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Article ; Online: Caregiver-reported infant motor and imitation skills predict M-CHAT-R/F.

Levick, Samantha / Staples, Angela D / Warschausky, Seth / Huth-Bocks, Alissa / Taylor, H Gerry / Gidley Larson, Jennifer C / Peterson, Catherine / Lukomski, Angela / Lajiness-O'Neill, Renée

Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence

2024 , Page(s) 1–19

Abstract: Altered motor and social-communicative abilities in infancy have been linked to later ASD diagnosis. Most diagnostic instruments for ASD cannot be utilized until 12 months, and the average child is diagnosed substantially later. Imitation combines motor ... ...

Abstract	Altered motor and social-communicative abilities in infancy have been linked to later ASD diagnosis. Most diagnostic instruments for ASD cannot be utilized until 12 months, and the average child is diagnosed substantially later. Imitation combines motor and social-communicative skills and is commonly atypical in infants at risk for ASD. However, few measures have been developed to assess infant imitation clinically. One barrier to the diagnostic age gap of ASD is accessibility of screening and diagnostic services. Utilization of caregiver report to reliably screen for ASD mitigates such barriers and could aid in earlier detection. The present study developed and validated a caregiver-report measure of infant imitation at 4, 6, and 9 months and explored the relationship between caregiver-reported imitation and motor abilities with later ASD risk. Participants (
Language	English
Publishing date	2024-01-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1262599-1
ISSN	1744-4136 ; 0929-7049
ISSN (online)	1744-4136
ISSN	0929-7049
DOI	10.1080/09297049.2024.2304378
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Article ; Online: Real-world study of the impact of recurrent/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) on quality of life and productivity in Europe.

Singh, Prianka / Bennett, Bryan / Bailey, Tom / Taylor-Stokes, Gavin / Rajkovic, Ivana / Contente, Marta / Curtis, Sharon / Curtis, Chris

BMC cancer

2021 Volume 21, Issue 1, Page(s) 854

Abstract: ... metastatic (R/M) SCCHN have a poor prognosis and substantial disease burden, including impaired ... The aim of this study was to characterize the impact of R/M SCCHN and its first-line treatment on patient ... from Europe.: Methods: This was a multicentre retrospective study of patients with R/M SCCHN in France ...

Abstract	Background: Although current therapy for patients with early-stage squamous cell carcinoma of the head and neck (SCCHN) is potentially curative, the recurrence rate is high. Patients with recurrent or metastatic (R/M) SCCHN have a poor prognosis and substantial disease burden, including impaired health-related quality of life (HRQoL), productivity loss and indirect costs, such as need for caregiver support. The aim of this study was to characterize the impact of R/M SCCHN and its first-line treatment on patient and caregiver quality of life, daily activities and work productivity using real-world evidence from Europe. Methods: This was a multicentre retrospective study of patients with R/M SCCHN in France, Germany, Italy, Spain and the United Kingdom incorporating patient and caregiver surveys, and a physician-reported medical chart review, conducted between January and May 2019. Patients aged 18 or over with a physician confirmed diagnosis R/M SCCHN completed four validated measures of disease activity and its impact on quality of life and work productivity, while caregivers also completed questionnaire to assess the burden of providing care. Physicians provided data for clinical characteristics, patient management, testing history and treatment patterns. Results: A total of 195 medical/clinical oncologists provided data for 937, predominantly male (72%) patients, with almost half of patients aged over 65 years. The most frequently reported symptoms were fatigue (43%), weight loss (40%), pain (35%) and difficulty swallowing (32%). The EXTREME regimen was the most common first line therapy in over half of patients, who reported moderate or extreme pain/discomfort, and anxiety/depression, and problems with self-care resulting in a diminished health status compared with the general population. Only 14% were employed with high absenteeism or presenteeism, and over half of patients had a caregiver for whom the burden of care was substantial. Conclusion: Our results provide real-world insight into the multi-faceted burden associated with R/M SCCHN. The combination of poor HRQoL and the impairment in daily activities, social life and employment illustrates the wider impact of R/M SCCHN on patients and their caregivers, and highlights a need for novel 1 L treatment regimens to improve the humanistic and productivity burdens of this cancer.
MeSH term(s)	Activities of Daily Living ; Combined Modality Therapy ; Cost of Illness ; Efficiency ; Europe/epidemiology ; Female ; Humans ; Male ; Neoplasm Staging ; Prognosis ; Public Health Surveillance ; Quality of Life ; Retrospective Studies ; Squamous Cell Carcinoma of Head and Neck/diagnosis ; Squamous Cell Carcinoma of Head and Neck/epidemiology ; Squamous Cell Carcinoma of Head and Neck/therapy ; Treatment Outcome
Language	English
Publishing date	2021-07-24
Publishing country	England
Document type	Journal Article ; Multicenter Study
ISSN	1471-2407
ISSN (online)	1471-2407
DOI	10.1186/s12885-021-08557-2
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Article ; Online: Commentary on: Hahn M, Anslinger K, Eckert M, Fimmers R, Grethe S, Hohoff C, et al. [Joint recommendations of the project group "Biostatistical DNA Calculations" and the Trace Commission on the Biostatistical Evaluation of Forensic DNA Analytical Findings with Fully Continuous Models (FCM)]. Rechtsmedizin (Berl). 2023; 33(1):3-12. doi: 10.1007/s00194-022-00599-5.

