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Article: The analgesic power of pleasant touch in individuals with chronic pain: Recent findings and new insights.

Fusaro, Martina / Bufacchi, Rory J / Nicolardi, Valentina / Provenzano, Luca

2022 Volume 16, Page(s) 956510

Abstract: This mini-review covers recent works on the study of pleasant touch in patients with chronic pain (CP) and its potential use as a treatment. While experiments have demonstrated that pleasant touch, through the activation of CT-afferents and the brain ... ...

Abstract	This mini-review covers recent works on the study of pleasant touch in patients with chronic pain (CP) and its potential use as a treatment. While experiments have demonstrated that pleasant touch, through the activation of CT-afferents and the brain regions involved in its affective value, might reduce the unpleasantness and intensity of induced pain, the interaction between pleasant touch and CP remains under-examined. Some experiments show that CP might disrupt the positive aspects of receiving pleasant touch, while in other studies the perception of pleasantness is preserved. Moreover, only a few attempts have been made to test whether touch can have a modulatory effect on CP, but these results also remain inconclusive. Indeed, while one recent study demonstrated that CT-touch can diminish CP after a short stimulation, another study suggested that pleasant touch might not be sufficient. Future studies should further investigate the psychological and neural interplay between pleasant touch and CP. In the conclusion of this mini-review, we propose a new tool we have recently developed using immersive virtual reality (IVR).
Language	English
Publishing date	2022-09-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2452962-X
ISSN	1662-5145
ISSN	1662-5145
DOI	10.3389/fnint.2022.956510
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Article: Cerebral Venous Thrombosis after SARS-CoV-2 Infection and Pfizer-BioNTech Vaccination against COVID-19.

Nicolardi, Martina / Urso, Daniele / Luceri, Silvia / Logroscino, Giancarlo / De Blasi, Roberto

Diagnostics (Basel, Switzerland)

2022 Volume 12, Issue 5

Abstract: In the last 3 years, COVID-19 pandemic has produced great impacts on global population in terms of health and social costs. Pneumonia represents only one of several pathologies associated to COVID-19 disease. Among these, the cerebral venous thrombosis ( ... ...

Abstract	In the last 3 years, COVID-19 pandemic has produced great impacts on global population in terms of health and social costs. Pneumonia represents only one of several pathologies associated to COVID-19 disease. Among these, the cerebral venous thrombosis (CVT), constitutes an important cause of stroke. Here, we report a case of CVT diagnosed approximately 2 weeks after first dose of Pfizer-BioNTech vaccination, in a patient affected by COVID-19 few months earlier. He presented with headache and severe asthenia. The laboratory tests put in evidence thrombocytopenia and D-dimer elevation. A brain magnetic resonance imaging (MRI) and a computed tomography (CT) demonstrated hemorrhagic and ischemic phenomena on the right ventral thalamic nuclei, left thalamus, hippocampal and parahippocampal regions and the splenium of the corpus callosum. The study revealed a poorly opacified vein of Galeno and straight sinus. Heparin administration improved his clinical status; platelets values also arose over time.
Language	English
Publishing date	2022-05-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12051253
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Article ; Online: Deep Learning-based Approach for Brainstem and Ventricular MR Planimetry: Application in Patients with Progressive Supranuclear Palsy.

Nigro, Salvatore / Filardi, Marco / Tafuri, Benedetta / Nicolardi, Martina / De Blasi, Roberto / Giugno, Alessia / Gnoni, Valentina / Milella, Giammarco / Urso, Daniele / Zoccolella, Stefano / Logroscino, Giancarlo

Radiology. Artificial intelligence

2024 Volume 6, Issue 3, Page(s) e230151

Abstract: Purpose To develop a fast and fully automated deep learning (DL)-based method for the MRI planimetric segmentation and measurement of the brainstem and ventricular structures most affected in patients with progressive supranuclear palsy (PSP). Materials ... ...

