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  1. Book: Neuropathology of AIDS

    Vinters, Harry V. / Anders, Karl H.

    1990  

    Author's details authors Harry V. Vinters ; Karl H. Anders
    Keywords Acquired Immunodeficiency Syndrome / complications ; Nervous System Diseases / complications ; Aids ; Neurologie
    Subject Klinische Neurologie ; Acquired immune deficiency syndrome ; Erworbenes Immundefektsyndrom
    Size 229 S. : zahlr. Ill.
    Publisher CRC Pr
    Publishing place Boca Raton, Fla
    Publishing country United States
    Document type Book
    HBZ-ID HT003520790
    ISBN 0-8493-5074-3 ; 978-0-8493-5074-0
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1990 A 3333 order for loan Magazin

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  2. Article ; Online: HIV and COVID-19: two pandemics with significant (but different) central nervous system complications.

    Magaki, Shino / Zhang, Ting / Han, Karam / Hilda, Mirbaha / Yong, William H / Achim, Cristian / Fishbein, Gregory / Fishbein, Michael C / Garner, Omai / Salamon, Noriko / Williams, Christopher K / Valdes-Sueiras, Miguel A / Hsu, Jeffrey J / Kelesidis, Theodoros / Mathisen, Glenn E / Lavretsky, Helen / Singer, Elyse J / Vinters, Harry V

    Free neuropathology

    2024  Volume 5

    Abstract: Human immunodeficiency virus (HIV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause significant neurologic disease. Central nervous system (CNS) involvement of HIV has been extensively studied, with well-documented invasion of HIV ... ...

    Abstract Human immunodeficiency virus (HIV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause significant neurologic disease. Central nervous system (CNS) involvement of HIV has been extensively studied, with well-documented invasion of HIV into the brain in the initial stage of infection, while the acute effects of SARS-CoV-2 in the brain are unclear. Neuropathologic features of active HIV infection in the brain are well characterized whereas neuropathologic findings in acute COVID-19 are largely non-specific. On the other hand, neuropathologic substrates of chronic dysfunction in both infections, as HIV-associated neurocognitive disorders (HAND) and post-COVID conditions (PCC)/long COVID are unknown. Thus far, neuropathologic studies on patients with HAND in the era of combined antiretroviral therapy have been inconclusive, and autopsy studies on patients diagnosed with PCC have yet to be published. Further longitudinal, multidisciplinary studies on patients with HAND and PCC and neuropathologic studies in comparison to controls are warranted to help elucidate the mechanisms of CNS dysfunction in both conditions.
    Language English
    Publishing date 2024-03-05
    Publishing country Germany
    Document type Journal Article
    ISSN 2699-4445
    ISSN (online) 2699-4445
    DOI 10.17879/freeneuropathology-2024-5343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Biobanking of Cerebrospinal Fluid.

    Tashjian, Randy S / Vinters, Harry V / Yong, William H

    Methods in molecular biology (Clifton, N.J.)

    2018  Volume 1897, Page(s) 107–114

    Abstract: Cerebrospinal fluid (CSF) is a physiologically essential fluid produced by the brain that is involved in protecting the brain and in the exchange of nutrients and waste products. CSF has long been utilized to confirm clinical suspicion of various ... ...

    Abstract Cerebrospinal fluid (CSF) is a physiologically essential fluid produced by the brain that is involved in protecting the brain and in the exchange of nutrients and waste products. CSF has long been utilized to confirm clinical suspicion of various infectious and inflammatory disorders, such as meningitis and multiple sclerosis. However, there has been increasing interest in collecting CSF in order to study the clinical significance of additional biomarkers. This chapter outlines the procedures necessary to collect, process, store, and utilize CSF obtained for the purposes of biobanking from both living and deceased patients.
    MeSH term(s) Biological Specimen Banks ; Biomarkers/cerebrospinal fluid ; Brain/pathology ; Cerebrospinal Fluid/chemistry ; Humans ; Meningitis/cerebrospinal fluid ; Meningitis/pathology ; Multiple Sclerosis/cerebrospinal fluid ; Multiple Sclerosis/pathology ; Specimen Handling/methods
    Chemical Substances Biomarkers
    Language English
    Publishing date 2018-10-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-8935-5_11
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Intercellular Signaling Pathways as Therapeutic Targets for Vascular Dementia Repair.

