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  1. Article: [Cardiovascular Diseases and Neurological Impact: Ischemic Stroke from Heart and Aortic Problems].

    Iwamoto, Soya / Koga, Masatoshi

    Brain and nerve = Shinkei kenkyu no shinpo

    2024  Volume 76, Issue 3, Page(s) 249–259

    Abstract: Identifying the conditions leading to ischemic stroke is challenging due to their diverse nature. Conditions that are particularly difficult to diagnose are certain cardiovascular diseases intricately linked to ischemic stroke that require keen suspicion ...

    Abstract Identifying the conditions leading to ischemic stroke is challenging due to their diverse nature. Conditions that are particularly difficult to diagnose are certain cardiovascular diseases intricately linked to ischemic stroke that require keen suspicion and thorough examinations to ensure diagnostic accuracy. This article describes the cardiovascular diseases associated with ischemic stroke and offers concise insight into their pathophysiology, assessments, and treatments based on clinical evidence.
    MeSH term(s) Humans ; Cardiovascular Diseases/complications ; Stroke/complications ; Stroke/diagnosis ; Ischemic Stroke/complications
    Language Japanese
    Publishing date 2024-03-21
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416202595
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 398: Show issues Location:
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  2. Article ; Online: Cerebrorenal Interaction and Stroke Outcome.

    Koga, Masatoshi

    Journal of atherosclerosis and thrombosis

    2018  Volume 25, Issue 7, Page(s) 566–567

    MeSH term(s) Glomerular Filtration Rate ; Humans ; Registries ; Stroke
    Language English
    Publishing date 2018-02-07
    Publishing country Japan
    Document type Journal Article ; Comment
    ZDB-ID 2011474-6
    ISSN 1880-3873 ; 1340-3478
    ISSN (online) 1880-3873
    ISSN 1340-3478
    DOI 10.5551/jat.ED091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: More Benefits From Endovascular Thrombectomy in Patients With Atrial Fibrillation?

    Koga, Masatoshi

    Circulation journal : official journal of the Japanese Circulation Society

    2018  Volume 82, Issue 10, Page(s) 2483–2484

    MeSH term(s) Anticoagulants ; Atrial Fibrillation ; Brain Ischemia ; Endovascular Procedures ; Humans ; Stroke ; Thrombectomy
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2018-09-05
    Publishing country Japan
    Document type Editorial ; Comment
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-18-0931
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Controlling blood pressure soon after intracerebral hemorrhage: The SAMURAI-ICH Study and its successors.

    Toyoda, Kazunori / Koga, Masatoshi

    Hypertension research : official journal of the Japanese Society of Hypertension

    2022  Volume 45, Issue 4, Page(s) 583–590

    Abstract: The impact of acute therapy for intracerebral hemorrhage (ICH) lags far behind that for acute ischemic stroke. Intensive blood pressure lowering is a promising therapeutic strategy for acute ICH, especially for East Asian patients whose etiological ... ...

    Abstract The impact of acute therapy for intracerebral hemorrhage (ICH) lags far behind that for acute ischemic stroke. Intensive blood pressure lowering is a promising therapeutic strategy for acute ICH, especially for East Asian patients whose etiological mechanism is more commonly hypertension than that of patients in the Western population. A multicenter, prospective, observational study named the Stroke Acute Management with Urgent Risk-factor Assessment and Improvement-IntraCerebral Hemorrhage (SAMURAI-ICH) study, involving 211 patients from ten Japanese stroke centers, was performed to elucidate the safety and feasibility of blood pressure lowering to 160 mmHg or less in acute ICH patients using intravenous nicardipine. When we started the study, intravenous nicardipine was not officially approved for hyperacute ICH patients in Japan. The SAMURAI-ICH study was also a pilot study to judge the feasibility of participation by many Japanese investigators in an international, randomized, controlled trial named the Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH)-2 trial. The SAMURAI-ICH study, ATACH-2 trial, and their combined individual participant data meta-analysis produced several new interesting findings on how to control blood pressure levels in acute ICH patients. Some of the findings are introduced in the present review article.
    MeSH term(s) Antihypertensive Agents/pharmacology ; Antihypertensive Agents/therapeutic use ; Blood Pressure/physiology ; Cerebral Hemorrhage/drug therapy ; Humans ; Ischemic Stroke ; Multicenter Studies as Topic ; Observational Studies as Topic ; Pilot Projects ; Prospective Studies ; Randomized Controlled Trials as Topic ; Treatment Outcome
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2022-03-08
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-022-00866-8
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    Zs.A 3898: Show issues Location:
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  5. Article ; Online: Recognition of Strokes in the ICU: A Narrative Review.