Abstract	Purpose To develop a fast and fully automated deep learning (DL)-based method for the MRI planimetric segmentation and measurement of the brainstem and ventricular structures most affected in patients with progressive supranuclear palsy (PSP). Materials and Methods In this retrospective study, T1-weighted MR images in healthy controls (
MeSH term(s)	Humans ; Supranuclear Palsy, Progressive/diagnostic imaging ; Supranuclear Palsy, Progressive/pathology ; Deep Learning ; Magnetic Resonance Imaging/methods ; Female ; Retrospective Studies ; Brain Stem/diagnostic imaging ; Brain Stem/pathology ; Male ; Aged ; Middle Aged ; Reproducibility of Results ; Cerebral Ventricles/diagnostic imaging ; Cerebral Ventricles/pathology ; Image Interpretation, Computer-Assisted/methods
Language	English
Publishing date	2024-03-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2638-6100
ISSN (online)	2638-6100
DOI	10.1148/ryai.230151
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Article ; Online: Cerebral Venous Thrombosis after SARS-CoV-2 Infection and Pfizer-BioNTech Vaccination against COVID-19

Martina Nicolardi / Daniele Urso / Silvia Luceri / Giancarlo Logroscino / Roberto De Blasi

Diagnostics, Vol 12, Iss 1253, p

2022 Volume 1253

Abstract	In the last 3 years, COVID-19 pandemic has produced great impacts on global population in terms of health and social costs. Pneumonia represents only one of several pathologies associated to COVID-19 disease. Among these, the cerebral venous thrombosis (CVT), constitutes an important cause of stroke. Here, we report a case of CVT diagnosed approximately 2 weeks after first dose of Pfizer-BioNTech vaccination, in a patient affected by COVID-19 few months earlier. He presented with headache and severe asthenia. The laboratory tests put in evidence thrombocytopenia and D-dimer elevation. A brain magnetic resonance imaging (MRI) and a computed tomography (CT) demonstrated hemorrhagic and ischemic phenomena on the right ventral thalamic nuclei, left thalamus, hippocampal and parahippocampal regions and the splenium of the corpus callosum. The study revealed a poorly opacified vein of Galeno and straight sinus. Heparin administration improved his clinical status; platelets values also arose over time.
Keywords	cerebral venous thrombosis ; COVID-19 ; vaccination ; Susceptibility-Weighted Images ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Streak artefacts in Computed Tomography Urography: Comparative evaluation between two different iodinated contrast media.

Pedote, Pasquale / Cozzolino, Monica / Nicolardi, Martina / Accogli, Rocco Umberto / Sardaro, Angela / Scardapane, Arnaldo / Stabile Ianora, Amato Antonio

Journal of medical imaging and radiation oncology

2021 Volume 66, Issue 7, Page(s) 940–945

Abstract: Introduction: The objective of this study was to compare the frequency and entity, in computed tomography (CT) urography, of streak artefacts on the urinary tract generated by two contrast agents with a different iodine concentration and osmolarity.: ... ...

Abstract	Introduction: The objective of this study was to compare the frequency and entity, in computed tomography (CT) urography, of streak artefacts on the urinary tract generated by two contrast agents with a different iodine concentration and osmolarity. Methods: Computed tomography scans including an excretory renal phase, performed on adult subjects in the period May-July 2020, were retrospectively evaluated in consensus by three expert radiologists, to detect any streak artefacts located in the urinary tract. Patients were administered either 1.6 mL/kg of Iodixanol 320 mgI/mL or 1.3 mL/kg of Iomeprol 400 mgI/mL. Results: In total, 144 CT scans were analysed, subdivided into two groups administered either Iodixanol (71/144 (49.3%) patients) or Iomeprol (73/144 (50.7%) patients). In 41% cases, no beam hardening artefacts were found; among these, 12/59 (20.3%) patients had received Iodixanol and 47/59 (79.7%) Iomeprol. In the Iodixanol group, the mean contrast density on the renal pelvis was 2565.6 HU and streak artefacts occurred in 59/71 cases (83.1%); in 33/59 (55.9%) cases, the artefacts were marked, and in 26/59 (44.1%) minimal. In the Iomeprol group, the mean contrast density on the renal pelvis was 1666 HU and streak artefacts occurred in 26/73 cases (35.6%); in 7/26 (27%) cases, the artefacts were marked and in 19/26 (73%) minimal. Conclusion: The study data demonstrate a significant difference in the attenuation values of iodine urine in the excretory system between the Iodixanol and Iomeprol group. Iodixanol induced a higher frequency and burden of artefacts, compared to Iomeprol.
MeSH term(s)	Adult ; Artifacts ; Contrast Media ; Humans ; Iodine ; Iopamidol/analogs & derivatives ; Retrospective Studies ; Tomography, X-Ray Computed/methods ; Triiodobenzoic Acids ; Urography
Chemical Substances	Contrast Media ; Triiodobenzoic Acids ; iomeprol (17E17JBP8L) ; Iodine (9679TC07X4) ; iodixanol (HW8W27HTXX) ; Iopamidol (JR13W81H44)
Language	English
Publishing date	2021-12-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2389687-5
ISSN	1754-9485 ; 1440-1673 ; 1754-9477 ; 0004-8461
ISSN (online)	1754-9485 ; 1440-1673
ISSN	1754-9477 ; 0004-8461
DOI	10.1111/1754-9485.13363
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Article ; Online: Prevalence and clinical features of bile acid diarrhea in patients with chronic diarrhea.

