LIVIVO - Search results -

Search results

Result 1 - 10 of total 6454

Search options

Article ; Online: K^{-}p Correlation Function from High-Energy Nuclear Collisions and Chiral SU(3) Dynamics.

Kamiya, Yuki / Hyodo, Tetsuo / Morita, Kenji / Ohnishi, Akira / Weise, Wolfram

2020 Volume 124, Issue 13, Page(s) 132501

Abstract: ... is evaluated in the K[over ¯]N-πΣ-πΛ coupled-channel framework. The effects of all coupled channels ... together with the Coulomb potential and the threshold energy difference between K^{-}p and K[over ¯]^{0}n ... function of πΣ with respect to that of K[over ¯]N. The predicted K^{-}p correlation function from larger ...

Abstract	The two-particle momentum correlation function of a K^{-}p pair from high-energy nuclear collisions is evaluated in the K[over ¯]N-πΣ-πΛ coupled-channel framework. The effects of all coupled channels together with the Coulomb potential and the threshold energy difference between K^{-}p and K[over ¯]^{0}n are treated completely for the first time. Realistic potentials based on the chiral SU(3) dynamics are used which fit the available scattering data. The recently measured correlation function is found to be well reproduced by allowing variations of the source size and the relative weight of the source function of πΣ with respect to that of K[over ¯]N. The predicted K^{-}p correlation function from larger systems indicates that the investigation of its source size dependence is useful in providing further constraints in the study of the K[over ¯]N interaction.
Language	English
Publishing date	2020-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.124.132501
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 4' 58/153: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Enhancement of membrane lipid peroxidation in lung cancer cells irradiated with monoenergetic X-rays at the K-shell resonance absorption peak of phosphorus.

Maezawa, Hiroshi / Indo, Hiroko P / Usami, Noriko / Majima, Hideyuki J / Ito, Hiromu / Ohnishi, Ken / Kobayashi, Katsumi

Journal of radiation research

2020 Volume 61, Issue 2, Page(s) 237–242

Abstract: ... enhanced by X-ray irradiation at the K-shell resonance absorption peak of phosphorus. A549 and wild-type ... with monoenergetic X-rays at 2.153 keV, the phosphorus K-shell resonance absorption peak, or those at 2.147 or 2.160 ... within the phosphorus K-shell resonance absorption. Our results indicate that membrane lipid peroxidation in cells is ...

Abstract	The aim of this study was to determine whether membrane lipid peroxidation in mammalian cells is enhanced by X-ray irradiation at the K-shell resonance absorption peak of phosphorus. A549 and wild-type p53-transfected H1299 (H1299/wtp53) cell lines derived from human lung carcinoma were irradiated with monoenergetic X-rays at 2.153 keV, the phosphorus K-shell resonance absorption peak, or those at 2.147 or 2.160 keV, which are off peaks. Immunofluorescence staining for 4-hydroxy-2-nonenal (HNE), a lipid peroxidation product, was used as marker for protein modification. In both cell lines, the HNE production was significantly enhanced after irradiation at 2.153 keV compared to sham-irradiation. The enhancement (E) was calculated as the ratio of the fluorescence intensity of irradiated cells to that of sham-irradiated cells. In both the cell lines, E2.153 was significantly larger than E2.147 and no significant difference between E2.147 and E2.160 was observed. The extra enhancement at 2.153 keV was possibly caused by energy transition within the phosphorus K-shell resonance absorption. Our results indicate that membrane lipid peroxidation in cells is enhanced by the Auger effect after irradiation at the K-shell resonance absorption peak of phosphorus rather than by the photoelectric effect of the constituent atoms in the membrane lipid at 2.147 keV.
MeSH term(s)	Aldehydes/chemistry ; Cell Line, Tumor ; Cell Membrane/metabolism ; Fluorescence ; Humans ; Lipid Peroxidation ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Phosphorus/chemistry ; Radiation Dosage ; X-Rays
Chemical Substances	Aldehydes ; Phosphorus (27YLU75U4W) ; 4-hydroxy-2-nonenal (K1CVM13F96)
Language	English
Publishing date	2020-01-06
Publishing country	England
Document type	Journal Article
ZDB-ID	603983-2
ISSN	1349-9157 ; 0449-3060
ISSN (online)	1349-9157
ISSN	0449-3060
DOI	10.1093/jrr/rrz098
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 388: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Fluid shear stress stimulates MATE2-K expression via Nrf2 pathway activation.