    Noda, Kotaro / Koga, Masatoshi / Toyoda, Kazunori

    Journal of cardiovascular development and disease

    2023  Volume 10, Issue 4

    Abstract: Despite the remarkable progress in acute treatment for stroke, in-hospital stroke is still devastating. The mortality and neurological sequelae are worse in patients with in-hospital stroke than in those with community-onset stroke. The leading cause of ... ...

    Abstract Despite the remarkable progress in acute treatment for stroke, in-hospital stroke is still devastating. The mortality and neurological sequelae are worse in patients with in-hospital stroke than in those with community-onset stroke. The leading cause of this tragic situation is the delay in emergent treatment. To achieve better outcomes, early stroke recognition and immediate treatment are crucial. In general, in-hospital stroke is initially witnessed by non-neurologists, but it is sometimes challenging for non-neurologists to diagnose a patient's state as a stroke and respond quickly. Therefore, understanding the risk and characteristics of in-hospital stroke would be helpful for early recognition. First, we need to know "the epicenter of in-hospital stroke". Critically ill patients and patients who undergo surgery or procedures are admitted to the intensive care unit, and they are potentially at high risk for stroke. Moreover, since they are often sedated and intubated, evaluating their neurological status concisely is difficult. The limited evidence demonstrated that the intensive care unit is the most common place for in-hospital strokes. This paper presents a review of the literature and clarifies the causes and risks of stroke in the intensive care unit.
    Language English
    Publishing date 2023-04-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd10040182
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  6. Article ; Online: Preoperative brain computed tomographic perfusion for quantitative evaluation of cerebral malperfusion caused by acute type A aortic dissection.

    Inoue, Yosuke / Inoue, Manabu / Koga, Masatoshi / Matsuda, Hitoshi

    JTCVS techniques

    2021  Volume 10, Page(s) 190–195

    Language English
    Publishing date 2021-09-22
    Publishing country United States
    Document type Case Reports
    ISSN 2666-2507
    ISSN (online) 2666-2507
    DOI 10.1016/j.xjtc.2021.09.031
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  7. Article ; Online: Liver enzymes and the risk of stroke among the general Japanese population: a prospective cohort study.

    Arafa, Ahmed / Kokubo, Yoshihiro / Kashima, Rena / Matsumoto, Chisa / Koga, Masatoshi

    Cerebrovascular diseases (Basel, Switzerland)

    2023  

    Abstract: Background: Stroke is a major cause of morbidity and mortality. Liver enzymes, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transpeptidase (GGT), are markers of liver diseases with potential cardiovascular ... ...

    Abstract Background: Stroke is a major cause of morbidity and mortality. Liver enzymes, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transpeptidase (GGT), are markers of liver diseases with potential cardiovascular implications.
    Objective: This study aimed to investigate the prospective association between liver enzymes and stroke risk.
    Methods: We analyzed data from 3,379 men and 4,007 women without cardiovascular disease and registered in the Suita Study; a Japanese population-based prospective cohort study. The hazard ratios (HRs) and 95% confidence intervals (95% CIs) of stroke risk were estimated per quintiles of ALT, AST, and GGT in men and women.
    Results: Within a median follow-up period of 16.7 years, 438 incident stroke events were diagnosed. In men, compared to the second quintiles, the fifth (highest) quintiles of liver enzymes showed increased stroke risks: HRs (95% CIs) = 2.07 (1.35, 3.18) in ALT, 1.66 (1.10, 2.53) in AST, and 1.76 (1.11, 2.81) in GGT. The associations did not change with cerebral infarction risk: HRs (95% CIs) = 2.09 (1.24, 3.50) in ALT, 1.84 (1.11, 3.06) in AST, and 1.74 (1.00, 3.04) in GGT, respectively. The lowest ALT, AST, and GGT quintiles tended to show increased stroke and cerebral infarction risks, yet these associations were statistically insignificant. No such associations were shown in women.
    Conclusion: Elevated ALT, AST, and GGT levels were associated with increased stroke and cerebral infarction risks among Japanese men.
    Language English
    Publishing date 2023-08-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1069462-6
    ISSN 1421-9786 ; 1015-9770
    ISSN (online) 1421-9786
    ISSN 1015-9770
    DOI 10.1159/000533654
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    Zs.A 3181: Show issues Location:
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  8. Article ; Online: Intravenous Thrombolysis for Acute Ischemic Stroke in Patients with End-Stage Renal Disease on Hemodialysis: A Narrative Review.

