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Article ; Online: Facile synthesis of CuO/g-C

Suresh, R / Karthikeyan, N S / Gnanasekaran, Lalitha / Rajendran, Saravanan / Soto-Moscoso, Matias

2023 Volume 315, Page(s) 137711

Abstract: The cupric oxide (CuO) loaded graphitic carbon nitride (g-C ...

Abstract	The cupric oxide (CuO) loaded graphitic carbon nitride (g-C
MeSH term(s)	Light ; Copper ; Spectroscopy, Fourier Transform Infrared
Chemical Substances	cupric oxide (V1XJQ704R4) ; Copper (789U1901C5) ; methyl orange (6B4TC34456)
Language	English
Publishing date	2023-01-03
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2022.137711
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Article: Microwave Synthesis of Visible-Light-Activated g-C

Matias, Maria Leonor / Reis-Machado, Ana S / Rodrigues, Joana / Calmeiro, Tomás / Deuermeier, Jonas / Pimentel, Ana / Fortunato, Elvira / Martins, Rodrigo / Nunes, Daniela

Nanomaterials (Basel, Switzerland)

2023 Volume 13, Issue 6

Abstract: ... characterization of graphitic carbon nitride/titanium dioxide (g-C ...

Abstract	The preparation of visible-light-driven photocatalysts has become highly appealing for environmental remediation through simple, fast and green chemical methods. The current study reports the synthesis and characterization of graphitic carbon nitride/titanium dioxide (g-C
Language	English
Publishing date	2023-03-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano13061090
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Article ; Online: Low peripheral blood chemokine (C-C motif) ligand 5 and tumor necrosis factor α gene expression is associated with unfavorable progression of respiratory syncytial virus bronchiolitis in infants.

Pita-Martínez, Carlos / Goez-Sanz, Carmen / Virseda-Berdices, Ana / Gonzalez-Praetorius, Alejandro / Mazario-Martín, Esther / Rodriguez-Mesa, María / Amigot-Sánchez, Rafael / Matías, Vanesa / Resino, Salvador / Martínez, Isidoro

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2023 Volume 138, Page(s) 97–101

Abstract: ... chemokine (C-C motif) ligand (CCL5) gene expression at baseline were inversely associated with unfavorable ...

Abstract	Objectives: We aimed to analyze whether the expression of inflammatory and antiviral genes in respiratory syncytial virus (RSV)-infected infants' peripheral blood is associated with bronchiolitis progression. Methods: We conducted a prospective study on 117 infants between 2015 and 2023. The expression levels of nine genes were quantified by quantitative polymerase chain reaction. Infants were classified according to their clinical evolution during hospital admission: (i) non-progression (n = 74), when the RSV bronchiolitis severity remained stable or improved; (ii) unfavorable progression (n = 43), when the RSV bronchiolitis severity increased. The association analysis was performed by logistic regression, adjusted by age, gender, prematurity, and RSV bronchiolitis severity in the emergency room. Results: Infants were 57.3% male, and the median age of the study population was 61 days. Thirty-five infants (30.7%) were admitted to the intensive care unit after hospital admission. Univariate logistic models showed that tumor necrosis factor (TNFα) and chemokine (C-C motif) ligand (CCL5) gene expression at baseline were inversely associated with unfavorable progression, which was confirmed by multivariate analyses: TNFα (adjusted odds ratio = 0.8 [95% confidence interval = 0.64-0.99], P-value = 0.038) and CCL5 (adjusted odds ratio = 0.76 [95% confidence interval = 0.62-0.93], P-value = 0.007). Conclusions: An inadequate immune response to RSV, characterized by reduced gene expression levels of CCL5 and TNFα in peripheral blood, was associated with an unfavorable progression of RSV bronchiolitis.
MeSH term(s)	Female ; Humans ; Infant ; Male ; Bronchiolitis/genetics ; Bronchiolitis/complications ; Bronchiolitis/metabolism ; Chemokines ; Gene Expression ; Ligands ; Prospective Studies ; Respiratory Syncytial Virus Infections/genetics ; Respiratory Syncytial Virus, Human/genetics ; Tumor Necrosis Factor-alpha/genetics
Chemical Substances	Chemokines ; Ligands ; Tumor Necrosis Factor-alpha ; CCL5 protein, human ; TNF protein, human
Language	English
Publishing date	2023-11-24
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2023.11.024
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Article ; Online: The m.9143T>C Variant

Diana Lehmann Urban / Leila Motlagh Scholle / Matias Wagner / Albert C. Ludolph / Angela Rosenbohm

Diseases, Vol 8, Iss 19, p

Recurrent Infections and Immunodeficiency as an Extension of the Phenotypic Spectrum in MT-ATP6 Mutations?

