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Article ; Online: Interleukin-6 gene polymorphism (-174 G/C) is associated with toxoplasmic retinochoroiditis.

Cordeiro, Cynthia A / Moreira, Paula R / Bessa, Thais F / Costa, Germano C / Dutra, Walderez O / Campos, Wesley R / Oréfice, Fernando / Young, Lucy H / Teixeira, Antônio L

Acta ophthalmologica

2013 Volume 91, Issue 4, Page(s) e311–4

Abstract: ... to distinguish allele G and C of the IL-6 gene, allowing the detection of the polymorphism and determination ...

Abstract	Purpose: Experimental data have demonstrated a relevant role for IL-6 in the modulation of acute ocular toxoplasmosis. Therefore, we aim to investigate the possible association between the IL-6 gene polymorphism at position -174 and toxoplasmic retinochoroiditis (TR) in humans. Methods: Ninety-seven patients with diagnosed TR were recruited from the Uveitis Section, Federal University of Minas Gerais. For comparison, 83 healthy blood donors with positive serology for toxoplasmosis and without retinal signs of previous TR were included in the study. Genomic DNA was obtained from oral swabs of individuals and amplified using polymerase chain reaction (PCR) with specific primers flanking the locus -174 of IL-6 (-174G/C). PCR products were submitted to restriction endonuclease digestion and analysed by polyacrylamide gel electrophoresis to distinguish allele G and C of the IL-6 gene, allowing the detection of the polymorphism and determination of genotypes. Results: There was a significant difference in the genotype (χ(2) = 12.9, p = 0.001) and allele (χ(2) = 6.62, p = 0.01) distribution between TR patients and control subjects. In a subgroup analysis, there was no significant difference in genotypes and allele frequencies regarding TR recurrence. Conclusions: This study suggests that the genotypes related with a lower production of IL-6 may be associated with the occurrence of TR.
MeSH term(s)	Adult ; Alleles ; Animals ; Chorioretinitis/genetics ; Chorioretinitis/metabolism ; Chorioretinitis/parasitology ; DNA/genetics ; Electrophoresis, Polyacrylamide Gel ; Female ; Follow-Up Studies ; Gene Frequency ; Genotype ; Humans ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Male ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Toxoplasmosis, Ocular/genetics ; Toxoplasmosis, Ocular/metabolism ; Toxoplasmosis, Ocular/parasitology
Chemical Substances	Interleukin-6 ; DNA (9007-49-2)
Language	English
Publishing date	2013-06
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2408333-1
ISSN	1755-3768 ; 1755-375X
ISSN (online)	1755-3768
ISSN	1755-375X
DOI	10.1111/aos.12046
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Article ; Online: Numerical study of bidisperse cohesive particle blends — Bulk properties and critical thresholds

Orefice, Luca / Khinast, Johannes G.

Powder Technology. 2023 July 08, p.118777-

2023 , Page(s) 118777–

Abstract: We present a numerical study of bulk properties of binary particle blends via DEM. Properties of settled particle bulks, such as packing fraction, are computed. We investigated the effects of components size ratio, their relative mass fraction and the ... ...

Abstract	We present a numerical study of bulk properties of binary particle blends via DEM. Properties of settled particle bulks, such as packing fraction, are computed. We investigated the effects of components size ratio, their relative mass fraction and the cohesion of smaller particles on bulk properties. Below a critical value of the mass fraction, bulk properties are independent of small particle properties. This value is connected with the particle contact network and is inversely proportional to the size ratio. Two critical thresholds in the Bond number exist, determining the dependence of bulk properties on relative mass fraction. For Bond numbers below unity, the effect of cohesion can be neglected. Above it, bulk properties reverse their dependency on small particles’ mass fraction proportionally to the cohesion strength. Finally, bulk properties measured become independent of small particles’ relative concentration when their cohesion strength is large enough to sustain a large particle.
Keywords	cohesion ; mixing ; particles ; powders ; technology ; Discrete elements method ; Bidisperse particle blends ; Packing fraction ; Size ratio ; Mass fraction
Language	English
Dates of publication	2023-0708
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ISSN	0032-5910
DOI	10.1016/j.powtec.2023.118777
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Article: Amphidinium

Orefice, Ida / Balzano, Sergio / Romano, Giovanna / Sardo, Angela

Life (Basel, Switzerland)

2023 Volume 13, Issue 11

Abstract: Dinoflagellates make up the second largest marine group of marine unicellular eukaryotes in the world ocean and comprise both heterotrophic and autotrophic species, encompassing a wide genetic and chemical diversity. They produce a plethora of secondary ... ...

Abstract	Dinoflagellates make up the second largest marine group of marine unicellular eukaryotes in the world ocean and comprise both heterotrophic and autotrophic species, encompassing a wide genetic and chemical diversity. They produce a plethora of secondary metabolites that can be toxic to other species and are mainly used against predators and competing species. Dinoflagellates are indeed often responsible for harmful algal bloom, where their toxic secondary metabolites can accumulate along the food chain, leading to significant damages to the ecosystem and human health. Secondary metabolites from dinoflagellates have been widely investigated for potential biomedical applications and have revealed multiple antimicrobial, antifungal, and anticancer properties. Species from the genus
Language	English
Publishing date	2023-11-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13112164
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Article ; Online: Prostaglandin pathway activation in the diatom Skeletonema marinoi under grazer pressure.

Barbarinaldi, Roberta / Di Costanzo, Federica / Orefice, Ida / Romano, Giovanna / Carotenuto, Ylenia / Di Dato, Valeria

Marine environmental research

2024 Volume 196, Page(s) 106395

Abstract: Prostaglandins (Pgs) are eicosanoid lipid mediators detected in all vertebrates, in some marine invertebrates, macroalgae and in diatoms, a class of eukaryotic microalgae composing the phytoplankton. The enzymes involved in the Pgs pathway were found to ... ...

Abstract	Prostaglandins (Pgs) are eicosanoid lipid mediators detected in all vertebrates, in some marine invertebrates, macroalgae and in diatoms, a class of eukaryotic microalgae composing the phytoplankton. The enzymes involved in the Pgs pathway were found to be differentially expressed in two strains of the diatom Skeletonema marinoi, named FE7 and FE60, already known to produce different levels of oxylipins, a class of secondary metabolites involved in the defence of diatoms against copepod predation, with FE7 being higher producer than FE60. In the present study we investigated the response of genes involved in the production of oxylipins and Pgs, evaluating their expression after the exposure to the copepod Temora stylifera. Our results highlighted a grazer feeding preference for FE60, the strain having low oxylipins content and reduced expression of Pgs enzymes, and an impact on the gene expression of the enzymes involved in oxylipins (i.e. lipoxygenase) and Pgs (i.e. cyclooxygenase) biosynthesis, especially in FE7. A time course evaluation of the gene expression over 24 h showed an upregulation of the essential enzyme in the Pgs pathway, the cyclooxygenase, in FE60 after 6 h of exposure to the grazer, differently from FE7 where no upregulation of gene expression in the presence of copepods was revealed. These results provide preliminary indications regarding the existence of a complex involvement of the Pgs pathway in the prey-predator interaction that requires further investigations.
MeSH term(s)	Animals ; Diatoms/metabolism ; Prostaglandins/metabolism ; Prostaglandin-Endoperoxide Synthases/metabolism ; Oxylipins/metabolism ; Phytoplankton
Chemical Substances	Prostaglandins ; Prostaglandin-Endoperoxide Synthases (EC 1.14.99.1) ; Oxylipins
Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1502505-6
ISSN	1879-0291 ; 0141-1136
ISSN (online)	1879-0291
ISSN	0141-1136
DOI	10.1016/j.marenvres.2024.106395
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A new dataset on product-level trade elasticities.

Fontagné, Lionel / Guimbard, Houssein / Orefice, Gianluca

Data in brief

2022 Volume 45, Page(s) 108668

Abstract: This data article describes a new dataset on product-level trade elasticity, here defined as the degree of substitutability between varieties, i.e. between products exported by different countries into a given destination. The dataset contains trade ... ...

Abstract	This data article describes a new dataset on product-level trade elasticity, here defined as the degree of substitutability between varieties, i.e. between products exported by different countries into a given destination. The dataset contains trade elasticities for a list of more than 5000 products of the HS 6-digit classification. Trade elasticities computed using alternative sector classifications are provided as well (TIVA, GTAP, WIOD classification), by pooling the product-level observations within each sector. Starting from the prior that the coefficient associated with tariffs - a variable trade cost - corresponds to the import-demand elasticity in a standard CES structural gravity model of bilateral trade, elasticities are recovered from country-pair specific information on applied tariffs and trade. For each HS 6-digit product category we observe the universe of bilateral trade flows between countries, in value, in a given year, and the tariff (preferential or not) applied to each exporter by each importer on the specific product for 2001, 2004, 2007, 2010, 2013 and 2016. The tariff elasticity is (minus) the elasticity of substitution across products coming from different origins. Product-specific trade elasticity estimations are crucial for the evaluation of the welfare consequences of trade policies, and for the comparison of the welfare gains from trade for countries at different level of development.
Language	English
Publishing date	2022-10-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2022.108668
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Article: A novel framework for a rational, fully-automatised calibration routine for DEM models of cohesive powders

Orefice, Luca / Khinast, Johannes G

Powder technology. 2020 Feb. 01, v. 361

2020

Abstract: A new framework for calibration of DEM models of cohesive materials is presented. DEM simulations are a widespread numerical tool for modelling granular assemblies and related processes, but require careful calibration to give realistic predictive ... ...

Abstract	A new framework for calibration of DEM models of cohesive materials is presented. DEM simulations are a widespread numerical tool for modelling granular assemblies and related processes, but require careful calibration to give realistic predictive results. To this aim routine small-scale laboratory tests are used to investigate powders rheology while limiting resource investment, in conjunction with a rational approach to reduce computational costs as well. A specific order in numerical tests and calibrated variables is defined, enabling the implementation of an automatic iterative routine to calibrate material parameters from a given dataset. This method is successfully applied to calibrate four common increasingly cohesive powders of pharmaceutical relevance. Our framework saves an important amount of computational expense when compared to traditional parameters design space approaches, and proved to be able to calibrate very cohesive powder exhibiting plastic bulk volume loss of up to 25% (after uniaxial consolidation up to 10kPa).
Keywords	data collection ; laboratory experimentation ; models ; powders ; rheology
Language	English
Dates of publication	2020-0201
Size	p. 687-703.
Publishing place	Elsevier B.V.
Document type	Article
ISSN	0032-5910
DOI	10.1016/j.powtec.2019.11.054
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Article ; Online: Blood lactate in mild and moderate ARDS secondary to SARS COV 2.

Pagano, A / Porta, G / Bosso, G / Allegorico, E / Serra, C / Mercurio, V / Sansone, G / Orefice, S / Numis, F G

The American journal of emergency medicine

2023 Volume 66, Page(s) 73–75

Abstract: Background and objectives: Elevated blood lactate levels are associated with poor outcome in several critical conditions. Patients with SARS-CoV-2 rarely develop hyperlactatemia. The purpose of this study is to evaluate the trend of lactatemia in ... ...

Abstract	Background and objectives: Elevated blood lactate levels are associated with poor outcome in several critical conditions. Patients with SARS-CoV-2 rarely develop hyperlactatemia. The purpose of this study is to evaluate the trend of lactatemia in patients affected by mild/moderate SARS-Co V-2-ARDS and if it affected prognosis. Methods: We analyzed blood lactate levels in thirty-eight patients with severe SARS-CoV-2 infection admitted to COVID Care Unit of Santa Maria delle Grazie Hospital, Pozzuoli. Results: Twenty patients survived and were discharged at home and 18 patients died. Despite severe hypoxia that affected all patients enrolled, T0 lactate was within normal values. All survivors showed a significant increase in lactate concentration the day prior to clinical improvement. In not-survivors levels of lactate did not increase significantly. Conclusion: In our study, patients who survive SARS CoV-2 ARDS have a fleeting increase in lactate, which precedes clinical improvement by one day.
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19/complications ; RNA, Viral ; Respiratory Distress Syndrome/etiology ; Lactic Acid
Chemical Substances	RNA, Viral ; Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2023-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	605890-5
ISSN	1532-8171 ; 0735-6757
ISSN (online)	1532-8171
ISSN	0735-6757
DOI	10.1016/j.ajem.2023.01.032
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Article ; Online: Fragility fractures in lupus patients: Associated factors and comparison of four fracture risk assessment tools.

Ceccarelli, Fulvia / Olivieri, Giulio / Orefice, Valeria / Picciariello, Licia / Natalucci, Francesco / Conti, Fabrizio

Lupus

2023 Volume 32, Issue 11, Page(s) 1320–1327

Abstract: Objective: Osteoporosis (OP) and fragility fractures (FF) are common comorbidities in patients with systemic lupus erythematosus (SLE). This study aimed to (1) assess the prevalence of these conditions in a cohort of SLE patients (2) evaluate the risk ... ...

Abstract	Objective: Osteoporosis (OP) and fragility fractures (FF) are common comorbidities in patients with systemic lupus erythematosus (SLE). This study aimed to (1) assess the prevalence of these conditions in a cohort of SLE patients (2) evaluate the risk factors associated with FF, and (3) compare the accuracy of four different FF risk assessment algorithms to determine which performs better in this specific rheumatologic population. Materials and methods: We conducted a cross-sectional study with SLE women who underwent bone mineral density assessment by dual-energy X-ray absorptiometry (DEXA) within 3 months of their last visit. Conventional radiology methods were used to evaluate the presence of FF. The 10-year risk of osteoporotic fractures was estimated using four tools: DeFRA, FRAX (adjusted for GC dosage), GARVAN, and QFracture. The comparison of these computational tools was analyzed by the area under the receiver operating characteristic (ROC) curves. Results: We analyzed 86 SLE patients with a median age of 56 years (IQR 12.1) and a median age at diagnosis of 34 years (IQR 17.2). The median T-score values at the femoral neck and lumbar spine were -1.6 (IQR 0.9) and -1.7 (IQR 1.1), respectively. Of the patients, 33 (38.4%) had OP, with 13 patients (15.1%) experiencing FF. Univariate analysis showed that the presence of FF was associated with thrombocytopenia ( Conclusions: OP is a common comorbidity in SLE patients, even in younger patients. FF appears to be more frequent in patients with hematologic involvement. The comparison of the four algorithms shows that DeFRA is the most accurate tool and should be applied to SLE patients.
MeSH term(s)	Humans ; Female ; Child ; Cross-Sectional Studies ; Risk Assessment/methods ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/epidemiology ; Osteoporosis/diagnosis ; Osteoporosis/epidemiology ; Osteoporosis/etiology ; Osteoporotic Fractures/epidemiology ; Osteoporotic Fractures/etiology ; Bone Density ; Risk Factors ; Absorptiometry, Photon/methods
Language	English
Publishing date	2023-09-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1154407-7
ISSN	1477-0962 ; 0961-2033
ISSN (online)	1477-0962
ISSN	0961-2033
DOI	10.1177/09612033231202701
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Article: The Importance of Detecting, Quantifying, and Characterizing Exosomes as a New Diagnostic/Prognostic Approach for Tumor Patients.

Logozzi, Mariantonia / Orefice, Nicola Salvatore / Di Raimo, Rossella / Mizzoni, Davide / Fais, Stefano

Cancers

2023 Volume 15, Issue 11

Abstract: ... than in controls and that plasmatic exosomes express well-known tumor markers (e.g., PSA and CEA), proteins ...

Abstract	Exosomes are extracellular vesicles (EVs) of nanometric size studied for their role in tumor pathogenesis and progression and as a new source of tumor biomarkers. The clinical studies have provided encouraging but probably unexpected results, including the exosome plasmatic levels' clinical relevance and well-known biomarkers' overexpression on the circulating EVs. The technical approach to obtaining EVs includes methods to physically purify EVs and characterize EVs, such as Nanosight Tracking Analysis (NTA), immunocapture-based ELISA, and nano-scale flow cytometry. Based on the above approaches, some clinical investigations have been performed on patients with different tumors, providing exciting and promising results. Here we emphasize data showing that exosome plasmatic levels are consistently higher in tumor patients than in controls and that plasmatic exosomes express well-known tumor markers (e.g., PSA and CEA), proteins with enzymatic activity, and nucleic acids. However, we also know that tumor microenvironment acidity is a key factor in influencing both the amount and the characteristics of the exosome released by tumor cells. In fact, acidity significantly increases exosome release by tumor cells, which correlates with the number of exosomes that circulate through the body of a tumor patient.
Language	English
Publishing date	2023-05-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15112878
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Book ; Article ; Online: Skilled Immigration, Task Allocation and the Innovation of Firms

Mayda, Anna Maria / Orefice, Gianluca / Santoni, Gianluca

2022

Abstract: This paper analyses the impact of skilled migrants on the innovation (patenting) activity of French firms between 1995 and 2010, and investigates the underlying mechanism. We present districtlevel and firm-level estimates and address endogeneity using a ... ...

Abstract	This paper analyses the impact of skilled migrants on the innovation (patenting) activity of French firms between 1995 and 2010, and investigates the underlying mechanism. We present districtlevel and firm-level estimates and address endogeneity using a modified version of the shift-share instrument. Skilled migrants increase the number of patents at both the district and firm level. Large, high-productivity and capital-intensive firms benefit the most, in terms of innovation activity, from skilled immigrant workers. Importantly, we provide evidence that one channel through which the effect works is task specialization (as in Peri and Sparber, 2009). The arrival of skilled immigrants drives French skilled workers towards language-intensive, managerial tasks while foreign skilled workers specialize in technical, research-oriented tasks. This mechanism manifests itself in the estimated increase in the share of foreign inventors in patenting teams as a consequence of skilled migration. Through this channel, greater innovation is the result of productivity gains from specialization.
Keywords	ddc:330 ; F22 ; J61 ; skilled immigration ; innovation ; patents
Subject code	338
Language	English
Publisher	Bonn: Institute of Labor Economics (IZA)
Publishing country	de
Document type	Book ; Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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