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Article ; Online: Processo formativo a distância em Segurança Alimentar e Nutricional na Comunidade dos Países de Língua Portuguesa

Lilian Fernanda Galesi-Pacheco / Humberto Perinelli Neto

Interface: Comunicação, Saúde, Educação, Vol

construindo práticas educativas

2023 Volume 27

Abstract: Resumo Processos formativos para fortalecer a segurança alimentar e nutricional (SAN) como política são demandas da Comunidade dos Países de Língua Portuguesa (CPLP). Objetivamos descrever e analisar práticas educativas desenvolvidas pelos docentes, ... ...

Abstract	Resumo Processos formativos para fortalecer a segurança alimentar e nutricional (SAN) como política são demandas da Comunidade dos Países de Língua Portuguesa (CPLP). Objetivamos descrever e analisar práticas educativas desenvolvidas pelos docentes, visando refletir e propor ajustes para aprimorar o processo formativo a distância em SAN no contexto da CPLP. O curso foi composto por alunos do Brasil; Cabo Verde; Moçambique e São Tomé e Príncipe. A pesquisa é aplicada, teve abordagem qualitativa e natureza descritiva e explicativa, empregando videoaulas como materiais de estudo, principalmente, com base na Análise Textual Discursiva. A proposta indica que cursos de mesma natureza requerem da gestão educacional formação docente; reconhecimento do conhecimento dos discentes; inserção de dialogia nas videoaulas; oferecimento de atividades locais capazes de gerar compreensão da realidade; criação de sequência para elaboração do Trabalho de Conclusão (TCC); e desenvolvimento do TCC visando à transformação da realidade.
Keywords	Comunidade dos Países de Língua Portuguesa ; Educação a distância ; Práticas educativas ; Segurança alimentar e nutricional ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Faculdade de Medicina de Botucatu (Unesp)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Challenges in Teaching Human Anatomy to Students with Intellectual Disabilities During the Covid-19 Pandemic.

Pacheco, Lílian Fernanda / Noll, Matias / Mendonça, Carolina Rodrigues

Anatomical sciences education

2020 Volume 13, Issue 5, Page(s) 556–557

MeSH term(s)	Anatomy/education ; COVID-19 ; Coronavirus Infections ; Education, Special ; Humans ; Pandemics ; Pneumonia, Viral
Keywords	covid19
Language	English
Publishing date	2020-07-14
Publishing country	United States
Document type	Letter
ZDB-ID	2483491-9
ISSN	1935-9780 ; 1935-9772
ISSN (online)	1935-9780
ISSN	1935-9772
DOI	10.1002/ase.1991
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Zs.A 6787: Show issues

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Article ; Online: Challenges in Teaching Human Anatomy to Students with Intellectual Disabilities During the Covid‐19 Pandemic

Pacheco, Lílian Fernanda / Noll, Matias / Mendonça, Carolina Rodrigues

Anatomical Sciences Education

2020 Volume 13, Issue 5, Page(s) 556–557

Keywords	Anatomy ; Embryology ; Histology ; General Medicine ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
ZDB-ID	2483491-9
ISSN	1935-9780 ; 1935-9772
ISSN (online)	1935-9780
ISSN	1935-9772
DOI	10.1002/ase.1991
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Article: Challenges in teaching human anatomy to students with intellectual disabilities during the Covid-19 pandemic

Pacheco, Lílian Fernanda / Noll, Matias / Mendonça, Carolina Rodrigues

Abstract: In the context of the Covid-19 pandemic and the various subsequent changes and behavioral adjustments necessary in the educational field, two important articles were recently published in Anatomical Sciences Education (Franchi, 2020; Srinivasan, 2020). ... ...

Abstract	In the context of the Covid-19 pandemic and the various subsequent changes and behavioral adjustments necessary in the educational field, two important articles were recently published in Anatomical Sciences Education (Franchi, 2020; Srinivasan, 2020). The first study (Franchi, 2020) reported the impact of the pandemic on human anatomy education in the United Kingdom. This article described from the perspective of a medical student how the lack of practical teaching with cadavers can adversely impact training and lead to losses for students.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32543006
Database	COVID19

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Article ; Online: Oral Treatment with Angiotensin-(1-7) Attenuates the Kidney Injury Induced by Gentamicin in Wistar Rats.

Pacheco, Lílian Fernanda / de Castro, Carlos Henrique / Dutra, João Batista Rodrigues / de Souza Lino Junior, Ruy / Ferreira, Patrícia Maria / Dos Santos, Robson Augusto Souza / Ulhoa, Cirano José

Protein and peptide letters

2021 Volume 28, Issue 12, Page(s) 1425–1433

Abstract: Background: Acute Kidney Injury (AKI), a common disease of the urinary system, can be induced by high doses of gentamicin (GM). The renin-angiotensin system exerts a key role in the progression of the AKI since elevated intrarenal levels of Ang II, and ... ...

Abstract	Background: Acute Kidney Injury (AKI), a common disease of the urinary system, can be induced by high doses of gentamicin (GM). The renin-angiotensin system exerts a key role in the progression of the AKI since elevated intrarenal levels of Ang II, and ACE activity is found in this condition. However, it is unknown whether oral administration of angiotensin (Ang)-(1-7), a heptapeptide that evokes opposite effects of Ang II, may attenuate the renal injuries induced by gentamicin. Objectives: To evaluate the effects of Ang-(1-7) on GM-induced renal dysfunction in rats. Methods: AKI was induced by subcutaneous administration of GM (80 mg/Kg) for 5 days. Simultaneously, Ang-(1-7) included in hydroxypropyl β-cyclodextrin (HPβCD) was administered by gavage [46 μg/kg HPβCD + 30 μg/kg Ang-(1-7)]. At the end of the treatment period (sixth day), the rats were housed in metabolic cages for renal function evaluation. Thereafter, blood and kidney samples were collected. Results: Ang-(1-7) attenuated the increase of the plasmatic creatinine and proteinuria caused by GM but did not change the glomerular filtration rate nor tubular necrosis. Ang-(1-7) attenuated the increased urinary flow and the fractional excretion of H2O and potassium observed in GM rats but intensified the elevated excretion of sodium in these animals. Morphological analysis showed that Ang-(1-7) also reduced the tubular vacuolization in kidneys from GM rats. Conclusion: Ang-(1-7) promotes selective beneficial effects in renal injuries induced by GM.
MeSH term(s)	Acute Kidney Injury/blood ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/drug therapy ; Administration, Oral ; Angiotensin I/pharmacology ; Animals ; Drug Evaluation ; Gentamicins/adverse effects ; Gentamicins/pharmacology ; Male ; Peptide Fragments/pharmacology ; Rats ; Rats, Wistar
Chemical Substances	Gentamicins ; Peptide Fragments ; Angiotensin I (9041-90-1) ; angiotensin I (1-7) (IJ3FUK8MOF)
Language	English
Publishing date	2021-12-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1280776-x
ISSN	1875-5305 ; 0929-8665
ISSN (online)	1875-5305
ISSN	0929-8665
DOI	10.2174/0929866528666211118091810
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Zs.A 4452: Show issues

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Article ; Online: Brain and kidney GHS-R1a underexpression is associated with changes in renal function and hemodynamics during neurogenic hypertension.

Sales da Silva, Elder / Ferreira, Patrícia Maria / Castro, Carlos Henrique / Pacheco, Lilian Fernanda / Graziani, Daniel / Pontes, Carolina Nobre Ribeiro / Bessa, Amanda de Sá Martins de / Fernandes, Erika / Naves, Lara Marques / Ribeiro, Larissa Cristina Dos Santos / Mendonça, Michelle Mendanha / Gomes, Rodrigo Mello / Pedrino, Gustavo Rodrigues / Ferreira, Reginaldo Nassar / Xavier, Carlos Henrique

Molecular and cellular endocrinology

2020 Volume 518, Page(s) 110984

Abstract: Ghrelin is a peptide hormone whose effects are mediated by the growth hormone secretagogue receptor subtype 1a (GHS-R1a), mainly expressed in the brain but also in kidneys. The hypothesis herein raised is that GHS-R1a would be player in the renal ... ...

