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  1. Article ; Online: Elucidating the development of cooperative anode-biofilm-structures.

    Klein, Edina / Wurst, René / Rehnlund, David / Gescher, Johannes

    Biofilm

    2024  Volume 7, Page(s) 100193

    Abstract: Microbial electrochemical systems are a highly versatile platform technology with a particular focus on the interplay of chemical and electrical energy conversion and offer immense potential for a sustainable bioeconomy. The industrial realization of ... ...

    Abstract Microbial electrochemical systems are a highly versatile platform technology with a particular focus on the interplay of chemical and electrical energy conversion and offer immense potential for a sustainable bioeconomy. The industrial realization of this potential requires a critical focus on biofilm optimization if performance is to be controlled over a long period of time. Moreover, the aspect and influence of cooperativity has to be addressed as many applied anodic bioelectrochemical systems will most likely be operated with a diversity of interacting microbial species. Hence, the aim of this study was to analyze how interspecies dependence and cooperativity of a model community influence the development of anodic biofilms. To investigate biofilm activity in a spatially resolved manner, a microfluidic bioelectrochemical flow cell was developed that can be equipped with user-defined electrode materials and operates under laminar flow conditions. With this infrastructure, the development of single and co-culture biofilms of the two model organisms
    Language English
    Publishing date 2024-03-25
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-2075
    ISSN (online) 2590-2075
    DOI 10.1016/j.bioflm.2024.100193
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  2. Article ; Online: Twelve tips for developing simulation-based mastery learning clinical skills checklists.

    Klein, Matthew R / Loke, Dana E / Barsuk, Jeffrey H / Adler, Mark D / McGaghie, William C / Salzman, David H

    Medical teacher

    2024  , Page(s) 1–6

    Abstract: Simulation-based mastery learning is a powerful educational paradigm that leads to high levels of performance through a combination of strict standards, deliberate practice, formative feedback, and rigorous assessment. Successful mastery learning ... ...

    Abstract Simulation-based mastery learning is a powerful educational paradigm that leads to high levels of performance through a combination of strict standards, deliberate practice, formative feedback, and rigorous assessment. Successful mastery learning curricula often require well-designed checklists that produce reliable data that contribute to valid decisions. The following twelve tips are intended to help educators create defensible and effective clinical skills checklists for use in mastery learning curricula. These tips focus on defining the scope of a checklist using established principles of curriculum development, crafting the checklist based on a literature review and expert input, revising and testing the checklist, and recruiting judges to set a minimum passing standard. While this article has a particular focus on mastery learning, with the exception of the tips related to standard setting, the general principles discussed apply to the development of any clinical skills checklist.
    Language English
    Publishing date 2024-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 424426-6
    ISSN 1466-187X ; 0142-159X
    ISSN (online) 1466-187X
    ISSN 0142-159X
    DOI 10.1080/0142159X.2024.2345270
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2176: Show issues Location:
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  3. Article ; Online: Unstable Middle Phalanx Base Fractures Treated With an Internal Joint Stabilizer: Preliminary Results.

    Klein, David M / Teytelbaum, David E / Patel, Jay S / Combs, Taylor E / Heifner, John J / Orbay, Jorge L

    Hand (New York, N.Y.)

    2023  , Page(s) 15589447231160210

    Abstract: Background: Unstable fractures of the base of the middle phalanx are notorious for causing chronic loss of proximal interphalangeal (PIP) joint function, and they remain a challenge for the hand surgeon. We report on a temporary intraoperatively ... ...

    Abstract Background: Unstable fractures of the base of the middle phalanx are notorious for causing chronic loss of proximal interphalangeal (PIP) joint function, and they remain a challenge for the hand surgeon. We report on a temporary intraoperatively constructed internal joint stabilizer for unstable PIP joint injuries.
    Methods: Across 2 institutions, a retrospective chart review was performed for cases with acute presentation of pilon fracture or fracture-dislocation of the base of the middle phalanx which were surgically treated with an internal joint stabilizer. Information collected included time from injury to surgical intervention, time from implantation to device removal, complications, and preoperative and postoperative range of motion.
    Results: Seven patients met the inclusion criteria with a mean age of 51 (range: 24-72) years and a mean follow-up of 29 (range: 11-72) months. After removal of the fixator, the mean arc of PIP joint motion was 8° to 88° (range: 0°-100°). There were no infections, no hardware loosening or failures, and no revision procedures.
    Conclusion: The current findings are comparable to the results for dynamic external fixators. An internal joint stabilizer for unstable injuries to the base of the middle phalanx provides satisfactory functional outcomes, allows early postoperative motion, and mitigates the routine complications which may arise with external fixation.
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2277325-3
    ISSN 1558-9455 ; 1558-9447
    ISSN (online) 1558-9455
    ISSN 1558-9447
    DOI 10.1177/15589447231160210
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  4. Article ; Online: A time-dependent Poisson-Gamma model for recruitment forecasting in multicenter studies.