Fukuda, Yasunori / Kaishima, Misato / Ohnishi, Toshiyuki / Tohyama, Kimio / Chisaki, Ikumi / Nakayama, Yusuke / Ogasawara-Shimizu, Mari / Kawamata, Yuji

Biochemical and biophysical research communications

2017 Volume 484, Issue 2, Page(s) 358–364

Abstract: ... revealed upregulation of MATE2-K and activation of Nrf2 signaling in response to fluid shear stress ... Network and cell biological analysis additionally showed that expression of MATE2-K is regulated by Nrf2 ...

Abstract	Accurate prediction of drug-induced renal toxicity is necessary for development of safer drugs for patients. Cellular assay systems that recapitulate physiologically relevant microenvironments have been proposed for correct estimation of drug responses in the human body. However, establishment of such assay systems for accurate prediction of renal toxicity is challenging because of the lack of readily available in vitro assay systems. In this study, we investigated the cellular response to fluid shear stress, which is a characteristic of the environment in the kidney proximal tubules, using microfluidic devices. The global gene expression profiles of human primary proximal tubule cells under the fluidic conditions revealed upregulation of MATE2-K and activation of Nrf2 signaling in response to fluid shear stress. Network and cell biological analysis additionally showed that expression of MATE2-K is regulated by Nrf2 signaling. These results strongly suggest that fluid shear stress is involved in the expression and maintenance of function of tissue-specific drug transporters in the proximal tubule, where the cells are exposed to continuous shear stress by primary urine. Furthermore, the microfluidic culture of human proximal tubules was demonstrated to be a useful system to analyze the regulatory mechanisms of gene expression in physiologically relevant cell conditions.
MeSH term(s)	Cells, Cultured ; Gene Expression Profiling ; Humans ; Kidney Tubules, Proximal/cytology ; Kidney Tubules, Proximal/metabolism ; NF-E2-Related Factor 2/metabolism ; Organic Cation Transport Proteins/genetics ; Stress, Mechanical
Chemical Substances	NF-E2-Related Factor 2 ; NFE2L2 protein, human ; Organic Cation Transport Proteins ; SLC47A2 protein, human
Language	English
Publishing date	2017-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2017.01.124
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 116: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Observation of B-->K*l+l-.

Ishikawa, A / Abe, K / Abe, K / Abe, T / Adachi, I / Ahn, Byoung Sup / Aihara, H / Akai, K / Akatsu, M / Akemoto, M / Asano, Y / Aso, T / Aulchenko, V / Aushev, T / Bakich, A M / Ban, Y / Bay, A / Bizjak, I / Bondar, A /

