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Article: Associations between Outpatient Laboratory Test Age and Healthcare Utilization in Type 2 Diabetes Care.

Wiley, Kevin / Blackburn, Justin / Mendonca, Eneida / Menachemi, Nir / De Groot, Mary / Vest, Joshua R

Journal of diabetes and metabolic disorders

2023 Volume 22, Issue 2, Page(s) 1319–1326

Abstract: Purpose: To examine the longitudinal relationship between the age or shelf-life of common type 2 diabetes laboratory tests for serum creatinine, cholesterol, and glycated hemoglobin A1c conducted in outpatient settings and subsequent inpatient ... ...

Abstract	Purpose: To examine the longitudinal relationship between the age or shelf-life of common type 2 diabetes laboratory tests for serum creatinine, cholesterol, and glycated hemoglobin A1c conducted in outpatient settings and subsequent inpatient hospitalizations and emergency department visits. Methods: This study analyzes panel data from two healthcare delivery systems' electronic health records (EHR) for patients aged 18 years and older managing type 2 diabetes. We used EHR data to quantify the age of three laboratory tests: serum creatinine, cholesterol, and glycated hemoglobin A1c. Encounter data were used to determine the frequency of inpatient hospitalizations and emergency department visits. Negative binomial regressions with fixed effects were performed to compute marginal effects, levels of statistical significance, and 95% confidence intervals. Results: The average age for serum creatinine laboratory tests was 1.51 months (95%CI: 1.49-1.53). We computed older average ages for hemoglobin A1c (mean:6.17 months; 95%CI: 6.11-6.23) and serum creatinine tests (mean: 8.73; 95%CI: 8.65-8.81). Older laboratory tests were associated with an increase in the total expected counts of subsequent inpatient hospitalizations (ME = 0.047; p < 0.001) and ED visits (ME = 0.034; p < 0.001). Conclusion: Findings from this study indicate that older type 2 diabetes laboratory tests are associated with increases in the total expected count of subsequent inpatient hospitalizations and emergency department visits. Future research should examine the actionability of laboratory test values to determine associations with healthcare outcomes. Supplementary information: The online version contains supplementary material available at 10.1007/s40200-023-01250-0.
Language	English
Publishing date	2023-07-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2680289-2
ISSN	2251-6581
ISSN	2251-6581
DOI	10.1007/s40200-023-01250-0
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Article: Contribution of non-native galliforms to annual variation in biomass of British birds

Blackburn, Tim M / Gaston, Kevin J

Biological invasions. 2021 May, v. 23, no. 5

2021

Abstract: Millions of individuals of two species of non-native galliform birds, the Common Pheasant (Phasianus colchicus) and Red-legged Partridge (Alectoris rufa) are released into the British countryside annually in late summer, supplementing established ... ...

Abstract	Millions of individuals of two species of non-native galliform birds, the Common Pheasant (Phasianus colchicus) and Red-legged Partridge (Alectoris rufa) are released into the British countryside annually in late summer, supplementing established breeding populations of these two species. The biomass of birds involved in these releases has been compared to the British breeding bird biomass. However, the validity of this comparison is compromised because the biomass of wild birds varies across the year due to reproduction, mortality and migration. How the biomass of Common Pheasants and Red-legged Partridges compares to that of other British bird species in late summer, or across the whole year, is currently unknown. Here, we produce estimates of how British bird biomass varies across the year, to assess the contribution of the two non-native galliforms to this variation. We show that overall British bird biomass is probably lowest around the start of the breeding season in April, and peaks in late summer and autumn. We estimate that around a quarter of British bird biomass annually is contributed by Common Pheasants and Red-legged Partridges, and that at their peak in August these two species represent about half of all wild bird biomass in Britain.
Keywords	Alectoris rufa ; Phasianus colchicus ; autumn ; biomass ; mortality ; partridges ; pheasants ; summer ; wild birds ; United Kingdom
Language	English
Dates of publication	2021-05
Size	p. 1549-1562.
Publishing place	Springer International Publishing
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1438729-3
ISSN	1573-1464 ; 1387-3547
ISSN (online)	1573-1464
ISSN	1387-3547
DOI	10.1007/s10530-021-02458-y
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Identification of multiple proteins whose interaction with mannitol dehydrogenase is induced by salicylic acid: Implications for unconventional secretion.

