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  1. Book ; Online ; E-Book: Biomedical innovations to combat COVID-19

    Comas García, Mauricio / González-Ortega, Omar / Rosales Mendoza, Sergio

    2022  

    Author's details edited by Sergio Rosales-Mendoza, Mauricio Comas-García, Omar González-Ortega
    Keywords COVID-19 (Disease)/Diagnosis ; COVID-19 (Disease)/Treatment
    Subject code 616.2414
    Language English
    Size 1 online resource (411 pages)
    Publisher Academic Press
    Publishing place London, England
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-90249-9 ; 0-323-90248-0 ; 978-0-323-90249-6 ; 978-0-323-90248-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Will plant-made biopharmaceuticals play a role in the fight against COVID-19?

    Rosales-Mendoza, Sergio

    Expert opinion on biological therapy

    2020  Volume 20, Issue 6, Page(s) 545–548

    Abstract: Given the dramatic impact of the COVID-19 pandemic, it is imperative to divulge all the available technologies with the potential to fight against this virus. Plant biotechnology offers potential solutions to this pandemic through the development of low- ... ...

    Abstract Given the dramatic impact of the COVID-19 pandemic, it is imperative to divulge all the available technologies with the potential to fight against this virus. Plant biotechnology offers potential solutions to this pandemic through the development of low-cost vaccines and antibodies useful for therapy, prophylaxis, and diagnosis. The technology to produce plant-made biopharmaceuticals is already established; two examples of these are: a therapeutic enzyme that has entered the market and the influenza vaccines that are currently under clinical trials with encouraging results. Thus far, some companies have started developing anti-COVID-19 antibodies and vaccines. In particular, plant-made antibodies might be timely produced and approved for human use in the short term, while the development of vaccines will take longer time (clinical evaluations could be concluded by the end of 2021); nonetheless, the candidates obtained will be valuable tools for future outbreaks. The key aspects that will define the exploitation of this technology in the fight against COVID-19 are discussed.
    MeSH term(s) Antibodies, Viral/biosynthesis ; Betacoronavirus ; Biological Products/therapeutic use ; Biotechnology ; COVID-19 ; COVID-19 Vaccines ; Coronavirus Infections/drug therapy ; Coronavirus Infections/prevention & control ; Humans ; Molecular Farming ; Pandemics ; Plants, Genetically Modified ; Pneumonia, Viral/drug therapy ; SARS-CoV-2 ; Viral Vaccines/biosynthesis
    Chemical Substances Antibodies, Viral ; Biological Products ; COVID-19 Vaccines ; Viral Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-04-13
    Publishing country England
    Document type Editorial
    ZDB-ID 2052501-1
    ISSN 1744-7682 ; 1471-2598
    ISSN (online) 1744-7682
    ISSN 1471-2598
    DOI 10.1080/14712598.2020.1752177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Current status of mucosal vaccines against SARS-CoV2: a hope for protective immunity.

    García-Silva, Ileana / Govea-Alonso, Dania O / Rosales-Mendoza, Sergio

    Expert opinion on biological therapy

    2023  Volume 23, Issue 2, Page(s) 207–222

    Abstract: Introduction: The current vaccines used to fight against COVID-19 are effective, however the induction of protective immunity is a pending goal required to prevent viral transmission, prevent the generation of new variants, and ultimately eradicate SARS- ...

    Abstract Introduction: The current vaccines used to fight against COVID-19 are effective, however the induction of protective immunity is a pending goal required to prevent viral transmission, prevent the generation of new variants, and ultimately eradicate SARS-CoV-2. Mucosal immunization stands as a promising approach to achieve protective immunity against SARS-CoV-2; therefore, it is imperative to innovate the current vaccines by developing mucosal candidates, focusing not only on their ability to prevent severe COVID-19 but to neutralize the virus before invasion of the respiratory system and other mucosal compartments.
    Areas covered: This review covers the current advances on the development of anti-COVID-19 mucosal vaccines. Biomedical literature, including PubMed and clinicaltrials.gov website, was analyzed to identify the state of the art for this field. The achievements in preclinical and clinical evaluations are presented and critically analyzed.
    Expert opinion: There is a significant advance on the development of mucosal vaccines against SARSCoV-2, which is a promise to increase the efficacy of immunization against this pathogen. Both preclinical and clinical evaluation for several candidates have been performed. The challenges in this road (e.g. low immunogenicity, a reduced number of adjuvants available, and inaccurate dosage) are identified and also critical perspectives for the field are provided.
    MeSH term(s) Humans ; RNA, Viral ; COVID-19/prevention & control ; SARS-CoV-2 ; Vaccines ; Vaccination ; COVID-19 Vaccines
    Chemical Substances RNA, Viral ; Vaccines ; COVID-19 Vaccines
    Language English
    Publishing date 2023-01-11
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2052501-1
    ISSN 1744-7682 ; 1471-2598
    ISSN (online) 1744-7682
    ISSN 1471-2598
    DOI 10.1080/14712598.2022.2156284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Will plant-made biopharmaceuticals play a role in the fight against COVID-19?

