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Article: Phenolic phytochemistry,

Almasoudi, Hassan Hussain / Saeed Jan, Muhammad / Nahari, Mohammed H / Alhazmi, Abdulfattah Yahya M / Binshaya, Abdulkarim S / Abdulaziz, Osama / Mahnashi, Mater H / Ibrar, Muhammad / Zafar, Rehman / Sadiq, Abdul

Frontiers in pharmacology

2024 Volume 15, Page(s) 1346526

Abstract: Excessive and imbalance of free radicals within the body lead to inflammation. The objective of the current research work was to explore the anti-inflammatory and antioxidant potential of the isolated compounds ... ...

Abstract	Excessive and imbalance of free radicals within the body lead to inflammation. The objective of the current research work was to explore the anti-inflammatory and antioxidant potential of the isolated compounds from
Language	English
Publishing date	2024-02-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1346526
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Insight into Genetic Mutations of SZT2: Is It a Syndrome?

Muthaffar, Osama Y / Jan, Mohammed M S / Alyazidi, Anas S / Alotibi, Taif K / Alsulami, Eman A

Biomedicines

2023 Volume 11, Issue 9

Abstract: Background: The seizure threshold 2 (: Aim of the study: To review every reported case and present two novel cases to expand the current knowledge and understanding of the mutation.: Methods: Whole exome sequencing (WES) was used to identify the ... ...

Abstract	Background: The seizure threshold 2 ( Aim of the study: To review every reported case and present two novel cases to expand the current knowledge and understanding of the mutation. Methods: Whole exome sequencing (WES) was used to identify the novel cases and present their clinical and radiological findings. A detailed revision of the literature was conducted to illustrate and compare findings. The clinical, genetical, neuroimaging, and electrophysiological data were extracted. Results: The study included 16 female patients and 13 male patients in addition to the 2 novel male cases. Eighteen patients had heterozygous mutations; others were homozygous. The majority presented with facial dysmorphism ( Conclusion: Several promising features are becoming strongly linked to patients with
Language	English
Publishing date	2023-08-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11092402
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Article: The Association Between Long-Term Corticosteroids Use and Dental Caries: A Systematic Review.

Jan, Basil M / Khayat, Mohammed A / Bushnag, Anaan I / Zahid, Abdullah I / Alkarim, Abdulaziz S / Alshehri, Mohammed T / Almasoudi, Faisal M / Zahran, Mohammed / Almazrooa, Soulafa A / Mawardi, Hani H

Cureus

2023 Volume 15, Issue 9, Page(s) e44600

Abstract: Corticosteroids (CSs) are a group of medications prescribed regularly to treat a wide range of inflammatory and immune-related conditions with great benefit. The impact of long-term use of CSs on the oral cavity has been reported before, including ... ...

Abstract	Corticosteroids (CSs) are a group of medications prescribed regularly to treat a wide range of inflammatory and immune-related conditions with great benefit. The impact of long-term use of CSs on the oral cavity has been reported before, including increased risk of periodontal disease and dental caries. Thus, the aim of this study is to evaluate the prevalence of dental caries in patients using CSs. A literature review was completed using PubMed and Cochrane search engines. The search was based on questions related to adults and children (P); corticosteroids (I); no corticosteroids (C); and dental caries (O) (PICO questions) using the keywords "steroids" and "caries" with all relevant variations and MeSH terms. Decay missing filling tooth/decay missing filling surface (DMFT/DMFS) scores were selected as parameters to assess the effects of CSs on caries prevalence. Data was extracted and analyzed for comparisons. The search yielded 1,206 articles from January 2001 to January 2023, of which 21 papers were eligible for analysis. Overall, 14 studies reported an increase in caries with CSs use. However, seven studies failed to report an association of caries prevalence with CSs use. Current evidence supports the correlation between increased risk of caries with chronic CSs use, specifically for inhaler formulation. Future studies with randomized controlled clinical studies are warranted to confirm these findings.
Language	English
Publishing date	2023-09-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.44600
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Article: Thermal injury from forced-air warmer device precipitated by massive extravasation from peripheral venous cannula.

