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  1. Book ; Conference proceedings: From sleep to arousal to attention deficits in neuropsychiatric disorders

    Thome, Johannes

    (Journal of trauma transmission ; volume 124, supplement 1 (February 2017))

    2017  

    Event/congress Hansesymposium Sleep and Rhythms - Relevance for Psychiatry and Neurology (2014, Rostock)
    Author's details guest editors: Johannes Thome, Oliver Tucha ; 12th Hanse Symposium: Sleep and Rhythms - Relevance for Psychiatry and Neurology
    Series title Journal of trauma transmission ; volume 124, supplement 1 (February 2017)
    Journal of neural transmission
    Collection Journal of neural transmission
    Language English
    Size S201 Seiten, Illustrationen
    Publisher Springer
    Publishing place Vienna
    Publishing country Austria
    Document type Book ; Conference proceedings
    Note Tagungsdaten: 5-6 September 2014, Rostock, Germany
    HBZ-ID HT019275432
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ui II Zs 150 -124,Suppl.1- verfügbar in Königswinter Königswinter

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  2. Article ; Conference proceedings: Abstracts of the 30th Symposium of the AGNP

    Thome, Johannes

    Pharmacopsychiatry volume 50, 5 (September 2017), Seite 213-227

    Date/venue: October 4th-6th, 2017, Munich, Germany

    2017  

    Event/congress AGNP-Symposium (30., 2017, München)
    Author's details chairs: Johannes Thome, Jens Wiltfang, Golo Kronenberg
    Collection Pharmacopsychiatry
    Language English
    Publishing place Stuttgart, [2017]
    Publishing country Germany
    Document type Article ; Conference proceedings
    HBZ-ID HT019493019
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Zs A 481 -50-

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  3. Book: Integrating pharmacotherapy and psychotherapy

    Thome, Johannes

    (Journal of trauma transmission ; 122, Suppl. 1)

    2015  

    Author's details guest ed.: Johannes Thome
    Series title Journal of trauma transmission ; 122, Suppl. 1
    Journal of neural transmission
    Collection Journal of neural transmission
    Language English
    Size S134 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book
    HBZ-ID HT018762865
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ui II Zs 150 -122,Suppl.1- verfügbar in Königswinter Königswinter

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  4. Book ; Thesis: Validierung und prognostischer Nutzen des globalen longitudinalen Strain bei Patienten mit nicht-ischämischer dilatativer Kardiomyopathie

    Thome, Simeon / Buß, Sebastian Johannes

    2021  

    Institution Universität Heidelberg
    Author's details vorgelegt von Simeon Thome ; Doktorvater: Prof. Dr. med. Sebastian Johannes Buß
    Language German
    Size IV, 73 Seiten, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2021
    HBZ-ID HT021249975
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2022 E 244 order for loan Magazin

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  5. Article ; Online: The Role of Circadian Rhythmicity and CLOCK Genes in Psychiatry.

    Palm, Denise / Thome, Johannes

    Pharmacopsychiatry

    2023  Volume 56, Issue 3, Page(s) 85–86

    Abstract: Circadian rhythms are biological oscillations, that perpetuate themselves even in the absence of "zeitgebers" (external time cues), with a period of approximately 24 hours. The master pacemaker is the suprachiasmatic nucleus (SCN) of the hypothalamus. ... ...

    Abstract Circadian rhythms are biological oscillations, that perpetuate themselves even in the absence of "zeitgebers" (external time cues), with a period of approximately 24 hours. The master pacemaker is the suprachiasmatic nucleus (SCN) of the hypothalamus. The SCN is entrained by environmental factors, particularly light, to the 24-hour light-dark cycle by the Earth's rotation. Peripheral circadian oscillators, located in multiple cell types and tissues, are controlled by signals arising from the SCN and from the environment, particularly food intake, hormonal signals and body-temperature fluctuations. Circadian rhythmicity is observable in almost every cell of living organisms including humans and, for example in cell cultures, these rhythms persist even without the SCN 1 2.
    MeSH term(s) Humans ; Circadian Rhythm/genetics ; CLOCK Proteins/genetics ; Psychiatry ; Suprachiasmatic Nucleus/metabolism
    Chemical Substances CLOCK Proteins (EC 2.3.1.48)
    Language English
    Publishing date 2023-05-15
    Publishing country Germany
    Document type Editorial
    ZDB-ID 605670-2
    ISSN 1439-0795 ; 0720-4280 ; 0176-3679
    ISSN (online) 1439-0795
    ISSN 0720-4280 ; 0176-3679
    DOI 10.1055/a-2078-4905
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 481: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Book: Molekulare Psychiatrie

    Thome, Johannes

    theoretische Grundlagen, Forschung und Klinik

    2005  

    Author's details Johannes Thome
    Language German
    Size 265 S. : Ill., graph. Darst.
    Edition 1. Aufl.
    Publisher Huber
    Publishing place Bern u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT014258871
    ISBN 3-456-83503-5 ; 978-3-456-83503-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2005 A 132 order for loan Magazin

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  7. Article ; Online: Same but different. Incidental and symptomatic lower grade gliomas show differences in molecular features and survival.

    Demetz, Matthias / Krigers, Aleksandrs / Moser, Patrizia / Kerschbaumer, Johannes / Thomé, Claudius / Freyschlag, Christian F

    Journal of neuro-oncology

    2023  Volume 162, Issue 2, Page(s) 397–405

    Abstract: Purpose: Data on differences in overall survival and molecular characteristics between incidental (iLGG) and symptomatic lower grade Glioma (sLGG) are limited. The aim of this study was to investigate differences between patients with iLGG and sLGG.: ... ...

    Abstract Purpose: Data on differences in overall survival and molecular characteristics between incidental (iLGG) and symptomatic lower grade Glioma (sLGG) are limited. The aim of this study was to investigate differences between patients with iLGG and sLGG.
    Methods: All adult patients with a histologically proven diffuse (WHO°II) or anaplastic (WHO°III) glioma who underwent their first surgery at the authors' institution between 2010 and 2019 were retrospectively included. Tumor volume on pre- and postoperative MRI scans was determined. Clinical and routine neuropathological data were gained from patients' charts. If IDH1, ATRX and EGFR were not routinely assessed, they were re-determined.
    Results: Out of 161 patients included, 23 (14%) were diagnosed as incidental findings. Main reasons for obtaining MRI were: headache(n = 12), trauma(n = 2), MRI indicated by other departments(n = 7), staging examination for cancer(n = 1), volunteering for MRI sequence testing(n = 1). The asymptomatic patients were significantly younger with a median age of 38 years (IqR28-48) vs. 50 years (IqR38-61), p = 0.011. Incidental LGG showed significantly lower preoperative tumor volumes in T1 CE (p = 0.008), FLAIR (p = 0.038) and DWI (p = 0.028). Incidental LGG demonstrated significantly lower incidence of anaplasia (p = 0.004) and lower expression of MIB-1 (p = 0.008) compared to sLGG. IDH1-mutation was significantly more common in iLGG (p = 0.024). Incidental LGG showed a significantly longer OS (mean 212 vs. 70 months, p = 0.005) and PFS (mean 201 vs. 61 months, p = 0.001) compared to sLGG.
    Conclusion: Our study is the first to depict a significant difference in molecular characteristics between iLGG and sLGG. The findings of this study confirmed and extended the results of previous studies showing a better outcome and more favorable radiological, volumetric and neuropathological features of iLGG.
    MeSH term(s) Adult ; Humans ; Middle Aged ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Retrospective Studies ; Glioma/diagnostic imaging ; Glioma/genetics ; Glioma/pathology ; Magnetic Resonance Imaging ; Headache
    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604875-4
    ISSN 1573-7373 ; 0167-594X
    ISSN (online) 1573-7373
    ISSN 0167-594X
    DOI 10.1007/s11060-023-04301-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1825: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Human Derived Dermal Fibroblasts as in Vitro Research Tool to Study Circadian Rhythmicity in Psychiatric Disorders.

    Palm, Denise / Uzoni, Adriana / Kronenberg, Golo / Thome, Johannes / Faltraco, Frank

    Pharmacopsychiatry

    2023  Volume 56, Issue 3, Page(s) 87–100

    Abstract: A number of psychiatric disorders are defined by persistent or recurrent sleep-wake disturbances alongside disruptions in circadian rhythm and altered clock gene expression. Circadian rhythms are present not only in the hypothalamic suprachiasmatic ... ...

    Abstract A number of psychiatric disorders are defined by persistent or recurrent sleep-wake disturbances alongside disruptions in circadian rhythm and altered clock gene expression. Circadian rhythms are present not only in the hypothalamic suprachiasmatic nucleus but also in peripheral tissues. In this respect, cultures of human derived dermal fibroblasts may serve as a promising new tool to investigate cellular and molecular mechanisms underlying the pathophysiology of mental illness. In this article, we discuss the advantages of fibroblast cultures to study psychiatric disease. More specifically, we provide an update on recent advances in modeling circadian rhythm disorders using human fibroblasts.
    MeSH term(s) Humans ; Circadian Rhythm/genetics ; Mental Disorders ; Fibroblasts/metabolism ; Circadian Clocks/genetics
    Language English
    Publishing date 2023-05-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 605670-2
    ISSN 1439-0795 ; 0720-4280 ; 0176-3679
    ISSN (online) 1439-0795
    ISSN 0720-4280 ; 0176-3679
    DOI 10.1055/a-1147-1552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 481: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Integrating pharmacotherapy and psychotherapy.

    Thome, Johannes

    Journal of neural transmission (Vienna, Austria : 1996)

    2015  Volume 122 Suppl 1, Page(s) S1–2

    MeSH term(s) Antipsychotic Agents/therapeutic use ; Humans ; Mental Disorders/drug therapy ; Mental Disorders/rehabilitation ; Psychotherapy/methods
    Chemical Substances Antipsychotic Agents
    Language English
    Publishing date 2015-08
    Publishing country Austria
    Document type Editorial
    ZDB-ID 184163-4
    ISSN 1435-1463 ; 0300-9564
    ISSN (online) 1435-1463
    ISSN 0300-9564
    DOI 10.1007/s00702-015-1415-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.150: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Journal of molecular psychiatry.

    Thome, Johannes

    Journal of molecular psychiatry

    2013  Volume 1, Issue 1, Page(s) 1

    Language English
    Publishing date 2013-04-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2713307-2
    ISSN 2049-9256
    ISSN 2049-9256
    DOI 10.1186/2049-9256-1-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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