Bozek, A / Bracko, M / Browder, T E / Chang, P / Chao, Y / Chen, K-F / Cheon, B G / Chistov, R / Choi, S-K / Choi, Y / Choi, Y K / Chuvikov, A / Danilov, M / Dong, L Y / Drutskoy, A / Eidelman, S / Eiges, V / Enari, Y / Flanagan, J / Fukunaga, C / Funakoshi, Y / Furukawa, K / Gabyshev, N / Garmash, A / Gershon, T / Golob, B / Guo, R / Haba, J / Hagner, C / Handa, F / Hayashii, H / Hazumi, M / Hinz, L / Hokuue, T / Hoshi, Y / Hou, W-S / Hsiung, Y B / Huang, H-C / Iijima, T / Inami, K / Itoh, R / Iwasaki, H / Iwasaki, M / Iwasaki, Y / Kang, J H / Kang, J S / Katayama, N / Kawai, H / Kawasaki, T / Kichimi, H / Kikutani, E / Kim, H J / Kim, Hyunwoo / Kim, J H / Kim, S K / Kinoshita, K / Koppenburg, P / Korpar, S / Krizan, P / Krokovny, P / Kuzmin, A / Kwon, Y-J / Lange, J S / Leder, G / Lee, S H / Lesiak, T / Li, J / Limosani, A / Lin, S-W / Liventsev, D / MacNaughton, J / Majumder, G / Mandl, F / Masuzawa, M / Matsumoto, T / Matyja, A / Michizono, S / Mimashi, T / Mitaroff, W / Miyabayashi, K / Miyake, H / Miyata, H / Mohapatra, D / Mori, T / Nagamine, T / Nagasaka, Y / Nakadaira, T / Nakamura, T T / Nakao, M / Nakazawa, H / Natkaniec, Z / Nishida, S / Nitoh, O / Nozaki, T / Ogawa, S / Ogawa, Y / Ohmi, K / Ohnishi, Y / Ohshima, T / Ohuchi, N / Okabe, T / Okuno, S / Olsen, S L / Ostrowicz, W / Ozaki, H / Palka, H / Park, C W / Park, H / Parslow, N / Peak, L S / Piilonen, L E / Root, N / Sagawa, H / Saitoh, S / Sakai, Y / Sarangi, T R / Satapathy, M / Satpathy, A / Schneider, O / Schümann, J / Schwanda, C / Schwartz, A J / Semenov, S / Senyo, K / Seuster, R / Sevior, M E / Shibuya, H / Shidara, T / Sidorov, V / Singh, J B / Soni, N / Stanic, S / Staric, M / Sugi, A / Sugiyama, A / Sumisawa, K / Sumiyoshi, T / Suzuki, S / Suzuki, S Y / Swain, S K / Takasaki, F / Tamai, K / Tamura, N / Tanaka, M / Tawada, M / Taylor, G N / Teramoto, Y / Tomura, T / Tsuboyama, T / Tsukamoto, T / Uehara, S / Ueno, K / Uno, S / Varner, G / Wang, C C / Wang, C H / Wang, J G / Wang, M-Z / Watanabe, Y / Won, E / Yabsley, B D / Yamada, Y / Yamaguchi, A / Yamashita, Y / Yamauchi, M / Yanai, H / Yang, Heyoung / Ying, J / Yoshida, M / Yusa, Y / Zhang, Z P / Zhilich, V / Zontar, D

Physical review letters

2003 Volume 91, Issue 26 Pt 1, Page(s) 261601

Abstract: We report the observation of the flavor-changing neutral current decay B-->K(*)l(+)l(-) and an im ... The results for the branching fractions are B(B-->K(*)l(+)l(-))=(11.5(+2.6)(-2.4)+/-0.8+/-0.2)x10(-7) and B(B ...

Abstract	We report the observation of the flavor-changing neutral current decay B-->K()l(+)l(-) and an im-proved measurement of the decay B-->Kl(+)l(-), where l represents an electron or a muon, with a data sample of 140 fb(-1) accumulated at the Upsilon(4S) resonance with the Belle detector at KEKB. The results for the branching fractions are B(B-->K()l(+)l(-))=(11.5(+2.6)(-2.4)+/-0.8+/-0.2)x10(-7) and B(B-->Kl(+)l(-))=(4.8(+1.0)(-0.9)+/-0.3+/-0.1)x10(-7), where the first error is statistical, the second is systematic and the third is from model dependence.
Language	English
Publishing date	2003-12-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.91.261601
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 4' 58/153: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly.

