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  1. Article ; Online: Venetoclax in the treatment of acute myeloid leukemia: Beyond VIALE-A.

    Gangat, Naseema / Tefferi, Ayalew

    American journal of hematology

    2024  Volume 99, Issue 4, Page(s) 515–518

    Abstract: Venetoclax and hypomethylating agent therapy in acute myeloid leukemia. ...

    Abstract Venetoclax and hypomethylating agent therapy in acute myeloid leukemia.
    MeSH term(s) Humans ; Leukemia, Myeloid, Acute/drug therapy ; Bridged Bicyclo Compounds, Heterocyclic/therapeutic use ; Sulfonamides/therapeutic use ; Remission Induction ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
    Chemical Substances venetoclax (N54AIC43PW) ; Bridged Bicyclo Compounds, Heterocyclic ; Sulfonamides
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.27256
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: New drugs in myelofibrosis: Critical assessment of additional value to monotherapy with JAK inhibitors.

    Gangat, Naseema / Tefferi, Ayalew

    American journal of hematology

    2024  Volume 99, Issue 5, Page(s) 978–981

    Abstract: Ruxolitinib in combination with navitoclax or pelabresib in myelofibrosis: activity in JAKi-naïve patients. ...

    Abstract Ruxolitinib in combination with navitoclax or pelabresib in myelofibrosis: activity in JAKi-naïve patients.
    MeSH term(s) Humans ; Janus Kinase Inhibitors/therapeutic use ; Primary Myelofibrosis/drug therapy ; Nitriles/therapeutic use ; Protein Kinase Inhibitors/therapeutic use
    Chemical Substances Janus Kinase Inhibitors ; Nitriles ; Protein Kinase Inhibitors
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Letter
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.27248
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Emergence of

    Gangat, Naseema / Bellam, Naresh / Reichard, Kaaren / Tefferi, Ayalew

    Haematologica

    2024  Volume 109, Issue 4, Page(s) 1306–1309

    MeSH term(s) Humans ; Chromosome Deletion ; Chromosomes, Human, Pair 5/genetics ; Decitabine/therapeutic use ; Lenalidomide/therapeutic use ; Mutation ; Myelodysplastic Syndromes/drug therapy ; Myelodysplastic Syndromes/genetics ; Salvage Therapy ; Tumor Suppressor Protein p53/genetics
    Chemical Substances Decitabine (776B62CQ27) ; Lenalidomide (F0P408N6V4) ; TP53 protein, human ; Tumor Suppressor Protein p53
    Language English
    Publishing date 2024-04-01
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2023.284547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Treatment-emergent mutations in myelodysplastic syndrome with del(5q) - lenalidomide related or disease-intrinsic clonal evolution?

    Abdallah, Mostafa / Reichard, Kaaren / Gangat, Naseema / Tefferi, Ayalew

    Blood cancer journal

    2024  Volume 14, Issue 1, Page(s) 49

    MeSH term(s) Humans ; Lenalidomide/therapeutic use ; Myelodysplastic Syndromes/drug therapy ; Myelodysplastic Syndromes/genetics ; Thalidomide/therapeutic use ; Mutation ; Clonal Evolution/genetics ; Chromosomes, Human, Pair 5/genetics ; Chromosome Deletion
    Chemical Substances Lenalidomide (F0P408N6V4) ; Thalidomide (4Z8R6ORS6L)
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Letter
    ZDB-ID 2600560-8
    ISSN 2044-5385 ; 2044-5385
    ISSN (online) 2044-5385
    ISSN 2044-5385
    DOI 10.1038/s41408-024-01027-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Sodium-glucose co-transporter-2 inhibitor use and erythrocytosis: assessment of risk and need for referral to haematology.

    Gangat, Naseema / Tefferi, Ayalew

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2023  Volume 38, Issue 12, Page(s) 2670–2672

    MeSH term(s) Humans ; Sodium-Glucose Transporter 2 Inhibitors/adverse effects ; Polycythemia/chemically induced ; Polycythemia/diagnosis ; Hypoglycemic Agents/pharmacology ; Diabetes Mellitus, Type 2 ; Referral and Consultation ; Hematology ; Symporters ; Glucose ; Sodium
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors ; Hypoglycemic Agents ; Symporters ; Glucose (IY9XDZ35W2) ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2023-07-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfad171
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    Zs.MO 329: Show issues

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  6. Article ; Online: Momelotinib expands the therapeutic armamentarium for myelofibrosis: Impact on hierarchy of treatment choices.

    Tefferi, Ayalew / Pardanani, Animesh / Gangat, Naseema

    American journal of hematology

    2024  Volume 99, Issue 2, Page(s) 300–308

    Abstract: The primary objective of treatment in myelofibrosis (MF) is prolongation of life, which is currently accomplished only by allogeneic hematopoietic stem cell transplantation (AHSCT). Determination of optimal timing for AHSCT is facilitated by molecular ... ...