Bithal, Parmod K / Jan, Ravees / Kalou, Mohammed M / Bafaquh, Mohammad S

Saudi journal of anaesthesia

2022 Volume 16, Issue 4, Page(s) 463–465

Abstract: Extravasation injury (EVI) is an iatrogenic complication of venous cannulation. Usually innocuous but occasionally it engenders sequelae. Its severity is determined by various physicochemical properties of infusate. A 50-year-old patient developed leg ... ...

Abstract	Extravasation injury (EVI) is an iatrogenic complication of venous cannulation. Usually innocuous but occasionally it engenders sequelae. Its severity is determined by various physicochemical properties of infusate. A 50-year-old patient developed leg EVI from crystalloids infused through a pressurized digital infuser (PDI), likely from cannula tip displacement during positioning for craniotomy. We ignored checking gravity-aided free-fluids flow before switching on PDI. Following surgery, the patient had an edematous leg with bullae and epidermal peelings from severe extravasation and burns, respectively. Doppler revealed patent leg arteries. Therefore, EVI was conservatively managed, with complete recovery. Apparently, increased local tissue pressure from extravasation produced conditions of peripheral circulation sufficiency predisposing the leg to thermal injury from the forced-air warmer. On inspecting PDI postoperatively, its upper-pressure alarm limit was 300 mmHg, which prevented it from sounding alarm during extravasation.
Language	English
Publishing date	2022-09-03
Publishing country	India
Document type	Case Reports
ZDB-ID	2562174-9
ISSN	0975-3125 ; 1658-354X
ISSN (online)	0975-3125
ISSN	1658-354X
DOI	10.4103/sja.sja_786_21
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Article: Common Mental Disorders in Smart City Settings and Use of Multimodal Medical Sensor Fusion to Detect Them.

Alwakeel, Ahmed / Alwakeel, Mohammed / Zahra, Syed Rameem / Saleem, Tausifa Jan / Hijji, Mohammad / Alwakeel, Sami S / Alwakeel, Abdullah M / Alzorgi, Sultan

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 6

Abstract: Cities have undergone numerous permanent transformations at times of severe disruption. The Lisbon earthquake of 1755, for example, sparked the development of seismic construction rules. In 1848, when cholera spread through London, the first health law ... ...

Abstract	Cities have undergone numerous permanent transformations at times of severe disruption. The Lisbon earthquake of 1755, for example, sparked the development of seismic construction rules. In 1848, when cholera spread through London, the first health law in the United Kingdom was passed. The Chicago fire of 1871 led to stricter building rules, which led to taller skyscrapers that were less likely to catch fire. Along similar lines, the COVID-19 epidemic may have a lasting effect, having pushed the global shift towards greener, more digital, and more inclusive cities. The pandemic highlighted the significance of smart/remote healthcare. Specifically, the elderly delayed seeking medical help for fear of contracting the infection. As a result, remote medical services were seen as a key way to keep healthcare services running smoothly. When it comes to both human and environmental health, cities play a critical role. By concentrating people and resources in a single location, the urban environment generates both health risks and opportunities to improve health. In this manuscript, we have identified the most common mental disorders and their prevalence rates in cities. We have also identified the factors that contribute to the development of mental health issues in urban spaces. Through careful analysis, we have found that multimodal feature fusion is the best method for measuring and analysing multiple signal types in real time. However, when utilizing multimodal signals, the most important issue is how we might combine them; this is an area of burgeoning research interest. To this end, we have highlighted ways to combine multimodal features for detecting and predicting mental issues such as anxiety, mood state recognition, suicidal tendencies, and substance abuse.
Language	English
Publishing date	2023-03-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13061082
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Article ; Online: Common Mental Disorders in Smart City Settings and Use of Multimodal Medical Sensor Fusion to Detect Them

Ahmed Alwakeel / Mohammed Alwakeel / Syed Rameem Zahra / Tausifa Jan Saleem / Mohammad Hijji / Sami S. Alwakeel / Abdullah M. Alwakeel / Sultan Alzorgi

Diagnostics, Vol 13, Iss 1082, p

2023 Volume 1082

Abstract	Cities have undergone numerous permanent transformations at times of severe disruption. The Lisbon earthquake of 1755, for example, sparked the development of seismic construction rules. In 1848, when cholera spread through London, the first health law in the United Kingdom was passed. The Chicago fire of 1871 led to stricter building rules, which led to taller skyscrapers that were less likely to catch fire. Along similar lines, the COVID-19 epidemic may have a lasting effect, having pushed the global shift towards greener, more digital, and more inclusive cities. The pandemic highlighted the significance of smart/remote healthcare. Specifically, the elderly delayed seeking medical help for fear of contracting the infection. As a result, remote medical services were seen as a key way to keep healthcare services running smoothly. When it comes to both human and environmental health, cities play a critical role. By concentrating people and resources in a single location, the urban environment generates both health risks and opportunities to improve health. In this manuscript, we have identified the most common mental disorders and their prevalence rates in cities. We have also identified the factors that contribute to the development of mental health issues in urban spaces. Through careful analysis, we have found that multimodal feature fusion is the best method for measuring and analysing multiple signal types in real time. However, when utilizing multimodal signals, the most important issue is how we might combine them; this is an area of burgeoning research interest. To this end, we have highlighted ways to combine multimodal features for detecting and predicting mental issues such as anxiety, mood state recognition, suicidal tendencies, and substance abuse.
Keywords	smart city ; data fusion ; mental health ; depression ; smart health ; Medicine (General) ; R5-920
Subject code	360
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Ten-Year Trends in Psychotropic Prescribing and Polypharmacy in Australian General Practice Patients with and without Dementia.

Bezabhe, Woldesellassie M / Radford, Jan / Salahudeen, Mohammed S / Bindoff, Ivan / Ling, Tristan / Gee, Peter / Wimmer, Barbara C / Peterson, Gregory M

Journal of clinical medicine

2023 Volume 12, Issue 10

Abstract: Objective: Little research has evaluated trends in psychotropic prescribing and polypharmacy in primary care patients, especially those with dementia. We sought to examine this in Australia from 2011 to 2020 using the primary care dataset, ... ...

Abstract	Objective: Little research has evaluated trends in psychotropic prescribing and polypharmacy in primary care patients, especially those with dementia. We sought to examine this in Australia from 2011 to 2020 using the primary care dataset, MedicineInsight. Methods: Ten consecutive serial cross-sectional analyses were performed to evaluate the proportion of patients aged 65 years or more, with a recorded diagnosis of dementia, who were prescribed psychotropic medications within the first six months of each year from 2011 to 2020. This proportion was compared with propensity score-matched control patients without dementia. Results: Before matching, 24,701 patients (59.2% females) with, and 72,105 patients (59.2% females) without, a recorded diagnosis of dementia were included. In 2011, 42% (95% confidence interval [CI] 40.5-43.5%) of patients in the dementia group had at least one recorded prescription of a psychotropic medication, which declined to 34.2% (95% CI 33.3-35.1%; Conclusions: The decline in psychotropic prescribing, particularly antipsychotics, in Australian primary care patients with dementia is encouraging. However, psychotropic polypharmacy still occurred in almost one in five patients with dementia at the end of the study period. Programs focused on encouraging further reductions in the use of multiple psychotropic drugs in patients with dementia are recommended, particularly in rural and remote regions.
Language	English
Publishing date	2023-05-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12103389
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Article: Incidence of Osteoporosis in Primary Care Patients with Atrial Fibrillation Receiving Different Oral Anticoagulants.

Bezabhe, Woldesellassie M / Radford, Jan / Wimmer, Barbara C / Salahudeen, Mohammed S / Bindoff, Ivan / Peterson, Gregory M

Journal of clinical medicine

2022 Volume 11, Issue 21

Abstract: Background: Studies investigating the association between the use of oral anticoagulants (OACs) and osteoporosis are limited. We aimed to determine the risk of osteoporosis in patients with atrial fibrillation (AF) and receiving different OACs. Methods: ... ...

Abstract	Background: Studies investigating the association between the use of oral anticoagulants (OACs) and osteoporosis are limited. We aimed to determine the risk of osteoporosis in patients with atrial fibrillation (AF) and receiving different OACs. Methods: We performed a population-based cohort study using a nationwide primary care dataset, MedicineInsight. Patients aged between 18 and 111 years with AF and newly recorded OAC prescriptions between 1 January 2013 and 31 December 2017 were included and followed until 31 December 2018. We applied propensity score matching to control for patients’ baseline characteristic differences before calculating adjusted hazard ratios (aHRs) for a new diagnosis of osteoporosis, using Cox proportional hazard models. Results: A total of 18,454 patients (1714 prescribed dabigatran, 5871 rivaroxaban, 5248 apixaban and 5621 warfarin) were included. Of these, 39.5% were females, and the overall mean age (standard deviation [SD] was 73.2(10.3) years. Over a mean follow-up of 841 days, 1627 patients (1028 receiving direct-acting oral anticoagulants (DOACs) and 599 warfarin) had a newly recorded diagnosis of osteoporosis. The weighted incidence rates (95% confidence interval; CI) per 100 person-years of treatment were 5.0 (4.7−5.2) for warfarin, 4.3 (3.8−4.8) for dabigatran, 3.6 (3.3−3.8) for rivaroxaban, and 4.4 (4.0−4.7) for apixaban. Overall, DOAC use was associated with a significantly lower risk of a new diagnosis of osteoporosis than warfarin use (aHR, 0.79, 95% confidence interval (CI) 0.74−0.85; p < 0.001). Use of each individual DOAC was associated with a significantly lower risk of osteoporosis compared with warfarin (aHRs, 0.75, 95% CI 0.69−0.82 for rivaroxaban; 0.78, 95% CI 0.71−0.86 for apixaban; 0.88, 95% CI 0.77−0.99 for dabigatran). Conclusion: Compared with warfarin, the use of DOACs was associated with a significantly lower risk of developing osteoporosis in patients with AF. This association remained significant when individual DOACs were compared with warfarin.
Language	English
Publishing date	2022-10-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11216438
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Article: Knowledge, Attitudes, and Practices Toward the Prevention of Hepatitis B Virus Infection Among Medical Students in Medina City, Kingdom of Saudi Arabia.

Albadrani, Muayad S / Abdulaal, Abdullah M / Aljabri, Ahmed M / Aljohani, Saleh S / Aljohani, Salman F / Sindi, Mohammed A / Jan, Hassan K / Alsaedi, Hatim / Alamri, Waleed M / Alharbi, Abdulrahman M / Alraddadi, Abdulaziz A

Cureus

2023 Volume 15, Issue 11, Page(s) e48845

Abstract: Introduction: This study focuses on assessing the knowledge, attitudes, and practices related to Hepatitis B virus (HBV) prevention among medical students in Medina, Saudi Arabia. HBV is a significant global health concern, with a high prevalence in ... ...

Abstract	Introduction: This study focuses on assessing the knowledge, attitudes, and practices related to Hepatitis B virus (HBV) prevention among medical students in Medina, Saudi Arabia. HBV is a significant global health concern, with a high prevalence in Saudi Arabia. Medical students due to their field, are at higher risk of exposure. Prior studies in Saudi Arabia show varied levels of awareness. This research aims to provide insights that can inform educational initiatives for this specific population. Methods: This was a cross-sectional study conducted from June 2023 to September 2023 by using a pre-designed online questionnaire that was distributed among medical students in Medina. Data was analyzed using IBM Corp. Released 2020. IBM SPSS Statistics for Windows, Version 27.0. Armonk, NY: IBM Corp. Results: This study included 307 participants. 67.8% of the participants correctly identified the link between HBV and liver cancer, and 77.5% recognized the transmission risk from carriers. 91.9% acknowledged the transmission via contaminated blood and fluids, and 88.9% recognized the risk from unsterilized instruments. Positive attitudes were observed, with 92.2% agreeing that following infection control guidelines would protect them at work. Practice scores were generally positive, including high rates of screening (57.3%) and adherence to infection control measures (90.2%). Knowledge scores correlated positively with attitude (rho = 0.204) and practice scores (rho = 0.390). Conclusion: A significant proportion of participants had a strong understanding of HBV transmission and the importance of infection control measures. Positive attitudes towards infection control were prevalent, although some reluctance to provide care to HBV-infected individuals was noted.
Language	English
Publishing date	2023-11-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.48845
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Article: Ten-Year Trends in the Use of Oral Anticoagulants in Australian General Practice Patients With Atrial Fibrillation.

Bezabhe, Woldesellassie M / Bereznicki, Luke R / Radford, Jan / Wimmer, Barbara C / Curtain, Colin / Salahudeen, Mohammed S / Peterson, Gregory M

Frontiers in pharmacology

2021 Volume 12, Page(s) 586370

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2021-03-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.586370
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