Ho, Tricia C / Blackburn, R Kevin / Goshe, Michael B / Williamson, John D

Proteomics

2021 Volume 22, Issue 1-2, Page(s) e2100091

Abstract: Although protein secretion was previously believed to be solely via ER/Golgi pathways, Golgi-independent secretion has now been described in both animals and plants. Secretion of the mannitol catabolic enzyme mannitol dehydrogenase (MTD) in response to ... ...

Abstract	Although protein secretion was previously believed to be solely via ER/Golgi pathways, Golgi-independent secretion has now been described in both animals and plants. Secretion of the mannitol catabolic enzyme mannitol dehydrogenase (MTD) in response to the endogenous pathogen response signal salicylic acid (SA) was one of the first reports of unconventional protein secretion in plants. To begin assessing potential secretion-associated MTD protein interactors, we present here high-quality databases describing changes in MTD-interacting proteins following SA treatment of Arabidopsis thaliana cells expressing MTD.
MeSH term(s)	Arabidopsis/metabolism ; Arabidopsis Proteins/metabolism ; Gene Expression Regulation, Plant ; Mannitol Dehydrogenases/genetics ; Mannitol Dehydrogenases/metabolism ; Plants/metabolism ; Proteins ; Salicylic Acid/pharmacology
Chemical Substances	Arabidopsis Proteins ; Proteins ; Mannitol Dehydrogenases (EC 1.1.-) ; Salicylic Acid (O414PZ4LPZ)
Language	English
Publishing date	2021-09-24
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2032093-0
ISSN	1615-9861 ; 1615-9853
ISSN (online)	1615-9861
ISSN	1615-9853
DOI	10.1002/pmic.202100091
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Zs.A 5386: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.A 1868: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Expression, purification, and phylogenetic analysis of MDIS1-INTERACTING RECEPTOR-LIKE KINASE1 (MIK1).

Trihemasava, Krittin / Chakraborty, Sayan / Blackburn, Kevin / Xu, Guozhou

The protein journal

2020 Volume 39, Issue 5, Page(s) 461–471

Abstract: An abundance of protein structures has been solved in the last six decades that are paramount in defining the function of such proteins. For unsolved protein structures, however, predictions based on sequence and phylogenetic similarity can be useful for ...

Abstract	An abundance of protein structures has been solved in the last six decades that are paramount in defining the function of such proteins. For unsolved protein structures, however, predictions based on sequence and phylogenetic similarity can be useful for identifying key domains of interaction. Here, we describe expression and purification of a recombinant plant LRR-RLK ectodomain MIK1 using a modified baculovirus-mediated expression system with subsequent N-linked glycosylation analysis using LC-MS/MS and computational sequence-based analyses. Though highly ubiquitous, glycosylation site specificity and the degree of glycosylation influenced by genetic and exogenous factors are still largely unknown. Our experimental analysis of N-glycans on MIK1 identified clusters of glycosylation that may explicate the regions involved in MIK1 ectodomain binding. Whether these glycans are necessary for function is yet to be determined. Phylogenetic comparison using multiple sequence alignment between MIK1 and other LRR-RLKs, namely TDR in Arabidopsis thaliana, revealed conserved structural motifs that are known to play functional roles in ligand and receptor binding.
MeSH term(s)	Arabidopsis/enzymology ; Arabidopsis/genetics ; Arabidopsis Proteins/biosynthesis ; Arabidopsis Proteins/chemistry ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/isolation & purification ; Gene Expression ; Phylogeny ; Protein Kinases/biosynthesis ; Protein Kinases/chemistry ; Protein Kinases/genetics ; Protein Kinases/isolation & purification ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification
Chemical Substances	Arabidopsis Proteins ; Recombinant Proteins ; MIK1 protein, Arabidopsis (EC 2.7.-) ; Protein Kinases (EC 2.7.-)
Language	English
Publishing date	2020-10-26
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2143071-8
ISSN	1875-8355 ; 1572-3887
ISSN (online)	1875-8355
ISSN	1572-3887
DOI	10.1007/s10930-020-09926-9
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Article ; Online: A Multilingual Chatbot Can Effectively Engage Arthroplasty Patients Who Have Limited English Proficiency.

Rainey, Joshua P / Blackburn, Brenna E / McCutcheon, Chance L / Kenyon, Courtney M / Campbell, Kevin J / Anderson, Lucas A / Gililland, Jeremy M

The Journal of arthroplasty

2023 Volume 38, Issue 7 Suppl 2, Page(s) S78–S83

Abstract: Background: In the United States, English language proficiency is widely accepted as a key social determinant of health. For patients with limited English proficiency (LEP), language barriers can make the delivery of perioperative instructions ... ...

Abstract	Background: In the United States, English language proficiency is widely accepted as a key social determinant of health. For patients with limited English proficiency (LEP), language barriers can make the delivery of perioperative instructions challenging. The purpose of this study was to evaluate whether a multilingual chatbot could effectively engage LEP patients and improve their outcome after total joint arthroplasty (TJA). Methods: We identified 1,282 TJA patients (705 knees, 577 hips) who enrolled in a short message service (SMS) chatbot from 2020-2022. Forty-seven patients enrolled in the chatbot received their messages in a language other than English. A historical control of 68 LEP patients not enrolled in the chatbot was identified. Chi-squared, Fisher's exact test, and t-tests were performed to measure the effect that conversational engagement had on emergency department (ED) visits, hospital readmissions, and reoperations. Results: There was no difference in the conversational engagement between LEP patients and those with English as their primary language (EPL) (12.3 versus 12.2 text responses, P = .959). The LEP cohort who enrolled in the chatbot had fewer readmissions (0% versus 8.3%, P = .013) and a near significant reduction in ED visits (0.9% versus 8.0%, P = .085) compared to those not enrolled. There was no difference in reoperations between the 2 cohorts. Conclusion: LEP and EPL patients engaged equally with the multilingual chatbot. LEP patients who enrolled in the chatbot had fewer readmissions and a near significant reduction in ED visits. Multilingual platforms such as this chatbot may provide more equitable care to our frequently encountered LEP patients.
MeSH term(s)	Humans ; United States ; Limited English Proficiency ; Language ; Communication Barriers ; Emergency Service, Hospital ; Arthroplasty
Language	English
Publishing date	2023-04-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	632770-9
ISSN	1532-8406 ; 0883-5403
ISSN (online)	1532-8406
ISSN	0883-5403
DOI	10.1016/j.arth.2023.04.014
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Jg. 1995 - 2021: Lesesall (1.OG)
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Article ; Online: Quantifying Electronic Health Record Data Quality in Telehealth and Office-Based Diabetes Care.

Wiley, Kevin K / Mendonca, Eneida / Blackburn, Justin / Menachemi, Nir / Groot, Mary De / Vest, Joshua R

Applied clinical informatics

2022 Volume 13, Issue 5, Page(s) 1172–1180

Abstract: Objective: Data derived from the electronic health record (EHR) are commonly reused for quality improvement, clinical decision-making, and empirical research despite having data quality challenges. Research highlighting EHR data quality concerns has ... ...

Abstract	Objective: Data derived from the electronic health record (EHR) are commonly reused for quality improvement, clinical decision-making, and empirical research despite having data quality challenges. Research highlighting EHR data quality concerns has largely been examined and identified during traditional in-person visits. To understand variations in data quality among patients managing type 2 diabetes mellitus (T2DM) with and without a history of telehealth visits, we examined three EHR data quality dimensions: timeliness, completeness, and information density. Methods: We used EHR data (2016-2021) from a local enterprise data warehouse to quantify timeliness, completeness, and information density for diagnostic and laboratory test data. Means and chi-squared significance tests were computed to compare data quality dimensions between patients with and without a history of telehealth use. Results: Mean timeliness or T2DM measurement age for the study sample was 77.8 days (95% confidence interval [CI], 39.6-116.4). Mean completeness for the sample was 0.891 (95% CI, 0.868-0.914). The mean information density score was 0.787 (95% CI, 0.747-0.827). EHR data for patients managing T2DM with a history of telehealth use were timelier (73.3 vs. 79.8 days), and measurements were more uniform across visits (0.795 vs. 0.784) based on information density scores, compared with patients with no history of telehealth use. Conclusion: Overall, EHR data for patients managing T2DM with a history of telehealth visits were generally timelier and measurements were more uniform across visits than for patients with no history of telehealth visits. Chronic disease care relies on comprehensive patient data collected via hybrid care delivery models and includes important domains for continued data quality assessments prior to secondary reuse purposes.
MeSH term(s)	Humans ; Infant ; Electronic Health Records ; Diabetes Mellitus, Type 2/therapy ; Telemedicine ; Delivery of Health Care
Language	English
Publishing date	2022-12-14
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1869-0327
ISSN (online)	1869-0327
DOI	10.1055/s-0042-1758737
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Article ; Online: Development of Peptide Ligands for Targeted Capture of Host Cell Proteins from Cell Culture Production Harvests.

Lavoie, R Ashton / Williams, Taufika Islam / Blackburn, R Kevin / Carbonell, Ruben G / Menegatti, Stefano

Methods in molecular biology (Clifton, N.J.)

2021 Volume 2261, Page(s) 489–506

Abstract: Capture of host cell proteins (HCPs) from cell culture production harvests is critical to ensure the maximum levels specified by international regulatory bodies of product purity for therapeutic monoclonal antibodies (mAbs). Peptide ligands that ... ...

Abstract	Capture of host cell proteins (HCPs) from cell culture production harvests is critical to ensure the maximum levels specified by international regulatory bodies of product purity for therapeutic monoclonal antibodies (mAbs). Peptide ligands that selectively target the whole spectrum of the HCPs, while letting the mAb product flow through unbound, are an ideal complement to the affinity-based capture step via Protein A chromatography. In this work, we describe the development of HCP-binding peptide ligands, especially focusing on the steps of (1) peptide selection via library screening and (2) quantification of HCP removal via proteomics by mass spectrometry.
MeSH term(s)	Animals ; CHO Cells ; Cricetulus ; Enzyme-Linked Immunosorbent Assay ; Humans ; Ligands ; Microscopy, Fluorescence ; Peptide Library ; Peptides/metabolism ; Protein Binding ; Proteins/isolation & purification ; Proteins/metabolism ; Proteomics ; Solid Phase Extraction ; Tandem Mass Spectrometry
Chemical Substances	Ligands ; Peptide Library ; Peptides ; Proteins
Language	English
Publishing date	2021-01-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1186-9_31
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Article: Recalling war trauma of the Pacific War and the Japanese occupation in the oral history of Malaysia and Singapore.

Blackburn, Kevin

The Oral history review

2009 Volume 36, Issue 2, Page(s) 231–252

Abstract: The Pacific War and the Japanese Occupation were traumatic periods in the lives of people now over seventy years old in Malaysia and Singapore. This study traces why individuals interviewed for oral history of the Pacific War and the Japanese Occupation ... ...

Abstract	The Pacific War and the Japanese Occupation were traumatic periods in the lives of people now over seventy years old in Malaysia and Singapore. This study traces why individuals interviewed for oral history of the Pacific War and the Japanese Occupation have often been able to tell stories of trauma without being overwhelmed by their reminiscences. It emphasizes that memories of traumatic experiences of the Pacific War and the Japanese Occupation in Malaysia and Singapore are mediated and eased by supportive social networks that are part of the interview subject's community. The individual's personal memories of traumatic war experiences are positioned in the context of the collective memory of the group and, thus, are made easier to recall. However, for individuals whose personal memories are at variance with the collective memory of the group they belong to, recalling traumatic experiences is more difficult and alienating as they do not have the support in their community. The act of recalling traumatic memories in the context of the collective memory of a group is particularly relevant in Malaysia and Singapore. These countries have a long history of being plural societies, where although the major ethnic groups -- the Malays, Chinese, and Indians -- have lived side by side peacefully, they have lived in culturally and socially separate worlds, not interacting much with the other groups. The self -- identity of many older people who lived through the Pacific War and the Japanese Occupation is inextricably bound up with their ethnicity. Oral history on war trauma strongly reflects these identities.
MeSH term(s)	Asian Continental Ancestry Group/education ; Asian Continental Ancestry Group/ethnology ; Asian Continental Ancestry Group/history ; Asian Continental Ancestry Group/legislation & jurisprudence ; Asian Continental Ancestry Group/psychology ; Culture ; Ethnic Groups/education ; Ethnic Groups/ethnology ; Ethnic Groups/history ; Ethnic Groups/legislation & jurisprudence ; Ethnic Groups/psychology ; History, 20th Century ; Humans ; Interview, Psychological ; Interviews as Topic ; Japan/ethnology ; Malaysia/ethnology ; Memory ; Oceanic Ancestry Group/education ; Oceanic Ancestry Group/ethnology ; Oceanic Ancestry Group/history ; Oceanic Ancestry Group/legislation & jurisprudence ; Oceanic Ancestry Group/psychology ; Pacific Ocean/ethnology ; Race Relations/history ; Race Relations/legislation & jurisprudence ; Race Relations/psychology ; Shock, Traumatic/ethnology ; Shock, Traumatic/history ; Shock, Traumatic/psychology ; Singapore/ethnology ; War Crimes/ethnology ; War Crimes/history ; War Crimes/psychology ; World War II ; Wounds and Injuries/ethnology ; Wounds and Injuries/history ; Wounds and Injuries/psychology
Language	English
Publishing date	2009-12-01
Publishing country	United States
Document type	Historical Article ; Journal Article
ZDB-ID	2054773-0
ISSN	1533-8592 ; 0094-0798
ISSN (online)	1533-8592
ISSN	0094-0798
DOI	10.1093/ohr/ohp041
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Article ; Online: Academic Activism: An Avenue to Action.

Astle, Kevin N / Arya, Vibhuti / Blackburn, Hayley / Gahbauer, Alice / Hirsch, Elizabeth B / Fravel, Michelle / Ko, Caroline L / Saunders, Ila M / Abdul-Mutakabbir, Jacinda C / Brown, Judah E / Childs-Kean, Lindsey M

American journal of pharmaceutical education

2023 Volume 87, Issue 6, Page(s) 100080

Abstract: Until now, the term "advocacy" in pharmacy education and practice has focused on advocating for the advancement of the pharmacy profession or patient advocacy. With the 2022 Curricular Outcomes and Entrustable Professional Activities publication, the ... ...

Abstract	Until now, the term "advocacy" in pharmacy education and practice has focused on advocating for the advancement of the pharmacy profession or patient advocacy. With the 2022 Curricular Outcomes and Entrustable Professional Activities publication, the focus of advocacy has broadened to include advocacy for other causes that impact the health of patients. This commentary will highlight 3 pharmacy-focused organizations advocating for social issues impacting the health of patients as well as encourage members of the Academy to continue to expand personal social advocacy efforts.
MeSH term(s)	Humans ; Education, Pharmacy ; Academies and Institutes ; Patient Advocacy ; Pharmaceutical Services ; Pharmacies
Language	English
Publishing date	2023-05-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	603807-4
ISSN	1553-6467 ; 0002-9459
ISSN (online)	1553-6467
ISSN	0002-9459
DOI	10.1016/j.ajpe.2023.100080
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Zs.A 924: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Article: An Artificial Intelligence Approach to Predicting Unplanned Intubation Following Anterior Cervical Discectomy and Fusion.

Veeramani, Ashwin / Zhang, Andrew S / Blackburn, Amy Z / Etzel, Christine M / DiSilvestro, Kevin J / McDonald, Christopher L / Daniels, Alan H

Global spine journal

2022 Volume 13, Issue 7, Page(s) 1849–1855

Abstract: Study design: Level III retrospective database study.: Objectives: The purpose of this study is to determine if machine learning algorithms are effective in predicting unplanned intubation following anterior cervical discectomy and fusion (ACDF).: ... ...

Abstract	Study design: Level III retrospective database study. Objectives: The purpose of this study is to determine if machine learning algorithms are effective in predicting unplanned intubation following anterior cervical discectomy and fusion (ACDF). Methods: The National Surgical Quality Initiative Program (NSQIP) was queried to select patients who had undergone ACDF. Machine learning analysis was conducted in Python and multivariate regression analysis was conducted in R. C-Statistics area under the curve (AUC) and prediction accuracy were used to measure the classifier's effectiveness in distinguishing cases. Results: In total, 54 502 patients met the study criteria. Of these patients, .51% underwent an unplanned re-intubation. Machine learning algorithms accurately classified between 72%-100% of the test cases with AUC values of between .52-.77. Multivariable regression indicated that the number of levels fused, male sex, COPD, American Society of Anesthesiologists (ASA) > 2, increased operating time, Age > 65, pre-operative weight loss, dialysis, and disseminated cancer were associated with increased risk of unplanned intubation. Conclusions: The models presented here achieved high accuracy in predicting risk factors for re-intubation following ACDF surgery. Machine learning analysis may be useful in identifying patients who are at a higher risk of unplanned post-operative re-intubation and their treatment plans can be modified to prophylactically prevent respiratory compromise and consequently unplanned re-intubation.
Language	English
Publishing date	2022-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2648287-3
ISSN	2192-5690 ; 2192-5682
ISSN (online)	2192-5690
ISSN	2192-5682
DOI	10.1177/21925682211053593
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