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  1. Article ; Online: Who uses connected health technologies after a cancer diagnosis? evidence from the US Health Information National Trends Survey.

    Gitonga, Isaiah / Desmond, Deirdre / Maguire, Rebecca

    Journal of cancer survivorship : research and practice

    2024  

    Abstract: Purpose: As the number of people living with and beyond cancer increases, connected health technologies offer promise to enhance access to care and support, while reducing costs. However, uptake of connected health technologies may vary depending on ... ...

    Abstract Purpose: As the number of people living with and beyond cancer increases, connected health technologies offer promise to enhance access to care and support, while reducing costs. However, uptake of connected health technologies may vary depending on sociodemographic and health-related variables. This study aimed to investigate demographic and health predictors of connected health technology use among people living with and beyond cancer.
    Methods: Cross-sectional data from the US Health Information National Trends Survey Version 5 Cycle 4 (H5c4) was used. Regression analysis was used to examine associations between sociodemographic factors and the use of connected health technologies. The sample was restricted to individuals who self-reported a cancer diagnosis or history of cancer.
    Results: In this cycle, 626 respondents self-reported a cancer diagnosis, with 41.1% using connected health technologies (health and wellness apps and/or wearable devices). Most were female (58.9%) and white (82.5%); 43.4% had graduated college or higher education. One third (33.6%) had a household income of $75,000 or more. Respondents who were younger, have higher education, were living as married, had higher incomes, had higher self-rated health and had higher health-related self-efficacy were significantly more likely to use connected health technologies. There were no significant associations between gender, race, stratum, time since diagnosis, history of anxiety or depression, and use of connected health technologies among people living with and beyond cancer.
    Conclusions: Connected health technology use among people living with and beyond cancer is associated with sociodemographic factors. Future research should examine these demographic disparities as the use of connected health technologies in healthcare continues to gather momentum.
    Implications for cancer survivors: The study underscores a disparity in connected heath technology usage among people living with and beyond cancer. There is a pressing need for research into adoption barriers and interventions to ensure equitable digital healthcare integration among this population, especially with the heightened adoption of technology post COVID-19 pandemic.
    Language English
    Publishing date 2024-05-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2388888-X
    ISSN 1932-2267 ; 1932-2259
    ISSN (online) 1932-2267
    ISSN 1932-2259
    DOI 10.1007/s11764-024-01615-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Experiences of Sentencing and the Pains of Punishment: Prisoners' Perspectives.

    Atkins, Deirdre / Maguire, Niamh / Cleere, Geraldine

    International journal of offender therapy and comparative criminology

    2023  , Page(s) 306624X221148127

    Abstract: Although sentencing is often described as a human process, the subjective experiences of those subject to sentencing are seldom discussed or highlighted as an important source of guidance for how sentencing might be made more fair, consistent, or ... ...

    Abstract Although sentencing is often described as a human process, the subjective experiences of those subject to sentencing are seldom discussed or highlighted as an important source of guidance for how sentencing might be made more fair, consistent, or proportionate. Tyler's work on the links between experiences of procedural justice and perceptions of legitimacy in the criminal justice system show that how people are treated during sentencing and/or when serving their sentence matters in that it impacts their long-term compliance with the law. However, we suggest here that it may not only be long-term compliance that is impacted; subjective experiences of imprisonment, in terms of the pains of imprisonment, may also be exacerbated for those whose experiences of the sentencing process are predominantly negative. This article draws on 37 in-depth interviews with Irish prisoners that explored their subjective experiences of their own sentencing in court and how this related to their subjective experiences of their prison sentences. Those who felt they had received unreasonably harsh or unfair sentences, or who felt they were effectively excluded from the sentencing process, were more likely to experience specific pains and increased salience of punishment. The article concludes by arguing that these findings have a role to play in educating sentencers about how their treatment of convicted persons during sentencing can have meaningful, long-term consequences on the subjective experiences of those serving prison sentences.
    Language English
    Publishing date 2023-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218274-9
    ISSN 1552-6933 ; 0306-624X
    ISSN (online) 1552-6933
    ISSN 0306-624X
    DOI 10.1177/0306624X221148127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Refractory paraneoplastic hypercalcaemia responding to cinacalcet.