2020 Volume 19

Abstract: ... Single-exome sequencing revealed a variant in the MT-ATP6 gene: m.9143T>C. Analysis of further specimen ...

Abstract	Pathogenic variants in the MT-ATP6 are a well-known cause for maternally inherited mitochondrial disorders associated with a wide range of clinical phenotypes. Here, we present a 31- year old female with insulin-dependent diabetes mellitus, recurrent lactic acidosis and ketoacidosis recurrent infections with suspected immunodeficiency with T cell lymphopenia and hypogammaglobulinemia as well as proximal tetraparesis with severe muscle and limb pain and rapid physical exhaustion. Muscle biopsy and respiratory chain activities were normal. Single-exome sequencing revealed a variant in the MT-ATP6 gene: m.9143T>C. Analysis of further specimen of the index and mother (segregation studies) revealed the highest mutation load in muscle (99% level of mtDNA heteroplasmy) of the index patient. Interestingly, acute metabolic and physical decompensation during recurrent illness was documented to be a common clinical feature in patients with MT-ATP6 variants. However, it was not mentioned as a key symptom. Thus, we suggest that the clinical spectrum might be expanded in ATP6 -associated diseases.
Keywords	MT-ATP6 ; mitochondrial disease ; immune deficiency ; phenotypic spectrum ; Medicine ; R
Subject code	610
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Does prone positioning decrease mechanical power in C-ARDS?

Accoce, Matías / Dorado, Javier Hernan / Cardoso, Gimena Paola / Bertozzi, Matías Nicolas / Gilgado, Daniela Ines / Pérez, Joaquín

Medicina intensiva

2023

Language	English
Publishing date	2023-09-27
Publishing country	Spain
Document type	Case Reports
ISSN	2173-5727
ISSN (online)	2173-5727
DOI	10.1016/j.medine.2023.07.015
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Article ; Online: Assessment of the Long-Range NMR C,H Coupling of a Series of Carbazolequinone Derivatives.

Monroy-Cárdenas, Matías / Gavín, José A / Araya-Maturana, Ramiro

International journal of molecular sciences

2023 Volume 24, Issue 24

Abstract: Synthesis, the ... ...

Abstract	Synthesis, the complete
MeSH term(s)	Protons ; Magnetic Resonance Spectroscopy ; Carbon/chemistry ; Hydrogen/chemistry ; Magnetic Resonance Imaging
Chemical Substances	Protons ; Carbon (7440-44-0) ; Hydrogen (7YNJ3PO35Z)
Language	English
Publishing date	2023-12-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242417450
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Article ; Online: The Lambda Variant in Argentina: Analyzing the Evolution and Spread of SARS-CoV-2 Lineage C.37.

Nabaes Jodar, Mercedes Soledad / Torres, Carolina / Mojsiejczuk, Laura / Acuña, Dolores / Valinotto, Laura Elena / Goya, Stephanie / Natale, Monica / Lusso, Silvina / Alexay, Sofia / Amadio, Ariel / Irazoqui, Matias / Fernandez, Franco / Acevedo, Maria Elina / Alvarez Lopez, Cristina / Angelletti, Andres / Aulicino, Paula / Bolatti, Elisa / Brusés, Bettina / Cacciahue, Marco /

Cavatorta, Ana / Cerri, Agustina / Cordero, Andres / Debat, Humberto / Dus Santos, Maria Jose / Eberhardt, Maria Florencia / Ercole, Regina / Espul, Carlos / Farber, Marisa / Fay, Fabián / Fernandez, Ailen / Ferrini, Florencia / Formichelli, Laura / Ceballos, Santiago / Gallego, Fernando / Giri, Adriana / Gismondi, Maria / Acevedo, Raul Maximiliano / Gramundi, Ivan / Ibañez, María Eugenia / Konig, Guido / Leiva, Viviana / Lorenzini Campos, Melina / Lucero, Horacio / Marquez, Nathalie / Mazzeo, Melina / Mistchenko, Alicia Susana / Montoto, Luciana / Muñoz, Marianne / Nadalich, Victoria / Nardi, Cristina / Ortiz, Belén / Pianciola, Luis / Pintos, Carolina / Puebla, Andrea / Rastellini, Carolina / Rojas, Alejandro Ezequiel / Sfalcin, Javier / Suarez, Ariel / Theaux, Clara / Thomas, Guillermo / Tittarelli, Estefania / Toro, Rosana / Villanova, Vanina / Wenk, Gretel / Ziehm, Cecilia / Zimmermann, Maria Carla / Zunino, Sebastian / Pais, Proyecto / Viegas, Mariana

Viruses

2023 Volume 15, Issue 6

Abstract: The second wave of COVID-19 occurred in South America in early 2021 and was mainly driven by Gamma and Lambda variants. In this study, we aimed to describe the emergence and local genomic diversity of the SARS-CoV-2 Lambda variant in Argentina, from its ... ...

