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  1. Article ; Online: La possibile sospensione dei Trattati UE in conseguenza dell’inadempimento delle altre parti contraenti e l’inutilizzabilità del MES per far fronte alla pandemia da covid-19

    Maiello, Francesco

    2020  

    Keywords covid19
    Language Italian
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Methodical issues: AIB press releases to support libraries and librarians facing the emergency from Covid-19/ Questioni di metodo: I comunicati AIB a supporto delle biblioteche e dei bibliotecari di fronte all'emergenza da Covid-19

    Ponzani, Vittorio / Maiello, Rosa

    AIB Studi

    Abstract: This paper describes the methodology applied by AIB, during the Covid-19 emergency, to provide information and recommendations in support of libraries and librarians. We focus in particular on the AIB recommended solutions to react to two different ... ...

    Abstract This paper describes the methodology applied by AIB, during the Covid-19 emergency, to provide information and recommendations in support of libraries and librarians. We focus in particular on the AIB recommended solutions to react to two different emergencies, one related to the public health, and the other to the employment in our sector-which weigh on the prospects of our sector. While the first one is of a contingent nature, but requires expensive solutions even in the medium term, the second one is structural.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #706718
    Database COVID19

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  3. Article ; Online: Un’ idea di biblioteca, un’idea di professione

    Rosa Maiello

    AIB Studi, Vol 61, Iss

    2022  Volume 3

    Abstract: Prendendo spunto dalla carriera di Giovanni Solimine e dal suo decisivo contributo al mondo ... della cultura, alla comunità biblioteconomica e a quella bibliotecaria, l’articolo riflette sull’importanza e ... sulla necessità di uno scambio continuo e sistematico tra il mondo scientifico e quello professionale, tanto per l ...

    Abstract Prendendo spunto dalla carriera di Giovanni Solimine e dal suo decisivo contributo al mondo della cultura, alla comunità biblioteconomica e a quella bibliotecaria, l’articolo riflette sull’importanza e sulla necessità di uno scambio continuo e sistematico tra il mondo scientifico e quello professionale, tanto per l’avanzamento degli studi, quanto per lo sviluppo di un servizio bibliotecario qualificato, per la crescita dei livelli occupazionali nel settore e per la diffusione della consapevolezza del ruolo che le biblioteche rivestono nella crescita e nel miglioramento della società.
    Keywords ruolo delle biblioteche ; formazione LIS ; professione ; Bibliography. Library science. Information resources ; Z
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Associazione italiana biblioteche
    Document type Article ; Online
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  4. Article ; Online: Despite Impaired Binocular Function, Binocular Disparity Integration Across the Visual Field Is Spared in Normal Aging and Glaucoma.

    Maiello, Guido / Kwon, MiYoung

    Investigative ophthalmology & visual science

    2023  Volume 64, Issue 5, Page(s) 2

    Abstract: ... varied across spatial frequencies and visual field sectors (i.e., with full-field stimuli spanning ...

    Abstract Purpose: To examine how binocularly asymmetric glaucomatous visual field damage affects binocular disparity processing across the visual field.
    Methods: We recruited 18 patients with primary open-angle glaucoma, 16 age-matched controls, and 13 young controls. Participants underwent standard clinical assessments of binocular visual acuity, binocular contrast sensitivity, stereoacuity, and perimetry. We employed a previously validated psychophysical procedure to measure how sensitivity to binocular disparity varied across spatial frequencies and visual field sectors (i.e., with full-field stimuli spanning the central 21° of the visual field and with stimuli restricted to annular regions spanning 0°-3°, 3°-9°, or 9°-21°). We employed measurements with annular stimuli to model different possible scenarios regarding how disparity information is combined across visual field sectors. We adjudicated between potential mechanisms by comparing model predictions to the patterns observed with full-field stimuli.
    Results: Perimetry confirmed that patients with glaucoma exhibited binocularly asymmetric visual field damage (P < 0.001). Across participant groups, foveal regions preferentially processed disparities at finer spatial scales, whereas periphery regions were tuned for coarser scales (P < 0.001). Disparity sensitivity also decreased from fovea to periphery (P < 0.001) and across participant groups (Ps < 0.01). Finally, similar to controls, patients with glaucoma exhibited near-optimal disparity integration, specifically at low spatial frequencies (P < 0.001).
    Conclusions: Contrary to the conventional view that glaucoma spares central vision, we find that glaucomatous damage causes a widespread loss of disparity sensitivity across both foveal and peripheral regions. Despite these losses, cortical integration mechanisms appear to be well preserved, suggesting that patients with glaucoma make the best possible use of their remaining binocular function.
    MeSH term(s) Humans ; Visual Fields ; Vision Disparity ; Glaucoma, Open-Angle ; Glaucoma ; Visual Field Tests ; Aging ; Vision, Binocular
    Language English
    Publishing date 2023-05-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 391794-0
    ISSN 1552-5783 ; 0146-0404
    ISSN (online) 1552-5783
    ISSN 0146-0404
    DOI 10.1167/iovs.64.5.2
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  5. Article: I meccanismi di difesa come misura dell'outcome in psicoterapia breve in relazione ai sintomi, alla gravità clinica e al funzionamento globale: uno studio preliminare.