    Shah, Preet Mukesh / Rasool, Irum / Maguire, Deirdre

    BMJ case reports

    2022  Volume 15, Issue 11

    Abstract: A woman in her late 70s presented with an increased frequency of micturition, suprapubic pain and weight loss. She was found to be having advanced cancer of the urinary bladder, coupled with bilateral hydronephrosis.Whilst undergoing surgical ... ...

    Abstract A woman in her late 70s presented with an increased frequency of micturition, suprapubic pain and weight loss. She was found to be having advanced cancer of the urinary bladder, coupled with bilateral hydronephrosis.Whilst undergoing surgical intervention for the latter, she was incidentally found to be having hypercalcaemia. This was found to be paraneoplastic in nature, possibly due to elevated parathyroid hormone related peptide with no evidence of bone metastasis. The histology of the resected tumour revealed squamous and sarcomatoid differentiation. Her hypercalcaemia initially responded to intravenous fluids, and later on zolendronate,but the problem recurred again, with the response to a repeat dose of zolendronate and even denosumab being unsatisfactory. As a last resort cinacalcet was started, and although there was a good response to it, our patient sadly died a few weeks later.We believe our case to be the first case of hypercalcaemia associated with isolated bladder cancer which showed a successful response to cinacalcet.
    MeSH term(s) Female ; Humans ; Cinacalcet/therapeutic use ; Hypercalcemia/drug therapy ; Hypercalcemia/etiology ; Neoplasm Recurrence, Local/drug therapy ; Bone Neoplasms/secondary ; Urinary Bladder Neoplasms/complications ; Urinary Bladder Neoplasms/drug therapy ; Parathyroid Hormone/therapeutic use
    Chemical Substances Cinacalcet (UAZ6V7728S) ; Parathyroid Hormone
    Language English
    Publishing date 2022-11-15
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-250576
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact of connected health interventions on psychological wellbeing and quality of life in patients with cancer: A systematic review and meta-analysis.

    Gitonga, Isaiah / Desmond, Deirdre / Duda, Natalia / Maguire, Rebecca

    Psycho-oncology

    2022  Volume 31, Issue 10, Page(s) 1621–1636

    Abstract: Objective: Connected health technologies have the potential to improve access to cancer care and support and reduce costs. We aimed to assess the impacts of interventions delivered using connected health technologies on psychological and quality of life ...

    Abstract Objective: Connected health technologies have the potential to improve access to cancer care and support and reduce costs. We aimed to assess the impacts of interventions delivered using connected health technologies on psychological and quality of life (QoL) outcomes in people living with and beyond cancer.
    Methods: PUBMED, PsycINFO, Web of Science, and EMBASE were searched using terms relating to (i) cancer, (ii) connected health, and (iii) QoL/psychological wellbeing. Studies were included if they evaluated interventions using connected health technologies and assessed psychological and/or QoL outcomes for adults at any stage of cancer treatment or survivorship.
    Results: Thirty-seven studies met the inclusion criteria with a total of 8956 participants. Connected health technologies included web-based applications (n = 24), smart applications (n = 12), and wearable devices (n = 1). Studies were heterogeneous in terms of intervention components. We identified five clusters: (i) Psychosocial support and rehabilitation, (ii) psychoeducation and information support, (iii) symptom monitoring, reporting and self-management, (iv) peer and social support, and (v) health coaching and physical activity training. Due to heterogeneity of outcome measures, the meta-analysis included only seven RCTs; pooled mean estimates showed connected health interventions were moderately effective in reducing symptoms of depression (SMD: -0.226, 95% CI -0.303/-0.149) and anxiety (SMD: -0.188, 95% CI: 0.279/-0.0963) compared with usual care.
    Conclusion: While the considerable heterogeneity observed highlights the need for more rigorous studies to improve reproducibility and efficiency, results suggest that connected health interventions have the potential to improve psychological wellbeing and QoL outcomes in people living with and beyond cancer.
    MeSH term(s) Adult ; Anxiety/therapy ; Anxiety Disorders ; Humans ; Neoplasms/psychology ; Quality of Life ; Reproducibility of Results
    Language English
    Publishing date 2022-09-22
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1118536-3
    ISSN 1099-1611 ; 1057-9249
    ISSN (online) 1099-1611
    ISSN 1057-9249
    DOI 10.1002/pon.6019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Lesson of the month 2: An unusual presentation of hyperinsulinaemic hypoglycaemia with possible underlying diagnosis of glucose-sensitive insulinoma or islet cell hyperplasia.

    Maguire, Deirdre

    Clinical medicine (London, England)

    2015  Volume 15, Issue 5, Page(s) 495–496

    Abstract: Postprandial hypoglycaemia can occur in islet cell hyperplasia and in reactive hypoglycaemia. Less commonly, it can occur with insulinoma. A case is described where the differential diagnosis was glucose-sensitive insulinoma or islet cell hyperplasia. ... ...

    Abstract Postprandial hypoglycaemia can occur in islet cell hyperplasia and in reactive hypoglycaemia. Less commonly, it can occur with insulinoma. A case is described where the differential diagnosis was glucose-sensitive insulinoma or islet cell hyperplasia. Typical provocation was prolonged exertion or fasting followed by ingestion of sugary snacks resulting in hypoglycaemic seizures and collapse. Biochemistry and computerised tomography imaging were consistent with an insulinoma in the pancreatic tail, but this was not confirmed on endoscopic ultrasound. Selective intra-arterial calcium stimulation with hepatic venous sampling results suggested a diagnosis of islet cell hyperplasia. Ten years later, repeat imaging was consistent with a neuroendocrine tumour. Surgical resection has resulted in remission of symptoms. The patient will be monitored long term to ensure no recurrence.
    MeSH term(s) Adult ; Congenital Hyperinsulinism/etiology ; Diagnosis, Differential ; Humans ; Hyperinsulinism/etiology ; Hyperplasia ; Hypoglycemia/etiology ; Insulinoma/diagnosis ; Islets of Langerhans/pathology ; Male ; Pancreatic Neoplasms/diagnosis
    Language English
    Publishing date 2015-10-01
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmedicine.15-5-495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The role of expectations and future-oriented cognitions in quality of life of people with multiple sclerosis: A systematic review.

    Maguire, Rebecca / McKeague, Beth / Kóka, Nathalie / Coffey, Laura / Maguire, Phil / Desmond, Deirdre

    Multiple sclerosis and related disorders

    2021  Volume 56, Page(s) 103293

    Abstract: Purpose: Multiple Sclerosis (MS) is a highly variable condition characterised by uncertainty of disease course which can make formation of expectations about the future difficult. This systematic review aimed to examine associations between expectations, ...

    Abstract Purpose: Multiple Sclerosis (MS) is a highly variable condition characterised by uncertainty of disease course which can make formation of expectations about the future difficult. This systematic review aimed to examine associations between expectations, or Future Oriented Cognitions (FOCs), and Quality of Life (QOL) in people with MS (PwMS).
    Methods: Following PRISMA guidelines, literature up to October 2019 was searched using Medline, EMBASE, PsycINFO and Web of Science. Quantitative studies that investigated relationships between FOCs and QOL in PwMS (assessed using a standardised QOL assessment) were considered for inclusion. After data extraction, results were analysed using narrative synthesis, focusing on the valence of FOCs (positive, negative, unvalenced). Quality appraisal was conducted using the Mixed Methods Appraisal Tool (MMAT). All stages of the review were patient-led by a person with MS.
    Results: A total of 13 studies met the review inclusion criteria, with a combined sample size of 4,179. Of these studies, 11 involved measures of positive FOCs, most commonly self-efficacy, one measured a negative FOC, with one FOC unclassified. Nine studies found significant associations between QOL and self-efficacy. Although other positively valenced constructs were less frequently reported, significant associations with higher QOL were also evidenced.
    Conclusions: Identifying ways to foster positive FOCs, particularly self-efficacy, may have beneficial effects on QOL. More research is needed to understand the impacts of negative FOCs on QOL to determine whether these processes could be meaningfully targeted in interventions.
    MeSH term(s) Cognition ; Humans ; Motivation ; Multiple Sclerosis ; Quality of Life ; Self Efficacy
    Language English
    Publishing date 2021-10-01
    Publishing country Netherlands
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2645330-7
    ISSN 2211-0356 ; 2211-0348
    ISSN (online) 2211-0356
    ISSN 2211-0348
    DOI 10.1016/j.msard.2021.103293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Excess weight gain in the paediatric bleeding disorders population: Impact of the COVID-19 Pandemic.