Berger, Charles E H / Kruijver, Maarten / Hicks, Tacha / Champod, Christophe / Taylor, Duncan / Buckleton, John

Journal of forensic sciences

2023 Volume 69, Issue 2, Page(s) 730–735

MeSH term(s)	DNA ; Forensic Genetics
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2023-11-20
Publishing country	United States
Document type	Letter
ZDB-ID	219216-0
ISSN	1556-4029 ; 0022-1198
ISSN (online)	1556-4029
ISSN	0022-1198
DOI	10.1111/1556-4029.15424
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Article ; Online: Structural analysis of a novel class of R-M controller proteins: C.Csp231I from Citrobacter sp. RFL231.

McGeehan, J E / Streeter, S D / Thresh, S-J / Taylor, James E N / Shevtsov, M B / Kneale, G G

Journal of molecular biology

2011 Volume 409, Issue 2, Page(s) 177–188

Abstract: ... restriction-modification (R-M) systems and are important mediators of horizontal gene transfer. They form ... repression of R-M genes. Here we present biophysical, biochemical, and high-resolution structural analysis ...

Abstract	Controller proteins play a key role in the temporal regulation of gene expression in bacterial restriction-modification (R-M) systems and are important mediators of horizontal gene transfer. They form the basis of a highly cooperative, concentration-dependent genetic switch involved in both activation and repression of R-M genes. Here we present biophysical, biochemical, and high-resolution structural analysis of a novel class of controller proteins, exemplified by C.Csp231I. In contrast to all previously solved C-protein structures, each protein subunit has two extra helices at the C-terminus, which play a large part in maintaining the dimer interface. The DNA binding site of the protein is also novel, having largely AAAA tracts between the palindromic recognition half-sites, suggesting tight bending of the DNA. The protein structure shows an unusual positively charged surface that could form the basis for wrapping the DNA completely around the C-protein dimer.
MeSH term(s)	Amino Acid Sequence ; Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Citrobacter/metabolism ; Crystallography, X-Ray ; DNA, Bacterial/metabolism ; Models, Molecular ; Molecular Sequence Data ; Promoter Regions, Genetic ; Protein Conformation ; Protein Multimerization ; Sequence Homology, Amino Acid
Chemical Substances	Bacterial Proteins ; DNA, Bacterial
Language	English
Publishing date	2011-04-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80229-3
ISSN	1089-8638 ; 0022-2836
ISSN (online)	1089-8638
ISSN	0022-2836
DOI	10.1016/j.jmb.2011.03.033
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Article: Substituted 2-(R)-methyl piperazines as muscarinic M(2) selective ligands.

Kozlowski, Joseph A / Zhou, Guowei / Tagat, Jayaram R / Lin, Sue Ing / McCombie, Stuart W / Ruperto, Vilma B / Duffy, Ruth A / McQuade, Robert A / Crosby, Gordon / Taylor, Lisa A / Billard, William / Binch, Herbert / Lachowicz, Jean E

Bioorganic & medicinal chemistry letters

2002 Volume 12, Issue 5, Page(s) 791–794

Abstract: A novel series of 2-(R)-methyl-substituted piperazines (e.g., 2) is described. They are potent M(2 ... selective ligands that have >100-fold selectivity versus the M(1) receptor. In the rat microdialysis assay ...