    Tian, Min / Kawaguchi, Riki / Shen, Yang / Machnicki, Michal / Villegas, Nikole G / Cooper, Delaney R / Montgomery, Natalia / Haring, Jacqueline / Lan, Ruirui / Yuan, Angelina H / Williams, Christopher K / Magaki, Shino / Vinters, Harry V / Zhang, Ye / De Biase, Lindsay M / Silva, Alcino J / Carmichael, S Thomas

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Vascular dementia (VaD) is a white matter ischemic disease and the second-leading cause of dementia, with no direct therapy. Within the lesion site, cell-cell interactions dictate the trajectory towards disease progression or repair. To elucidate the ... ...

    Abstract Vascular dementia (VaD) is a white matter ischemic disease and the second-leading cause of dementia, with no direct therapy. Within the lesion site, cell-cell interactions dictate the trajectory towards disease progression or repair. To elucidate the underlying intercellular signaling pathways, a VaD mouse model was developed for transcriptomic and functional studies. The mouse VaD transcriptome was integrated with a human VaD snRNA-Seq dataset. A custom-made database encompassing 4053 human and 2032 mouse ligand-receptor (L-R) interactions identified significantly altered pathways shared between human and mouse VaD. Two intercellular L-R systems, Serpine2-Lrp1 and CD39-A3AR, were selected for mechanistic study as both the ligand and receptor were dysregulated in VaD. Decreased Seprine2 expression enhances OPC differentiation in VaD repair. A clinically relevant drug that reverses the loss of CD39-A3AR function promotes tissue and behavioral recovery in the VaD model. This study presents novel intercellular signaling targets and may open new avenues for VaD therapies.
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.24.585301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Improving the solubility of pseudo-hydrophobic Alzheimer's Disease medicinal chemicals through co-crystal formulation.

    Tse, A / Janilkarn-Urena, I / Lin, J / Chang, X / Efthymiou, C / Idrissova, A / Zhang, M / Williams, C K / Magaki, S / Vinters, H V / Davies, D L / Gonen, T / Gukasyan, H J / Seidler, P M

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Natural products are ligands and potential inhibitors of Alzheimer's disease (AD) tau. Dihydromyricetin (DHM) is a CNS active natural product. Despite having signature polyphenolic character, DHM is ostensibly hydrophobic owing to intermolecular hydrogen ...

    Abstract Natural products are ligands and potential inhibitors of Alzheimer's disease (AD) tau. Dihydromyricetin (DHM) is a CNS active natural product. Despite having signature polyphenolic character, DHM is ostensibly hydrophobic owing to intermolecular hydrogen bonds that shield hydrophilic phenols. Our research shows DHM becomes ionized at near-neutral pH allowing formulation of salts with transformed solubility. The MicroED co-crystal structure with trolamine reveals DHM salts as metastable solids with unlocked hydrogen bonding and a thermodynamic bent to solubilize in water. All salt formulations show better inhibitory activity against AD tau than the non-salt form, with efficacies correlating to enhanced solubilities. These results underscore the role of structural chemistry in guiding selection of solubilizing agents for chemical formulation. We propose DHM salts are appropriate formulations for research as dietary supplements to promote healthy aging by combating protein misfolding. Additionally, DHM is a suitable lead for medicinal chemistry and possible development of CNS pharmaceuticals.
    Language English
    Publishing date 2023-04-28
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.25.538327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Neuropathology of AIDS dementia.