Abstract	The second wave of COVID-19 occurred in South America in early 2021 and was mainly driven by Gamma and Lambda variants. In this study, we aimed to describe the emergence and local genomic diversity of the SARS-CoV-2 Lambda variant in Argentina, from its initial entry into the country until its detection ceased. Molecular surveillance was conducted on 9356 samples from Argentina between October 2020 and April 2022, and sequencing, phylogenetic, and phylogeographic analyses were performed. Our findings revealed that the Lambda variant was first detected in Argentina in January 2021 and steadily increased in frequency until it peaked in April 2021, with continued detection throughout the year. Phylodynamic analyses showed that at least 18 introductions of the Lambda variant into the country occurred, with nine of them having evidence of onward local transmission. The spatial--temporal reconstruction showed that Argentine clades were associated with Lambda sequences from Latin America and suggested an initial diversification in the Metropolitan Area of Buenos Aires before spreading to other regions in Argentina. Genetic analyses of genome sequences allowed us to describe the mutational patterns of the Argentine Lambda sequences and detect the emergence of rare mutations in an immunocompromised patient. Our study highlights the importance of genomic surveillance in identifying the introduction and geographical distribution of the SARS-CoV-2 Lambda variant, as well as in monitoring the emergence of mutations that could be involved in the evolutionary leaps that characterize variants of concern.
MeSH term(s)	Humans ; Argentina/epidemiology ; SARS-CoV-2/genetics ; Phylogeny ; COVID-19/epidemiology ; Mutation
Language	English
Publishing date	2023-06-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15061382
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Article ; Online: C-ferroptosis is an iron-dependent form of regulated cell death in cyanobacteria.

Aguilera, Anabella / Berdun, Federico / Bartoli, Carlos / Steelheart, Charlotte / Alegre, Matías / Bayir, Hülya / Tyurina, Yulia Y / Kagan, Valerian E / Salerno, Graciela / Pagnussat, Gabriela / Martin, María Victoria

The Journal of cell biology

2021 Volume 221, Issue 2

Abstract: Ferroptosis is an oxidative and iron-dependent form of regulated cell death (RCD) recently described in eukaryotic organisms like animals, plants, and parasites. Here, we report that a similar process takes place in the photosynthetic prokaryote ... ...

Abstract	Ferroptosis is an oxidative and iron-dependent form of regulated cell death (RCD) recently described in eukaryotic organisms like animals, plants, and parasites. Here, we report that a similar process takes place in the photosynthetic prokaryote Synechocystis sp. PCC 6803 in response to heat stress. After a heat shock, Synechocystis sp. PCC 6803 cells undergo a cell death pathway that can be suppressed by the canonical ferroptosis inhibitors, CPX, vitamin E, Fer-1, liproxstatin-1, glutathione (GSH), or ascorbic acid (AsA). Moreover, as described for eukaryotic ferroptosis, this pathway is characterized by an early depletion of the antioxidants GSH and AsA, and by lipid peroxidation. These results indicate that all of the hallmarks described for eukaryotic ferroptosis are conserved in photosynthetic prokaryotes and suggest that ferroptosis might be an ancient cell death program.
MeSH term(s)	Antioxidants/metabolism ; Ascorbic Acid/metabolism ; Calcium/metabolism ; Caspase 3/metabolism ; Caspase 7/metabolism ; Cyanobacteria/cytology ; Cyanobacteria/metabolism ; Cytosol/metabolism ; Ferroptosis ; Glutathione/metabolism ; Heat-Shock Response ; Iron/metabolism ; Lipidomics ; Lipids/chemistry ; Oxidation-Reduction ; Reactive Oxygen Species/metabolism ; Synechocystis/metabolism ; Thylakoids/metabolism
Chemical Substances	Antioxidants ; Lipids ; Reactive Oxygen Species ; Iron (E1UOL152H7) ; Caspase 3 (EC 3.4.22.-) ; Caspase 7 (EC 3.4.22.-) ; Glutathione (GAN16C9B8O) ; Ascorbic Acid (PQ6CK8PD0R) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-11-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218154-x
ISSN	1540-8140 ; 0021-9525
ISSN (online)	1540-8140
ISSN	0021-9525
DOI	10.1083/jcb.201911005
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Book ; Online: Atomistic simulations of ductile failure in a b.c.c. high entropy alloy

Aquistapace, Franco / Vazquez, Nicolás / Chiarpotti, Matías / Deluigi, Orlando / Ruestes, Carlos J. / Bringa, Eduardo M.