Ohnishi, Takayuki / Yanazawa, Masako / Sasahara, Tomoya / Kitamura, Yasuki / Hiroaki, Hidekazu / Fukazawa, Yugo / Kii, Isao / Nishiyama, Takashi / Kakita, Akiyoshi / Takeda, Hiroyuki / Takeuchi, Akihide / Arai, Yoshie / Ito, Akane / Komura, Hitomi / Hirao, Hajime / Satomura, Kaori / Inoue, Masafumi / Muramatsu, Shin-ichi / Matsui, Ko /

Tada, Mari / Sato, Michio / Saijo, Eri / Shigemitsu, Yoshiki / Sakai, Satoko / Umetsu, Yoshitaka / Goda, Natsuko / Takino, Naomi / Takahashi, Hitoshi / Hagiwara, Masatoshi / Sawasaki, Tatsuya / Iwasaki, Genji / Nakamura, Yu / Nabeshima, Yo-ichi / Teplow, David B / Hoshi, Minako

Proceedings of the National Academy of Sciences of the United States of America

2015 Volume 112, Issue 32, Page(s) E4465–74

Abstract: ... degeneration of mature neurons. Here, we show that the ASPD target is neuron-specific Na(+)/K(+)-ATPase α3 ...

Abstract	Neurodegeneration correlates with Alzheimer's disease (AD) symptoms, but the molecular identities of pathogenic amyloid β-protein (Aβ) oligomers and their targets, leading to neurodegeneration, remain unclear. Amylospheroids (ASPD) are AD patient-derived 10- to 15-nm spherical Aβ oligomers that cause selective degeneration of mature neurons. Here, we show that the ASPD target is neuron-specific Na(+)/K(+)-ATPase α3 subunit (NAKα3). ASPD-binding to NAKα3 impaired NAKα3-specific activity, activated N-type voltage-gated calcium channels, and caused mitochondrial calcium dyshomeostasis, tau abnormalities, and neurodegeneration. NMR and molecular modeling studies suggested that spherical ASPD contain N-terminal-Aβ-derived "thorns" responsible for target binding, which are distinct from low molecular-weight oligomers and dodecamers. The fourth extracellular loop (Ex4) region of NAKα3 encompassing Asn(879) and Trp(880) is essential for ASPD-NAKα3 interaction, because tetrapeptides mimicking this Ex4 region bound to the ASPD surface and blocked ASPD neurotoxicity. Our findings open up new possibilities for knowledge-based design of peptidomimetics that inhibit neurodegeneration in AD by blocking aberrant ASPD-NAKα3 interaction.
MeSH term(s)	Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amino Acid Sequence ; Amyloid beta-Peptides/toxicity ; Animals ; Calcium/metabolism ; Cell Death/drug effects ; Cells, Cultured ; HEK293 Cells ; Homeostasis/drug effects ; Humans ; Mass Spectrometry ; Models, Biological ; Models, Molecular ; Molecular Imaging ; Molecular Sequence Data ; Molecular Weight ; Neurons/drug effects ; Neurons/metabolism ; Neurons/pathology ; Peptides/metabolism ; Protein Aggregates ; Protein Binding/drug effects ; Rats ; Signal Transduction/drug effects ; Sodium/metabolism ; Sodium-Potassium-Exchanging ATPase/chemistry ; Sodium-Potassium-Exchanging ATPase/metabolism
Chemical Substances	Amyloid beta-Peptides ; Peptides ; Protein Aggregates ; Sodium (9NEZ333N27) ; Sodium-Potassium-Exchanging ATPase (EC 3.6.3.9) ; Atp1a3 protein, rat (EC 7.2.2.13) ; sodium potassium ATPase alpha3 subunit, human (EC 7.2.2.13) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2015-07-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1421182112
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1148: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Rate-equation approach to optimal density ratio of K-Rb hybrid cells for optically pumped atomic magnetometers.

Ito, Yosuke / Ohnishi, Hiroyuki / Kamada, Keigo / Kobayashi, Tetsuo

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2013 Volume 2013, Page(s) 3254–3257

Abstract: The goal of this study is to determine optimal conditions of optically pumped atomic magnetometers using a hybrid cell of potassium and rubidium atoms. We theoretically investigated the properties of the magnetometers and considered the optimal density ... ...