    Vinters, H V

    The Western journal of medicine

    2008  Volume 149, Issue 5, Page(s) 596–597

    Language English
    Publishing date 2008-08-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189235-6
    ISSN 1476-2978 ; 0093-0415 ; 0008-1264
    ISSN (online) 1476-2978
    ISSN 0093-0415 ; 0008-1264
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  7. Article: Learning fast and fine-grained detection of amyloid neuropathologies from coarse-grained expert labels.

    Wong, Daniel R / Magaki, Shino D / Vinters, Harry V / Yong, William H / Monuki, Edwin S / Williams, Christopher K / Martini, Alessandra C / DeCarli, Charles / Khacherian, Chris / Graff, John P / Dugger, Brittany N / Keiser, Michael J

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Precise, scalable, and quantitative evaluation of whole slide images is crucial in neuropathology. We release a deep learning model for rapid object detection and precise information on the identification, locality, and counts of cored plaques and ... ...

    Abstract Precise, scalable, and quantitative evaluation of whole slide images is crucial in neuropathology. We release a deep learning model for rapid object detection and precise information on the identification, locality, and counts of cored plaques and cerebral amyloid angiopathies (CAAs). We trained this object detector using a repurposed image-tile dataset without any human-drawn bounding boxes. We evaluated the detector on a new manually-annotated dataset of whole slide images (WSIs) from three institutions, four staining procedures, and four human experts. The detector matched the cohort of neuropathology experts, achieving 0.64 (model) vs. 0.64 (cohort) average precision (AP) for cored plaques and 0.75 vs. 0.51 AP for CAAs at a 0.5 IOU threshold. It provided count and locality predictions that correlated with gold-standard CERAD-like WSI scoring (p=0.07± 0.10). The openly-available model can quickly score WSIs in minutes without a GPU on a standard workstation.
    Language English
    Publishing date 2023-01-17
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.01.13.524019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Learning fast and fine-grained detection of amyloid neuropathologies from coarse-grained expert labels.

    Wong, Daniel R / Magaki, Shino D / Vinters, Harry V / Yong, William H / Monuki, Edwin S / Williams, Christopher K / Martini, Alessandra C / DeCarli, Charles / Khacherian, Chris / Graff, John P / Dugger, Brittany N / Keiser, Michael J

    Communications biology

    2023  Volume 6, Issue 1, Page(s) 668

    Abstract: Precise, scalable, and quantitative evaluation of whole slide images is crucial in neuropathology. We release a deep learning model for rapid object detection and precise information on the identification, locality, and counts of cored plaques and ... ...

    Abstract Precise, scalable, and quantitative evaluation of whole slide images is crucial in neuropathology. We release a deep learning model for rapid object detection and precise information on the identification, locality, and counts of cored plaques and cerebral amyloid angiopathy (CAA). We trained this object detector using a repurposed image-tile dataset without any human-drawn bounding boxes. We evaluated the detector on a new manually-annotated dataset of whole slide images (WSIs) from three institutions, four staining procedures, and four human experts. The detector matched the cohort of neuropathology experts, achieving 0.64 (model) vs. 0.64 (cohort) average precision (AP) for cored plaques and 0.75 vs. 0.51 AP for CAAs at a 0.5 IOU threshold. It provided count and locality predictions that approximately correlated with gold-standard human CERAD-like WSI scoring (p = 0.07 ± 0.10). The openly-available model can quickly score WSIs in minutes without a GPU on a standard workstation.
    MeSH term(s) Humans ; Amyloidogenic Proteins ; Plaque, Amyloid ; Records ; Staining and Labeling ; Virion
    Chemical Substances Amyloidogenic Proteins
    Language English
    Publishing date 2023-06-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-023-05031-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Neuropathology of microbleeds in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

    Magaki, Shino / Chen, Zesheng / Severance, Alyscia / Williams, Christopher K / Diaz, Ramiro / Fang, Chuo / Khanlou, Negar / Yong, William H / Paganini-Hill, Annlia / Kalaria, Rajesh N / Vinters, Harry V / Fisher, Mark

    Journal of neuropathology and experimental neurology

    2023  Volume 82, Issue 4, Page(s) 333–344

    Abstract: Cerebral microbleeds (CMBs) detected on magnetic resonance imaging are common in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). The neuropathologic correlates of CMBs are unclear. In ... ...

