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Article ; Online: Epidemiology of multidrug-resistant organisms before and during COVID-19 in Hong Kong.

Wong, Shuk-Ching / Chau, Pui-Hing / So, Simon Yung-Chun / Chiu, Kelvin Hei-Yeung / Yuen, Lithia Lai-Ha / AuYeung, Christine Ho-Yan / Lam, Germaine Kit-Ming / Chan, Veronica Wing-Man / Chen, Jonathan Hon-Kwan / Chen, Hong / Li, Xin / Ho, Pak-Leung / Chan, Sophia Siu-Chee / Yuen, Kwok-Yung / Cheng, Vincent Chi-Chung

Infection prevention in practice

2023 Volume 5, Issue 2, Page(s) 100286

Abstract: ... during the COVID-19 pandemic in Hong Kong.: Methods: With the maintenance of infection control ...

Abstract	Background: The coronavirus disease 2019 (COVID-19) has influenced antimicrobial consumption and incidence of multidrug-resistant organisms (MDROs). We aimed to study the epidemiology of MDROs before and during the COVID-19 pandemic in Hong Kong. Methods: With the maintenance of infection control measures, we described the trend of MDRO infections, including methicillin-resistant Results: Between period 1 and 2, we observed a significant increase in the trend of CRA infections ( Conclusion: Infection control measures may control the surge of MDROs despite an increasing trend of antimicrobial consumption.
Language	English
Publishing date	2023-05-08
Publishing country	England
Document type	Journal Article
ISSN	2590-0889
ISSN (online)	2590-0889
DOI	10.1016/j.infpip.2023.100286
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Article: Oral Health Status and Oral Health-Related Behaviours of Hong Kong Students with Vision Impairment.

Lee, Jessica Ka Yi / Yuen, Agatha Wing Tung / Leung, Karen Pui Yan / Li, Joyce Tin Wing / Bae, Seon Yeong / Chan, Yi Yung / Ip, Ching Kiu / Lau, Sik Hong / Lau, Yin Ngai / Lo, Hei Yuet / Tang, Shuk Kwan / Duangthip, Duangporn

Healthcare (Basel, Switzerland)

2024 Volume 12, Issue 3

Abstract: ... conditions among visually impaired students in Hong Kong. Students aged 6-21 years from two specialised ...

Abstract	This cross-sectional epidemiological study aimed to describe dental caries and oral hygiene conditions among visually impaired students in Hong Kong. Students aged 6-21 years from two specialised schools for those with vision impairment were invited. Information on sociodemographic background and oral health-related behaviours was collected through an online parent-reported questionnaire. Dental caries and oral hygiene were assessed using the Decayed, Missing and Filled Teeth (DMFT) index and the Visible Plaque Index (VPI), respectively. Chi-square, Mann-Whitney U and Kruskal-Wallis H tests were conducted to analyse the association between students' background and oral health status. A total of 73 participants were recruited, of whom 57.5% were male. Their mean (SD) age was 12.9 (4.7) years. Their mean DMFT score (SD) was 1.0 (1.8), and 43.8% had caries experience. The mean VPI (SD) was 0.76 (0.30). Their caries experience was significantly associated with their snacking habits (
Language	English
Publishing date	2024-02-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare12030391
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Article ; Online: Mitochondrial diseases in Hong Kong: prevalence, clinical characteristics and genetic landscape.

Wong, Tsz-Sum / Belaramani, Kiran M / Chan, Chun-Kong / Chan, Wing-Ki / Chan, Wai-Lun Larry / Chang, Shek-Kwan / Cheung, Sing-Ngai / Cheung, Ka-Yin / Cheung, Yuk-Fai / Chong, Shuk-Ching Josephine / Chow, Chi-Kwan Jasmine / Chung, Hon-Yin Brian / Fan, Sin-Ying Florence / Fok, Wai-Ming Joshua / Fong, Ka-Wing / Fung, Tsui-Hang Sharon / Hui, Kwok-Fai / Hui, Ting-Hin / Hui, Joannie /

Ko, Chun-Hung / Kwan, Min-Chung / Kwok, Mei-Kwan Anne / Kwok, Sung-Shing Jeffrey / Lai, Moon-Sing / Lam, Yau-On / Lam, Ching-Wan / Lau, Ming-Chung / Law, Chun-Yiu Eric / Lee, Wing-Cheong / Lee, Han-Chih Hencher / Lee, Chin-Nam / Leung, Kin-Hang / Leung, Kit-Yan / Li, Siu-Hung / Ling, Tsz-Ki Jacky / Liu, Kam-Tim Timothy / Lo, Fai-Man / Lui, Hiu-Tung / Luk, Ching-On / Luk, Ho-Ming / Ma, Che-Kwan / Ma, Karen / Ma, Kam-Hung / Mew, Yuen-Ni / Mo, Alex / Ng, Sui-Fun / Poon, Wing-Kit Grace / Rodenburg, Richard / Sheng, Bun / Smeitink, Jan / Szeto, Cheuk-Ling Charing / Tai, Shuk-Mui / Tse, Choi-Ting Alan / Tsung, Li-Yan Lilian / Wong, Ho-Ming June / Wong, Wing-Yin Winnie / Wong, Kwok-Kui / Wong, Suet-Na Sheila / Wong, Chun-Nei Virginia / Wong, Wai-Shan Sammy / Wong, Chi-Kin Felix / Wu, Shun-Ping / Wu, Hiu-Fung Jerome / Yau, Man-Mut / Yau, Kin-Cheong Eric / Yeung, Wai-Lan / Yeung, Hon-Ming Jonas / Yip, Kin-Keung Edwin / Young, Pui-Hong Terence / Yuan, Gao / Yuen, Yuet-Ping Liz / Yuen, Chi-Lap / Fung, Cheuk-Wing

Orphanet journal of rare diseases

2023 Volume 18, Issue 1, Page(s) 43

Abstract: Objective: To determine the prevalence of mitochondrial diseases (MD) in Hong Kong (HK) and ... providing the first available prevalence rate of MD in Hong Kong. The findings of this study aim ...

Abstract	Objective: To determine the prevalence of mitochondrial diseases (MD) in Hong Kong (HK) and to evaluate the clinical characteristics and genetic landscape of MD patients in the region. Methods: This study retrospectively reviewed the phenotypic and molecular characteristics of MD patients from participating public hospitals in HK between January 1985 to October 2020. Molecularly and/or enzymatically confirmed MD cases of any age were recruited via the Clinical Analysis and Reporting System (CDARS) using relevant keywords and/or International Classification of Disease (ICD) codes under the HK Hospital Authority or through the personal recollection of treating clinicians among the investigators. Results: A total of 119 MD patients were recruited and analyzed in the study. The point prevalence of MD in HK was 1.02 in 100,000 people (95% confidence interval 0.81-1.28 in 100,000). 110 patients had molecularly proven MD and the other nine were diagnosed by OXPHOS enzymology analysis or mitochondrial DNA depletion analysis with unknown molecular basis. Pathogenic variants in the mitochondrial genome (72 patients) were more prevalent than those in the nuclear genome (38 patients) in our cohort. The most commonly involved organ system at disease onset was the neurological system, in which developmental delay, seizures or epilepsy, and stroke-like episodes were the most frequently reported presentations. The mortality rate in our cohort was 37%. Conclusion: This study is a territory-wide overview of the clinical and genetic characteristics of MD patients in a Chinese population, providing the first available prevalence rate of MD in Hong Kong. The findings of this study aim to facilitate future in-depth evaluation of MD and lay the foundation to establish a local MD registry.
MeSH term(s)	Humans ; Hong Kong ; Prevalence ; Retrospective Studies ; Asian People ; Mitochondrial Diseases
Language	English
Publishing date	2023-03-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2225857-7
ISSN	1750-1172 ; 1750-1172
ISSN (online)	1750-1172
ISSN	1750-1172
DOI	10.1186/s13023-023-02632-6
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Article ; Online: Compound floods in Hong Kong

Yangchen Lai / Jianfeng Li / Yongqin David Chen / Faith Ka Shun Chan / Xihui Gu / Shengzhi Huang

Journal of Hydrology: Regional Studies, Vol 46, Iss , Pp 101321- (2023)

Hazards, triggers, and socio-economic consequences

2023

Abstract: Study region: Hong Kong is a megalopolis located on the southeast coast of China. Study focus ... Megalopolis located in low-lying coastal areas such as Hong Kong is especially vulnerable to compound flood ... socio-economic impacts of compound floods from precipitation and sea level in Hong Kong. New hydrological ...

Abstract	Study region: Hong Kong is a megalopolis located on the southeast coast of China. Study focus: Megalopolis located in low-lying coastal areas such as Hong Kong is especially vulnerable to compound flood risks from multiple flood drivers (e.g., heavy rainstorms and extreme sea levels). Using long-term hydrological observations and socio-economic data, this study aims to reveal the risks, causes and socio-economic impacts of compound floods from precipitation and sea level in Hong Kong. New hydrological insights for the region: We find that the most extreme sea levels are mostly accompanied by heavy precipitation and thus lead to compound floods, while the most extreme precipitation events are less likely to coincide with extreme sea levels. TCs are the major trigger of compound floods with fractional contributions ranging from 48.8% to 83.8% in the gauges. Typhoon Wanda (1962) triggered the most severe compound flood with a joint return period of 178 years which is much shorter than the return period (>10,000 years) without the consideration of the dependence between the extremes. During the past decades, Hong Kong has experienced an increase in compound flood hazards, which is mainly attributed to the mean sea level rise. Socio-economic data reveals that TCs associated with compound floods are more destructive than TCs that induced single-type floods, highlighting the urgent need to establish a multi-hazard flood risk management strategy.
Keywords	Compound floods ; Extreme sea levels ; Tropical cyclones ; Socio-economic damage ; Hong Kong ; Physical geography ; GB3-5030 ; Geology ; QE1-996.5
Subject code	910
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hong Kong UrbanNav

Li-Ta Hsu / Feng Huang / Hoi-Fung Ng / Guohao Zhang / Yihan Zhong / Xiwei Bai / Weisong Wen

Navigation, Vol 70, Iss

An Open-Source Multisensory Dataset for Benchmarking Urban Navigation Algorithms

2023 Volume 4

Abstract: ... a multisensory dataset, UrbanNav, collected in diverse, challenging urban scenarios in Hong Kong. The dataset ...

Abstract	Accurate positioning in urban canyons remains a challenging problem. To facilitate the research and development of reliable and precise positioning methods using multiple sensors in urban canyons, we built a multisensory dataset, UrbanNav, collected in diverse, challenging urban scenarios in Hong Kong. The dataset provides multi-sensor data, including data from multi-frequency global navigation satellite system (GNSS) receivers, an inertial measurement unit (IMU), multiple light detection and ranging (lidar) units, and cameras. Meanwhile, the ground truth of the positioning (with centimeter-level accuracy) is postprocessed by commercial software from NovAtel using an integrated GNSS real-time kinematic and fiber optics gyroscope inertial system. In this paper, the sensor systems, spatial and temporal calibration, data formats, and scenario descriptions are presented in detail. Meanwhile, the benchmark performance of several existing positioning methods is provided as a baseline. Based on the evaluations, we conclude that GNSS can provide satisfactory results in a middle-class urban canyon if an appropriate receiver and algorithms are applied. Both visual and lidar odometry are satisfactory in deep urban canyons, whereas tunnels are still a major challenge. Multisensory integration with the aid of an IMU is a promising solution for achieving seamless positioning in cities. The dataset in its entirety can be found on GitHub at https://github.com/IPNL-POLYU/UrbanNavDataset.
Keywords	Canals and inland navigation. Waterways ; TC601-791 ; Naval Science ; V
Subject code	629
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	Institute of Navigation
Document type	Article ; Online
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Article ; Online: Abnormal hemoglobin anti-Lepore Hong Kong compound with β

Bao, Xiuqin / Wang, Jicheng / Qin, Danqing / Yao, Cuize / Liang, Jie / Liang, Kailing / Du, Li

Scientific reports

2024 Volume 14, Issue 1, Page(s) 6682

Abstract: Abnormal hemoglobin anti-Lepore Hong Kong is a rare βδ fusion variants resulting from non ... homologous crossover during meiosis. Anti-Lepore Hong Kong is known to consistently exhibit significantly ... heterozygous for anti-Lepore Hong Kong. Among them, two families showed co-occurrence of β ...

Abstract	Abnormal hemoglobin anti-Lepore Hong Kong is a rare βδ fusion variants resulting from non-homologous crossover during meiosis. Anti-Lepore Hong Kong is known to consistently exhibit significantly increased level of HbA2. In this study, we used multiplex ligation-dependent probe amplification (MLPA) and single molecular real-time (SMRT) sequencing, as well as Sanger sequencing, to identify variants in five unrelated families with abnormal elevated HbA2 level. All probands in these five families were found to be heterozygous for anti-Lepore Hong Kong. Among them, two families showed co-occurrence of β
MeSH term(s)	Humans ; Pregnancy ; Female ; alpha-Thalassemia/genetics ; Hemoglobins, Abnormal/genetics ; beta-Thalassemia/genetics ; beta-Globins/genetics
Chemical Substances	hemoglobin anti-Lepore Hong Kong ; Hemoglobins, Abnormal ; beta-Globins
Language	English
Publishing date	2024-03-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-56921-6
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Article: Stevens-Johnson syndrome and toxic epidermal necrolysis in Hong Kong.

Cheung, C M T / Chang, M M / Li, J J X / Chan, A W S

Hong Kong medical journal = Xianggang yi xue za zhi

2024 Volume 30, Issue 2, Page(s) 102–109

Abstract: ... in many populations worldwide, data from Hong Kong are limited. Here, we explored the epidemiology, disease ... characteristics, aetiology, morbidity, and mortality of SJS/TEN in Hong Kong.: Methods: This retrospective ... in Hong Kong but can cause substantial morbidity and mortality. Early recognition, prompt withdrawal ...

Abstract	Introduction: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) [hereafter, SJS/TEN] are uncommon but severe mucocutaneous reactions. Although they have been described in many populations worldwide, data from Hong Kong are limited. Here, we explored the epidemiology, disease characteristics, aetiology, morbidity, and mortality of SJS/TEN in Hong Kong. Methods: This retrospective cohort study included all hospitalised patients who had been diagnosed with SJS/TEN in Prince of Wales Hospital from 1 January 2004 to 31 December 2020. Results: There were 125 cases of SJS/TEN during the 17-year study period. The annual incidence was 5.07 cases per million. The mean age at onset was 51.4 years. The mean maximal body surface area of epidermal detachment was 23%. Overall, patients in 32% of cases required burns unit or intensive care unit admission. Half of the cases involved concomitant sepsis, and 23.2% of cases resulted in multiorgan failure or disseminated intravascular coagulation. The mean length of stay was 23.9 days. The cause of SJS/TEN was attributed to a drug in 91.9% of cases, including 84.2% that involved anticonvulsants, allopurinol, antibiotics, or analgesics. In most cases, patients received treatment comprising either best supportive care alone (35.2%) or combined with intravenous immunoglobulin (43.2%). The in-hospital mortality rate was 21.6%. Major causes of death were multiorgan failure and/or fulminant sepsis (81.5%). Conclusion: This study showed that SJS/TEN are uncommon in Hong Kong but can cause substantial morbidity and mortality. Early recognition, prompt withdrawal of offending agents, and multidisciplinary supportive management are essential for improving clinical outcomes.
MeSH term(s)	Humans ; Stevens-Johnson Syndrome/epidemiology ; Stevens-Johnson Syndrome/therapy ; Stevens-Johnson Syndrome/mortality ; Stevens-Johnson Syndrome/etiology ; Hong Kong/epidemiology ; Middle Aged ; Retrospective Studies ; Male ; Female ; Adult ; Incidence ; Aged ; Length of Stay/statistics & numerical data ; Allopurinol/adverse effects ; Anticonvulsants/adverse effects ; Anticonvulsants/therapeutic use ; Sepsis/epidemiology ; Multiple Organ Failure/epidemiology ; Multiple Organ Failure/etiology ; Multiple Organ Failure/mortality
Chemical Substances	Allopurinol (63CZ7GJN5I) ; Anticonvulsants
Language	English
Publishing date	2024-03-26
Publishing country	China
Document type	Journal Article
ZDB-ID	1239255-8
ISSN	1024-2708
ISSN	1024-2708
DOI	10.12809/hkmj2210131
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Article ; Online: Hong Kong Medical Journal

Li, Kenneth Kw / Ma, Edmond Sk / Lui, Rashid Ns / Huang, Junjie / Xue, Hao / Wong, Martin Cs

Journal of Korean medical science

2021 Volume 36, Issue 31, Page(s) e226

MeSH term(s)	Bibliometrics ; Biomedical Research ; Hong Kong ; Humans ; Journal Impact Factor ; Medical Writing ; Periodicals as Topic/trends ; Societies, Medical
Language	English
Publishing date	2021-08-09
Publishing country	Korea (South)
Document type	Editorial
ZDB-ID	639262-3
ISSN	1598-6357 ; 1011-8934
ISSN (online)	1598-6357
ISSN	1011-8934
DOI	10.3346/jkms.2021.36.e226
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Article ; Online: Pharmacokinetic study of multicomponent in Hong-Hua-Xiao-Yao tablet.

Li, Xiaofeng / Huang, Leyi / Xiao, Junping / Zhang, Xuemei

Biomedical chromatography : BMC

2024 Volume 38, Issue 5, Page(s) e5830

Abstract: Hong-Hua-Xiao-Yao tablet (HHXYT) is attracting attention increasingly because of its use ...

Abstract	Hong-Hua-Xiao-Yao tablet (HHXYT) is attracting attention increasingly because of its use in treatment of mammary gland hyperplasia (MGH) and menopausal syndrome. However, its pharmacokinetics remains unclear. This study developed a sensitive and rapid method for simultaneous determination of 10 compounds of HHXYT in rat plasma by liquid chromatography-tandem mass spectrometry and to compare the pharmacokinetics of these compounds in MGH rats and sham operated rats. The linearity, accuracy, precision, stability and matrix effect were within acceptable ranges. This established method was successfully applied to a pharmacokinetics study of 10 compounds in sham operated and MGH rats. According to the results, the bioavailability of glycyrrhetinic acid was highest in MGH rats and sham operated rats. The mean residence times of glycyrrhetinic acid and glycyrrhetinic acid 3-O-glucuronide were higher than those of the other compounds while the mean residence time and half-life of liquiritin, isoliquiritin and paeoniflorin were lower. Some pharmacokinetic parameters of ormononetin, liquiritigenin, isoliquiritigenin, liquiritin, isoliquiritin, paeoniflorin, protocatechuic acid and senkyunolide I were significantly different between MGH rats and sham operated rats. This study elucidated the dynamic changes of multiple components in rats after oral administration of HHXYT systematically and comprehensively, which provided guidance for clinical application.
MeSH term(s)	Animals ; Rats ; Drugs, Chinese Herbal/pharmacokinetics ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/chemistry ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry/methods ; Reproducibility of Results ; Female ; Linear Models ; Chromatography, Liquid/methods ; Tablets/pharmacokinetics ; Chalcones/pharmacokinetics ; Chalcones/chemistry ; Chalcones/blood ; Biological Availability ; Limit of Detection ; Glycyrrhetinic Acid/pharmacokinetics ; Glycyrrhetinic Acid/blood ; Glycyrrhetinic Acid/chemistry
Chemical Substances	Drugs, Chinese Herbal ; Tablets ; Chalcones ; Glycyrrhetinic Acid (P540XA09DR)
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Journal Article
ZDB-ID	632848-9
ISSN	1099-0801 ; 0269-3879
ISSN (online)	1099-0801
ISSN	0269-3879
DOI	10.1002/bmc.5830
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Article ; Online: Multimodal digital assessment of depression with actigraphy and app in Hong Kong Chinese.

Chen, Jie / Chan, Ngan Yin / Li, Chun-Tung / Chan, Joey W Y / Liu, Yaping / Li, Shirley Xin / Chau, Steven W H / Leung, Kwong Sak / Heng, Pheng-Ann / Lee, Tatia M C / Li, Tim M H / Wing, Yun-Kwok

Translational psychiatry

2024 Volume 14, Issue 1, Page(s) 150

Abstract: There is an emerging potential for digital assessment of depression. In this study, Chinese patients with major depressive disorder (MDD) and controls underwent a week of multimodal measurement including actigraphy and app-based measures (D-MOMO) to ... ...

Abstract	There is an emerging potential for digital assessment of depression. In this study, Chinese patients with major depressive disorder (MDD) and controls underwent a week of multimodal measurement including actigraphy and app-based measures (D-MOMO) to record rest-activity, facial expression, voice, and mood states. Seven machine-learning models (Random Forest [RF], Logistic regression [LR], Support vector machine [SVM], K-Nearest Neighbors [KNN], Decision tree [DT], Naive Bayes [NB], and Artificial Neural Networks [ANN]) with leave-one-out cross-validation were applied to detect lifetime diagnosis of MDD and non-remission status. Eighty MDD subjects and 76 age- and sex-matched controls completed the actigraphy, while 61 MDD subjects and 47 controls completed the app-based assessment. MDD subjects had lower mobile time (P = 0.006), later sleep midpoint (P = 0.047) and Acrophase (P = 0.024) than controls. For app measurement, MDD subjects had more frequent brow lowering (P = 0.023), less lip corner pulling (P = 0.007), higher pause variability (P = 0.046), more frequent self-reference (P = 0.024) and negative emotion words (P = 0.002), lower articulation rate (P < 0.001) and happiness level (P < 0.001) than controls. With the fusion of all digital modalities, the predictive performance (F1-score) of ANN for a lifetime diagnosis of MDD was 0.81 and 0.70 for non-remission status when combined with the HADS-D item score, respectively. Multimodal digital measurement is a feasible diagnostic tool for depression in Chinese. A combination of multimodal measurement and machine-learning approach has enhanced the performance of digital markers in phenotyping and diagnosis of MDD.
MeSH term(s)	Humans ; Depressive Disorder, Major/diagnosis ; Bayes Theorem ; Actigraphy ; Depression/diagnosis ; Hong Kong ; Mobile Applications
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2609311-X
ISSN	2158-3188 ; 2158-3188
ISSN (online)	2158-3188
ISSN	2158-3188
DOI	10.1038/s41398-024-02873-4
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