Abstract	The goal of this study is to determine optimal conditions of optically pumped atomic magnetometers using a hybrid cell of potassium and rubidium atoms. We theoretically investigated the properties of the magnetometers and considered the optimal density ratio of potassium and rubidium atoms. We found that the experimental results agreed well with the theoretical estimations and the density ratio of potassium and rubidium atoms should be around 200 to achieve the highest sensitivity.
MeSH term(s)	Algorithms ; Electric Power Supplies ; Humans ; Magnetics ; Magnetocardiography ; Magnetoencephalography ; Potassium/chemistry ; Quantum Theory ; Rubidium/chemistry
Chemical Substances	Rubidium (MLT4718TJW) ; Potassium (RWP5GA015D)
Language	English
Publishing date	2013-10-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC.2013.6610235
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Search for the K−pp bound state via the in-flight 3He(K−, n) reaction

Sada Y. / Ajimura S. / Beer G. / Bhang H. / Bragadireanu M. / Buehler P. / Busso L. / Cargnelli M. / Choi S. / Curceanu C. / Enomoto S. / Faso D. / Fujioka H. / Fujiwara Y. / Fukuda T. / Guaraldo C. / Hashimoto T. / Hayano R. S. / Hiraiwa T. /

Iio M. / Iliescu M. / Inoue K. / Ishiguro Y. / Ishikawa T. / Ishimoto S. / Ishiwatari T. / Itahashi K. / Iwai M. / Iwasaki M. / Kato Y. / Kawasaki S. / Kienle P. / Kou H. / Ma Y. / Marton J. / Matsuda Y. / Mizoi Y. / Morra O. / Nagae T. / Noumi H. / Ohnishi H. / Okada S. / Outa H. / Piscicchia K. / Poli Lener M. / Romero Vidal A. / Sakaguchi A. / Sakuma F. / Sato M. / Scordo A. / Sekimoto M. / Shi H. / Sirghi D. / Sirghi F. / Suzuki K. / Suzuki S. / Suzuki T. / Tanida K. / Tatsuno H. / Tokuda M. / Tomono D. / Toyoda A. / Tsukada K. / Vazquez Doce O. / Widmann E. / Weunschek B. K. / Yamaga T. / Yamazaki T. / Yim H. / Zhang Q. / Zmeskal J.

EPJ Web of Conferences, Vol 81, p

2014 Volume 02016

Abstract: In the J-PARC E15 experiment, a K− pp search was performed via the 3He(K−, n) reaction at 1.0 GeV/c ... from K− pp are simultaneously measured by a cylindrical detector system that surrounds a liquid 3He target ... on the 3He target, and we have obtained a preliminary exclusive analysis result of 3He(K−, Λp)n reaction. ...

Abstract	In the J-PARC E15 experiment, a K− pp search was performed via the 3He(K−, n) reaction at 1.0 GeV/c. A forward-going neutron is detected by a neutron counter with 15 m flight length, and decay particles from K− pp are simultaneously measured by a cylindrical detector system that surrounds a liquid 3He target system. In March and May, 2013, we carried out the first physics data-taking with 5×109 incident kaons on the 3He target, and we have obtained a preliminary exclusive analysis result of 3He(K−, Λp)n reaction.
Keywords	Physics ; QC1-999 ; Science ; Q
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Search for the K−pp bound state via the in-flight 3He(K−, n) reaction

EPJ Web of Conferences, Vol 81, p

2014 Volume 02016

Abstract	In the J-PARC E15 experiment, a K− pp search was performed via the 3He(K−, n) reaction at 1.0 GeV/c. A forward-going neutron is detected by a neutron counter with 15 m flight length, and decay particles from K− pp are simultaneously measured by a cylindrical detector system that surrounds a liquid 3He target system. In March and May, 2013, we carried out the first physics data-taking with 5×109 incident kaons on the 3He target, and we have obtained a preliminary exclusive analysis result of 3He(K−, Λp)n reaction.
Keywords	Physics ; QC1-999 ; Science ; Q
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Nitrative and oxidative DNA damage caused by K-ras mutation in mice.