    Coccanari de' Fornari, Maria Antonietta / Piccione, Michele / Maiello, Luca / Giampà, Alessio

    Rivista di psichiatria

    2011  Volume 46, Issue 1, Page(s) 44–56

    Abstract: Unlabelled: The assessment of defense mechanisms in psychotherapy is currently one of the most used ways to evaluate the effectiveness of psychotherapy. In literature there are few reports on defense mechanisms changes by short-term treatments.: Aim: ...

    Title translation Defense mechanisms as outcome measure in short-term psychotherapy related to symptoms, severity and overall functioning: a preliminary study.
    Abstract Unlabelled: The assessment of defense mechanisms in psychotherapy is currently one of the most used ways to evaluate the effectiveness of psychotherapy. In literature there are few reports on defense mechanisms changes by short-term treatments.
    Aim: To determine whether the defense mechanisms are changed after twelve sessions of short-term psychotherapy related to psychopathological symptoms, severity and overall functioning.
    Methods: Twenty patients (12 F and 8 M; age 38.4) affected by anxiety and mood disorders were recruited to the study between November 2008 and July 2009 and were assessed with the Defense Style Questionnaire-88 (DSQ-88), scale Symptom Checklist-90-Revised (SCL-90-R), scale Clinical Global Impression (CGI) and scale Valutazione Globale del Funzionamento (VGF) at the beginning and after short-term psychotherapy. Half the sample also assumed drugs. The treatment was supportive-expressive psychotherapy of Luborsky, a short focal dynamic therapy, characterized by the integration of supportive and expressive techniques.
    Results: Both patients showed a significant decrease in immature defenses and a significant-increase in mature defenses (p < 0.01). Mature defenses were significantly correlated with severity (r = -0632; p = 0.003) and overall functioning (r = 0529; p = 0.01).
    Discussion: Immature and mature defenses seem to be a useful outcome measure in short-term psychotherapy as well as severity and overall functioning and the combined treatment may be most effective in reducing immature defenses.
    MeSH term(s) Adult ; Aged ; Defense Mechanisms ; Female ; Humans ; Male ; Mental Disorders/psychology ; Mental Disorders/therapy ; Middle Aged ; Psychotherapy ; Severity of Illness Index ; Young Adult
    Language Italian
    Publishing date 2011-01
    Publishing country Italy
    Document type English Abstract ; Journal Article
    ZDB-ID 205570-3
    ISSN 0035-6484
    ISSN 0035-6484
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  6. Article: Olaparib and advanced ovarian cancer: Summary of the past and looking into the future.

    Maiorano, Brigida Anna / Maiorano, Mauro Francesco Pio / Maiello, Evaristo

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1162665

    Abstract: Ovarian cancer (OC) is women's eighth most common cancer, bearing the highest mortality rates of all female reproductive system malignancies. Poly (ADP-ribose) polymerase inhibitors (PARPis) have reshaped the treatment scenario of metastatic OC as a ... ...

    Abstract Ovarian cancer (OC) is women's eighth most common cancer, bearing the highest mortality rates of all female reproductive system malignancies. Poly (ADP-ribose) polymerase inhibitors (PARPis) have reshaped the treatment scenario of metastatic OC as a maintenance post platinum-based chemotherapy. Olaparib is the first PARPi developed for this disease. Results from Study 42, Study 19, SOLO2, OPINION, SOLO1, and PAOLA-1 clinical trials, led to the FDA and EMA approval of olaparib for the maintenance treatment of women with high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer without platinum progression: in the platinum-sensitive recurrent OC; in the newly diagnosed setting in case Breast Cancer (BRCA) mutations and, in combination with bevacizumab, in case of BRCA mutation or deficiency of homologous recombination genes. In this review, we synthetized olaparib's pharmacokinetic and pharmacodynamic properties and its use in special populations. We summarized the efficacy and safety of the studies leading to the current approvals and discussed the future developments of this agent.
    Language English
    Publishing date 2023-04-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1162665
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  7. Article: Enfortumab vedotin in metastatic urothelial carcinoma: the solution EVentually?