    Malcolmson, Caroline / Tetzlaff, Deirdre / Maguire, Bryan / Wakefield, Cindy / Carcao, Manuel / Bouskill, Vanessa

    Haemophilia : the official journal of the World Federation of Hemophilia

    2021  Volume 28, Issue 1, Page(s) 91–96

    Abstract: Introduction: The COVID-19 pandemic has resulted in lifestyle changes for children. The aim of this study was to evaluate the impact of the pandemic on weight/BMI in children with severe bleeding disorders.: Methods: We conducted a retrospective ... ...

    Abstract Introduction: The COVID-19 pandemic has resulted in lifestyle changes for children. The aim of this study was to evaluate the impact of the pandemic on weight/BMI in children with severe bleeding disorders.
    Methods: We conducted a retrospective review of patients age 3-18 years with severe bleeding disorders on prophylactic therapy treated at SickKids Hospital (Toronto, Canada) between February 01, 2018 and March 31, 2021. We evaluated the following pre- and post-COVID variables: weight (kg), weight percentile, BMI (kg/m
    Results: One hundred and four patients were included in the final analysis. Diagnoses were as follows:  haemophilia A (n = 92; 70.8%), haemophilia B (n = 17; 13.1%), type 3 von Willebrand disease (n = 11; 8.5%), the remainder were diagnosed with rare factor deficiencies.  Median interval time from pre-COVID measurements to latest follow-up was 12.4 months (IQR 10.32-14.52 months) during which there was a statistically significant increase in median weight percentile +5.75 centiles (from 63
    Conclusion: There was a trend to weight gain over the study period. More long-term data is required to evaluate the impact of this increase in weight and BMI on children with bleeding disorders.
    MeSH term(s) Adolescent ; Body Mass Index ; COVID-19 ; Child ; Child, Preschool ; Humans ; Pandemics ; Retrospective Studies ; SARS-CoV-2 ; Weight Gain
    Language English
    Publishing date 2021-11-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1229713-6
    ISSN 1365-2516 ; 1351-8216 ; 1355-0691
    ISSN (online) 1365-2516
    ISSN 1351-8216 ; 1355-0691
    DOI 10.1111/hae.14449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Prescription drugs with potential for misuse: protocol for a multi-indicator analysis of supply, detection and the associated health burden in Ireland between 2010 and 2020.

    Cousins, Gráinne / Durand, Louise / O'Kane, Aoife / Tierney, Julie / Maguire, Richard / Stokes, Siobhán / O'Reilly, Deirdre / Arensman, Ella / Bennett, Kathleen E / Vázquez, María Otero / Corcoran, Paul / Lyons, Suzi / Kavanagh, Yvonne / Keenan, Eamon

    BMJ open

    2023  Volume 13, Issue 3, Page(s) e069665

    Abstract: Introduction: There is an increasing concern about the misuse of prescription drugs. Misuse refers to the intentional repurposing of prescribed drugs and/or the use of illicitly sourced prescription drugs, which may be counterfeit or contaminated. Drugs ...

    Abstract Introduction: There is an increasing concern about the misuse of prescription drugs. Misuse refers to the intentional repurposing of prescribed drugs and/or the use of illicitly sourced prescription drugs, which may be counterfeit or contaminated. Drugs with the greatest potential for misuse are prescription opioids, gabapentinoids, benzodiazepines, Z-drugs and stimulants.
    Objective: The aim of this study is to provide a comprehensive analysis of the supply, patterns of use and health burden associated with prescription drugs with potential for misuse (PDPM) in Ireland between 2010 and 2020. Three inter-related studies will be carried out. The first study will describe trends in supply of PDPM using law enforcement drug seizures data and national prescription records from national community and prison settings. The second study aims to estimate trends in the detection of PDPM across multiple early warning systems using national forensic toxicology data. The third study aims to quantify the health burden associated with PDPM nationally, using epidemiological indicators of drug-poisoning deaths, non-fatal intentional drug overdose presentations to hospitals and drug treatment demand.
    Methods and analysis: A retrospective observational study design, with repeated cross-sectional analyses, using negative binomial regression models or, where appropriate, joinpoint regression.
    Ethics and dissemination: The study has received approval from the RCSI Ethics Committee (REC202202020). Results will be disseminated in peer-reviewed journals, scientific and drug policy meetings and with key stakeholders via research briefs.
    MeSH term(s) Humans ; Analgesics, Opioid ; Cross-Sectional Studies ; Ireland/epidemiology ; Prescription Drugs ; Prescriptions
    Chemical Substances Analgesics, Opioid ; Prescription Drugs
    Language English
    Publishing date 2023-03-02
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2022-069665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Prescription drugs with potential for misuse

    Gráinne Cousins / Kathleen E Bennett / Paul Corcoran / Ella Arensman / Eamon Keenan / Suzi Lyons / Louise Durand / Aoife O’Kane / Julie Tierney / Richard Maguire / Siobhán Stokes / Deirdre O’Reilly / María Otero Vázquez / Yvonne Kavanagh

    BMJ Open, Vol 13, Iss

    protocol for a multi-indicator analysis of supply, detection and the associated health burden in Ireland between 2010 and 2020

    2023  Volume 3

    Abstract: Introduction There is an increasing concern about the misuse of prescription drugs. Misuse refers to the intentional repurposing of prescribed drugs and/or the use of illicitly sourced prescription drugs, which may be counterfeit or contaminated. Drugs ... ...

    Abstract Introduction There is an increasing concern about the misuse of prescription drugs. Misuse refers to the intentional repurposing of prescribed drugs and/or the use of illicitly sourced prescription drugs, which may be counterfeit or contaminated. Drugs with the greatest potential for misuse are prescription opioids, gabapentinoids, benzodiazepines, Z-drugs and stimulants.Objective The aim of this study is to provide a comprehensive analysis of the supply, patterns of use and health burden associated with prescription drugs with potential for misuse (PDPM) in Ireland between 2010 and 2020. Three inter-related studies will be carried out. The first study will describe trends in supply of PDPM using law enforcement drug seizures data and national prescription records from national community and prison settings. The second study aims to estimate trends in the detection of PDPM across multiple early warning systems using national forensic toxicology data. The third study aims to quantify the health burden associated with PDPM nationally, using epidemiological indicators of drug-poisoning deaths, non-fatal intentional drug overdose presentations to hospitals and drug treatment demand.Methods and analysis A retrospective observational study design, with repeated cross-sectional analyses, using negative binomial regression models or, where appropriate, joinpoint regression.Ethics and dissemination The study has received approval from the RCSI Ethics Committee (REC202202020). Results will be disseminated in peer-reviewed journals, scientific and drug policy meetings and with key stakeholders via research briefs.
    Keywords Medicine ; R
    Subject code 360
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: ChAdOx1 SARS-CoV-2 vaccination: A putative precipitant of adrenal crises.

    Maguire, Deirdre / McLaren, David S / Rasool, Irum / Shah, Preet M / Lynch, Julie / Murray, Robert D

    Clinical endocrinology

    2021  Volume 99, Issue 5, Page(s) 470–473

    Abstract: Background: Patients with adrenal insufficiency (AI) have excess mortality, in part due to the occurrence of life-threatening adrenal crises. Infective processes, including that of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are ... ...

    Abstract Background: Patients with adrenal insufficiency (AI) have excess mortality, in part due to the occurrence of life-threatening adrenal crises. Infective processes, including that of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are recognised as the major precipitant of adrenal crises. Adverse reactions to the ChAdOx1 SARS-CoV-2 vaccine occur in a significant proportion of individuals, however, are mild-moderate in the majority of cases.
    Design: Case series.
    Patients & results: We describe five cases where more severe adverse reactions to the ChAdOx1 SARS-CoV-2 vaccine led to actual or incipient adrenal crises requiring parenteral hydrocortisone within 24 h of receiving the first ChAdOx1 SARS-CoV-2 vaccination.
    Conclusion: In individuals with adrenal insufficiency, adverse reactions to the initial dose of the ChAdOx1 SARS-CoV-2 vaccination can precipitate adrenal crises. We recommend that patients with AI should immediately increase their maintenance glucocorticoid dosage 2-3 fold on experiencing any symptoms in the initial 24 h following vaccination.
    MeSH term(s) Humans ; Acute Disease ; Adrenal Insufficiency/etiology ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; SARS-CoV-2 ; Vaccination/adverse effects
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-08-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 121745-8
    ISSN 1365-2265 ; 0300-0664
    ISSN (online) 1365-2265
    ISSN 0300-0664
    DOI 10.1111/cen.14566
    Database MEDical Literature Analysis and Retrieval System OnLINE

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