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Article ; Online: GW190521: A Binary Black Hole Merger with a Total Mass of 150 M_{⊙}.

Abbott, R / Abbott, T D / Abraham, S / Acernese, F / Ackley, K / Adams, C / Adhikari, R X / Adya, V B / Affeldt, C / Agathos, M / Agatsuma, K / Aggarwal, N / Aguiar, O D / Aich, A / Aiello, L / Ain, A / Ajith, P / Akcay, S / Allen, G /

Allocca, A / Altin, P A / Amato, A / Anand, S / Ananyeva, A / Anderson, S B / Anderson, W G / Angelova, S V / Ansoldi, S / Antier, S / Appert, S / Arai, K / Araya, M C / Areeda, J S / Arène, M / Arnaud, N / Aronson, S M / Arun, K G / Asali, Y / Ascenzi, S / Ashton, G / Aston, S M / Astone, P / Aubin, F / Aufmuth, P / AultONeal, K / Austin, C / Avendano, V / Babak, S / Bacon, P / Badaracco, F / Bader, M K M / Bae, S / Baer, A M / Baird, J / Baldaccini, F / Ballardin, G / Ballmer, S W / Bals, A / Balsamo, A / Baltus, G / Banagiri, S / Bankar, D / Bankar, R S / Barayoga, J C / Barbieri, C / Barish, B C / Barker, D / Barkett, K / Barneo, P / Barone, F / Barr, B / Barsotti, L / Barsuglia, M / Barta, D / Bartlett, J / Bartos, I / Bassiri, R / Basti, A / Bawaj, M / Bayley, J C / Bazzan, M / Bécsy, B / Bejger, M / Belahcene, I / Bell, A S / Beniwal, D / Benjamin, M G / Bentley, J D / Bergamin, F / Berger, B K / Bergmann, G / Bernuzzi, S / Berry, C P L / Bersanetti, D / Bertolini, A / Betzwieser, J / Bhandare, R / Bhandari, A V / Bidler, J / Biggs, E / Bilenko, I A / Billingsley, G / Birney, R / Birnholtz, O / Biscans, S / Bischi, M / Biscoveanu, S / Bisht, A / Bissenbayeva, G / Bitossi, M / Bizouard, M A / Blackburn, J K / Blackman, J / Blair, C D / Blair, D G / Blair, R M / Bobba, F / Bode, N / Boer, M / Boetzel, Y / Bogaert, G / Bondu, F / Bonilla, E / Bonnand, R / Booker, P / Boom, B A / Bork, R / Boschi, V / Bose, S / Bossilkov, V / Bosveld, J / Bouffanais, Y / Bozzi, A / Bradaschia, C / Brady, P R / Bramley, A / Branchesi, M / Brau, J E / Breschi, M / Briant, T / Briggs, J H / Brighenti, F / Brillet, A / Brinkmann, M / Brockill, P / Brooks, A F / Brooks, J / Brown, D D / Brunett, S / Bruno, G / Bruntz, R / Buikema, A / Bulik, T / Bulten, H J / Buonanno, A / Buscicchio, R / Buskulic, D / Byer, R L / Cabero, M / Cadonati, L / Cagnoli, G / Cahillane, C / Calderón Bustillo, J / Callaghan, J D / Callister, T A / Calloni, E / Camp, J B / Canepa, M / Cannon, K C / Cao, H / Cao, J / Carapella, G / Carbognani, F / Caride, S / Carney, M F / Carullo, G / Casanueva Diaz, J / Casentini, C / Castañeda, J / Caudill, S / Cavaglià, M / Cavalier, F / Cavalieri, R / Cella, G / Cerdá-Durán, P / Cesarini, E / Chaibi, O / Chakravarti, K / Chan, C / Chan, M / Chandra, K / Chao, S / Charlton, P / Chase, E A / Chassande-Mottin, E / Chatterjee, D / Chaturvedi, M / Chatziioannou, K / Chen, H Y / Chen, X / Chen, Y / Cheng, H-P / Cheong, C K / Chia, H Y / Chiadini, F / Chierici, R / Chincarini, A / Chiummo, A / Cho, G / Cho, H S / Cho, M / Christensen, N / Chu, Q / Chua, S / Chung, K W / Chung, S / Ciani, G / Ciecielag, P / Cieślar, M / Ciobanu, A A / Ciolfi, R / Cipriano, F / Cirone, A / Clara, F / Clark, J A / Clearwater, P / Clesse, S / Cleva, F / Coccia, E / Cohadon, P-F / Cohen, D / Colleoni, M / Collette, C G / Collins, C / Colpi, M / Constancio, M / Conti, L / Cooper, S J / Corban, P / Corbitt, T R / Cordero-Carrión, I / Corezzi, S / Corley, K R / Cornish, N / Corre, D / Corsi, A / Cortese, S / Costa, C A / Cotesta, R / Coughlin, M W / Coughlin, S B / Coulon, J-P / Countryman, S T / Couvares, P / Covas, P B / Coward, D M / Cowart, M J / Coyne, D C / Coyne, R / Creighton, J D E / Creighton, T D / Cripe, J / Croquette, M / Crowder, S G / Cudell, J-R / Cullen, T J / Cumming, A / Cummings, R / Cunningham, L / Cuoco, E / Curylo, M / Canton, T Dal / Dálya, G / Dana, A / Daneshgaran-Bajastani, L M / D'Angelo, B / Danilishin, S L / D'Antonio, S / Danzmann, K / Darsow-Fromm, C / Dasgupta, A / Datrier, L E H / Dattilo, V / Dave, I / Davier, M / Davies, G S / Davis, D / Daw, E J / DeBra, D / Deenadayalan, M / Degallaix, J / De Laurentis, M / Deléglise, S / Delfavero, M / De Lillo, N / Del Pozzo, W / DeMarchi, L M / D'Emilio, V / Demos, N / Dent, T / De Pietri, R / De Rosa, R / De Rossi, C / DeSalvo, R / de Varona, O / Dhurandhar, S / Díaz, M C / Diaz-Ortiz, M / Dietrich, T / Di Fiore, L / Di Fronzo, C / Di Giorgio, C / Di Giovanni, F / Di Giovanni, M / Di Girolamo, T / Di Lieto, A / Ding, B / Di Pace, S / Di Palma, I / Di Renzo, F / Divakarla, A K / Dmitriev, A / Doctor, Z / Donovan, F / Dooley, K L / Doravari, S / Dorrington, I / Downes, T P / Drago, M / Driggers, J C / Du, Z / Ducoin, J-G / Dupej, P / Durante, O / D'Urso, D / Dwyer, S E / Easter, P J / Eddolls, G / Edelman, B / Edo, T B / Edy, O / Effler, A / Ehrens, P / Eichholz, J / Eikenberry, S S / Eisenmann, M / Eisenstein, R A / Ejlli, A / Errico, L / Essick, R C / Estelles, H / Estevez, D / Etienne, Z B / Etzel, T / Evans, M / Evans, T M / Ewing, B E / Fafone, V / Fairhurst, S / Fan, X / Farinon, S / Farr, B / Farr, W M / Fauchon-Jones, E J / Favata, M / Fays, M / Fazio, M / Feicht, J / Fejer, M M / Feng, F / Fenyvesi, E / Ferguson, D L / Fernandez-Galiana, A / Ferrante, I / Ferreira, E C / Ferreira, T A / Fidecaro, F / Fiori, I / Fiorucci, D / Fishbach, M / Fisher, R P / Fittipaldi, R / Fitz-Axen, M / Fiumara, V / Flaminio, R / Floden, E / Flynn, E / Fong, H / Font, J A / Forsyth, P W F / Fournier, J-D / Frasca, S / Frasconi, F / Frei, Z / Freise, A / Frey, R / Frey, V / Fritschel, P / Frolov, V V / Fronzè, G / Fulda, P / Fyffe, M / Gabbard, H A / Gadre, B U / Gaebel, S M / Gair, J R / Galaudage, S / Ganapathy, D / Ganguly, A / Gaonkar, S G / García-Quirós, C / Garufi, F / Gateley, B / Gaudio, S / Gayathri, V / Gemme, G / Genin, E / Gennai, A / George, D / George, J / Gergely, L / Ghonge, S / Ghosh, Abhirup / Ghosh, Archisman / Ghosh, S / Giacomazzo, B / Giaime, J A / Giardina, K D / Gibson, D R / Gier, C / Gill, K / Glanzer, J / Gniesmer, J / Godwin, P / Goetz, E / Goetz, R / Gohlke, N / Goncharov, B / González, G / Gopakumar, A / Gossan, S E / Gosselin, M / Gouaty, R / Grace, B / Grado, A / Granata, M / Grant, A / Gras, S / Grassia, P / Gray, C / Gray, R / Greco, G / Green, A C / Green, R / Gretarsson, E M / Griggs, H L / Grignani, G / Grimaldi, A / Grimm, S J / Grote, H / Grunewald, S / Gruning, P / Guidi, G M / Guimaraes, A R / Guixé, G / Gulati, H K / Guo, Y / Gupta, A / Gupta, Anchal / Gupta, P / Gustafson, E K / Gustafson, R / Haegel, L / Halim, O / Hall, E D / Hamilton, E Z / Hammond, G / Haney, M / Hanke, M M / Hanks, J / Hanna, C / Hannam, M D / Hannuksela, O A / Hansen, T J / Hanson, J / Harder, T / Hardwick, T / Haris, K / Harms, J / Harry, G M / Harry, I W / Hasskew, R K / Haster, C-J / Haughian, K / Hayes, F J / Healy, J / Heidmann, A / Heintze, M C / Heinze, J / Heitmann, H / Hellman, F / Hello, P / Hemming, G / Hendry, M / Heng, I S / Hennes, E / Hennig, J / Heurs, M / Hild, S / Hinderer, T / Hoback, S Y / Hochheim, S / Hofgard, E / Hofman, D / Holgado, A M / Holland, N A / Holt, K / Holz, D E / Hopkins, P / Horst, C / Hough, J / Howell, E J / Hoy, C G / Huang, Y / Hübner, M T / Huerta, E A / Huet, D / Hughey, B / Hui, V / Husa, S / Huttner, S H / Huxford, R / Huynh-Dinh, T / Idzkowski, B / Iess, A / Inchauspe, H / Ingram, C / Intini, G / Isac, J-M / Isi, M / Iyer, B R / Jacqmin, T / Jadhav, S J / Jadhav, S P / James, A L / Jani, K / Janthalur, N N / Jaranowski, P / Jariwala, D / Jaume, R / Jenkins, A C / Jiang, J / Johns, G R / Johnson-McDaniel, N K / Jones, A W / Jones, D I / Jones, J D / Jones, P / Jones, R / Jonker, R J G / Ju, L / Junker, J / Kalaghatgi, C V / Kalogera, V / Kamai, B / Kandhasamy, S / Kang, G / Kanner, J B / Kapadia, S J / Karki, S / Kashyap, R / Kasprzack, M / Kastaun, W / Katsanevas, S / Katsavounidis, E / Katzman, W / Kaufer, S / Kawabe, K / Kéfélian, F / Keitel, D / Keivani, A / Kennedy, R / Key, J S / Khadka, S / Khalili, F Y / Khan, I / Khan, S / Khan, Z A / Khazanov, E A / Khetan, N / Khursheed, M / Kijbunchoo, N / Kim, Chunglee / Kim, G J / Kim, J C / Kim, K / Kim, W / Kim, W S / Kim, Y-M / Kimball, C / King, P J / Kinley-Hanlon, M / Kirchhoff, R / Kissel, J S / Kleybolte, L / Klimenko, S / Knowles, T D / Knyazev, E / Koch, P / Koehlenbeck, S M / Koekoek, G / Koley, S / Kondrashov, V / Kontos, A / Koper, N / Korobko, M / Korth, W Z / Kovalam, M / Kozak, D B / Kringel, V / Krishnendu, N V / Królak, A / Krupinski, N / Kuehn, G / Kumar, A / Kumar, P / Kumar, Rahul / Kumar, Rakesh / Kumar, S / Kuo, L / Kutynia, A / Lackey, B D / Laghi, D / Lalande, E / Lam, T L / Lamberts, A / Landry, M / Lane, B B / Lang, R N / Lange, J / Lantz, B / Lanza, R K / La Rosa, I / Lartaux-Vollard, A / Lasky, P D / Laxen, M / Lazzarini, A / Lazzaro, C / Leaci, P / Leavey, S / Lecoeuche, Y K / Lee, C H / Lee, H M / Lee, H W / Lee, J / Lee, K / Lehmann, J / Leroy, N / Letendre, N / Levin, Y / Li, A K Y / Li, J / Li, K / Li, T G F / Li, X / Linde, F / Linker, S D / Linley, J N / Littenberg, T B / Liu, J / Liu, X / Llorens-Monteagudo, M / Lo, R K L / Lockwood, A / London, L T / Longo, A / Lorenzini, M / Loriette, V / Lormand, M / Losurdo, G / Lough, J D / Lousto, C O / Lovelace, G / Lück, H / Lumaca, D / Lundgren, A P / Ma, Y / Macas, R / Macfoy, S / MacInnis, M / Macleod, D M / MacMillan, I A O / Macquet, A / Magaña Hernandez, I / Magaña-Sandoval, F / Magee, R M / Majorana, E / Maksimovic, I / Malik, A / Man, N / Mandic, V / Mangano, V / Mansell, G L / Manske, M / Mantovani, M / Mapelli, M / Marchesoni, F / Marion, F / Márka, S / Márka, Z / Markakis, C / Markosyan, A S / Markowitz, A / Maros, E / Marquina, A / Marsat, S / Martelli, F / Martin, I W / Martin, R M / Martinez, V / Martynov, D V / Masalehdan, H / Mason, K / Massera, E / Masserot, A / Massinger, T J / Masso-Reid, M / Mastrogiovanni, S / Matas, A / Matichard, F / Mavalvala, N / Maynard, E / McCann, J J / McCarthy, R / McClelland, D E / McCormick, S / McCuller, L / McGuire, S C / McIsaac, C / McIver, J / McManus, D J / McRae, T / McWilliams, S T / Meacher, D / Meadors, G D / Mehmet, M / Mehta, A K / Mejuto Villa, E / Melatos, A / Mendell, G / Mercer, R A / Mereni, L / Merfeld, K / Merilh, E L / Merritt, J D / Merzougui, M / Meshkov, S / Messenger, C / Messick, C / Metzdorff, R / Meyers, P M / Meylahn, F / Mhaske, A / Miani, A / Miao, H / Michaloliakos, I / Michel, C / Middleton, H / Milano, L / Miller, A L / Millhouse, M / Mills, J C / Milotti, E / Milovich-Goff, M C / Minazzoli, O / Minenkov, Y / Mishkin, A / Mishra, C / Mistry, T / Mitra, S / Mitrofanov, V P / Mitselmakher, G / Mittleman, R / Mo, G / Mogushi, K / Mohapatra, S R P / Mohite, S R / Molina-Ruiz, M / Mondin, M / Montani, M / Moore, C J / Moraru, D / Morawski, F / Moreno, G / Morisaki, S / Mours, B / Mow-Lowry, C M / Mozzon, S / Muciaccia, F / Mukherjee, Arunava / Mukherjee, D / Mukherjee, S / Mukherjee, Subroto / Mukund, N / Mullavey, A / Munch, J / Muñiz, E A / Murray, P G / Nagar, A / Nardecchia, I / Naticchioni, L / Nayak, R K / Neil, B F / Neilson, J / Nelemans, G / Nelson, T J N / Nery, M / Neunzert, A / Ng, K Y / Ng, S / Nguyen, C / Nguyen, P / Nichols, D / Nichols, S A / Nissanke, S / Nitz, A / Nocera, F / Noh, M / North, C / Nothard, D / Nuttall, L K / Oberling, J / O'Brien, B D / Oganesyan, G / Ogin, G H / Oh, J J / Oh, S H / Ohme, F / Ohta, H / Okada, M A / Oliver, M / Olivetto, C / Oppermann, P / Oram, Richard J / O'Reilly, B / Ormiston, R G / Ortega, L F / O'Shaughnessy, R / Ossokine, S / Osthelder, C / Ottaway, D J / Overmier, H / Owen, B J / Pace, A E / Pagano, G / Page, M A / Pagliaroli, G / Pai, A / Pai, S A / Palamos, J R / Palashov, O / Palomba, C / Pan, H / Panda, P K / Pang, P T H / Pankow, C / Pannarale, F / Pant, B C / Paoletti, F / Paoli, A / Parida, A / Parker, W / Pascucci, D / Pasqualetti, A / Passaquieti, R / Passuello, D / Patricelli, B / Payne, E / Pearlstone, B L / Pechsiri, T C / Pedersen, A J / Pedraza, M / Pele, A / Penn, S / Perego, A / Perez, C J / Périgois, C / Perreca, A / Perriès, S / Petermann, J / Pfeiffer, H P / Phelps, M / Phukon, K S / Piccinni, O J / Pichot, M / Piendibene, M / Piergiovanni, F / Pierro, V / Pillant, G / Pinard, L / Pinto, I M / Piotrzkowski, K / Pirello, M / Pitkin, M / Plastino, W / Poggiani, R / Pong, D Y T / Ponrathnam, S / Popolizio, P / Porter, E K / Powell, J / Prajapati, A K / Prasai, K / Prasanna, R / Pratten, G / Prestegard, T / Principe, M / Prodi, G A / Prokhorov, L / Punturo, M / Puppo, P / Pürrer, M / Qi, H / Quetschke, V / Quinonez, P J / Raab, F J / Raaijmakers, G / Radkins, H / Radulesco, N / Raffai, P / Rafferty, H / Raja, S / Rajan, C / Rajbhandari, B / Rakhmanov, M / Ramirez, K E / Ramos-Buades, A / Rana, Javed / Rao, K / Rapagnani, P / Raymond, V / Razzano, M / Read, J / Regimbau, T / Rei, L / Reid, S / Reitze, D H / Rettegno, P / Ricci, F / Richardson, C J / Richardson, J W / Ricker, P M / Riemenschneider, G / Riles, K / Rizzo, M / Robertson, N A / Robinet, F / Rocchi, A / Rodriguez-Soto, R D / Rolland, L / Rollins, J G / Roma, V J / Romanelli, M / Romano, R / Romel, C L / Romero-Shaw, I M / Romie, J H / Rose, C A / Rose, D / Rose, K / Rosińska, D / Rosofsky, S G / Ross, M P / Rowan, S / Rowlinson, S J / Roy, P K / Roy, Santosh / Roy, Soumen / Ruggi, P / Rutins, G / Ryan, K / Sachdev, S / Sadecki, T / Sakellariadou, M / Salafia, O S / Salconi, L / Saleem, M / Salemi, F / Samajdar, A / Sanchez, E J / Sanchez, L E / Sanchis-Gual, N / Sanders, J R / Santiago, K A / Santos, E / Sarin, N / Sassolas, B / Sathyaprakash, B S / Sauter, O / Savage, R L / Savant, V / Sawant, D / Sayah, S / Schaetzl, D / Schale, P / Scheel, M / Scheuer, J / Schmidt, P / Schnabel, R / Schofield, R M S / Schönbeck, A / Schreiber, E / Schulte, B W / Schutz, B F / Schwarm, O / Schwartz, E / Scott, J / Scott, S M / Seidel, E / Sellers, D / Sengupta, A S / Sennett, N / Sentenac, D / Sequino, V / Sergeev, A / Setyawati, Y / Shaddock, D A / Shaffer, T / Sharifi, S / Shahriar, M S / Sharma, A / Sharma, P / Shawhan, P / Shen, H / Shikauchi, M / Shink, R / Shoemaker, D H / Shoemaker, D M / Shukla, K / ShyamSundar, S / Siellez, K / Sieniawska, M / Sigg, D / Singer, L P / Singh, D / Singh, N / Singha, A / Singhal, A / Sintes, A M / Sipala, V / Skliris, V / Slagmolen, B J J / Slaven-Blair, T J / Smetana, J / Smith, J R / Smith, R J E / Somala, S / Son, E J / Soni, S / Sorazu, B / Sordini, V / Sorrentino, F / Souradeep, T / Sowell, E / Spencer, A P / Spera, M / Srivastava, A K / Srivastava, V / Staats, K / Stachie, C / Standke, M / Steer, D A / Steinke, M / Steinlechner, J / Steinlechner, S / Steinmeyer, D / Stevenson, S / Stocks, D / Stops, D J / Stover, M / Strain, K A / Stratta, G / Strunk, A / Sturani, R / Stuver, A L / Sudhagar, S / Sudhir, V / Summerscales, T Z / Sun, L / Sunil, S / Sur, A / Suresh, J / Sutton, P J / Swinkels, B L / Szczepańczyk, M J / Tacca, M / Tait, S C / Talbot, C / Tanasijczuk, A J / Tanner, D B / Tao, D / Tápai, M / Tapia, A / Tapia San Martin, E N / Tasson, J D / Taylor, R / Tenorio, R / Terkowski, L / Thirugnanasambandam, M P / Thomas, M / Thomas, P / Thompson, J E / Thondapu, S R / Thorne, K A / Thrane, E / Tinsman, C L / Saravanan, T R / Tiwari, Shubhanshu / Tiwari, S / Tiwari, V / Toland, K / Tonelli, M / Tornasi, Z / Torres-Forné, A / Torrie, C I / Tosta E Melo, I / Töyrä, D / Travasso, F / Traylor, G / Tringali, M C / Tripathee, A / Trovato, A / Trudeau, R J / Tsang, K W / Tse, M / Tso, R / Tsukada, L / Tsuna, D / Tsutsui, T / Turconi, M / Ubhi, A S / Udall, R / Ueno, K / Ugolini, D / Unnikrishnan, C S / Urban, A L / Usman, S A / Utina, A C / Vahlbruch, H / Vajente, G / Valdes, G / Valentini, M / van Bakel, N / van Beuzekom, M / van den Brand, J F J / Van Den Broeck, C / Vander-Hyde, D C / van der Schaaf, L / Van Heijningen, J V / van Veggel, A A / Vardaro, M / Varma, V / Vass, S / Vasúth, M / Vecchio, A / Vedovato, G / Veitch, J / Veitch, P J / Venkateswara, K / Venugopalan, G / Verkindt, D / Veske, D / Vetrano, F / Viceré, A / Viets, A D / Vinciguerra, S / Vine, D J / Vinet, J-Y / Vitale, S / Vivanco, Francisco Hernandez / Vo, T / Vocca, H / Vorvick, C / Vyatchanin, S P / Wade, A R / Wade, L E / Wade, M / Walet, R / Walker, M / Wallace, G S / Wallace, L / Walsh, S / Wang, J Z / Wang, S / Wang, W H / Ward, R L / Warden, Z A / Warner, J / Was, M / Watchi, J / Weaver, B / Wei, L-W / Weinert, M / Weinstein, A J / Weiss, R / Wellmann, F / Wen, L / Weßels, P / Westhouse, J W / Wette, K / Whelan, J T / Whiting, B F / Whittle, C / Wilken, D M / Williams, D / Willis, J L / Willke, B / Winkler, W / Wipf, C C / Wittel, H / Woan, G / Woehler, J / Wofford, J K / Wong, I C F / Wright, J L / Wu, D S / Wysocki, D M / Xiao, L / Yamamoto, H / Yang, L / Yang, Y / Yang, Z / Yap, M J / Yazback, M / Yeeles, D W / Yu, Hang / Yu, Haocun / Yuen, S H R / Zadrożny, A K / Zadrożny, A / Zanolin, M / Zelenova, T / Zendri, J-P / Zevin, M / Zhang, J / Zhang, L / Zhang, T / Zhao, C / Zhao, G / Zhou, M / Zhou, Z / Zhu, X J / Zimmerman, A B / Zucker, M E / Zweizig, J