Abstract	A novel series of 2-(R)-methyl-substituted piperazines (e.g., 2) is described. They are potent M(2) selective ligands that have >100-fold selectivity versus the M(1) receptor. In the rat microdialysis assay, compound 14 showed significantly enchanced levels of acetylcholine after oral administration.
MeSH term(s)	Acetylcholine/metabolism ; Administration, Oral ; Animals ; Binding Sites ; Ligands ; Microdialysis ; Molecular Structure ; Piperazines/chemical synthesis ; Piperazines/chemistry ; Piperazines/metabolism ; Rats ; Receptor, Muscarinic M1 ; Receptor, Muscarinic M2 ; Receptors, Muscarinic/metabolism
Chemical Substances	Ligands ; Piperazines ; Receptor, Muscarinic M1 ; Receptor, Muscarinic M2 ; Receptors, Muscarinic ; Acetylcholine (N9YNS0M02X)
Language	English
Publishing date	2002-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/s0960-894x(02)00023-9
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Article: Structural Analysis of a Novel Class of R–M Controller Proteins: C.Csp231I from Citrobacter sp. RFL231

McGeehan, J.E / Streeter, S.D / Thresh, S.-J / Taylor, J.E.N / Shevtsov, M.B / Kneale, G.G

Journal of molecular biology. 2011 June 3, v. 409, no. 2

2011

Abstract: ... restriction–modification (R–M) systems and are important mediators of horizontal gene transfer. They form ... repression of R–M genes. Here we present biophysical, biochemical, and high-resolution structural analysis ...

Abstract	Controller proteins play a key role in the temporal regulation of gene expression in bacterial restriction–modification (R–M) systems and are important mediators of horizontal gene transfer. They form the basis of a highly cooperative, concentration-dependent genetic switch involved in both activation and repression of R–M genes. Here we present biophysical, biochemical, and high-resolution structural analysis of a novel class of controller proteins, exemplified by C.Csp231I. In contrast to all previously solved C-protein structures, each protein subunit has two extra helices at the C-terminus, which play a large part in maintaining the dimer interface. The DNA binding site of the protein is also novel, having largely AAAA tracts between the palindromic recognition half-sites, suggesting tight bending of the DNA. The protein structure shows an unusual positively charged surface that could form the basis for wrapping the DNA completely around the C-protein dimer.
Keywords	Citrobacter ; DNA ; binding sites ; gene expression regulation ; genes ; horizontal gene transfer ; protein subunits ; proteins
Language	English
Dates of publication	2011-0603
Size	p. 177-188.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	80229-3
ISSN	1089-8638 ; 0022-2836
ISSN (online)	1089-8638
ISSN	0022-2836
DOI	10.1016/j.jmb.2011.03.033
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Article: G. R. Girdlestone, M.D., F.R.C.S.

Taylor, R G

Clinical orthopaedics and related research

1983 , Issue 173, Page(s) 125–129

MeSH term(s)	England ; History, 19th Century ; History, 20th Century ; Orthopedics/history
Language	English
Publishing date	1983-03
Publishing country	United States
Document type	Biography ; Historical Article ; Journal Article ; Portrait
ZDB-ID	80301-7
ISSN	1528-1132 ; 0009-921X
ISSN (online)	1528-1132
ISSN	0009-921X
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Article: Alternative syntheses and related n.m.r. studies of precursors for internal beta-D-galactopyranosyl residues in oligosaccharides, allowing chain extension at O-4.

Kovác, P / Taylor, R B

Carbohydrate research

1987 Volume 167, Page(s) 153–173

Abstract: ... m.r. experiments. The sites of glycosidic linkages in orthoesters were directly determined by 1 D ... INAPT n.m.r. experiments. Characteristic features of the 1H- and 13C-n.m.r. spectra of orthoesters ...

