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Article ; Online: Inflammaging at the Time of COVID-19.

Zazzara, Maria Beatrice / Bellieni, Andrea / Calvani, Riccardo / Coelho-Junior, Hélio Jose / Picca, Anna / Marzetti, Emanuele

Clinics in geriatric medicine

2022 Volume 38, Issue 3, Page(s) 473–481

Abstract: Severe coronavirus disease 2019 (COVID-19) is associated with overproduction of proinflammatory cytokines. The ensuing cytokine storm contributes to the development of severe pneumonia and, possibly, to long-term symptom persistence (long COVID). The ... ...

Abstract	Severe coronavirus disease 2019 (COVID-19) is associated with overproduction of proinflammatory cytokines. The ensuing cytokine storm contributes to the development of severe pneumonia and, possibly, to long-term symptom persistence (long COVID). The chronic state of low-grade inflammation that accompanies aging (inflammaging) might predispose older adults to severe COVID-19. Inflammaging may also contribute to symptom persistence following acute COVID-19. Antiinflammatory drugs and immunomodulatory agents can achieve significant therapeutic gain during acute COVID-19. Lifestyle interventions (eg, physical activity, diet) may be proposed as strategies to counteract inflammation and mitigate long-term symptom persistence.
MeSH term(s)	Aged ; COVID-19/complications ; COVID-19/therapy ; Cytokines ; Humans ; Inflammation/therapy ; SARS-CoV-2 ; Post-Acute COVID-19 Syndrome
Chemical Substances	Cytokines
Language	English
Publishing date	2022-03-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1064151-8
ISSN	1879-8853 ; 0749-0690
ISSN (online)	1879-8853
ISSN	0749-0690
DOI	10.1016/j.cger.2022.03.003
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Article: Sarcopenia Diagnosis and Management in Hematological Malignancies and Differences with Cachexia and Frailty.

Colloca, Giuseppe Ferdinando / Bellieni, Andrea / Di Capua, Beatrice / Iervolino, Marialuisa / Bracci, Serena / Fusco, Domenico / Tagliaferri, Luca / Landi, Francesco / Valentini, Vincenzo

Cancers

2023 Volume 15, Issue 18

Abstract: Sarcopenia is a geriatric syndrome characterized by a progressive loss of systemic muscle mass and decreased muscle strength or physical function. Several conditions have a role in its pathogenesis, significantly impacting adverse outcomes such as falls, ...

Abstract	Sarcopenia is a geriatric syndrome characterized by a progressive loss of systemic muscle mass and decreased muscle strength or physical function. Several conditions have a role in its pathogenesis, significantly impacting adverse outcomes such as falls, functional decline, frailty, disability, multiple hospitalizations, and mortality. In the oncological setting, sarcopenia is associated with an increased risk of treatment toxicity, postoperative complications, and a higher mortality rate related to other causes (e.g., pneumonia). In the hematological field, even more so, sarcopenia predicts toxicity and response to treatments. In patients with hematologic malignancy, low muscle mass is associated with adverse outcomes and is a predictor of overall survival and non-relapse mortality. Therefore, it is essential to correctly recognize sarcopenia, evaluate the risk factors and their impact on the patient's trajectory, and effectively treat sarcopenia. Sarcopenia is a reversible condition. The most effective intervention for reversing it is physical exercise combined with nutrition. The objective of clinical assessment focused on sarcopenia is to be able to carry out a "tailor-made treatment".
Language	English
Publishing date	2023-09-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15184600
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Article: Association between Older Age and Psychiatric Symptoms in a Population of Hospitalized Patients with COVID-19.

Cipriani, Maria Camilla / Pais, Cristina / Savoia, Vezio / Falsiroli, Cinzia / Bellieni, Andrea / Cingolani, Antonella / Fantoni, Massimo / Chieffo, Daniela Pia Rosaria / Sani, Gabriele / Landi, Francesco / Landi, Giovanni / Liperoti, Rosa

Journal of personalized medicine

2023 Volume 13, Issue 6

Abstract: Increased rates of anxiety and depression have been reported for older adults during the COVID-19 pandemic. However, little is known regarding the onset of mental health morbidity during the acute phase of the disease and the role of age as potential ... ...