2022

Abstract: Ductile failure is studied in a bcc HfNbTaZr High Entropy Alloy (HEA) with a pre-existing void. Using molecular dynamics simulations of uniaxial tensile tests, we explore the effect of void radius on the elastic modulus and yield stress. The elastic ... ...

Abstract	Ductile failure is studied in a bcc HfNbTaZr High Entropy Alloy (HEA) with a pre-existing void. Using molecular dynamics simulations of uniaxial tensile tests, we explore the effect of void radius on the elastic modulus and yield stress. The elastic modulus scales with porosity as in closed-cell foams. The critical stress for dislocation nucleation as a function of the void radius is very well described by a model designed after pure bcc metals, taking into account a larger core radius for the HEA. Twinning takes place as a complementary deformation mechanism, and some detwinning occurs at large strain. No solid-solid phase transitions are identified. The concurrent effects of element size mismatch and plasticity lead to significant lattice disorder. By comparing our HEA results to pure tantalum simulations, we show that the critical stress for dislocation nucleation and the resulting dislocation densities are much lower than for pure Ta, as expected from lower energy barriers due to chemical complexity Comment: Total: 33 pages. Main article: 25 pages, 10 figures. Supplementary Material: 8 pages, 9 figures
Keywords	Condensed Matter - Materials Science
Subject code	669
Publishing date	2022-07-30
Publishing country	us
Document type	Book ; Online
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Article ; Online: Gene Polymorphisms Increasing the Risk of Intracranial Aneurysms: Interleukin-6 -174G>C and -572G>C (Part II).

Giotta Lucifero, Alice / Baldoncini, Matias / Brambilla, Ilaria / Rutigliano, Monica / Savioli, Gabriele / Galzio, Renato / Campero, Alvaro / Lawton, Michael T / Luzzi, Sabino

Acta bio-medica : Atenei Parmensis

2022 Volume 92, Issue S4, Page(s) e2021420

Abstract: ... the adaptive immune response and regulates inflammatory processes. The -174 G>C and -572 G>C promoter polymorphisms of the IL-6 ... 5.0 software. Results 9 studies were eligible. No associations were found between -174 G>C ... polymorphisms and IAs susceptibility. Notable results were reported by the analysis of -572G>C polymorphisms ...

Abstract	Introduction The interleukin-6 (IL-6), a proinflammatory cytokine, supports the adaptive immune response and regulates inflammatory processes. The -174 G>C and -572 G>C promoter polymorphisms of the IL-6 gene take part in the pathogenesis of intracranial aneurysms (IAs) and influence the clinical presentation of subarachnoid hemorrhage. This meta-analysis purposes to evaluate whether and which IL-6 allelic variations are related to a risk of IAs formation. Methods A PRISMA-based literature search was performed on the PubMed/Medline and Web of Science databases. The keywords used were "interleukin-6," "IL-6," "polymorphism," "interleukin-6 genotype," combined with "intracranial aneurysms" and "subarachnoid hemorrhage." Only human case-control studies, with a study (IAs) and a control group, written in English, and published in the last 15 years were selected. A meta-analysis was performed, estimating odds ratios and 95% confidence intervals in fixed- or random-effects models, as applicable. Statistical analysis was conducted with RevMan 5.0 software. Results 9 studies were eligible. No associations were found between -174 G>C polymorphisms and IAs susceptibility. Notable results were reported by the analysis of -572G>C polymorphisms. -572GG/GC/CC genotypes were strongly related to IAs occurrence with a statistical significance of p=0.03, p=0.0009, and p=0.00001, respectively. Conclusion A higher incidence of -572G>C promoter polymorphisms were demonstrated in the IAs group, highlighting the pivotal role of inflammatory genes in the natural history of brain aneurysms. Additional studies are required considering the racial heterogenicity and the need to widen the population sample.
MeSH term(s)	Genetic Predisposition to Disease ; Humans ; Interleukin-6/genetics ; Intracranial Aneurysm/genetics ; Polymorphism, Genetic ; Subarachnoid Hemorrhage/genetics
Chemical Substances	IL6 protein, human ; Interleukin-6
Language	English
Publishing date	2022-03-21
Publishing country	Italy
Document type	Journal Article ; Meta-Analysis
ZDB-ID	2114240-3
ISSN	2531-6745 ; 0392-4203
ISSN (online)	2531-6745
ISSN	0392-4203
DOI	10.23750/abm.v92iS4.12669
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