    Turchetta, Armando / Savy, Nicolas / Stephens, David A / Moodie, Erica E M / Klein, Marina B

    Statistics in medicine

    2023  Volume 42, Issue 23, Page(s) 4193–4206

    Abstract: Forecasting recruitments is a key component of the monitoring phase of multicenter studies. One of the most popular techniques in this field is the Poisson-Gamma recruitment model, a Bayesian technique built on a doubly stochastic Poisson process. This ... ...

    Abstract Forecasting recruitments is a key component of the monitoring phase of multicenter studies. One of the most popular techniques in this field is the Poisson-Gamma recruitment model, a Bayesian technique built on a doubly stochastic Poisson process. This approach is based on the modeling of enrollments as a Poisson process where the recruitment rates are assumed to be constant over time and to follow a common Gamma prior distribution. However, the constant-rate assumption is a restrictive limitation that is rarely appropriate for applications in real studies. In this paper, we illustrate a flexible generalization of this methodology which allows the enrollment rates to vary over time by modeling them through B-splines. We show the suitability of this approach for a wide range of recruitment behaviors in a simulation study and by estimating the recruitment progression of the Canadian Co-infection Cohort.
    MeSH term(s) Humans ; Models, Statistical ; Bayes Theorem ; Poisson Distribution ; Canada ; Computer Simulation
    Language English
    Publishing date 2023-07-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 843037-8
    ISSN 1097-0258 ; 0277-6715
    ISSN (online) 1097-0258
    ISSN 0277-6715
    DOI 10.1002/sim.9855
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    Zs.A 1756: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Two-Dimensional Thin Layer Chromatography of Melatonin and Related Compounds.

    Klein, David C

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2550, Page(s) 3–6

    Abstract: ... arylalkylamine N-acetyltransferase (E.C. 2.3.1.87), has been the focus of hundreds of papers which probed ...

    Abstract Two-dimensional thin layer chromatography has been used by workers in the field to separate radiolabeled serotonin derivatives from complex mixtures of culture media and homogenates of glands. The compounds resolved include N-acetylserotonin, melatonin, hydroxytryptophol, methoxytryptophol, hydroxyindole acetic acid, and methoxyindole acetic acid. The method requires either radiolabeled tryptophan or serotonin, if an investigator wants to study conversion. It is also useful in the chemical synthesis of serotonin metabolites because it is relatively fast. It pointed to the enzyme that converts serotonin to N-acetylserotonin as being key in controlling the nocturnal increase in vertebrate melatonin production. This enzyme, arylalkylamine N-acetyltransferase (E.C. 2.3.1.87), has been the focus of hundreds of papers which probed its biology, biochemistry, molecular biology, structural biology, neural regulation, development, evolution, and genetics.
    MeSH term(s) Arylalkylamine N-Acetyltransferase/metabolism ; Chromatography, Thin Layer ; Complex Mixtures/metabolism ; Culture Media/metabolism ; Humans ; Hydroxytryptophol ; Melatonin/metabolism ; Pineal Gland/chemistry ; Pineal Gland/metabolism ; Serotonin/analogs & derivatives ; Serotonin/metabolism ; Tryptophan/metabolism
    Chemical Substances Complex Mixtures ; Culture Media ; Hydroxytryptophol (154-02-9) ; Serotonin (333DO1RDJY) ; Tryptophan (8DUH1N11BX) ; Arylalkylamine N-Acetyltransferase (EC 2.3.1.87) ; Melatonin (JL5DK93RCL) ; N-acetylserotonin (P4TO3C82WV)
    Language English
    Publishing date 2022-09-27
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2593-4_1
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  6. Article ; Online: Surgical Techniques and Nuances for Superior Cervical Ganglionectomy and Decentralization in Rats.

    Madhani, Sarosh Irfan / Klein, David C / Muñoz, Estela M / Savastano, Luis E

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2550, Page(s) 53–62

    Abstract: The sympathetic nervous system has been implicated in various physiological and pathological processes, including regulation of homeostatic functions, maintenance of the circadian rhythms, and neuronal disruption and recovery after injury. Of special ... ...

    Abstract The sympathetic nervous system has been implicated in various physiological and pathological processes, including regulation of homeostatic functions, maintenance of the circadian rhythms, and neuronal disruption and recovery after injury. Of special interest is focus on the role of the superior cervical ganglion (SCG) in regulating the daily changes in pineal function. Removal of the superior cervical ganglion (SCGx) and decentralization have served as valuable microsurgical models to investigate the effects of surgical denervation on this gland or organ. In this chapter, we offer information about methodologies for performing SCGx along with decentralization and denervation procedures, including details about recommended equipment as well as tips that can improve these techniques.
    MeSH term(s) Animals ; Circadian Rhythm/physiology ; Ganglia, Sympathetic ; Ganglionectomy/methods ; Neurons ; Politics ; Rats ; Superior Cervical Ganglion
    Language English
    Publishing date 2022-09-27
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2593-4_8
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  7. Article ; Online: Electrochemical Preparation of Sm(II) Reagent Facilitated by Weakly Coordinating Anions.