Costa, Stefania / Gattoni, Serena / Nicolardi, Maria Luisa / Costetti, Martina / Maimaris, Stiliano / Schiepatti, Annalisa / Biagi, Federico

Journal of digestive diseases

2021 Volume 22, Issue 2, Page(s) 108–112

Abstract: Objective: Bile acid diarrhea is a form of chronic diarrhea caused by excessive bile reaching the colon. Conditions involving the terminal ileum and cholecystectomy are predisposing factors but an idiopathic form of bile acid diarrhea has also been ... ...

Abstract	Objective: Bile acid diarrhea is a form of chronic diarrhea caused by excessive bile reaching the colon. Conditions involving the terminal ileum and cholecystectomy are predisposing factors but an idiopathic form of bile acid diarrhea has also been described. In this study we aimed to evaluate the prevalence of bile acid diarrhea in patients consecutively evaluated for chronic diarrhea in an Outpatient Gastroenterology Clinic. Methods: Medical records of all patients admitted for chronic diarrhea (>4 weeks) between June 2018 and April 2019 were retrospectively reviewed. Bile acid diarrhea was suspected in patients with ileal disease, cholecystectomy or post-prandial diarrhea. Patients' age at diagnosis, sex, presenting symptoms, results of main test and examinations, final diagnoses and date of last follow-up visit were also collected. Exclusion of chronic diarrhea of other causes and a 6-month clinical improvement with cholestyramine treatment confirmed the diagnosis of bile acid diarrhea. Results: In total, 139 patients aged 46 ± 20 years (76 women and 63 men) were included. Diarrhea due to an organic cause was diagnosed in 16 patients. A clinical response to cholestyramine persisting for more than 6 months led to a diagnosis of bile acid diarrhea in 39 (aged 52 ± 19 years) out of the remaining 123 patients with functional forms of diarrhea. Therefore, the prevalence of bile acid diarrhea was 28.1% (95% confidence interval 19.9%-38.4%) in patients with chronic diarrhea. Conclusions: Bile acid diarrhea is a very common, yet under-recognized cause of chronic functional diarrhea. A therapeutic trial of cholestyramine is a valid diagnostic strategy.
MeSH term(s)	Adult ; Aged ; Bile Acids and Salts ; Chronic Disease ; Diarrhea ; Female ; Humans ; Malabsorption Syndromes ; Male ; Middle Aged ; Prevalence ; Retrospective Studies ; Taurocholic Acid
Chemical Substances	Bile Acids and Salts ; Taurocholic Acid (5E090O0G3Z)
Language	English
Publishing date	2021-02-03
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2317117-0
ISSN	1751-2980 ; 1751-2972
ISSN (online)	1751-2980
ISSN	1751-2972
DOI	10.1111/1751-2980.12969
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Article ; Online: Determinants and Trends of Adherence to a Gluten-Free Diet in Adult Celiac Patients on a Long-term Follow-up (2000-2020).

Schiepatti, Annalisa / Maimaris, Stiliano / Nicolardi, Maria Luisa / Alimenti, Eleonora / Vernero, Marta / Costetti, Martina / Costa, Stefania / Biagi, Federico

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

2020 Volume 20, Issue 4, Page(s) e741–e749

Abstract: Background & aims: Data on factors governing long-term adherence to a gluten-free diet (GFD) in celiac disease (CD) are scarce. We aimed to determine trends and clinical predictors of long-term GFD adherence in adult CD.: Methods: Initial and long- ... ...