    Rosales-Mendoza, Sergio

    Expert Opinion on Biological Therapy

    2020  Volume 20, Issue 6, Page(s) 545–548

    Keywords Clinical Biochemistry ; Pharmacology ; Drug Discovery ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2052501-1
    ISSN 1471-2598
    ISSN 1471-2598
    DOI 10.1080/14712598.2020.1752177
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

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  5. Article: Will plant-made biopharmaceuticals play a role in the fight against COVID-19?

    Rosales-Mendoza, Sergio

    Expert Opin Biol Ther

    Abstract: Given the dramatic impact of the COVID-19 pandemic, it is imperative to divulge all the available technologies with the potential to fight against this virus. Plant biotechnology offers potential solutions to this pandemic through the development of low- ... ...

    Abstract Given the dramatic impact of the COVID-19 pandemic, it is imperative to divulge all the available technologies with the potential to fight against this virus. Plant biotechnology offers potential solutions to this pandemic through the development of low-cost vaccines and antibodies useful for therapy, prophylaxis, and diagnosis. The technology to produce plant-made biopharmaceuticals is already established; two examples of these are: a therapeutic enzyme that has entered the market and the influenza vaccines that are currently under clinical trials with encouraging results. Thus far, some companies have started developing anti-COVID-19 antibodies and vaccines. In particular, plant-made antibodies might be timely produced and approved for human use in the short term, while the development of vaccines will take longer time (clinical evaluations could be concluded by the end of 2021); nonetheless, the candidates obtained will be valuable tools for future outbreaks. The key aspects that will define the exploitation of this technology in the fight against COVID-19 are discussed.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #35089
    Database COVID19

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  6. Article ; Online: The potential of plant-made vaccines to fight picornavirus.

    Bolaños-Martínez, Omayra C / Rosales-Mendoza, Sergio

    Expert review of vaccines

    2020  Volume 19, Issue 7, Page(s) 599–610

    Abstract: Introduction: Several : Areas covered: In the present review the advances in the development of plant-made vaccines against picornaviruses are summarized and placed in perspective. The main diseases that have been targeted using this approach include ...

    Abstract Introduction: Several
    Areas covered: In the present review the advances in the development of plant-made vaccines against picornaviruses are summarized and placed in perspective. The main diseases that have been targeted using this approach include Poliovirus, Food and mouth disease virus, Hepatitis A virus, and Enterovirus 71.
    Expert opinion: Several vaccine candidates against picornavirus have been characterized at the preclinical level; with many of them capable of inducing humoral and cellular responses that led to neutralization of pathogens when evaluated in vitro and test animal challenge assays. Plant-made vaccines are a promise to fight picornaviruses; especially in the developing world where limited resources hamper vaccination coverage. A critical analysis of the road ahead for this technology is provided.
    MeSH term(s) Animals ; Antigens, Plant/immunology ; Developing Countries ; Humans ; Picornaviridae Infections/immunology ; Picornaviridae Infections/prevention & control ; Plants/immunology ; Vaccination ; Viral Vaccines/administration & dosage ; Viral Vaccines/economics ; Viral Vaccines/immunology
    Chemical Substances Antigens, Plant ; Viral Vaccines
    Language English
    Publishing date 2020-07-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2181284-6
    ISSN 1744-8395 ; 1476-0584
    ISSN (online) 1744-8395
    ISSN 1476-0584
    DOI 10.1080/14760584.2020.1791090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6077: Show issues Location:
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  7. Article: Efficient Transient Expression of Recombinant Proteins Using DNA Viral Vectors in Freshwater Microalgal Species.

    Malla, Ashwini / Rosales-Mendoza, Sergio / Phoolcharoen, Waranyoo / Vimolmangkang, Sornkanok

    Frontiers in plant science

    2021  Volume 12, Page(s) 650820

    Abstract: The increase in the world population, the advent of new infections and health issues, and the scarcity of natural biological products have spotlighted the importance of recombinant protein technology and its large-scale production in a cost-effective ... ...

    Abstract The increase in the world population, the advent of new infections and health issues, and the scarcity of natural biological products have spotlighted the importance of recombinant protein technology and its large-scale production in a cost-effective manner. Microalgae have become a significant promising platform with the potential to meet the increasing demand for recombinant proteins and other biologicals. Microalgae are safe organisms that can grow rapidly and are easily cultivated with basic nutrient requirements. Although continuous efforts have led to considerable progress in the algae genetic engineering field, there are still many hurdles to overcome before these microorganisms emerge as a mature expression system. Hence, there is a need to develop efficient expression approaches to exploit microalgae for the production of recombinant proteins at convenient yields. This study aimed to test the ability of the DNA geminiviral vector with Rep-mediated replication to transiently express recombinant proteins in the freshwater microalgal species
    Language English
    Publishing date 2021-04-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711035-7
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2021.650820
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: An Algae-Made RBD from SARS-CoV-2 Is Immunogenic in Mice.

    Govea-Alonso, Dania O / Malla, Ashwini / Bolaños-Martínez, Omayra C / Vimolmangkang, Sornkanok / Rosales-Mendoza, Sergio

    Pharmaceuticals (Basel, Switzerland)

    2022  Volume 15, Issue 10

    Abstract: Despite the current advances in global vaccination against SARS-CoV-2, boosting is still required to sustain immunity in the population, and the induction of sterilizing immunity remains as a pending goal. Low-cost oral immunogens could be used as the ... ...

    Abstract Despite the current advances in global vaccination against SARS-CoV-2, boosting is still required to sustain immunity in the population, and the induction of sterilizing immunity remains as a pending goal. Low-cost oral immunogens could be used as the basis for the design of affordable and easy-to-administer booster vaccines. Algae stand as promising platforms to produce immunogens at low cost, and it is possible to use them as oral delivery carriers since they are edible (not requiring complex purification and formulation processes). Herein, a
    Language English
    Publishing date 2022-10-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15101298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Current Status and Perspective on the Use of Viral-Based Vectors in Eukaryotic Microalgae.

    Bolaños-Martínez, Omayra C / Mahendran, Ganesan / Rosales-Mendoza, Sergio / Vimolmangkang, Sornkanok

    Marine drugs

    2022  Volume 20, Issue 7

    Abstract: During the last two decades, microalgae have attracted increasing interest, both commercially and scientifically. Commercial potential involves utilizing valuable natural compounds, including carotenoids, polysaccharides, and polyunsaturated fatty acids, ...

    Abstract During the last two decades, microalgae have attracted increasing interest, both commercially and scientifically. Commercial potential involves utilizing valuable natural compounds, including carotenoids, polysaccharides, and polyunsaturated fatty acids, which are widely applicable in food, biofuel, and pharmaceutical industries. Conversely, scientific potential focuses on bioreactors for producing recombinant proteins and developing viable technologies to significantly increase the yield and harvest periods. Here, viral-based vectors and transient expression strategies have significantly contributed to improving plant biotechnology. We present an updated outlook covering microalgal biotechnology for pharmaceutical application, transformation techniques for generating recombinant proteins, and genetic engineering tactics for viral-based vector construction. Challenges in industrial application are also discussed.
    MeSH term(s) Biofuels ; Biotechnology/methods ; Eukaryota/metabolism ; Microalgae/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism
    Chemical Substances Biofuels ; Recombinant Proteins
    Language English
    Publishing date 2022-06-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md20070434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Harnessing the advances of genetic engineering in microalgae for the production of cannabinoids.

    Bolaños-Martínez, Omayra C / Malla, Ashwini / Rosales-Mendoza, Sergio / Vimolmangkang, Sornkanok

    Critical reviews in biotechnology

    2022  Volume 43, Issue 6, Page(s) 823–834

    Abstract: Cannabis is widely recognized as a medicinal plant owing to bioactive cannabinoids. However, it is still considered a narcotic plant, making it hard to be accessed. Since the biosynthetic pathway of cannabinoids is disclosed, biotechnological methods can ...

    Abstract Cannabis is widely recognized as a medicinal plant owing to bioactive cannabinoids. However, it is still considered a narcotic plant, making it hard to be accessed. Since the biosynthetic pathway of cannabinoids is disclosed, biotechnological methods can be employed to produce cannabinoids in heterologous systems. This would pave the way toward biosynthesizing any cannabinoid compound of interest, especially minor substances that are less produced by a plant but have a high medicinal value. In this context, microalgae have attracted increasing scientific interest given their unique potential for biopharmaceutical production. In the present review, the current knowledge on cannabinoid production in different hosts is summarized and the biotechnological potential of microalgae as an emerging platform for synthetic production is put in perspective. A critical survey of genetic requirements and various transformation approaches are also discussed.
    MeSH term(s) Cannabinoids/genetics ; Cannabinoids/metabolism ; Microalgae/genetics ; Microalgae/metabolism ; Genetic Engineering ; Biotechnology ; Cannabis/genetics ; Cannabis/metabolism
    Chemical Substances Cannabinoids
    Language English
    Publishing date 2022-06-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1042364-3
    ISSN 1549-7801 ; 0738-8551
    ISSN (online) 1549-7801
    ISSN 0738-8551
    DOI 10.1080/07388551.2022.2071672
    Database MEDical Literature Analysis and Retrieval System OnLINE

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