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  1. Article ; Online: Bilateral Medial Medullary Infarction: The Airpod Sign.

    Agarwal, Shashank / Raz, Eytan / Yaghi, Shadi

    Stroke

    2023  Volume 54, Issue 4, Page(s) e157–e158

    MeSH term(s) Humans ; Medulla Oblongata/diagnostic imaging ; Magnetic Resonance Imaging ; Infarction
    Language English
    Publishing date 2023-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.122.042054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Systematic review and meta‑analysis of observational studies to check the protective role of non‑steroidal anti‑inflammatory drugs in Alzheimer's disease.

    Asthana, Akash / Tripathi, Shashank / Agarwal, Rachna

    Acta neurobiologiae experimentalis

    2023  Volume 83, Issue 4, Page(s) 386–394

    Abstract: Alzheimer's disease (AD) is a major neurodegenerative disease, affecting more than two third cases of dementia in the world. Non‑steroidal anti‑inflammatory drugs (NSAIDs) are widely used anti‑inflammatory analgesic agents representing 7.7% of worldwide ... ...

    Abstract Alzheimer's disease (AD) is a major neurodegenerative disease, affecting more than two third cases of dementia in the world. Non‑steroidal anti‑inflammatory drugs (NSAIDs) are widely used anti‑inflammatory analgesic agents representing 7.7% of worldwide prescriptions of which 90% are in patients over 65 years old. Based on mixed findings a systematic review and meta‑analysis were conducted to develop a better understanding of the protective role of NSAIDs in AD. We used three database PubMed, Web of Science, and Embase to identify the literatures. The studies following cohort and case‑control design were investigated separately to check the effect of NSAIDs on AD, by the using their fundamental indicators (relative risk and odds ratio). The fixed effect or random effects model were used to estimate the pooled relative risk and pooled odds ratio separately for both the study design, based on magnitude of heterogeneity. A total of 14 studies were selected for meta‑analysis. Eight studies were following cohort study design, whereas, six studies were following case‑control study design. In meta‑analysis of cohort studies, the pooled relative risk was 0.67 with 95% C.I 0.39 to 1.15, which was statistically insignificant. In meta‑analysis of case‑control studies, the pooled odds ratio was 0.71 with 95% C.I 0.46 to 1.10, which was statistically insignificant. NSAIDs do not act as a protective factor for Alzheimer's disease. Additionally, methodologically sound randomized controlled trials are required to produce a robust result.
    MeSH term(s) Humans ; Aged ; Alzheimer Disease/drug therapy ; Neurodegenerative Diseases ; Case-Control Studies ; Cohort Studies ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal
    Language English
    Publishing date 2023-12-04
    Publishing country Poland
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 184409-x
    ISSN 1689-0035 ; 0065-1400
    ISSN (online) 1689-0035
    ISSN 0065-1400
    DOI 10.55782/ane-2023-2467
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mechanistic framework for reduced-order models in soft materials: Application to three-dimensional granular intrusion.

    Agarwal, Shashank / Goldman, Daniel I / Kamrin, Ken

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 4, Page(s) e2214017120

    Abstract: Soft materials often display complex behaviors that transition through apparent solid- and fluid-like regimes. While a growing number of microscale simulation methods exist for these materials, reduced-order models that encapsulate the macroscale physics ...

    Abstract Soft materials often display complex behaviors that transition through apparent solid- and fluid-like regimes. While a growing number of microscale simulation methods exist for these materials, reduced-order models that encapsulate the macroscale physics are often desired to predict how external bodies interact with soft media. Such an approach could provide direct insights in diverse situations from impact and penetration problems to locomotion over natural terrains. This work proposes a systematic program to develop three-dimensional (3D) reduced-order models for soft materials from a fundamental basis using continuum symmetries and rheological principles. In particular, we derive a reduced-order, 3D resistive force theory (3D-RFT), which is capable of accurately and quickly predicting the resistive stress distribution on arbitrary-shaped bodies intruding through granular media. Aided by a continuum description of the granular medium, a comprehensive set of spatial symmetry constraints, and a limited amount of reference data, we develop a self-consistent and accurate 3D-RFT. We verify the model capabilities in a wide range of cases and show that it can be quickly recalibrated to different media and intruder surface types. The premises leading to 3D-RFT anticipate application to other soft materials with strongly hyperlocalized intrusion behavior.
    MeSH term(s) Mechanical Phenomena ; Locomotion ; Rheology
    Language English
    Publishing date 2023-01-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2214017120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Olfactory Neuroblastoma: A Novel Site of Presentation.

    Lohar, Nand Kishor / Agarwal, Sunita / Singh, Shashank N

    Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

    2021  Volume 74, Issue Suppl 2, Page(s) 1468–1471

    Abstract: Olfactory neuroblastoma (ONB) or esthesioneuroblastoma is a rare malignant intranasal tumor, commonly originated from upper part of nasal cavity. Majority of cases presented with nasal obstruction or epistaxis. ONB is rarely reported in ectopic locations. ...

    Abstract Olfactory neuroblastoma (ONB) or esthesioneuroblastoma is a rare malignant intranasal tumor, commonly originated from upper part of nasal cavity. Majority of cases presented with nasal obstruction or epistaxis. ONB is rarely reported in ectopic locations. Here we present the first-ever documented case of an olfactory neuroblastoma situated anterior to body of maxilla, presented as left sided facial swelling. This case report is aimed at achieving the consideration of this rare tumour as a differential diagnosis in the lesions of the anatomical region surrounding the commonly known site of origin i.e. the sinonasal cavity.
    Language English
    Publishing date 2021-05-08
    Publishing country India
    Document type Journal Article
    ZDB-ID 1471137-0
    ISSN 0973-7707 ; 2231-3796 ; 0019-5421
    ISSN (online) 0973-7707
    ISSN 2231-3796 ; 0019-5421
    DOI 10.1007/s12070-021-02595-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Endophytic Alkalotolerant Plant Growth-Promoting Bacteria Render Maize (Zea mays L.) Growth Under Alkaline Stress.

    Kar, Srishti / Mishra, Shashank Kumar / Misra, Sankalp / Agarwal, Renuka / Kumar, Susheel / Chauhan, Puneet Singh

    Current microbiology

    2023  Volume 81, Issue 1, Page(s) 43

    Abstract: This study investigates the role of bacterial endophytes from extreme alkaline environments in alleviating alkaline stress and plant development. Stressful environmental factors, such as soil acidity and alkalinity/sodicity, frequently affect plant ... ...

    Abstract This study investigates the role of bacterial endophytes from extreme alkaline environments in alleviating alkaline stress and plant development. Stressful environmental factors, such as soil acidity and alkalinity/sodicity, frequently affect plant development. In the present study, alkaline-tolerant endophytic strains were isolated from three plant species Saccharum munja, Calotropis procera, and Chenopodium album, and 15 out of the total of 48 isolates were selected for further examination of their abiotic stress tolerance. Molecular analysis based on 16S rRNA gene sequencing revealed strains from Enterobacter, Acinetobacter, Stenotrophomonas, Bacillus, Lysinibacillus, and Mammaliicoccus genera. Out of 15 isolates based on their quantitative PGP traits and abiotic stress tolerance, 6 were finally selected for greenhouse experiments. Under alkaline conditions, results demonstrated that the strains from the genera Enterobacter, Bacillus, Stenotrophomonas, and Lysinibacillus had beneficial effects on maize growth. These findings suggest that using a combination of bacteria with multiple plant growth-promoting attributes could be a sustainable approach to enhance agricultural yield, even in a challenging alkaline environment. The study concludes that the application of bacterial endophytes from plants growing in extremely alkaline environments might provide other plants with similar stress-tolerance abilities. The outcome of the study provides a basis for future exploration of the mechanisms underlying endophyte-induced stress tolerance.
    MeSH term(s) Zea mays ; RNA, Ribosomal, 16S/genetics ; Bacillaceae ; Bacillus ; Enterobacter/genetics ; Endophytes/genetics ; Plant Development
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 134238-1
    ISSN 1432-0991 ; 0343-8651
    ISSN (online) 1432-0991
    ISSN 0343-8651
    DOI 10.1007/s00284-023-03557-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Investigation of optimal planning strategy in gamma knife perfexion for vestibular schwannoma tumor using hybrid plan technique.

    Agarwal, Priyanka / Natanasabapathi, Gopishankar / Bisht, Raj Kishor / Malhotra, Rajeev Kumar / Kale, Shashank Sharad

    Biomedical physics & engineering express

    2022  Volume 8, Issue 6

    Abstract: Purpose. ...

    Abstract Purpose.
    MeSH term(s) Humans ; Radiosurgery/methods ; Neuroma, Acoustic/diagnostic imaging ; Neuroma, Acoustic/surgery ; Radiotherapy Dosage ; Algorithms ; Magnetic Resonance Imaging
    Language English
    Publishing date 2022-11-18
    Publishing country England
    Document type Journal Article
    ISSN 2057-1976
    ISSN (online) 2057-1976
    DOI 10.1088/2057-1976/ac9abb
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Response by Agarwal et al to Letter Regarding Article, "Redefined Measure of Early Neurological Improvement Shows Treatment Benefit of Alteplase Over Placebo".

    Agarwal, Shashank / Yaghi, Shadi / Mistry, Eva

    Stroke

    2020  Volume 51, Issue 7, Page(s) e136–e137

    MeSH term(s) Fibrinolytic Agents/therapeutic use ; Thrombolytic Therapy ; Tissue Plasminogen Activator
    Chemical Substances Fibrinolytic Agents ; Tissue Plasminogen Activator (EC 3.4.21.68)
    Language English
    Publishing date 2020-06-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.120.030262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Bioengineering Strategies for Developing Vaccines against Respiratory Viral Diseases.

    Iyer, Shalini / Yadav, Rajesh / Agarwal, Smriti / Tripathi, Shashank / Agarwal, Rachit

    Clinical microbiology reviews

    2021  Volume 35, Issue 1, Page(s) e0012321

    Abstract: Respiratory viral pathogens like influenza and coronaviruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have caused outbreaks leading to millions of deaths. Vaccinations are, to date, the best and most economical way to control ... ...

    Abstract Respiratory viral pathogens like influenza and coronaviruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have caused outbreaks leading to millions of deaths. Vaccinations are, to date, the best and most economical way to control such outbreaks and have been highly successful for several pathogens. Currently used vaccines for respiratory viral pathogens are primarily live attenuated or inactivated and can risk reversion to virulence or confer inadequate immunity. The recent trend of using potent biomolecules like DNA, RNA, and protein antigenic components to synthesize vaccines for diseases has shown promising results. Still, it remains challenging to translate due to their high susceptibility to degradation during storage and after delivery. Advances in bioengineering technology for vaccine design have made it possible to control the physicochemical properties of the vaccines for rapid synthesis, heightened antigen presentation, safer formulations, and more robust immunogenicity. Bioengineering techniques and materials have been used to synthesize several potent vaccines, approved or in trials, against coronavirus disease 2019 (COVID-19) and are being explored for influenza, SARS, and Middle East respiratory syndrome (MERS) vaccines as well. Here, we review bioengineering strategies such as the use of polymeric particles, liposomes, and virus-like particles in vaccine development against influenza and coronaviruses and the feasibility of adopting these technologies for clinical use.
    MeSH term(s) Bioengineering ; COVID-19 ; Humans ; SARS-CoV-2 ; Vaccination ; Vaccine Development
    Language English
    Publishing date 2021-11-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 645015-5
    ISSN 1098-6618 ; 0893-8512
    ISSN (online) 1098-6618
    ISSN 0893-8512
    DOI 10.1128/CMR.00123-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Role of Rituximab in Patients with Resistant Nephrotic Syndrome.

    Singh, Seetaram / Agarwal, Dhananjai / Gupta, Rakesh / Malhotra, Vinay / Bhardwaj, Shashank

    The Journal of the Association of Physicians of India

    2022  Volume 70, Issue 4, Page(s) 11–12

    Abstract: Resistant nephrotic syndrome is a group of disorders with diverse histological findings, which are by definition resistant to corticosteroids given in adequate dose for adequate duration and many are resistant to other therapy as well. In many patients ... ...

    Abstract Resistant nephrotic syndrome is a group of disorders with diverse histological findings, which are by definition resistant to corticosteroids given in adequate dose for adequate duration and many are resistant to other therapy as well. In many patients progression to end-stage renal disease is the ultimate outcome. The role of B cells has not been fully explained in man, agents that specifically interfere with B cells would ideally represent the first step toward selective therapy. We studied short term and long term effects of rituximab in patients with resistent primary nephrotic syndrome.
    Material: Study was conducted at SMS-medical college and Hospital Jaipur, four doses of rituximab were given weakly, in fixed dose of 500 mg per dose and proteinuria was evaluated before start of therapy and at 3 months, 6 months and 12 months of therapy. Patients with resistant primary nephrotic syndrome who failed to respond to other therapies, with stable eGFR >30, and controlled BP were included in study. Patients with Active infection, Uncontrolled hypertension, pregnancy were excluded from study.
    Observation: 10 patients were enrolled in study out of which 7 FSGS (focal segmental glomeruloscllerosis) and 3 were IMN (idiopathic membranous nephropathy), 5 were female and 5 were male, age 17-61years (average 34.6), weight were 48-70 kg (avg 57.9), BMI 19.4-23 (AVG 21.18), all patients have normal renal function (average creatinine value of 0.8, range= 0.5 to 1.1). At 3 months 1 patient had partial response and 9 had no response. At 6 months of treatment 2 patients had partial response, 3 had complete response and 5 no response. At 12 months of treatment 4 had partial response, 5 had complete response and 1 no response. Out of 10 patients no one had relapse of Nephrotic syndrome at 12 month of therapy. Renal function remain normal in all patients over 12 months followup.
    Conclusion: This prospective, observational study evaluated 3 month, 6 month, and 12 month outcome of 3 IMN and 7 FSGS patients, with persistent nephrotic range proteinuria and showed that rituximab promoted sustained remission in proteinuria in resistent nephrotic syndrome with normal renal function.
    MeSH term(s) Adolescent ; Adult ; Female ; Glomerulonephritis, Membranous/chemically induced ; Glomerulonephritis, Membranous/drug therapy ; Glomerulosclerosis, Focal Segmental/chemically induced ; Glomerulosclerosis, Focal Segmental/drug therapy ; Humans ; Immunosuppressive Agents/therapeutic use ; Male ; Middle Aged ; Nephrotic Syndrome/drug therapy ; Prospective Studies ; Proteinuria/drug therapy ; Proteinuria/etiology ; Rituximab/therapeutic use ; Treatment Outcome ; Young Adult
    Chemical Substances Immunosuppressive Agents ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2022-04-20
    Publishing country India
    Document type Journal Article ; Observational Study
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Journal Club: Association between aspirin dose and subarachnoid hemorrhage from saccular aneurysms: A case-control study.

    Agarwal, Shashank / Zhou, Ting / Frontera, Jennifer

    Neurology

    2019  Volume 92, Issue 19, Page(s) 920–922

    MeSH term(s) Aneurysm, Ruptured ; Aspirin ; Case-Control Studies ; Humans ; Subarachnoid Hemorrhage
    Chemical Substances Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2019-05-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000007460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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