Abstract	Background & aims: Data on factors governing long-term adherence to a gluten-free diet (GFD) in celiac disease (CD) are scarce. We aimed to determine trends and clinical predictors of long-term GFD adherence in adult CD. Methods: Initial and long-term (>3 years) GFD adherence, clinical characteristics at baseline and follow-up were collected retrospectively from celiac patients followed-up over 20 years (2000-2020). Predictors of long-term GFD adherence at diagnosis, and follow-up were evaluated by multivariate logistic regression. Results: 248 patients (37 ± 12 years, 186F, median time on a GFD 90 months) were included. Twenty-five (10.1%) had only short-term follow-up (<3 years) while 223 (89.9%) had initial and long-term dietary assessment. 187/223 (83.9%) patients were initially adherent and 36/223 (16.1%) were not. 17/36 (47.2%) patients initially not adherent become adherent, while only 4/187 (2.1%) initially adherent patients became not adherent. In the long-term, 200/223 (89.7%) were adherent and 21/223 (9.4%) patients were not. Adherence improved more frequently than worsened (OR, 39.5; 95% CI, 11.4-178.5; P < .01). Classical symptoms (diarrhea, weight loss) at diagnosis of CD predicted stricter long-term GFD adherence (OR, 3.27; 95% CI, 1.21-8.81; P = .02), while anemia (OR, 0.31; 95% CI, 0.12-0.82; P = .02) and dermatitis herpetiformis (OR, 0.23; 95% CI, 0.06-0.91; P = .04) predicted poorer long-term adherence. At follow-up, initial GFD adherence (OR, 42.70; 95% CI, 10.70-171.00; P = .04) was the major determinant of long-term GFD adherence. Conclusions: GFD adherence changes over time in <10% of patients, generally improving when it does. Major determinants of long-term GFD adherence are classical symptoms at diagnosis and initial adherence to a GFD. Patients with anemia or dermatitis herpetiformis at diagnosis require stricter dietetic input.
MeSH term(s)	Adult ; Celiac Disease/diagnosis ; Diet, Gluten-Free ; Follow-Up Studies ; Humans ; Patient Compliance ; Retrospective Studies
Language	English
Publishing date	2020-12-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2119789-1
ISSN	1542-7714 ; 1542-3565
ISSN (online)	1542-7714
ISSN	1542-3565
DOI	10.1016/j.cgh.2020.12.015
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Zs.A 5836: Show issues

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Article ; Online: Type 2 Diabetes Mellitus and Efficacy Outcomes from Immune Checkpoint Blockade in Patients with Cancer.

Cortellini, Alessio / D'Alessio, Antonio / Cleary, Siobhan / Buti, Sebastiano / Bersanelli, Melissa / Bordi, Paola / Tonini, Giuseppe / Vincenzi, Bruno / Tucci, Marco / Russo, Alessandro / Pantano, Francesco / Russano, Marco / Stucci, Luigia Stefania / Sergi, Maria Chiara / Falconi, Martina / Zarzana, Maria Antonietta / Santini, Daniele / Spagnolo, Francesco / Tanda, Enrica T /

Rastelli, Francesca / Giorgi, Francesca Chiara / Pergolesi, Federica / Giusti, Raffaele / Filetti, Marco / Lo Bianco, Francesca / Marchetti, Paolo / Botticelli, Andrea / Gelibter, Alain / Siringo, Marco / Ferrari, Marco / Marconcini, Riccardo / Vitale, Maria Giuseppa / Nicolardi, Linda / Chiari, Rita / Ghidini, Michele / Nigro, Olga / Grossi, Francesco / De Tursi, Michele / Di Marino, Pietro / Queirolo, Paola / Bracarda, Sergio / Macrini, Serena / Inno, Alessandro / Zoratto, Federica / Veltri, Enzo / Spoto, Chiara / Vitale, Maria Grazia / Cannita, Katia / Gennari, Alessandra / Morganstein, Daniel L / Mallardo, Domenico / Nibid, Lorenzo / Sabarese, Giovanna / Brunetti, Leonardo / Perrone, Giuseppe / Ascierto, Paolo A / Ficorella, Corrado / Pinato, David J

Clinical cancer research : an official journal of the American Association for Cancer Research

2023 Volume 29, Issue 14, Page(s) 2714–2724

Abstract: Purpose: No evidence exists as to whether type 2 diabetes mellitus (T2DM) impairs clinical outcome from immune checkpoint inhibitors (ICI) in patients with solid tumors.: Experimental design: In a large cohort of ICI recipients treated at 21 ... ...