    Ware, Skyler D / Zhang, Wendy / Charboneau, David J / Klein, Channing K / Reisman, Sarah E / See, Kimberly A

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 29, Issue 46, Page(s) e202301045

    Abstract: Samarium diiodide ( ... ...

    Abstract Samarium diiodide (SmI
    Language English
    Publishing date 2023-07-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202301045
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  8. Article ; Online: Eating Disorders in Primary Care: Diagnosis and Management.

    Klein, David A / Sylvester, Jillian E / Schvey, Natasha A

    American family physician

    2021  Volume 103, Issue 1, Page(s) 22–32

    Abstract: ... physical examination, orthostatic vital signs, and testing (e.g., a metabolic panel with magnesium and phosphate levels ... electrocardiography) when indicated. Additional care team members (i.e., dietitian, therapist, and caregivers ... on health status (e.g., acute food refusal, uncontrollable binge eating or purging, co-occurring conditions ...

    Abstract Eating disorders are potentially life-threatening conditions characterized by disordered eating and weight-control behaviors that impair physical health and psychosocial functioning. Early intervention may decrease the risk of long-term pathology and disability. Clinicians should interpret disordered eating and body image concerns and carefully monitor patients' height, weight, and body mass index trends for subtle changes. After diagnosis, visits should include the sensitive review of psychosocial and clinical factors, physical examination, orthostatic vital signs, and testing (e.g., a metabolic panel with magnesium and phosphate levels, electrocardiography) when indicated. Additional care team members (i.e., dietitian, therapist, and caregivers) should provide a unified, evidence-based therapeutic approach. The escalation of care should be based on health status (e.g., acute food refusal, uncontrollable binge eating or purging, co-occurring conditions, suicidality, test abnormalities), weight patterns, outpatient options, and social support. A healthy weight range is determined by the degree of malnutrition and pre-illness trajectories. Weight gain of 2.2 to 4.4 lb per week stabilizes cardiovascular health. Treatment options may include cognitive behavior interventions that address body image and dietary and physical activity behaviors; family-based therapy, which is a first-line treatment for youths; and pharmacotherapy, which may treat co-occurring conditions, but should not be pursued alone. Evidence supports select antidepressants or topiramate for bulimia nervosa and lisdexamfetamine for binge-eating disorder. Remission is suggested by healthy biopsychosocial functioning, cognitive flexibility with eating, resolution of disordered behaviors and decision-making, and if applicable, restoration of weight and menses. Prevention should emphasize a positive focus on body image instead of a focus on weight or dieting.
    MeSH term(s) Anorexia Nervosa/diagnosis ; Anorexia Nervosa/therapy ; Binge-Eating Disorder/diagnosis ; Binge-Eating Disorder/therapy ; Body Image ; Bulimia Nervosa/diagnosis ; Bulimia Nervosa/therapy ; Cognitive Behavioral Therapy/methods ; Feeding and Eating Disorders/diagnosis ; Feeding and Eating Disorders/therapy ; Female ; Humans ; Male ; Medical History Taking ; Primary Health Care/organization & administration ; Referral and Consultation/organization & administration ; Risk Factors
    Language English
    Publishing date 2021-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412694-4
    ISSN 1532-0650 ; 0002-838X ; 0572-3612
    ISSN (online) 1532-0650
    ISSN 0002-838X ; 0572-3612
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    Zs.B 848: Show issues Location:
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  9. Article ; Online: Synthesis, structure, and electrochemical properties of [LNi(R

    Shreiber, Scott T / Amin, Fatema / Schäfer, Sascha A / Cramer, Roger E / Klein, Axel / Vicic, David A

    Dalton transactions (Cambridge, England : 2003)

    2022  Volume 51, Issue 14, Page(s) 5515–5523

    Abstract: The new anionic nickelate complexes [(MeCN)Ni( ... ...

    Abstract The new anionic nickelate complexes [(MeCN)Ni(C
    Language English
    Publishing date 2022-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d2dt00511e
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  10. Article: QTL discovery for resistance to black spot and cercospora leaf spot, and defoliation in two interconnected F1 bi-parental tetraploid garden rose populations.

    Lau, Jeekin / Gill, Haramrit / Taniguti, Cristiane H / Young, Ellen L / Klein, Patricia E / Byrne, David H / Riera-Lizarazu, Oscar

    Frontiers in plant science

    2023  Volume 14, Page(s) 1209445

    Abstract: Garden roses are an economically important horticultural crop worldwide, and two major fungal pathogens, black spot ( ...

    Abstract Garden roses are an economically important horticultural crop worldwide, and two major fungal pathogens, black spot (
    Language English
    Publishing date 2023-07-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1209445
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