    Abstract The primary objective of treatment in myelofibrosis (MF) is prolongation of life, which is currently accomplished only by allogeneic hematopoietic stem cell transplantation (AHSCT). Determination of optimal timing for AHSCT is facilitated by molecular risk stratification. Non-transplant treatment options in MF are palliative in scope and include Janus kinase 2 (JAK2) inhibitors (JAKi): momelotinib (FDA approved on September 15, 2023), ruxolitinib (November 16, 2011), fedratinib (August 16, 2019), and pacritinib (February 28, 2022); all four JAKi are effective in reducing spleen size and alleviating symptoms, considered a drug class effect and attributed to their canonical JAK-STAT inhibitory mechanism of action. In addition, momelotinib exhibits erythropoietic effect, attributed to alleviation of ineffective erythropoiesis through inhibition of activin A receptor type-I (ACVR1). In transplant-ineligible or deferred patients, the order of treatment preference is based on specific symptoms and individual assessment of risk tolerance. Because of drug-induced immunosuppression and other toxicities attributed to JAKi, we prefer non-JAKi drugs as initial treatment for MF-associated anemia that is not accompanied by treatment-requiring splenomegaly or constitutional symptoms. Otherwise, it is reasonable to consider momelotinib as the first-line JAKi treatment of choice, in order to target the triad of quality-of-life offenders in MF: anemia, splenomegaly, and constitutional symptoms/cachexia. For second-line therapy, we favor ruxolitinib, over fedratinib, based on toxicity profile. Pacritinib and fedratinib provide alternative options in the presence of severe thrombocytopenia or ruxolitinib-resistance/intolerance, respectively. Splenectomy remains a viable option for drug-resistant symptomatic splenomegaly and cytopenia.
    MeSH term(s) Humans ; Primary Myelofibrosis/diagnosis ; Splenomegaly/drug therapy ; Splenomegaly/etiology ; Nitriles/therapeutic use ; Anemia/complications ; Janus Kinase 2 ; Protein Kinase Inhibitors/therapeutic use ; Benzamides ; Bridged-Ring Compounds ; Pyrazoles ; Pyrimidines
    Chemical Substances ruxolitinib (82S8X8XX8H) ; 11-(2-pyrrolidin-1-ylethoxy)-14,19-dioxa-5,7,26-triazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene ; N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide (6O01GMS00P) ; Nitriles ; Janus Kinase 2 (EC 2.7.10.2) ; Protein Kinase Inhibitors ; Benzamides ; Bridged-Ring Compounds ; Pyrazoles ; Pyrimidines
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.27163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1251: Show issues Location:
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  7. Article ; Online: To live is well but to live well is better: venetoclax combination therapy and quality-of-life in acute myeloid leukemia.

    Gangat, Naseema / Tefferi, Ayalew

    Blood cancer journal

    2022  Volume 12, Issue 4, Page(s) 75

    MeSH term(s) Bridged Bicyclo Compounds, Heterocyclic/therapeutic use ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; Quality of Life ; Sulfonamides/therapeutic use
    Chemical Substances Bridged Bicyclo Compounds, Heterocyclic ; Sulfonamides ; venetoclax (N54AIC43PW)
    Language English
    Publishing date 2022-04-25
    Publishing country United States
    Document type Editorial
    ZDB-ID 2600560-8
    ISSN 2044-5385 ; 2044-5385
    ISSN (online) 2044-5385
    ISSN 2044-5385
    DOI 10.1038/s41408-022-00672-y
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  8. Article ; Online: Sodium-glucose co-transporter-2 inhibitor treatment in essential thrombocythemia: Impact on hemoglobin/hematocrit levels and outcomes among 11 consecutive patients.

    Gangat, Naseema / Reichard, Kaaren / Tefferi, Ayalew

    American journal of hematology

    2023  Volume 98, Issue 11, Page(s) E298–E300

    MeSH term(s) Humans ; Hematocrit ; Hemoglobins ; Hypoglycemic Agents/therapeutic use ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Thrombocythemia, Essential/drug therapy
    Chemical Substances Hemoglobins ; Hypoglycemic Agents ; Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2023-08-08
    Publishing country United States
    Document type Letter
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.27048
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  9. Article ; Online: Sodium-glucose co-transporter-2 inhibitor therapy and unmasking of JAK2-mutated myeloproliferative neoplasm: A Mayo Clinic series of nine consecutive cases.

    Gangat, Naseema / Alkhateeb, Hassan / Reichard, Kaaren / Tefferi, Ayalew

    American journal of hematology

    2023  Volume 98, Issue 10, Page(s) E276–E280

    MeSH term(s) Humans ; Myeloproliferative Disorders/drug therapy ; Myeloproliferative Disorders/genetics ; Bone Marrow Neoplasms ; Symporters ; Glucose ; Sodium ; Janus Kinase 2/genetics ; Janus Kinase 2/metabolism ; Mutation
    Chemical Substances Symporters ; Glucose (IY9XDZ35W2) ; Sodium (9NEZ333N27) ; Janus Kinase 2 (EC 2.7.10.2) ; JAK2 protein, human (EC 2.7.10.2)
    Language English
    Publishing date 2023-07-20
    Publishing country United States
    Document type Letter
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.27034
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  10. Article ; Online: Incidental discovery of KIT-mutated mastocytoma in a colon polyp.

    Gangat, Naseema / McPhail, Ellen / Reichard, Kaaren / Orazi, Attilio / Pardanani, Animesh / Tefferi, Ayalew

    American journal of hematology

    2024  Volume 99, Issue 5, Page(s) 973–974

    Abstract: Mastocytoma in a colon polyp positive for tryptase, CD117/KIT, S100, weakly positive for CD25. ...

    Abstract Mastocytoma in a colon polyp positive for tryptase, CD117/KIT, S100, weakly positive for CD25.
    MeSH term(s) Humans ; Incidental Findings ; Mastocytoma ; Myeloproliferative Disorders ; Proto-Oncogene Proteins c-kit/genetics ; Colon
    Chemical Substances Proto-Oncogene Proteins c-kit (EC 2.7.10.1)
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.27209
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