    Maiorano, Brigida Anna / Catalano, Martina / Maiello, Evaristo / Roviello, Giandomenico

    Frontiers in oncology

    2023  Volume 13, Page(s) 1254906

    Abstract: ... This protein is highly expressed in UC cells. After binding, monomethyl auristatin E is released into cells ...

    Abstract Metastatic urothelial carcinoma (mUC) is an aggressive malignancy with a dismal prognosis. Enfortumab vedotin (EV) is an antibody-drug conjugate consisting of an antibody targeting Nectin-4. This protein is highly expressed in UC cells. After binding, monomethyl auristatin E is released into cells, causing UC cell death. EV has been approved as a single agent for pre-treated mUC, with interesting improvements in response rate and survival in a setting with limited treatment options. More recently, EV approval occurred in cisplatin-ineligible naïve mUC patients in combination with pembrolizumab. Our review aims to summarize the pharmacological properties, clinical studies, and future developments of EV in mUC.
    Language English
    Publishing date 2023-09-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1254906
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  8. Article ; Online: Immune checkpoint inhibitors plus chemotherapy in first-line endometrial cancer treatment: Still the era of microsatellites?

    Maiorano, Mauro Francesco Pio / Messina, Carlo / Maiello, Evaristo / Cormio, Gennaro / Maiorano, Brigida Anna

    BJOG : an international journal of obstetrics and gynaecology

    2024  

    Abstract: Objective: The combination of immune checkpoint inhibitors (ICIs) plus chemotherapy is currently being tested as the first-line treatment of advanced endometrial. We aimed to evaluate the efficacy and safety of this combination.: Design: We performed ...

    Abstract Objective: The combination of immune checkpoint inhibitors (ICIs) plus chemotherapy is currently being tested as the first-line treatment of advanced endometrial. We aimed to evaluate the efficacy and safety of this combination.
    Design: We performed a meta-analysis of randomized clinical trials.
    Population and setting: Patients with advanced endometrial carcinoma receiving ICIs plus chemotherapy in the experimental arm, compared with chemotherapy plus placebo in the control arm, were included.
    Methods and outcomes: We evaluated the progression-free survival (PFS) as an efficacy outcome and the number and grades of adverse events (AEs) for safety. Hazard ratios (HR) for PFS and risk ratios (RR) for AEs, with 95% confidence intervals (CI), were calculated.
    Results: 1303 patients were treated in the included studies. Adding ICIs to chemotherapy significantly improved PFS in mismatch repair deficient (dMMR-HR 0.29; 95% CI, 0.20-0.42; p < 0.00001) and in mismatch repair proficient (pMMR-HR 0.64; 95% CI, 0.46-0.90; p = 0.01) patients. No difference emerged for all-grades AEs (RR 1.00; p = 0.98), but the risk of ≥G3 AEs was increased in the ICIs + chemotherapy group (RR 1.22; 95% CI, 1.11-1.34; p < 0.0001).
    Conclusions: Adding ICIs to chemotherapy significantly improves PFS in first-line endometrial cancer, regardless of MMR status.
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2000931-8
    ISSN 1471-0528 ; 0306-5456 ; 1470-0328
    ISSN (online) 1471-0528
    ISSN 0306-5456 ; 1470-0328
    DOI 10.1111/1471-0528.17749
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  9. Article ; Online: Significance of PD-L1 in Metastatic Urothelial Carcinoma Treated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis.

    Maiorano, Brigida Anna / Di Maio, Massimo / Cerbone, Linda / Maiello, Evaristo / Procopio, Giuseppe / Roviello, Giandomenico

    JAMA network open

    2024  Volume 7, Issue 3, Page(s) e241215

    Abstract: Importance: Immune checkpoint inhibitors (ICIs) have broadened the metastatic urothelial carcinoma (mUC) therapeutic scenario. The association of programmed death ligand 1 (PD-L1) with response and survival in patients treated with ICIs is still ... ...