Abstract	Purpose: No evidence exists as to whether type 2 diabetes mellitus (T2DM) impairs clinical outcome from immune checkpoint inhibitors (ICI) in patients with solid tumors. Experimental design: In a large cohort of ICI recipients treated at 21 institutions from June 2014 to June 2020, we studied whether patients on glucose-lowering medications (GLM) for T2DM had shorter overall survival (OS) and progression-free survival (PFS). We used targeted transcriptomics in a subset of patients to explore differences in the tumor microenvironment (TME) of patients with or without diabetes. Results: A total of 1,395 patients were included. Primary tumors included non-small cell lung cancer (NSCLC; 54.7%), melanoma (24.7%), renal cell (15.0%), and other carcinomas (5.6%). After multivariable analysis, patients on GLM (n = 226, 16.2%) displayed an increased risk of death [HR, 1.29; 95% confidence interval (CI),1.07-1.56] and disease progression/death (HR, 1.21; 95% CI, 1.03-1.43) independent of number of GLM received. We matched 92 metformin-exposed patients with 363 controls and 78 patients on other oral GLM or insulin with 299 control patients. Exposure to metformin, but not other GLM, was associated with an increased risk of death (HR, 1.53; 95% CI, 1.16-2.03) and disease progression/death (HR, 1.34; 95% CI, 1.04-1.72). Patients with T2DM with higher pretreatment glycemia had higher neutrophil-to-lymphocyte ratio (P = 0.04), while exploratory tumoral transcriptomic profiling in a subset of patients (n = 22) revealed differential regulation of innate and adaptive immune pathways in patients with T2DM. Conclusions: In this study, patients on GLM experienced worse outcomes from immunotherapy, independent of baseline features. Prospective studies are warranted to clarify the relative impact of metformin over a preexisting diagnosis of T2DM in influencing poorer outcomes in this population.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Immune Checkpoint Inhibitors/adverse effects ; Diabetes Mellitus, Type 2/drug therapy ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Metformin/adverse effects ; Disease Progression ; Retrospective Studies ; Tumor Microenvironment
Chemical Substances	Immune Checkpoint Inhibitors ; Metformin (9100L32L2N)
Language	English
Publishing date	2023-05-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
DOI	10.1158/1078-0432.CCR-22-3116
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Zs.A 4223: Show issues

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Article ; Online: Brain and lower body protection during aortic arch surgery.

Calafiore, Antonio M / de Paulis, Ruggero / Iesu, Severino / Paparella, Domenico / Angelini, Gianni / Scognamiglio, Mattia / Centofanti, Paolo / Nicolardi, Salvatore / Chivasso, Pierpaolo / Canosa, Carlo / Zaccaria, Salvatore / de Martino, Luigi / Magnano, Diego / Mastrototaro, Giuseppe / Di Mauro, Michele

Journal of cardiac surgery

2022 Volume 37, Issue 12, Page(s) 4982–4990

Abstract: Background: Deep hypothermic circulatory arrest (DHCA) at ≤20°C for aortic arch surgery has been widely used for decades, with or without cerebral perfusion (CP), antegrade (antegrade cerebral perfusion [ACP]), or retrograde. In recent years nadir ... ...

Abstract	Background: Deep hypothermic circulatory arrest (DHCA) at ≤20°C for aortic arch surgery has been widely used for decades, with or without cerebral perfusion (CP), antegrade (antegrade cerebral perfusion [ACP]), or retrograde. In recent years nadir temperature progressively increased to 26°C-28°C (moderately hypothermic circulatory arrest [MHCA]), adding ACP. Aim of this multicentric study is to evaluate early results of aortic arch surgery and if DHCA with 10 min of cold reperfusion at the same nadir temperature of the CA before rewarming (delayed rewarming [DR]) can provide a neuroprotection and a lower body protection similar to that provided by MHCA + ACP. Methods: A total of 210 patients were included in the study. DHCA + DR was used in 59 patients and MHCA + ACP in 151. Primary endpoints were death, neurologic event (NE), temporary (TNE), or permanent (permanent neurologic deficit [PND]), and need of renal replacement therapy (RRT). Results: Operative mortality occurred in 14 patients (6.7%), NEs in 17 (8.1%), and PNDs in 10 (4.8%). A total of 23 patients (10.9%) needed RRT. Death + PND occurred in 21 patients (10%) and composite endpoint in 35 (19.2%). Intergroup weighed logistic regression analysis showed similar prevalence of deaths, NDs, and death + PND, but need of RRT (odds ratio [OR]: 7.39, confidence interval [CI]: 1.37-79.1) and composite endpoint (OR: 8.97, CI: 1.95-35.3) were significantly lower in DHCA + DR group compared with MHCA + ACP group. Conclusions: The results of our study demonstrate that DHCA + DR has the same prevalence of operative mortality, NE and association of death+PND than MHCA + ACP. However, the data suggests that DHCA + DR when compared with MHCA + ACP provides better renal protection and reduced prevalence of composite endpoint.
MeSH term(s)	Humans ; Aorta, Thoracic/surgery ; Treatment Outcome ; Circulatory Arrest, Deep Hypothermia Induced/methods ; Brain ; Cardiopulmonary Bypass/methods ; Perfusion/methods ; Cerebrovascular Circulation ; Retrospective Studies
Language	English
Publishing date	2022-11-20
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	639059-6
ISSN	1540-8191 ; 0886-0440
ISSN (online)	1540-8191
ISSN	0886-0440
DOI	10.1111/jocs.17207
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Zs.A 2221: Show issues