    Egashira, Shuhei / Koga, Masatoshi / Toyoda, Kazunori

    Journal of cardiovascular development and disease

    2022  Volume 9, Issue 12

    Abstract: Objectives: Acute ischemic stroke (AIS) is a significant and devastating complication in patients with end-stage renal disease on hemodialysis (ESRD/HD). Since one-third of AIS in ESRD/HD patients occurs during or soon after dialysis, patients are more ... ...

    Abstract Objectives: Acute ischemic stroke (AIS) is a significant and devastating complication in patients with end-stage renal disease on hemodialysis (ESRD/HD). Since one-third of AIS in ESRD/HD patients occurs during or soon after dialysis, patients are more likely to present within the time window when intravenous thrombolysis (IVT) can be performed. IVT may improve prognosis in ESRD/HD patients with AIS. However, ESRD/HD patients have been excluded from large trials and may have been withheld from IVT due to concerns about bleeding complications. To date, there is no clear evidence and firm guidance on the safety and efficacy of IVT in ESRD/HD patients with AIS. This narrative review aimed to evaluate critical scientific data on the benefits and risks of IVT use in patients with ESRD/HD and AIS.
    Materials and methods: We searched the electronic database of PubMed for studies evaluating the relationship between AIS, ESRD/HD, and IVT. Reference sections and additional publications were also searched manually. Studies on AIS in patients with ESRD/HD requiring maintenance dialysis that referred to IVT were included.
    Results: In total, 560 studies were found in the PubMed electronic database during the period covered, of which 10 met the selection criteria. IVT for AIS in ESRD/HD patients could improve neurological outcomes and be safely performed even with the possibility of hemorrhagic complications associated with hypertension. Despite the high complication and mortality rates in ESRD/HD patients with AIS after IVT, the association with IVT was unclear.
    Conclusions: IVT for AIS in ESRD/HD patients may improve outcomes and should not be withheld based solely on ESRD/HD status.
    Language English
    Publishing date 2022-12-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd9120446
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  9. Article: Current status and future aspects in the Japan Stroke Data Bank.

    Wada, Shinichi / Yoshimura, Sohei / Miwa, Kaori / Iwanaga, Yoshitaka / Koga, Masatoshi / Toyoda, Kazunori

    Frontiers in neurology

    2023  Volume 14, Page(s) 1090136

    Abstract: The Japanese National Plan for the Promotion of Measures Against Cerebrovascular and Cardiovascular Diseases was formulated on October 27, 2020. One purpose of this plan was to promote research on cerebrovascular and cardiovascular diseases. Therefore, ... ...

    Abstract The Japanese National Plan for the Promotion of Measures Against Cerebrovascular and Cardiovascular Diseases was formulated on October 27, 2020. One purpose of this plan was to promote research on cerebrovascular and cardiovascular diseases. Therefore, it is necessary to clarify the actual status of stroke treatment in Japan and operate a national stroke database with high public interest completely and accurately. The Japan Stroke Data Bank (JSDB; https://strokedatabank.ncvc.go.jp/en/) was established by the Ministry of Health, Labor and Welfare Scientific Research in Shimane University (Shimane, Japan) in 1999 and was transferred to the National Cerebral and Cardiovascular Center (Osaka, Japan) as a part of the Cardiovascular Disease Registry in 2015. More than 200,000 of stroke cases have been registered using individual forms from more than 100 nationwide stroke centers over ~20 years. Since there are few large-scale stroke registries with nationwide coverage in Asia, including Japan, compared with those in Europe and North America, the role of the JSDB in the plan will be important in the future. To construct a high-quality stroke registry, we aimed to (1) collect detailed data through individual questionnaires for each participating stroke center, (2) link to external databases (e.g., insurance claims and public death registries), (3) improve the quality of treatment at participating hospitals through benchmarking, and (4) obtain stable funding through sustained support from government and academic societies. We also describe the history of the JSDB and changes in the trend of real-world stroke treatment in Japan based on the results of analysis of data in the JSDB.
    Language English
    Publishing date 2023-03-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1090136
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  10. Article ; Online: Response by Tanaka et al to Letter Regarding Article, "Atrial Fibrillation-Associated Ischemic Stroke Patients With Prior Anticoagulation Have Higher Risk for Recurrent Stroke".

    Tanaka, Kanta / Koga, Masatoshi / Bae, Hee-Joon

    Stroke

    2020  Volume 51, Issue 8, Page(s) e164

    MeSH term(s) Anticoagulants/adverse effects ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/epidemiology ; Blood Coagulation ; Brain Ischemia/complications ; Brain Ischemia/epidemiology ; Humans ; Stroke/epidemiology
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2020-06-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.120.030414
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