Physical review letters

2021 Volume 125, Issue 10, Page(s) 101102

Abstract: ... with masses of 85_{-14}^{+21} M_{⊙} and 66_{-18}^{+17} M_{⊙} (90% credible intervals). We infer ... with only a 0.32% probability of being below 65 M_{⊙}. We calculate the mass of the remnant to be 142_{-16 ... 28} M_{⊙}, which can be considered an intermediate mass black hole (IMBH). The luminosity distance ...

Abstract	On May 21, 2019 at 03:02:29 UTC Advanced LIGO and Advanced Virgo observed a short duration gravitational-wave signal, GW190521, with a three-detector network signal-to-noise ratio of 14.7, and an estimated false-alarm rate of 1 in 4900 yr using a search sensitive to generic transients. If GW190521 is from a quasicircular binary inspiral, then the detected signal is consistent with the merger of two black holes with masses of 85_{-14}^{+21} M_{⊙} and 66_{-18}^{+17} M_{⊙} (90% credible intervals). We infer that the primary black hole mass lies within the gap produced by (pulsational) pair-instability supernova processes, with only a 0.32% probability of being below 65 M_{⊙}. We calculate the mass of the remnant to be 142_{-16}^{+28} M_{⊙}, which can be considered an intermediate mass black hole (IMBH). The luminosity distance of the source is 5.3_{-2.6}^{+2.4} Gpc, corresponding to a redshift of 0.82_{-0.34}^{+0.28}. The inferred rate of mergers similar to GW190521 is 0.13_{-0.11}^{+0.30} Gpc^{-3} yr^{-1}.
Language	English
Publishing date	2021-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.125.101102
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: GW190814: Gravitational Waves from the Coalescence of a 23 M$_\odot$ Black Hole with a 2.6 M$_\odot$ Compact Object

Collaboration, The LIGO Scientific / Abbott, the Virgo Collaboration R. / Abbott, T. D. / Abraham, S. / Acernese, F. / Ackley, K. / Adams, C. / Adhikari, R. X. / Adya, V. B. / Affeldt, C. / Agathos, M. / Agatsuma, K. / Aggarwal, N. / Aguiar, O. D. / Aich, A. / Aiello, L. / Ain, A. / Ajith, P. / Akcay, S. /

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R. / Tiwari, Shubhanshu / Tiwari, S. / Tiwari, V. / Toland, K. / Tonelli, M. / Tornasi, Z. / Torres-Forn'e, A. / Torrie, C. I. / Melo, I. Tosta e / Toyra, D. / Trail, E. A. / Travasso, F. / Traylor, G. / Tringali, M. C. / Tripathee, A. / Trovato, A. / Trudeau, R. J. / Tsang, K. W. / Tse, M. / Tso, R. / Tsukada, L. / Tsuna, D. / Tsutsui, T. / Turconi, M. / Ubhi, A. S. / Ueno, K. / Ugolini, D. / Unnikrishnan, C. S. / Urban, A. L. / Usman, S. A. / Utina, A. C. / Vahlbruch, H. / Vajente, G. / Valdes, G. / Valentini, M. / Bakel, N. van / Beuzekom, M. van / Brand, J. F. J. van den / Broeck, C. Van Den / Vander-Hyde, D. C. / Schaaf, L. van der / Heijningen, J. V. Van / Veggel, A. A. van / Vardaro, M. / Varma, V. / Vass, S. / Vas'uth, M. / Vecchio, A. / Vedovato, G. / Veitch, J. / Veitch, P. J. / Venkateswara, K. / Venugopalan, G. / Verkindt, D. / Veske, D. / Vetrano, F. / Vicer'e, A. / Viets, A. D. / Vinciguerra, S. / Vine, D. J. / Vinet, J.-Y. / Vitale, S. / Vivanco, Francisco Hernandez / Vo, T. / Vocca, H. / Vorvick, C. / Vyatchanin, S. P. / Wade, A. R. / Wade, L. E. / Wade, M. / Walet, R. / Walker, M. / Wallace, G. S. / Wallace, L. / Walsh, S. / Wang, J. Z. / Wang, S. / Wang, W. H. / Ward, R. L. / Warden, Z. A. / Warner, J. / Was, M. / Watchi, J. / Weaver, B. / Wei, L.-W. / Weinert, M. / Weinstein, A. J. / Weiss, R. / Wellmann, F. / Wen, L. / Wessels, P. / Westhouse, J. W. / Wette, K. / Whelan, J. T. / Whiting, B. F. / Whittle, C. / Wilken, D. M. / Williams, D. / Willis, J. L. / Willke, B. / Winkler, W. / Wipf, C. C. / Wittel, H. / Woan, G. / Woehler, J. / Wofford, J. K. / Wong, C. / Wright, J. L. / Wu, D. S. / Wysocki, D. M. / Xiao, L. / Yamamoto, H. / Yang, L. / Yang, Y. / Yang, Z. / Yap, M. J. / Yazback, M. / Yeeles, D. W. / Yu, Hang / Yu, Haocun / Yuen, S. H. R. / Zadro.zny, A. K. / Zadro.zny, A. / Zanolin, M. / Zelenova, T. / Zendri, J.-P. / Zevin, M. / Zhang, J. / Zhang, L. / Zhang, T. / Zhao, C. / Zhao, G. / Zhou, M. / Zhou, Z. / Zhu, X. J. / Zimmerman, A. B. / Zucker, M. E. / Zweizig, J.

Abstract: We report the observation of a compact binary coalescence involving a 22.2 - 24.3 $M_{\odot}$ black ... hole and a compact object with a mass of 2.50 - 2.67 $M_{\odot}$ (all measurements quoted at the 90$ ...

Abstract	We report the observation of a compact binary coalescence involving a 22.2 - 24.3 $M_{\odot}$ black hole and a compact object with a mass of 2.50 - 2.67 $M_{\odot}$ (all measurements quoted at the 90$\%$ credible level). The gravitational-wave signal, GW190814, was observed during LIGO's and Virgo's third observing run on August 14, 2019 at 21:10:39 UTC and has a signal-to-noise ratio of 25 in the three-detector network. The source was localized to 18.5 deg$^2$ at a distance of $241^{+41}_{-45}$ Mpc; no electromagnetic counterpart has been confirmed to date. The source has the most unequal mass ratio yet measured with gravitational waves, $0.112^{+0.008}_{-0.009}$, and its secondary component is either the lightest black hole or the heaviest neutron star ever discovered in a double compact-object system. The dimensionless spin of the primary black hole is tightly constrained to $\leq 0.07$. Tests of general relativity reveal no measurable deviations from the theory, and its prediction of higher-multipole emission is confirmed at high confidence. We estimate a merger rate density of 1-23 Gpc$^{-3}$ yr$^{-1}$ for the new class of binary coalescence sources that GW190814 represents. Astrophysical models predict that binaries with mass ratios similar to this event can form through several channels, but are unlikely to have formed in globular clusters. However, the combination of mass ratio, component masses, and the inferred merger rate for this event challenges all current models for the formation and mass distribution of compact-object binaries.
Keywords	covid19
Publisher	ArXiv
Document type	Article ; Online
DOI	10.3847/2041-8213/ab960f
Database	COVID19

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Article ; Online: Pongapin and Karanjin, furanoflavanoids of Pongamia pinnata, induce G2/M arrest and apoptosis in cervical cancer cells by differential reactive oxygen species modulation, DNA damage, and nuclear factor kappa-light-chain-enhancer of activated B cell signaling.

Roy, Rituparna / Pal, Debolina / Sur, Subhayan / Mandal, Suvra / Saha, Prosenjit / Panda, Chinmay Kumar

Phytotherapy research : PTR

2019 Volume 33, Issue 4, Page(s) 1084–1094

Abstract: ... expression. The compounds induced G2/M arrest and increase in SubG1 population, indicating induction ...

Abstract	In this study, the antitumor activity of two furanoflavanoid derivatives, Pongapin and Karanjin, was evaluated in comparison with Plumbagin, a plant-derived polyphenol with proven antitumor activity. The compounds differentially inhibit the growth of different cancer cell lines (most effective on HeLa cells), with very low inhibitory effect on the growth of normal mouse embryonic fibroblast cell line. Pongapin like Plumbagin could significantly increase the intracellular reactive oxygen species (ROS) in the HeLa cells by stabilization of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor (I-κB) expression and reduction of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) expression. In contrast, Karanjin could decrease ROS level by inhibition of I-κB degradation resulting restriction of NF-κB nuclear translocation. Pongapin and Plumbagin significantly increased DNA damage-induced p53 expression and p21 nuclear expression. However, Karanjin treatment showed low DNA damage with increased p53 expression. The compounds induced G2/M arrest and increase in SubG1 population, indicating induction of apoptosis. Apoptosis was further validated by acridine orange/ethidium bromide dual staining and terminal deoxynucleotidyl transferase dUTP nick-end labeling assay in HeLa cells after treatment with the compounds. The compounds induced caspase-dependent apoptosis through induction of Bax/Bcl-2 ratio either through increased expression of Bax by Pongapin and Plumbagin or low expression of Bcl-2 by Karanjin. Thus, Pongapin and Karanjin may be potential natural anticancer agents in the future, like Plumbagin.
MeSH term(s)	Apoptosis/drug effects ; B-Lymphocytes/metabolism ; Benzopyrans/pharmacology ; Benzopyrans/therapeutic use ; Cell Cycle Checkpoints/drug effects ; DNA Damage/genetics ; Female ; Flavones/pharmacology ; Flavones/therapeutic use ; HeLa Cells ; Humans ; Millettia/chemistry ; NF-kappa B/metabolism ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/pathology
Chemical Substances	Benzopyrans ; Flavones ; NF-kappa B ; Reactive Oxygen Species ; pongapin ; karanjin (WV7IM0I02M)
Language	English
Publishing date	2019-03-05
Publishing country	England
Document type	Journal Article
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.6302
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Article: Pongapin and Karanjin, furanoflavanoids of Pongamia pinnata, induce G2/M arrest and apoptosis in cervical cancer cells by differential reactive oxygen species modulation, DNA damage, and nuclear factor kappa‐light‐chain‐enhancer of activated B cell signaling

Roy, Rituparna / Pal, Debolina / Sur, Subhayan / Mandal, Suvra / Saha, Prosenjit / Panda, Chinmay Kumar

Phytotherapy research. 2019 Apr., v. 33, no. 4

2019

Abstract: ... expression. The compounds induced G2/M arrest and increase in SubG1 population, indicating induction ...

Abstract	In this study, the antitumor activity of two furanoflavanoid derivatives, Pongapin and Karanjin, was evaluated in comparison with Plumbagin, a plant‐derived polyphenol with proven antitumor activity. The compounds differentially inhibit the growth of different cancer cell lines (most effective on HeLa cells), with very low inhibitory effect on the growth of normal mouse embryonic fibroblast cell line. Pongapin like Plumbagin could significantly increase the intracellular reactive oxygen species (ROS) in the HeLa cells by stabilization of nuclear factor of kappa light polypeptide gene enhancer in B‐cells inhibitor (I‐κB) expression and reduction of nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐κB) expression. In contrast, Karanjin could decrease ROS level by inhibition of I‐κB degradation resulting restriction of NF‐κB nuclear translocation. Pongapin and Plumbagin significantly increased DNA damage‐induced p53 expression and p21 nuclear expression. However, Karanjin treatment showed low DNA damage with increased p53 expression. The compounds induced G2/M arrest and increase in SubG1 population, indicating induction of apoptosis. Apoptosis was further validated by acridine orange/ethidium bromide dual staining and terminal deoxynucleotidyl transferase dUTP nick‐end labeling assay in HeLa cells after treatment with the compounds. The compounds induced caspase‐dependent apoptosis through induction of Bax/Bcl‐2 ratio either through increased expression of Bax by Pongapin and Plumbagin or low expression of Bcl‐2 by Karanjin. Thus, Pongapin and Karanjin may be potential natural anticancer agents in the future, like Plumbagin.
Keywords	B-lymphocytes ; DNA ; DNA damage ; Millettia pinnata ; acridine orange ; antineoplastic activity ; antineoplastic agents ; apoptosis ; assays ; degradation ; ethidium ; fibroblasts ; genes ; human cell lines ; light ; mice ; neoplasm cells ; nucleotidyltransferases ; phytotherapy ; plumbagin ; polypeptides ; polyphenols ; population ; reactive oxygen species ; research ; staining ; uterine cervical neoplasms
Language	English
Dates of publication	2019-04
Size	p. 1084-1094.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	NAL-light ; JOURNAL ARTICLE
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.6302
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Article: Distribution of pteropods (Mollusca: Gastropoda: Thecosomata) in surface waters (0-100 m) of the Western Caribbean Sea (winter, 2007)

Parra-Flores, Ana(El Colegio de la Frontera Sur (ECOSUR), Unidad Chetumal) / Gasca, Rebeca(El Colegio de la Frontera Sur (ECOSUR), Unidad Chetumal)

Revista de biología marina y oceanografía

2009/12

Abstract: ... de los pterópodos tecosomados en la capa superior de los 100 m del Mar Caribe occidental. El zooplancton ... fue recolectado en 60 estaciones durante enero 2007 en intervalos de profundidad de 25 m desde la superficie a 100 ... m. La comunidad fue analizada en términos de diversidad, equidad, riqueza y similitud. Encontramos ...

Abstract	El principal objetivo de este estudio fue conocer la distribución vertical y horizontal de los pterópodos tecosomados en la capa superior de los 100 m del Mar Caribe occidental. El zooplancton fue recolectado en 60 estaciones durante enero 2007 en intervalos de profundidad de 25 m desde la superficie a 100 m. La comunidad fue analizada en términos de diversidad, equidad, riqueza y similitud. Encontramos 36 taxa de los que 12 son nuevos registros para el Caribe occidental. Los taxa más abundantes fueron Limacina inflata, L. trochiformis, Creseis acicula f. clava, Cuvierina columnella atlantica y Hyalocylis striata. En general, mostraron un mismo patrón, sus mayores abundancias ocurrieron consistentemente en el estrato 0-25 m de día y noche; la abundancia decrece con la profundidad. Se encontraron diferencias significativas día/noche en composición y abundancia, no así entre estratos. El estrato de 0-25 m contiene los mayores valores de riqueza, diversidad y abundancia de pterópodos, lo que representa un hallazgo sin precedente respecto a estudios previos. La estructura de la comunidad local está determinada en gran medida por las migraciones verticales día/noche. Los pterópodos tendieron a ser más abundantes en los sectores norte y sur del área, pero su mayor diversidad y riqueza se registró en el sector central. La baja variabilidad de las condiciones hidrográficas y la mezcla horizontal de los grupos generados por el análisis de similitud sugieren que los patrones migratorios día/noche explican la variabilidad observada en la comunidad de pterópodos.
Language	English
Document type	Article
ISSN	0718-1957
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

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Article ; Online: Algebraic approach for subspace decomposition and clustering of neural activity.

Adam, Elie M / Sur, Mriganka

STAR protocols

2022 Volume 3, Issue 4, Page(s) 101841

Abstract: We developed an approach to decompose neuronal signals into disjoint components, corresponding to task- or event-based epochs. This protocol describes how to project behavioral templates onto a low-dimensional subspace of neuronal responses to derive ... ...

Abstract	We developed an approach to decompose neuronal signals into disjoint components, corresponding to task- or event-based epochs. This protocol describes how to project behavioral templates onto a low-dimensional subspace of neuronal responses to derive neuronal templates, then how to decompose and cluster neuronal responses using these derived templates. We outline these steps on complementary datasets of calcium imaging and spiking activity. Our approach relies on fundamental, linear algebraic principles and is adaptive to the temporal structure of the neural data. For complete details on the use and execution of this protocol, please refer to Adam et al. (2022).
MeSH term(s)	Cluster Analysis ; Neurons/physiology
Language	English
Publishing date	2022-11-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2666-1667
ISSN (online)	2666-1667
DOI	10.1016/j.xpro.2022.101841
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Article ; Online: Comparison of measured and predicted herbicide concentrations in surface water catchments in Belgium.

Hörold-Willkomm, Claudia / Herrmann, Marco / Baets, Dirk / Sur, Robin

Integrated environmental assessment and management

2024

Abstract: In the process of approval of active substances and authorization in the European Union and at the member state level, it must be shown by the applicant that an unacceptable risk for nontarget organisms in the aquatic environment by the active substance ... ...

Abstract	In the process of approval of active substances and authorization in the European Union and at the member state level, it must be shown by the applicant that an unacceptable risk for nontarget organisms in the aquatic environment by the active substance can be excluded. To achieve this aim, standardized models, scenarios, and agreed pesticide input parameters have to be used to calculate the exposure as defined by the FOrum for the Co-ordination of pesticide fate models and their Use (FOCUS). During a period of daily surface water sampling lasting 3.5 years, a survey was conducted among farmers in the highly vulnerable catchment of Grote Kemmelbeek in Belgium to collect agronomic data on crops, application dates, and application rates of 12 applied herbicides and one metabolite. Daily surface water concentrations for the same herbicides were measured over 2.5 years for a second, much larger but less vulnerable, catchment of Kleine Aa (KAa). A comparison of realistic worst-case predicted environmental concentrations in surface water (PEC
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2234931-5
ISSN	1551-3793 ; 1551-3777
ISSN (online)	1551-3793
ISSN	1551-3777
DOI	10.1002/ieam.4921
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Article: Vaccines against Group B Coxsackieviruses and Their Importance.

Mone, Kiruthiga / Lasrado, Ninaad / Sur, Meghna / Reddy, Jay

Vaccines

2023 Volume 11, Issue 2

Abstract: The group B coxsackieviruses (CVBs) exist in six serotypes (CVB1 to CVB6). Disease associations have been reported for most serotypes, and multiple serotypes can cause similar diseases. For example, CVB1, CVB3, and CVB5 are generally implicated in the ... ...

Abstract	The group B coxsackieviruses (CVBs) exist in six serotypes (CVB1 to CVB6). Disease associations have been reported for most serotypes, and multiple serotypes can cause similar diseases. For example, CVB1, CVB3, and CVB5 are generally implicated in the causation of myocarditis, whereas CVB1 and CVB4 could accelerate the development of type 1 diabetes (T1D). Yet, no vaccines against these viruses are currently available. In this review, we have analyzed the attributes of experimentally tested vaccines and discussed their merits and demerits or limitations, as well as their impact in preventing infections, most importantly myocarditis and T1D.
Language	English
Publishing date	2023-01-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11020274
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Article: Phytoceramide Alleviates the Carrageenan/Kaolin-Induced Arthritic Symptoms by Modulation of Inflammation.

Sur, Bongjun / Kim, Mijin / Villa, Thea / Oh, Seikwan

Biomolecules & therapeutics

2023 Volume 31, Issue 5, Page(s) 536–543

Abstract: Phytoceramide (Pcer) is found mainly in plants and yeast. It can be neuroprotective and immunostimulatory on various cell types. In this study, the therapeutic effect of Pcer was explored using the carrageenan/kaolin (C/K)-induced arthritis rat model and ...

Abstract	Phytoceramide (Pcer) is found mainly in plants and yeast. It can be neuroprotective and immunostimulatory on various cell types. In this study, the therapeutic effect of Pcer was explored using the carrageenan/kaolin (C/K)-induced arthritis rat model and fibroblast-like synoviocytes (FLS). Pcer treatment (1, 10, and 30 mg/kg/day) were given to the arthritic rats for 6 days after disease induction. Weight distribution ration (WDR), knee thickness, squeaking score, serum levels of proinflammatory mediators, and histological analysis were measured and performed to evaluate arthritic symptoms in the rat model. In interleukin (IL)‑1β‑stimulated FLS, proinflammatory mediators were measured after Pcer (1-30 μM) treatment. Arthritic symptoms in rats with Pcer treatment were significantly decreased at days 4 to 6 after C/K arthritis induction. Inflammation in the knee joints were also significantly decreased in rats with Pcer treatment. Furthermore, in IL-1β‑stimulated FLS, the expressions of proinflammatory mediators were also inhibited by Pcer. As shown by the results, Pcer has anti-arthritic effects in the C/K rat model and in synovial cells, suggesting that Pcer has the potential to be a useful agent in arthritis treatment.
Language	English
Publishing date	2023-06-29
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2734146-X
ISSN	2005-4483 ; 1976-9148
ISSN (online)	2005-4483
ISSN	1976-9148
DOI	10.4062/biomolther.2023.031
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Article ; Online: Robust Prototypical Few-Shot Organ Segmentation With Regularized Neural-ODEs.

Pandey, Prashant / Chasmai, Mustafa / Sur, Tanuj / Lall, Brejesh

IEEE transactions on medical imaging

2023 Volume 42, Issue 9, Page(s) 2490–2501

Abstract: Despite the tremendous progress made by deep learning models in image semantic segmentation, they typically require large annotated examples, and increasing attention is being diverted to problem settings like Few-Shot Learning (FSL) where only a small ... ...

Abstract	Despite the tremendous progress made by deep learning models in image semantic segmentation, they typically require large annotated examples, and increasing attention is being diverted to problem settings like Few-Shot Learning (FSL) where only a small amount of annotation is needed for generalisation to novel classes. This is especially seen in medical domains where dense pixel-level annotations are expensive to obtain. In this paper, we propose Regularized Prototypical Neural Ordinary Differential Equation (R-PNODE), a method that leverages intrinsic properties of Neural-ODEs, assisted and enhanced by additional cluster and consistency losses to perform Few-Shot Segmentation (FSS) of organs. R-PNODE constrains support and query features from the same classes to lie closer in the representation space thereby improving the performance over the existing Convolutional Neural Network (CNN) based FSS methods. We further demonstrate that while many existing Deep CNN-based methods tend to be extremely vulnerable to adversarial attacks, R-PNODE exhibits increased adversarial robustness for a wide array of these attacks. We experiment with three publicly available multi-organ segmentation datasets in both in-domain and cross-domain FSS settings to demonstrate the efficacy of our method. In addition, we perform experiments with seven commonly used adversarial attacks in various settings to demonstrate R-PNODE's robustness. R-PNODE outperforms the baselines for FSS by significant margins and also shows superior performance for a wide array of attacks varying in intensity and design.
MeSH term(s)	Image Processing, Computer-Assisted/methods ; Neural Networks, Computer ; Semantics
Language	English
Publishing date	2023-08-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	622531-7
ISSN	1558-254X ; 0278-0062
ISSN (online)	1558-254X
ISSN	0278-0062
DOI	10.1109/TMI.2023.3258069
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