Ohnishi, Shiho / Saito, Hiromitsu / Suzuki, Noboru / Ma, Ning / Hiraku, Yusuke / Murata, Mariko / Kawanishi, Shosuke

Biochemical and biophysical research communications

2011 Volume 413, Issue 2, Page(s) 236–240

Abstract: ... with mutations in several genes. We investigated the role of DNA damage in carcinogenesis initiated by K-ras ... by mutated K-ras. 8-Nitroguanine was co-localized with iNOS, eNOS, NF-κB, IKK, MAPK, MEK, and mutated K-ras ... suggesting that oncogenic K-ras causes additional DNA damage via signaling pathway involving these molecules ...

Abstract	Ras mutation is important for carcinogenesis. Carcinogenesis consists of multi-step process with mutations in several genes. We investigated the role of DNA damage in carcinogenesis initiated by K-ras mutation, using conditional transgenic mice. Immunohistochemical analysis revealed that mutagenic 8-nitroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) were apparently formed in adenocarcinoma caused by mutated K-ras. 8-Nitroguanine was co-localized with iNOS, eNOS, NF-κB, IKK, MAPK, MEK, and mutated K-ras, suggesting that oncogenic K-ras causes additional DNA damage via signaling pathway involving these molecules. It is noteworthy that K-ras mutation mediates not only cell over-proliferation but also the accumulation of mutagenic DNA lesions, leading to carcinogenesis.
MeSH term(s)	Adenocarcinoma/genetics ; Adenocarcinoma/metabolism ; Animals ; Cell Proliferation ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; DNA Damage/genetics ; Genes, ras ; Guanine/analogs & derivatives ; Guanine/metabolism ; Mice ; Mutation ; Nitric Oxide Synthase Type II/biosynthesis ; Oxidative Stress/genetics
Chemical Substances	8-nitroguanine ; 8-hydroxyguanine (5614-64-2) ; Guanine (5Z93L87A1R) ; Nitric Oxide Synthase Type II (EC 1.14.13.39) ; Nos2 protein, mouse (EC 1.14.13.39)
Language	English
Publishing date	2011-09-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2011.08.076
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 116: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Fluid shear stress stimulates MATE2-K expression via Nrf2 pathway activation

Fukuda, Yasunori / Ikumi Chisaki / Kimio Tohyama / Mari Ogasawara-Shimizu / Misato Kaishima / Toshiyuki Ohnishi / Yuji Kawamata / Yusuke Nakayama

Biochemical and biophysical research communications. 2017 Mar. 04, v. 484

2017

Abstract	Accurate prediction of drug-induced renal toxicity is necessary for development of safer drugs for patients. Cellular assay systems that recapitulate physiologically relevant microenvironments have been proposed for correct estimation of drug responses in the human body. However, establishment of such assay systems for accurate prediction of renal toxicity is challenging because of the lack of readily available inÂ vitro assay systems. In this study, we investigated the cellular response to fluid shear stress, which is a characteristic of the environment in the kidney proximal tubules, using microfluidic devices. The global gene expression profiles of human primary proximal tubule cells under the fluidic conditions revealed upregulation of MATE2-K and activation of Nrf2 signaling in response to fluid shear stress. Network and cell biological analysis additionally showed that expression of MATE2-K is regulated by Nrf2 signaling. These results strongly suggest that fluid shear stress is involved in the expression and maintenance of function of tissue-specific drug transporters in the proximal tubule, where the cells are exposed to continuous shear stress by primary urine. Furthermore, the microfluidic culture of human proximal tubules was demonstrated to be a useful system to analyze the regulatory mechanisms of gene expression in physiologically relevant cell conditions.
Keywords	drugs ; gene expression ; humans ; in vitro studies ; nephrotoxicity ; patients ; prediction ; proximal tubules ; shear stress ; transporters ; urine
Language	English
Dates of publication	2017-0304
Size	p. 358-364.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2017.01.124
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 71/706: Show issues
Z 3.8: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED