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  1. Article: Editorial: Global excellence in cellular neuropathology: Europe.

    Pluta, Ryszard / Popa-Wagner, Aurel / Hermann, Dirk M

    Frontiers in cellular neuroscience

    2023  Volume 17, Page(s) 1289444

    Language English
    Publishing date 2023-10-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2023.1289444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comment on Minich et al. Is Melatonin the "Next Vitamin D"?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements.

    Pluta, Ryszard

    Nutrients

    2023  Volume 15, Issue 6

    Abstract: I read an article by Minich D.M. et al. [...]. ...

    Abstract I read an article by Minich D.M. et al. [...].
    MeSH term(s) Dietary Supplements ; Melatonin ; Nutrients ; Vitamin D ; Vitamins ; Humans
    Chemical Substances Melatonin (JL5DK93RCL) ; Vitamin D (1406-16-2) ; Vitamins
    Language English
    Publishing date 2023-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15061506
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: To Be-et, or Not to Be-et, That is the Question: The Role(s) of Nitrate and Nitrite in Health and Illness.

    Pluta, Ryszard M

    Reviews on recent clinical trials

    2016  Volume 11, Issue 2, Page(s) 135–140

    Abstract: Background: This manuscript addresses the multilevel role of dietary nitrate and nitrite in health and diseases because of increased interest in dietary supplementation.: Method: Review of research devoted to both beneficial but also possible ... ...

    Abstract Background: This manuscript addresses the multilevel role of dietary nitrate and nitrite in health and diseases because of increased interest in dietary supplementation.
    Method: Review of research devoted to both beneficial but also possible deleterious effects of uncontrolled indigestion of red beet-root juice and other sources of high concentrated nitrate and nitrite.
    Results: The body of evidence strongly suggested that persons using nitrate/nitrite supplementation and particularly patients treated with sodium nitrite, having kidney disease or impaired methemoglobin reeducates activity, should closely monitor nitrate/nitrite indigestion.
    Conclusion: Oral intake of red beet-root juice, green leaved veggies, cured meat, as well as urine excretion of nitrate/ nitrite, methemoglobin reeducates activity should be carefully assessed especially in patients treated with sodium nitrite.
    MeSH term(s) Diet ; Health Status ; Humans ; Nitrates ; Nitrites ; Nutritive Value
    Chemical Substances Nitrates ; Nitrites
    Language English
    Publishing date 2016-03-29
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2251879-4
    ISSN 1876-1038 ; 1574-8871
    ISSN (online) 1876-1038
    ISSN 1574-8871
    DOI 10.2174/1574887111666160330113803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6436: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Prolonged intravenous infusion of sodium nitrite delivers nitric oxide (NO) in humans.

    Pluta, Ryszard M

    Acta neurochirurgica. Supplement

    2013  Volume 115, Page(s) 49–51

    Abstract: In preclinical studies, infusion of sodium nitrite delivers nitric oxide (NO) as treatment of vasospasm after subarachnoid hemorrhage. We evaluated safety and toxicity of intravenous nitrite administration in healthy volunteers infused with increasing ... ...

    Abstract In preclinical studies, infusion of sodium nitrite delivers nitric oxide (NO) as treatment of vasospasm after subarachnoid hemorrhage. We evaluated safety and toxicity of intravenous nitrite administration in healthy volunteers infused with increasing doses of sodium nitrite for 48 h. Twelve volunteers (5 men, 7 women; mean age was 38.8 years, range 27-56 years) participated in the study. The starting sodium nitrite dose was 4.2 mg/kg/h, and it was doubled for each subsequent volunteer up to a maximal dose of 533.8 mg/kg/h at which a clinically silent dose-limiting toxicity (DLT) was observed. Toxicity included a transient decrease of mean arterial blood pressure or asymptomatic increase of methemoglobin level above 5%. The maximal tolerated dose (MTD) was 267 mg/kg/h. S-Nitrosothiols increased significantly in plasma, confirming in vivo sodium nitrite reduction to NO and encouraging its use against vasospasm and ischemia-reperfusion injury to the brain, kidneys, liver, and heart.
    MeSH term(s) Adult ; Arterial Pressure/drug effects ; Female ; Humans ; Infusions, Intravenous ; Male ; Maximum Tolerated Dose ; Middle Aged ; Nitric Oxide/blood ; Sodium Nitrite/administration & dosage ; Time Factors ; Young Adult
    Chemical Substances Nitric Oxide (31C4KY9ESH) ; Sodium Nitrite (M0KG633D4F)
    Language English
    Publishing date 2013
    Publishing country Austria
    Document type Clinical Trial ; Journal Article ; Research Support, N.I.H., Intramural
    ISSN 0065-1419
    ISSN 0065-1419
    DOI 10.1007/978-3-7091-1192-5_11
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Acetylated Tau Protein: A New Piece in the Puzzle between Brain Ischemia and Alzheimer's Disease.

    Pluta, Ryszard / Januszewski, Sławomir / Jabłoński, Mirosław

    International journal of molecular sciences

    2022  Volume 23, Issue 16

    Abstract: Cerebral ischemia in humans and animals is a life-threatening neuropathological event and leads to the development of dementia with the Alzheimer's disease phenotype [ ... ]. ...

    Abstract Cerebral ischemia in humans and animals is a life-threatening neuropathological event and leads to the development of dementia with the Alzheimer's disease phenotype [...].
    MeSH term(s) Alzheimer Disease/pathology ; Animals ; Brain/metabolism ; Brain Ischemia/pathology ; Humans ; tau Proteins/metabolism
    Chemical Substances tau Proteins
    Language English
    Publishing date 2022-08-16
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23169174
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  6. Article: New regulatory, signaling pathways, and sources of nitric oxide.

    Pluta, Ryszard M

    Acta neurochirurgica. Supplement

    2011  Volume 110, Issue Pt 1, Page(s) 7–12

    Abstract: Discovered in 1980 by the late Robert F. Furchgott, endothelium-derived relaxing factor, nitric oxide (NO), has been in the forefront of vascular research for several decades. What was originally a narrow approach, has been significantly widened due to ... ...

    Abstract Discovered in 1980 by the late Robert F. Furchgott, endothelium-derived relaxing factor, nitric oxide (NO), has been in the forefront of vascular research for several decades. What was originally a narrow approach, has been significantly widened due to major advances in understanding the chemical and biological properties of NO as well as its signaling pathways and discovering new sources of this notorious free radical gas. In this review, recent discoveries regarding NO and their implications on therapy for delayed cerebral vasospasm are presented.
    MeSH term(s) Animals ; Humans ; Models, Biological ; Nitrates/metabolism ; Nitric Oxide/metabolism ; Nitric Oxide/therapeutic use ; Nitric Oxide Synthase Type I/metabolism ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Vasospasm, Intracranial/drug therapy ; Vasospasm, Intracranial/enzymology
    Chemical Substances Nitrates ; Nitric Oxide (31C4KY9ESH) ; Nitric Oxide Synthase Type I (EC 1.14.13.39)
    Language English
    Publishing date 2011
    Publishing country Austria
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ISSN 0065-1419
    ISSN 0065-1419
    DOI 10.1007/978-3-7091-0353-1_2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Genes associated with Alzheimer's disease affecting ischemic neurodegeneration of the hippocampal CA3 region.

    Pluta, Ryszard / Ułamek-Kozioł, Marzena

    Neural regeneration research

    2020  Volume 16, Issue 7, Page(s) 1392–1393

    Language English
    Publishing date 2020-12-15
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.300982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Crosstalk between the aging intestinal microflora and the brain in ischemic stroke.

    Pluta, Ryszard / Jabłoński, Mirosław / Januszewski, Sławomir / Czuczwar, Stanisław J

    Frontiers in aging neuroscience

    2022  Volume 14, Page(s) 998049

    Abstract: Aging is an inevitable phenomenon experienced by animals and humans, and its intensity varies from one individual to another. Aging has been identified as a risk factor for neurodegenerative disorders by influencing the composition of the gut microbiota, ...

    Abstract Aging is an inevitable phenomenon experienced by animals and humans, and its intensity varies from one individual to another. Aging has been identified as a risk factor for neurodegenerative disorders by influencing the composition of the gut microbiota, microglia activity and cognitive performance. The microbiota-gut-brain axis is a two-way communication path between the gut microbes and the host brain. The aging intestinal microbiota communicates with the brain through secreted metabolites (neurotransmitters), and this phenomenon leads to the destruction of neuronal cells. Numerous external factors, such as living conditions and internal factors related to the age of the host, affect the condition of the intestinal microflora in the form of dysbiosis. Dysbiosis is defined as changes in the composition and function of the gut microflora that affect the pathogenesis, progress, and response to treatment of a disease entity. Dysbiosis occurs when changes in the composition and function of the microbiota exceed the ability of the microflora and its host to restore equilibrium. Dysbiosis leading to dysfunction of the microbiota-gut-brain axis regulates the development and functioning of the host's nervous, immune, and metabolic systems. Dysbiosis, which causes disturbances in the microbiota-gut-brain axis, is seen with age and with the onset of stroke, and is closely related to the development of risk factors for stroke. The review presents and summarizes the basic elements of the microbiota-gut-brain axis to better understand age-related changes in signaling along the microbiota-gut-brain axis and its dysfunction after stroke. We focused on the relationship between the microbiota-gut-brain axis and aging, emphasizing that all elements of the microbiota-gut-brain axis are subject to age-related changes. We also discuss the interaction between microbiota, microglia and neurons in the aged individuals in the brain after ischemic stroke. Finally, we presented preclinical and clinical studies on the role of the aged microbiota-gut-brain axis in the development of risk factors for stroke and changes in the post-stroke microflora.
    Language English
    Publishing date 2022-10-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2022.998049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Lymphocytes, Platelets, Erythrocytes, and Exosomes as Possible Biomarkers for Alzheimer's Disease Clinical Diagnosis.

    Pluta, Ryszard / Ułamek-Kozioł, Marzena

    Advances in experimental medicine and biology

    2019  Volume 1118, Page(s) 71–82

    Abstract: In the aging world population, Alzheimer's disease accounts for more than 70% of all cases of dementia and is the sixth leading cause of death. The neurodegenerative processes of this disorder can begin 10-20 years before the clinical symptoms develop. ... ...

    Abstract In the aging world population, Alzheimer's disease accounts for more than 70% of all cases of dementia and is the sixth leading cause of death. The neurodegenerative processes of this disorder can begin 10-20 years before the clinical symptoms develop. Postmortem brain autopsy of Alzheimer's disease cases reveals characteristic hallmarks like extracellular amyloid plaques and intraneuronal neurofibrillary tangles and synaptic and neuronal disintegration with severe brain atrophy. Some studies have reported that platelets contain the amyloid protein precursor and the secretase enzymes required for the amyloidogenic processing of this protein. Thus, platelets can be a good blood cell-based marker to investigate the onset of Alzheimer's disease. Other studies have indicated cellular and molecular alterations in erythrocytes and lymphocytes from Alzheimer's disease subjects, which emphasize the systemic nature of the disorder. In addition, small extracellular vesicles called exosomes appear to be an important factor during the progression of the disease. These vesicles contain disease-associated molecules such as the amyloid protein precursor and tau protein. In this chapter, we will summarize the recent knowledge on the involvement of lymphocytes, erythrocytes, platelets, and exosomes in the development of Alzheimer's disease. The data will be reviewed with a view to applying the above elements as Alzheimer's disease early preclinical and late-stage biomarkers with potential use for clinical diagnosis, prognosis, and monitoring disease progression and treatment responses.
    MeSH term(s) Alzheimer Disease/diagnosis ; Biomarkers ; Blood Platelets/cytology ; Erythrocytes/cytology ; Exosomes ; Humans ; Lymphocytes/cytology
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-02-07
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-05542-4_4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The role of degenerative pathways in the development of irreversible consequences after brain ischemia.

    Pluta, Ryszard / Ułamek-Kozioł, Marzena

    Neural regeneration research

    2019  Volume 14, Issue 6, Page(s) 982–983

    Language English
    Publishing date 2019-02-27
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.250574
    Database MEDical Literature Analysis and Retrieval System OnLINE

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