Abstract	Increased rates of anxiety and depression have been reported for older adults during the COVID-19 pandemic. However, little is known regarding the onset of mental health morbidity during the acute phase of the disease and the role of age as potential independent risk factor for psychiatric symptoms. The cross-sectional association between older age and psychiatric symptoms has been estimated in a sample of 130 patients hospitalized for COVID-19 during the first and second wave of the pandemic. Compared to younger patients, those who were 70 years of age or older resulted at a higher risk of psychiatric symptoms measured on the Brief Psychiatric Symptoms Rating Scale (BPRS) (adjusted (adj.) odds ratio (OR) 2.36, 95% confidence interval (CI) 1.05-5.30) and delirium (adj. OR 5.24, 95% CI 1.63-16.8)). No association was found between older age and depressive symptoms or anxiety. Age was associated with psychiatric symptoms independently of gender, marital status, history of psychiatric illness, severity of disease and cardiovascular morbidity. Older adults appear at high risk of developing psychiatric symptoms related to COVID-19 disease during hospital stay. Multidisciplinary preventive and therapeutic interventions should be implemented to reduce the risk of psychiatric morbidity and related adverse health care outcomes among older hospital inpatients with COVID-19.
Language	English
Publishing date	2023-06-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13060973
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Article ; Online: Causes of deaths in long-term care and hospice care facilities during the first year of COVID-19 pandemic: a snapshot of Italy during 2020.

Zazzara, Maria Beatrice / Colloca, Giuseppe Ferdinando / Maraschini, Alice / Bellieni, Andrea / Dispenza, Sabrina / Meloni, Eleonora / Ricciotti, Maria Adelaide / Penco, Italo / Minelli, Giada / Onder, Graziano

Aging clinical and experimental research

2023 Volume 35, Issue 6, Page(s) 1385–1392

Abstract: Background: Older adults living in long-term care facilities (LTCF) have been severely affected by COVID-19. Hospice care (HC) facilities and palliative care are essential in treating patients dying from COVID-19. In Italy, little is known about the ... ...

Abstract	Background: Older adults living in long-term care facilities (LTCF) have been severely affected by COVID-19. Hospice care (HC) facilities and palliative care are essential in treating patients dying from COVID-19. In Italy, little is known about the impact of COVID-19 on deaths in LTCF and the care provided in HC to COVID-19 patients. Aim: To assess overall and case-specific mortality in 2020 in LTC and HC facilities in comparison to the previous five years (2015-2019). Methods: We performed a descriptive study using data derived from the Italian national "Cause of Death" registry-managed by the Italian National Institute of Statistics-on deaths occurred in LTC and HC facilities during 2020 and the period 2015-2019. Results: Number of deaths significantly increased in 2020 compared with 2015-2019 in LTCF (83,062 deaths vs. 59,200) and slightly decreased in hospices (38,788 vs. 39,652). COVID-19 caused 12.5% of deaths in LTCF and only 2% in hospices. Other than COVID-19, in 2020, cancer accounted for 77% of all deaths that occurred in HC, while cardiovascular diseases (35.6%) and psychotic and behavioral disorders (10%) were the most common causes of death in LTCF. Overall, 22% of the excess mortality registered in Italy during 2020 is represented by the deaths that occurred in LTCF. Discussion and conclusion: LTCF were disproportionally affected by COVID-19, while the response to the pandemic in HC was limited. These data can help plan strategies to limit the impact of future epidemics and to better understand residential care response to COVID-19 epidemic.
MeSH term(s)	Humans ; Aged ; COVID-19 ; Hospices ; Long-Term Care ; Hospice Care ; Pandemics ; Italy/epidemiology
Language	English
Publishing date	2023-05-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2104785-6
ISSN	1720-8319 ; 1594-0667
ISSN (online)	1720-8319
ISSN	1594-0667
DOI	10.1007/s40520-023-02426-7
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Article: Sarcopenia: Diagnosis and Management, State of the Art and Contribution of Ultrasound.

Giovannini, Silvia / Brau, Fabrizio / Forino, Raffaele / Berti, Andrea / D'Ignazio, Federica / Loreti, Claudia / Bellieni, Andrea / D'Angelo, Emanuela / Di Caro, Francesca / Biscotti, Lorenzo / Coraci, Daniele / Fusco, Augusto / Padua, Luca / Bernabei, Roberto

Journal of clinical medicine

2021 Volume 10, Issue 23

Abstract: Age-related muscle loss is a phenomenon that has been extensively studied in recent decades. Sarcopenia is a multisystem disease, which predisposes to muscle weakness and frailty. At around 50 years of age, an individual begins to lose muscle strength, ... ...

Abstract	Age-related muscle loss is a phenomenon that has been extensively studied in recent decades. Sarcopenia is a multisystem disease, which predisposes to muscle weakness and frailty. At around 50 years of age, an individual begins to lose muscle strength, although this becomes more evident after 70. Sarcopenia is a condition typically found in older adults but can also affect younger people. Sarcopenia is a preventable and treatable condition. In past years, methods and tools to recognize the condition early have been researched. For the development of therapeutic interventions, agreement on diagnosis is fundamental. In recent years, a possible role of ultrasonography in the diagnosis of sarcopenia has been evaluated, compared with the best-known techniques.
Language	English
Publishing date	2021-11-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10235552
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Article ; Online: Association between Older Age and Psychiatric Symptoms in a Population of Hospitalized Patients with COVID-19

Maria Camilla Cipriani / Cristina Pais / Vezio Savoia / Cinzia Falsiroli / Andrea Bellieni / Antonella Cingolani / Massimo Fantoni / Daniela Pia Rosaria Chieffo / Gabriele Sani / Francesco Landi / Giovanni Landi / Rosa Liperoti

Journal of Personalized Medicine, Vol 13, Iss 973, p

2023 Volume 973

Abstract	Increased rates of anxiety and depression have been reported for older adults during the COVID-19 pandemic. However, little is known regarding the onset of mental health morbidity during the acute phase of the disease and the role of age as potential independent risk factor for psychiatric symptoms. The cross-sectional association between older age and psychiatric symptoms has been estimated in a sample of 130 patients hospitalized for COVID-19 during the first and second wave of the pandemic. Compared to younger patients, those who were 70 years of age or older resulted at a higher risk of psychiatric symptoms measured on the Brief Psychiatric Symptoms Rating Scale (BPRS) (adjusted (adj.) odds ratio (OR) 2.36, 95% confidence interval (CI) 1.05–5.30) and delirium (adj. OR 5.24, 95% CI 1.63–16.8)). No association was found between older age and depressive symptoms or anxiety. Age was associated with psychiatric symptoms independently of gender, marital status, history of psychiatric illness, severity of disease and cardiovascular morbidity. Older adults appear at high risk of developing psychiatric symptoms related to COVID-19 disease during hospital stay. Multidisciplinary preventive and therapeutic interventions should be implemented to reduce the risk of psychiatric morbidity and related adverse health care outcomes among older hospital inpatients with COVID-19.
Keywords	older adults ; COVID-19 ; psychiatric symptoms ; delirium ; hospitalization ; Medicine ; R
Subject code	150
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Biological and Functional Biomarkers of Aging: Definition, Characteristics, and How They Can Impact Everyday Cancer Treatment.

Colloca, Giuseppe / Di Capua, Beatrice / Bellieni, Andrea / Fusco, Domenico / Ciciarello, Francesca / Tagliaferri, Luca / Valentini, Vincenzo / Balducci, Lodovico

Current oncology reports

2020 Volume 22, Issue 11, Page(s) 115

Abstract: Purpose of review: Recognize which are the elements that predict why a person is aging faster or slower and which intervention we can arrange to slow down the process, which permits to prevent or delay the progression of multimorbidity and disability.!## ...

Abstract	Purpose of review: Recognize which are the elements that predict why a person is aging faster or slower and which intervention we can arrange to slow down the process, which permits to prevent or delay the progression of multimorbidity and disability. Recent findings: Aging is a complex process that leads to changes in all the systems of the body and all the functions of the person; however, aging develops at different rates in different people, and chronological age is not always consistent with biological age. Gerontologists are focused not only on finding the best theory able to explain aging but also on identifying one or more markers, which are able to describe aging processes. These biomarkers are necessary to better define the aging-related pathologies, manage multimorbidity, and improve the quality of life. The aim of this paper is to review the most recent evidence on aging biomarkers and the clusters related to them for personalization of treatments.
MeSH term(s)	Aging ; Biomarkers ; Frailty/diagnosis ; Geriatrics ; Humans ; Life Expectancy ; Multimorbidity ; Quality of Life
Chemical Substances	Biomarkers
Keywords	covid19
Language	English
Publishing date	2020-08-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057359-5
ISSN	1534-6269 ; 1523-3790
ISSN (online)	1534-6269
ISSN	1523-3790
DOI	10.1007/s11912-020-00977-w
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Article ; Online: Magnetic resonance-guided radiotherapy feasibility in elderly cancer patients: proposal of the MASTER scoring system.

Boldrini, Luca / Colloca, Giuseppe F / Villani, Emanuele / Chiloiro, Giuditta / Bellieni, Andrea / Manfrida, Stefania / Cellini, Francesco / Gambacorta, Maria Antonietta / Valentini, Vincenzo

Tumori

2020 Volume 107, Issue 1, Page(s) 26–31

Abstract: Background: Elderly patients are often excluded from advanced treatments owing to clinical complexity or frailty. Magnetic resonance-guided radiotherapy (MRgRT) represents a new frontier of radiotherapy delivery that can play an important role in the ... ...

Abstract	Background: Elderly patients are often excluded from advanced treatments owing to clinical complexity or frailty. Magnetic resonance-guided radiotherapy (MRgRT) represents a new frontier of radiotherapy delivery that can play an important role in the management of these patients. Aim: To assess MRgRT feasibility in elderly patients, describe their compliance with this treatment, and provide a scoring system for elderly patient selection. Methods: Patients aged >75 years were enrolled. No restrictions on tumor site, staging, or treatment intent were applied. Patients underwent joint radiation oncology-geriatrics visits to assess the feasibility of MRgRT and to identify the most significant items (i.e. clinical variables) for the setup of a scoring system. The proposed scoring system was then internally validated on a prospectively enrolled cohort of elderly patients who were candidates for MRgRT. Results: Thirty patients were enrolled between February and March 2018. Their mean age was 81.4 ± 3.4 years (range 75-88). Radiotherapy intent was curative in 26 patients; 14 patients were considered frail at screening tests before radiotherapy. Twelve items were identified as clinically significant for the setup of the MASTER score (MRI-Guided Radiotherapy Selection Elderly Score) score. Validation of the score showed 100% reliability, with no patient discharged after selection. Conclusions: MRgRT appears to be feasible in elderly patients and the MASTER score is proposed to support clinical decision-making in recommending elderly patients for this technology.
MeSH term(s)	Aged ; Aged, 80 and over ; Feasibility Studies ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Neoplasms/diagnostic imaging ; Neoplasms/pathology ; Neoplasms/radiotherapy ; Radiosurgery/methods ; Radiotherapy Dosage/standards ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy, Image-Guided/methods
Language	English
Publishing date	2020-05-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	280962-x
ISSN	2038-2529 ; 0300-8916
ISSN (online)	2038-2529
ISSN	0300-8916
DOI	10.1177/0300891620920709
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Article ; Online: Erratum to "Muscoloskeletal aging, sarcopenia and cancer" [Journal of Geriatric Oncology, Volume 10, Issue 3, May 2019, Pages 504-509].

Colloca, Giuseppe / Di Capua, Beatrice / Bellieni, Andrea / Cesari, Matteo / Marzetti, Emanuele / Valentini, Vincenzo / Calvani, Riccardo

Journal of geriatric oncology

2019 Volume 10, Issue 5, Page(s) 839

Language	English
Publishing date	2019-08-19
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	2556813-9
ISSN	1879-4076 ; 1879-4068
ISSN (online)	1879-4076
ISSN	1879-4068
DOI	10.1016/j.jgo.2019.08.002
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Article ; Online: Sarcopenia

Silvia Giovannini / Fabrizio Brau / Raffaele Forino / Andrea Berti / Federica D’Ignazio / Claudia Loreti / Andrea Bellieni / Emanuela D’Angelo / Francesca Di Caro / Lorenzo Biscotti / Daniele Coraci / Augusto Fusco / Luca Padua / Roberto Bernabei

Journal of Clinical Medicine, Vol 10, Iss 5552, p

Diagnosis and Management, State of the Art and Contribution of Ultrasound

2021 Volume 5552

Abstract	Age-related muscle loss is a phenomenon that has been extensively studied in recent decades. Sarcopenia is a multisystem disease, which predisposes to muscle weakness and frailty. At around 50 years of age, an individual begins to lose muscle strength, although this becomes more evident after 70. Sarcopenia is a condition typically found in older adults but can also affect younger people. Sarcopenia is a preventable and treatable condition. In past years, methods and tools to recognize the condition early have been researched. For the development of therapeutic interventions, agreement on diagnosis is fundamental. In recent years, a possible role of ultrasonography in the diagnosis of sarcopenia has been evaluated, compared with the best-known techniques.
Keywords	ultrasound ; sonography ; nerve ; muscle ; technology ; diagnostic tool ; Medicine ; R
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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