    Abstract Cerebral microbleeds (CMBs) detected on magnetic resonance imaging are common in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). The neuropathologic correlates of CMBs are unclear. In this study, we characterized findings relevant to CMBs in autopsy brain tissue of 8 patients with genetically confirmed CADASIL and 10 controls within the age range of the CADASIL patients by assessing the distribution and extent of hemosiderin/iron deposits including perivascular hemosiderin leakage (PVH), capillary hemosiderin deposits, and parenchymal iron deposits (PID) in the frontal cortex and white matter, basal ganglia and cerebellum. We also characterized infarcts, vessel wall thickening, and severity of vascular smooth muscle cell degeneration. CADASIL subjects had a significant increase in hemosiderin/iron deposits compared with controls. This increase was principally seen with PID. Hemosiderin/iron deposits were seen in the majority of CADASIL subjects in all brain areas. PVH was most pronounced in the frontal white matter and basal ganglia around small to medium sized arterioles, with no predilection for the vicinity of vessels with severe vascular changes or infarcts. CADASIL subjects have increased brain hemosiderin/iron deposits but these do not occur in a periarteriolar distribution. Pathogenesis of these lesions remains uncertain.
    MeSH term(s) Humans ; CADASIL/complications ; CADASIL/diagnostic imaging ; CADASIL/pathology ; Hemosiderin ; Cerebral Infarction/complications ; Cerebral Infarction/diagnostic imaging ; Cerebral Infarction/pathology ; Leukoencephalopathies/pathology ; Magnetic Resonance Imaging ; Cerebral Hemorrhage/complications ; Cerebral Hemorrhage/diagnostic imaging ; Cerebral Hemorrhage/pathology ; Iron
    Chemical Substances Hemosiderin (9011-92-1) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2023-11-09
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3088-0
    ISSN 1554-6578 ; 0022-3069
    ISSN (online) 1554-6578
    ISSN 0022-3069
    DOI 10.1093/jnen/nlad004
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    Ui II Zs.134: Show issues Location:
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  10. Article ; Online: Autopsy Biobanking: Biospecimen Procurement, Integrity, Storage, and Utilization.

    Tashjian, Randy S / Williams, Ryan R / Vinters, Harry V / Yong, William H

    Methods in molecular biology (Clifton, N.J.)

    2018  Volume 1897, Page(s) 77–87

    Abstract: An autopsy is a specialized surgical procedure consisting of external and internal examination of a deceased individual for the purposes of documenting abnormalities and determining or confirming medical diagnoses that may have contributed to their death. ...

    Abstract An autopsy is a specialized surgical procedure consisting of external and internal examination of a deceased individual for the purposes of documenting abnormalities and determining or confirming medical diagnoses that may have contributed to their death. One of the benefits of an autopsy is the opportunity to collect and store biospecimens for the purposes of biobanking. This chapter outlines the procedures necessary to procure, store, and utilize biospecimens obtained during an autopsy. With the emergence of molecular diagnostics, this chapter also discusses factors that influence the integrity of autopsy biospecimens prior to procurement. These include the postmortem interval, as well as premortem factors such as the patient's agonal state, biospecimen temperature, and pH.
    MeSH term(s) Autopsy/trends ; Biological Specimen Banks/trends ; Humans ; Pathology, Molecular/trends ; Quality Control ; Specimen Handling/methods ; Specimen Handling/trends ; Temperature
    Language English
    Publishing date 2018-12-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-8935-5_8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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