Abstract	Crystalline 2,3,6-tri-O-benzoyl-4-O-(bromoacetyl)-alpha-D-galactopyranosyl chloride (5) was prepared from methyl 2,3,6-tri-O-benzoyl-4-O-(bromoacetyl)-alpha- or -beta-D-galactopyranoside by cleavage with dichloromethyl methyl ether (DCMME) in the presence of zinc chloride. Silver trifluoromethanesulfonate (triflate) condensation of 5 with methyl 2,3,6-tri-O-benzoyl-beta-D-galactopyranoside gave the corresponding beta-linked disaccharide, which was O-de(bromoacetyl)ated and the resulting disaccharide nucleophile condensed with 5. The beta-linked trisaccharide obtained was deprotected, to give the methyl beta-glycoside of (1----4)-beta-linked D-galactotriose. Compound 5 was converted in high yield into the corresponding 1-O-beta-acetyl derivative, which was O-de(bromoacetyl)ated with thiourea to afford crystalline 1-O-acetyl-2,3,6-tri-O-benzoyl-beta-D-galactopyranose (9). Condensation of 9 with 5 yielded O-[2,3,6-tri-O-benzoyl-4-O-(bromoacetyl)-beta-D- galactopyranosyl]-(1----4)-1-O-acetyl-2,3,6-tri-O-benzoyl-beta-D- galactopyranose (17), which was cleaved with DCMME to give the corresponding glycosyl chloride (20). The same sequence of reactions involving 1,2,3,6-tetra-O-benzoyl-alpha-D-galactopyranose and 2,3,4,6-tetra-O-benzoyl-alpha-D-galactopyranosyl bromide afforded O-(2,3,4,6-tetra-O-benzoyl-beta-D-galactopyranosyl)-(1----4)-2,3,6-tri-O - benzoyl-alpha-D-galactopyranosyl chloride, which can be used to construct in an oligosaccharide the terminal, beta-linked (1----4)-beta-D-galactobiosyl group. Compounds 5, 17, and 20, when used as glycosyl donors, allow further chain extension at O-4 of the (terminal) beta-D-galactopyranosyl group. The structures of all mono- and di-saccharide intermediates, including those of orthoesters formed during glycosylations under neutral conditions, were confirmed by combination of homo- and hetero-nuclear-correlation n.m.r. experiments. The sites of glycosidic linkages in orthoesters were directly determined by 1 D INAPT n.m.r. experiments. Characteristic features of the 1H- and 13C-n.m.r. spectra of orthoesters which distinguish them from the corresponding oligosaccharides have been summarized.
MeSH term(s)	Carbohydrate Conformation ; Galactose ; Indicators and Reagents ; Isomerism ; Magnetic Resonance Spectroscopy/methods ; Oligosaccharides/chemical synthesis ; Structure-Activity Relationship
Chemical Substances	Indicators and Reagents ; Oligosaccharides ; Galactose (X2RN3Q8DNE)
Language	English
Publishing date	1987-09-15
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1435-7
ISSN	1873-426X ; 0008-6215
ISSN (online)	1873-426X
ISSN	0008-6215
DOI	10.1016/0008-6215(87)80276-8
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Article: N.m.r. characterization of trehalulose from the excrement of the sweet potato whitefly, Bemisia tabaci

Bates, R.B / Byrne, D.N / Kane, V.V / Miller, W.B / Taylor, S.R

Carbohydrate research. July 1, 1990. v. 201 (2)

1990

Keywords	Bemisia tabaci ; trehalose ; excreta ; honeydew ; separation ; spectral analysis ; nuclear magnetic resonance spectroscopy ; Euphorbia pulcherrima
Language	English
Dates of publication	1990-0701
Size	p. 342-345.
Document type	Article
ZDB-ID	1435-7
ISSN	1873-426X ; 0008-6215
ISSN (online)	1873-426X
ISSN	0008-6215
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Book: Gluten-free ancient grains

Awika, Joseph M. / Taylor, John R. N.

cereals, pseudocereals and legumes: sustainable, nutritious, and health-promoting foods for the 21st century

(Woodhead Publishing series in food science, technology and nutrition)

2017

Author's details	edited by John R. N. Taylor, Joseph M. Awika
Series title	Woodhead Publishing series in food science, technology and nutrition
Language	English
Size	xiv, 342 Seiten, Illustrationen
Publisher	Woodhead
Publishing place	Duxford ; Cambridge ; Kidlington
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT019394210
ISBN	978-0-08-100866-9 ; 9780081008911 ; 0-08-100866-X ; 0081008910
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

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