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Article ; Online: Alarming Drop in Early Stage Colorectal Cancer Diagnoses After COVID-19 Outbreak: A Real-World Analysis from the Italian COVID-DELAY Study.

Mentrasti, Giulia / Cantini, Luca / Zichi, Clizia / D'Ostilio, Nicola / Gelsomino, Fabio / Martinelli, Erika / Chiari, Rita / La Verde, Nicla / Bisonni, Renato / Cognigni, Valeria / Pinterpe, Giada / Pecci, Federica / Migliore, Antonella / Aimar, Giacomo / De Vita, Francesca / Traisci, Donatella / Spallanzani, Andrea / Martini, Giulia / Nicolardi, Linda /

Cona, Maria Silvia / Baleani, Maria Giuditta / Rocchi, Marco Luigi Bruno / Berardi, Rossana

The oncologist

2022 Volume 27, Issue 9, Page(s) e723–e730

Abstract: Background: Coronavirus disease 2019 (COVID-19) has triggered the disruption of health care on a global scale. With Italy tangled up in the pandemic response, oncology care has been largely diverted and cancer screenings suspended. Our multicenter ... ...

Abstract	Background: Coronavirus disease 2019 (COVID-19) has triggered the disruption of health care on a global scale. With Italy tangled up in the pandemic response, oncology care has been largely diverted and cancer screenings suspended. Our multicenter Italian study aimed to evaluate whether COVID-19 has impacted access to diagnosis, staging, and treatment for patients newly diagnosed with colorectal cancer (CRC), compared with pre-pandemic time. Methods: All consecutive new CRC patients referred to 8 Italian oncology institutions between March and December 2020 were included. Access rate and temporal intervals between date of symptoms onset, radiological and cytohistological diagnosis, treatment start and first radiological evaluation were analyzed and compared with the same months of 2019. Results: A reduction (29%) in newly diagnosed CRC cases was seen when compared with 2019 (360 vs 506). New CRC patients in 2020 were less likely to be diagnosed with early stage (stages I-II-III) CRC (63% vs 78%, P < .01). Gender and sidedness were similar regardless of the year. The percentage of tumors with any mutation among BRAF, NRAS, and KRAS genes were significantly different between the 2 years (61% in 2020 vs 50% in 2019, P = .04). Timing of access to cancer diagnosis, staging, and treatment for patients with CRC has not been negatively affected by the pandemic. Significantly shorter temporal intervals were observed between symptom onset and first oncological appointment (69 vs 79 days, P = .01) and between histological diagnosis and first oncological appointment (34 vs 42 days, P < .01) during 2020 compared with 2019. Fewer CRC cases were discussed in multidisciplinary meetings during 2020 (38% vs 50%, P = .01). Conclusions: Our data highlight a significant drop in CRC diagnosis after COVID-19, especially for early stage disease. The study also reveals a remarkable setback in the multidisciplinary management of patients with CRC. Despite this, Italian oncologists were able to ensure diagnostic-therapeutic pathways proper operation after March 2020.
MeSH term(s)	COVID-19/epidemiology ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/genetics ; Early Detection of Cancer ; Humans ; Italy/epidemiology ; Pandemics
Language	English
Publishing date	2022-07-18
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	1409038-7
ISSN	1549-490X ; 1083-7159
ISSN (online)	1549-490X
ISSN	1083-7159
DOI	10.1093/oncolo/oyac129
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In stock of ZB MED Cologne/Königswinter

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More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito