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  1. Article ; Online: An engineered surrogate poly(A) tail to wag translation initiation.

    Lohse, Stefan / Weber, Wilfried

    Cell research

    2024  Volume 34, Issue 2, Page(s) 95–96

    MeSH term(s) RNA, Messenger ; RNA Caps ; Poly A ; Poly(A)-Binding Proteins ; Eukaryotic Initiation Factor-4G/metabolism
    Chemical Substances RNA, Messenger ; RNA Caps ; Poly A (24937-83-5) ; Poly(A)-Binding Proteins ; Eukaryotic Initiation Factor-4G
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-023-00903-2
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  2. Book: Festschrift für Prof. Dr. J.-Matthias Graf von der Schulenburg

    Lohse, Ute / Körber, Torsten / Graf von der Schulenburg, J.-Matthias / Weber, Stefan

    Aktuelle versicherungs- und gesundheitsökonomische Beiträge

    (Hannoveraner Reihe / Versicherungswissenschaft in Hannover ; 27)

    2018  

    Abstract: Diese Festschrift für Prof. Dr. J.-M. Graf von der Schulenburg zum 30-jährigen Jubiläum des Institutes für Versicherungsbetriebslehre an der Leibniz Universität Hannover stellt aktuelle versicherungs- und gesundheitsökonomische Forschungsthemen vor: Im ... ...

    Author's details Dr. Ute Lohse ist Forschungsleiterin für den versicherungswissenschaftlichen Bereich des „Instituts für Versicherungsbetriebslehre“ der Leibniz Universität Hannover und auch als Senior Research Associate am "Kompetenzzentrum Versicherungswissenschaften" tätig
    Series title Hannoveraner Reihe / Versicherungswissenschaft in Hannover ; 27
    Abstract Diese Festschrift für Prof. Dr. J.-M. Graf von der Schulenburg zum 30-jährigen Jubiläum des Institutes für Versicherungsbetriebslehre an der Leibniz Universität Hannover stellt aktuelle versicherungs- und gesundheitsökonomische Forschungsthemen vor: Im Bereich Versicherungökonomie werden neben einer Branchenumfeldanalyse aufsichtsrechtliche und kapitalmarktspezifische Fragestellungen diskutiert sowie die Entwicklungen der Digitalisierung auf die Versicherungswirtschaft analysiert. Weitere Unt...
    Keywords Seltene Erkrankungen ; Krankenversicherung ; Gesundheitsökonomie ; Krankenhausmanagement ; Versicherungsnachfrage ; Branchenanalyse ; Digitalisierung ; Versicherungswirtschaft ; Gesundheitswesen ; Versicherungsökonomie ; Regulierung ; Versorgungsforschung
    Language German
    Size 404 p.
    Edition 1
    Publisher Verlag Versicherungswirtschaft
    Document type Book
    Note PDA Manuell_1
    Format 148 x 210
    ISBN 9783963290398 ; 3963290390
    Database PDA

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  3. Article ; Online: Diagnosis of abdominal tuberculosis by mini-laparoscopy.

    Brehm, Thomas Theo / Schmiedel, Stefan / Lohse, Ansgar W

    Infection

    2022  Volume 50, Issue 4, Page(s) 1049–1050

    MeSH term(s) Diagnosis, Differential ; Humans ; Laparoscopy ; Peritonitis, Tuberculous/diagnosis ; Tuberculosis/diagnosis
    Language English
    Publishing date 2022-03-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-022-01800-3
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  4. Article ; Online: Histological spectrum of autoimmune hepatitis-reply to Fujiwara K. et al.

    Sebode, Marcial / Lohse, Ansgar W / Hübscher, Stefan G / Tiniakos, Dina

    Liver international : official journal of the International Association for the Study of the Liver

    2022  Volume 42, Issue 7, Page(s) 1704–1705

    MeSH term(s) Hepatitis, Autoimmune/pathology ; Humans
    Language English
    Publishing date 2022-05-26
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15318
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  5. Article ; Online: Full-Field Strain Determination for Additively Manufactured Parts Using Radial Basis Functions

    Stefan Hartmann / Lutz Müller-Lohse / Jendrik-Alexander Tröger

    Applied Sciences, Vol 11, Iss 11434, p

    2021  Volume 11434

    Abstract: Additively manufactured components, especially those produced in deposition welding processes, have a rough curvilinear surface. Strain and surface deformation analysis of such components is increasingly performed using digital image correlation (DIC) ... ...

    Abstract Additively manufactured components, especially those produced in deposition welding processes, have a rough curvilinear surface. Strain and surface deformation analysis of such components is increasingly performed using digital image correlation (DIC) methods, which raises questions regarding interpretability of the results. Furthermore, in triangulation or local tangential plane based DIC strain analysis, the principal strain directions are difficult to be calculated at any point, which is due to the non-continuity of the approach. Thus, both questions will be addressed in this article. Apart from classical local strain analysis based on triangulation or local linearization concepts, the application of globally formulated radial basis functions (RBF) is investigated for the first time, with the advantage that it is possible to evaluate all interesting quantities at arbitrary points. This is performed for both interpolation and regression. Both approaches are studied at three-dimensional, curvilinear verification examples and real additively manufactured cylindrical specimens. It is found out that, if real applications are investigated, the RBF-approach based on interpolation and regression has to be considered carefully due to so-called boundary effects. This can be circumvented by only considering the region that has a certain distance to the edges of the evaluation domain. Independent of the evaluation scheme, the error of the maximum principal strains increases with increasing surface roughness, which has to be kept in mind for such applications when interpreting or evaluating the results of manufactured parts. However, the entire scheme offers interesting properties for the treatment of DIC-data.
    Keywords digital image correlation ; strain analysis ; radial basis function ; additive manufacturing ; WAAM ; tension ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 670
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Book ; Online ; Thesis: MR-morphologische Kriterien perimesencephaler Venen bei nicht traumatischen Subarachnoidalblutungen anhand von SWI-Sequenzen

    Lohse, Ann-Kathrin Verfasser] / [Müller-Hülsbeck, Stefan [Akademischer Betreuer] / Flüh, Charlotte [Gutachter]

    2022  

    Author's details Ann-Kathrin Lohse ; Gutachter: Charlotte Flüh ; Betreuer: Stefan Müller-Hülsbeck
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Kiel
    Publishing place Kiel
    Document type Book ; Online ; Thesis
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  7. Article ; Online: The cutaneous beta human papillomavirus type 8 E6 protein induces CCL2 through the CEBPα/miR-203/p63 pathway to support an inflammatory microenvironment in epidermodysplasia verruciformis skin lesions.

    Vella, Luca / Sternjakob, Anna / Lohse, Stefan / Fingerle, Alina / Sperling, Tanya / Wickenhauser, Claudia / Stöckle, Michael / Vogt, Thomas / Roemer, Klaus / Ołdak, Monika / Smola, Sigrun

    Frontiers in cellular and infection microbiology

    2024  Volume 14, Page(s) 1336492

    Abstract: Human papillomavirus type 8 (HPV8), a cutaneous genus beta HPV type, has co-carcinogenic potential at sun-exposed sites in patients suffering from the inherited skin disease epidermodysplasia verruciformis (EV). We had previously shown that Langerhans ... ...

    Abstract Human papillomavirus type 8 (HPV8), a cutaneous genus beta HPV type, has co-carcinogenic potential at sun-exposed sites in patients suffering from the inherited skin disease epidermodysplasia verruciformis (EV). We had previously shown that Langerhans cells responsible for epithelial immunosurveillance were strongly reduced at infected sites and that the HPV8 E7 protein interferes with the CCAAT/enhancer-binding protein (C/EBP)β to suppress the Langerhans cell chemokine CCL20. At the same time, however, we observed that EV lesions are heavily infiltrated with inflammatory immune cells, which is similar to the situation in HPV8 E6 transgenic mice. To identify critical inflammatory factors, we used a broad multiplex approach and found that the monocyte attracting chemokine CCL2 was significantly and strongly induced by HPV8 E6 but not E7-expressing HaCaT cells, which were used as a model for UV-damaged skin keratinocytes. Conditioned media from HPV8 E6-expressing keratinocytes enhanced CCL2-receptor (CCR2)-dependent monocyte recruitment
    MeSH term(s) Animals ; Humans ; Mice ; Chemokine CCL2/metabolism ; Epidermodysplasia Verruciformis/metabolism ; Human Papillomavirus Viruses ; Keratinocytes ; Mice, Transgenic ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances CCL2 protein, human ; Chemokine CCL2 ; MicroRNAs ; MIRN203 microRNA, human ; Tumor Necrosis Factor-alpha ; Ccl2 protein, mouse
    Language English
    Publishing date 2024-03-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2024.1336492
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  8. Article ; Online: Low incidence of colonic complications after severe Shiga toxin-producing E. coli O104:H4 infection.

    Fründt, Thorben / Leuffert, Julia / Groth, Stefan / Rösch, Thomas / Steurer, Stefan / Lohse, Ansgar W / Ullrich, Sebastian / Lüth, Stefan

    Zeitschrift fur Gastroenterologie

    2021  Volume 60, Issue 7, Page(s) 1104–1110

    Abstract: Background: In summer 2011, Shiga toxin producing Escherichia coli (EHEC) serotype O104:H4 caused the most severe EHEC outbreak in Germany to date. The case of a previously recovered patient with symptomatic postinflammatory colonic stenosis following ... ...

    Title translation Niedrige Inzidenz von Langzeitschäden des Kolon nach schwerer Infektion mit Shiga Toxin produzierenden E.coli O104: H4.
    Abstract Background: In summer 2011, Shiga toxin producing Escherichia coli (EHEC) serotype O104:H4 caused the most severe EHEC outbreak in Germany to date. The case of a previously recovered patient with symptomatic postinflammatory colonic stenosis following EHEC- infection prompted us to conduct a prospective study to assess the macro- and microscopic intestinal long-term damage in a cohort of patients who had suffered from severe EHEC colitis.
    Methods: Following EHEC infection in 2011, 182 patients were offered to participate in this study between January 2013 and October 2014 as part of the post-inpatient follow-up care at the University Medical Center Hamburg-Eppendorf and to undergo colonoscopy with stepwise biopsies. Prior to colonoscopy, medical history and persistent post-infectious complaints were assessed.
    Results: Out of 182 patients, 22 (12%) participated in the study, 18 (82%) were female. All patients had been hospitalized due severe EHEC enterocolitis: 20 patients (90%) had subsequently developed hemolytic uremic syndrome (HUS), 16 patients (72%) had additionally required dialysis. On assessment prior to colonoscopy, all patients denied any abdominal complaints before EHEC-infection but 8 (36%) patients reported persistent post-infectious symptoms. According to the ROME IV criteria, 4 (18%) patients met the definition for post-infectious irritable bowel syndrome (PI-IBS). In all patients with persistent symptoms, colonoscopies and histological examination were unremarkable. Only in one symptom-free patient, biopsy revealed a locally limited cryptitis of the caecum, while all patients without complaints had inconspicuous histological and endoscopical findings.
    Conclusion: Following infection colonic stenosis is a serious but rare long-term complication in patients who had suffered from severe enterocolitis. However, a significant proportion of these patients develop PI-IBS.
    MeSH term(s) Constriction, Pathologic/complications ; Disease Outbreaks ; Enterocolitis/complications ; Enterocolitis/diagnosis ; Enterocolitis/epidemiology ; Escherichia coli ; Escherichia coli Infections/complications ; Escherichia coli Infections/diagnosis ; Escherichia coli Infections/epidemiology ; Escherichia coli O104 ; Female ; Germany/epidemiology ; Humans ; Incidence ; Irritable Bowel Syndrome ; Male ; Prospective Studies ; Shiga Toxin
    Chemical Substances Shiga Toxin (75757-64-1)
    Language English
    Publishing date 2021-11-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0172-8504 ; 0044-2771
    ISSN (online) 1439-7803
    ISSN 0172-8504 ; 0044-2771
    DOI 10.1055/a-1545-5322
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  9. Article ; Online: Bilateral Hematothorax Without Hematemesis-An Unusual Presentation of Variceal Bleeding.

    Paparoupa, Maria / Schrader, Joerg / Jung, Caroline / Boenisch, Olaf / Lohse, Ansgar W / Kluge, Stefan

    Hepatology (Baltimore, Md.)

    2021  Volume 73, Issue 3, Page(s) 1233–1235

    MeSH term(s) Adult ; Alcoholism/complications ; Emergency Service, Hospital ; Endoscopy, Gastrointestinal ; Esophageal and Gastric Varices/complications ; Esophageal and Gastric Varices/diagnosis ; Esophageal and Gastric Varices/diagnostic imaging ; Esophageal and Gastric Varices/surgery ; Fatal Outcome ; Hemothorax/diagnostic imaging ; Hemothorax/etiology ; Humans ; Hypertension, Portal/complications ; Male ; Portasystemic Shunt, Transjugular Intrahepatic ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-02-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.31477
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  10. Article ; Online: Cross-talk of cutaneous beta human papillomaviruses and the immune system: determinants of disease penetrance.

    Venuti, Assunta / Lohse, Stefan / Tommasino, Massimo / Smola, Sigrun

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2019  Volume 374, Issue 1773, Page(s) 20180287

    Abstract: Human papillomaviruses (HPVs) infect the epithelia of skin or mucosa, where they can induce hyperproliferative lesions. More than 220 different HPV types have been characterized and classified into five different genera. Mucosal high-risk HPVs are ... ...

    Abstract Human papillomaviruses (HPVs) infect the epithelia of skin or mucosa, where they can induce hyperproliferative lesions. More than 220 different HPV types have been characterized and classified into five different genera. Mucosal high-risk HPVs are causative for cancers of the anogenital region and oropharynx. Clinical data from patients with the rare genetic disorder epidermodysplasia verruciformis (EV) indicate that genus beta-HPVs cooperate with ultraviolet (UV) radiation in the development of cutaneous squamous cell carcinoma. In addition, epidemiological and biological findings indicate that beta-HPV types play a role in UV-mediated skin carcinogenesis also in non-EV individuals. However, the mechanisms used by these cutaneous viruses to promote epithelial carcinogenesis differ significantly from those of mucosal HPVs. Recent studies point to a delicate cross-talk of beta-HPVs with the cell-autonomous immunity of the host keratinocytes and the local immune microenvironment that eventually determines the fate of cutaneous HPV infection and the penetrance of disease. This review gives an overview of the critical interactions of genus beta-HPVs with the local immune system that allow the virus to complete its life cycle, to escape from extrinsic immunity, and eventually to cause chronic inflammation contributing to skin carcinogenesis. This article is part of the theme issue 'Silent cancer agents: multi-disciplinary modelling of human DNA oncoviruses'.
    MeSH term(s) Animals ; Betapapillomavirus/physiology ; Disease Susceptibility/immunology ; Disease Susceptibility/virology ; Humans ; Immune System/immunology ; Immune System/virology ; Mice ; Papillomavirus Infections/immunology ; Papillomavirus Infections/virology ; Skin Neoplasms/immunology ; Skin Neoplasms/virology
    Language English
    Publishing date 2019-04-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2018.0287
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