    Abstract Importance: Immune checkpoint inhibitors (ICIs) have broadened the metastatic urothelial carcinoma (mUC) therapeutic scenario. The association of programmed death ligand 1 (PD-L1) with response and survival in patients treated with ICIs is still controversial.
    Objectives: To evaluate the association of PD-L1 with response rate and overall survival among patients with mUC treated with ICIs.
    Data sources: PubMed, Embase, American Society of Clinical Oncology and European Society for Medical Oncology Meeting Libraries, and Web of Science were searched up to December 10, 2023.
    Study selection: Two authors independently screened the studies. Included studies were randomized and nonrandomized clinical trials enrolling patients with mUC receiving ICIs with available overall survival (OS), progression-free survival (PFS), or overall response rate (ORR) data, separated between patients with PD-L1-positive and -negative tumors.
    Data extraction and synthesis: The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline was followed. Two reviewers independently extracted data. Fixed- or random-effects models were used depending on the heterogeneity among the studies.
    Main outcomes and measures: Primary outcomes were odds ratios (ORs) for ORR and hazard ratios (HRs) for OS, comparing patients with PD-L1-positive tumors and patients with PD-L1-negative tumors. Secondary outcomes were the PFS HR between patients with PD-L1-positive and -negative tumors and OS HR between ICI arms and non-ICI arms of only randomized clinical trials.
    Results: A total of 14 studies were selected, comprising 5271 patients treated with ICIs (2625 patients had PD-L1-positive tumors). The ORR was 13.8% to 78.6% in patients with PD-L1-positive tumors and 5.1% to 63.2% in patients with PD-L1-negative tumors, with an association between PD-L1 status and ORR favoring patients with PD-L1-positive tumors (OR, 1.94; 95% CI, 1.47-2.56; P < .001). Median OS ranged from 8.4 to 24.1 months in patients with PD-L1-positive tumors and from 6.0 to 19.1 months in patients with PD-L1-negative tumors. The pooled HR showed a significant reduction for patients with PD-L1-positive tumors compared with those with PD-L1-negative tumors in the risk of death (HR, 0.71; 95% CI, 0.57-0.89; P = .003) and risk of progression (HR, 0.55; 95% CI, 0.44-0.69; P < .001) when ICIs were administered. PD-L1 is not likely to be a predictive biomarker of ICI response.
    Conclusions and relevance: This systematic review and meta-analysis suggests that PD-L1 expression is associated with improved ORR, OS, and PFS for patients with mUC who receive ICIs, but it is unlikely to be useful as a predictive biomarker. Developing predictive biomarkers is essential to select patients most likely to benefit from ICIs and avoid toxic effects and financial burden with these agents.
    MeSH term(s) Humans ; B7-H1 Antigen ; Immune Checkpoint Inhibitors/therapeutic use ; Carcinoma, Transitional Cell/drug therapy ; Urinary Bladder Neoplasms/drug therapy ; Biomarkers ; Randomized Controlled Trials as Topic
    Chemical Substances B7-H1 Antigen ; Immune Checkpoint Inhibitors ; Biomarkers
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2024.1215
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  10. Article: Il leiomiosarcoma del tenue e del colon-retto. Contributo casistico.

    Ammaturo, C / Morra, C / D'Eliso, E / Giardiello, C / Vecchio, G / De Gregorio, A / Maiello, F M / Trinchese, G

    Minerva chirurgica

    1996  Volume 51, Issue 9, Page(s) 645–651

    Abstract: Smooth muscle tumors of the alimentary tract are uncommon. A retrospective study was made of 7 patients treated for leiomyosarcoma of the small and large bowel to identify prognostic factors that influence results. The symptoms associated with these ... ...

    Title translation Leiomyosarcoma of the small intestine and the colorectum. A case contribution.
    Abstract Smooth muscle tumors of the alimentary tract are uncommon. A retrospective study was made of 7 patients treated for leiomyosarcoma of the small and large bowel to identify prognostic factors that influence results. The symptoms associated with these tumors varied according to the anatomic sites of the lesions and the position of the growth in relation to the intestinal lumen but the most common presenting clinical signs are bleeding or obstruction. The differential diagnosis between benign and malignant smooth muscle tumors is sometimes quite difficult. Clinical behavior of the myosarcomas of the gastrointestinal tract can be predicted to a large extent by the site of the tumor, the presence or absence of invasion of adjacent vital organs, and the histopathologic grade of malignancy. Although the mitotic activity of a gastrointestinal stromal tumor remains the most critical prognostic factor, tumors have been seen to recur locally and to metastasize even with rare or absent mitotic figures. Further studies are needed to pinpoint the factors that may be correlated to the prognosis.
    MeSH term(s) Adult ; Aged ; Female ; Humans ; Intestinal Neoplasms/pathology ; Intestinal Neoplasms/surgery ; Leiomyosarcoma/pathology ; Leiomyosarcoma/surgery ; Male ; Middle Aged ; Retrospective Studies
    Language Italian
    Publishing date 1996-09
    Publishing country Italy
    Document type English Abstract ; Journal Article
    ZDB-ID 123603-9
    ISSN 1827-1626 ; 0026-4733
    ISSN (online) 1827-1626
    ISSN 0026-4733
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