    Tardieu, Marc

    AIDS (London, England)

    2009  Volume 23, Issue 14, Page(s) 1891–1892

    MeSH term(s) AIDS Dementia Complex/psychology ; Adolescent ; Antiretroviral Therapy, Highly Active ; Female ; HIV Infections/drug therapy ; HIV Infections/psychology ; HIV Infections/transmission ; HIV-1 ; Humans ; Infectious Disease Transmission, Vertical ; Mental Disorders/etiology ; Pregnancy ; Prenatal Exposure Delayed Effects
    Language English
    Publishing date 2009-09-10
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 639076-6
    ISSN 1473-5571 ; 0269-9370 ; 1350-2840
    ISSN (online) 1473-5571
    ISSN 0269-9370 ; 1350-2840
    DOI 10.1097/QAD.0b013e32832f316a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Lack of assent to dental examination in children with intellectual disabilities: Dentists' practices in Europe and ethical issues.

    Camoin, Ariane / Blanchet, Isabelle / Dany, Lionel / Le Coz, Pierr / Saliba-Serre, Bérengère / Tardieu, Corinne

    Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry

    2024  

    Abstract: Aim: (1) To determine the repartition of criteria which can be considered as marks of lack ...

    Abstract Aim: (1) To determine the repartition of criteria which can be considered as marks of lack of assent by the child with intellectual disabilities from the dentist's point of view and whether that influences the decision to examine the patient or not. (2) To explain the decision of practitioners and determine the ethical implications of these practices.
    Methods: An anonymous and structured questionnaire was distributed online using the scenario of a 9-year-old child with moderate cognitive impairment with eight different oppositional behaviours. The practitioners were asked about their perception of the patient's lack of assent and about their decision to perform the dental examination or not.
    Results: The proportion of them who performed a dental examination despite the patient's refusal represented between 13% and 28.8% of the population of respondents.
    Conclusion: There was an ambivalence among the practitioners who carried out a dental consultation when children were uncooperative. They adopted a teleological point of view. It calls for us to reflect on the ethical principles of autonomy and beneficence.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604118-8
    ISSN 1754-4505 ; 0275-1879
    ISSN (online) 1754-4505
    ISSN 0275-1879
    DOI 10.1111/scd.12982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Memorial lecture

    Tardieu Marc

    Retrovirology, Vol 6, Iss Suppl 1, p L

    viruses and the developing nervous system

    2009  Volume 10

    Keywords Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Immunologic diseases. Allergy ; RC581-607
    Language English
    Publishing date 2009-07-01T00:00:00Z
    Publisher BioMed Central
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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