Abstract	Ghrelin is a peptide hormone whose effects are mediated by the growth hormone secretagogue receptor subtype 1a (GHS-R1a), mainly expressed in the brain but also in kidneys. The hypothesis herein raised is that GHS-R1a would be player in the renal contribution to the neurogenic hypertension pathophysiology. To investigate GHS-R1a role on renal function and hemodynamics, we used Wistar (WT) and spontaneously hypertensive rats (SHR). First, we assessed the effect of systemically injected vehicle, ghrelin, GHS-R1a antagonist PF04628935, ghrelin plus PF04628935 or GHS-R1a synthetic agonist MK-677 in WT and SHR rats housed in metabolic cages (24 h). Blood and urine samples were also analyzed. Then, we assessed the GHS-R1a contribution to the control of renal vasomotion and hemodynamics in WT and SHR. Finally, we assessed the GHS-R1a levels in brain areas, aorta, renal artery, renal cortex and medulla of WT and SHR rats using western blot. We found that ghrelin and MK-677 changed osmolarity parameters of SHR, in a GHS-R1a-dependent manner. GHS-R1a antagonism reduced the urinary Na
Language	English
Publishing date	2020-08-16
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	187438-x
ISSN	1872-8057 ; 0303-7207
ISSN (online)	1872-8057
ISSN	0303-7207
DOI	10.1016/j.mce.2020.110984
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Zs.A 1127: Show issues

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Article ; Online: Quantitative polymerase chain reaction in paucibacillary leprosy diagnosis: A follow-up study.

Barbieri, Raquel R / Manta, Fernanda S N / Moreira, Suelen J M / Sales, Anna M / Nery, José A C / Nascimento, Lilian P R / Hacker, Mariana A / Pacheco, Antônio G / Machado, Alice M / Sarno, Euzenir M / Moraes, Milton O

PLoS neglected tropical diseases

2019 Volume 13, Issue 3, Page(s) e0007147

Abstract: Objective: The diagnosis of paucibacillary (PB) leprosy cases remains a challenge because of the absence of a confirmatory laboratory method. While quantitative polymerase chain reaction (qPCR) has been shown to provide reliable sensitivity and ... ...

Abstract	Objective: The diagnosis of paucibacillary (PB) leprosy cases remains a challenge because of the absence of a confirmatory laboratory method. While quantitative polymerase chain reaction (qPCR) has been shown to provide reliable sensitivity and specificity in PB diagnoses, a thorough investigation of its efficacy in clinical practice has not yet been published. The present study evaluated patients with suspected leprosy skin lesions by using qPCR to identify PB individuals in the Leprosy Outpatient clinic at the Oswaldo Cruz Foundation in Rio de Janeiro, Brazil. Methods: One hundred seventy-two suspected PB cases were included in the study. The patients were evaluated by a dermatologist at three different times. The clinical dermato-neurological examination and collected samples were performed on the first visit. On the second visit, the results of the histopathological analysis and PCR assay (DNA-based Mycobacterium leprae qPCR-targeting 16S gene) results were analyzed, and a decision regarding multi-drug therapy was made. A year later, the patients were re-examined, and the consensus diagnosis was established. Results: In 58% (100/172) of cases, a conclusive diagnosis via histopathological analysis was not possible; however, 30% (30/100) of these cases had a positive PCR. One hundred ten patients (110/172) attended the third visit. The analysis showed that while the sensitivity of the histopathological test was very low (35%), a qPCR alone was more effective for identifying leprosy, with 57% sensitivity. Conclusion: The use of qPCR in suspected PB cases with an inconclusive histology improved the sensitivity of leprosy diagnoses.
MeSH term(s)	Adolescent ; Adult ; Aged ; Brazil ; DNA, Bacterial/genetics ; DNA, Ribosomal/genetics ; Female ; Histocytochemistry ; Humans ; Leprosy, Paucibacillary/diagnosis ; Male ; Middle Aged ; Molecular Diagnostic Techniques/methods ; Mycobacterium leprae/genetics ; Mycobacterium leprae/isolation & purification ; Outpatients ; RNA, Ribosomal, 16S/genetics ; Real-Time Polymerase Chain Reaction/methods ; Sensitivity and Specificity ; Young Adult
Chemical Substances	DNA, Bacterial ; DNA, Ribosomal ; RNA, Ribosomal, 16S
Language	English
Publishing date	2019-03-05
Publishing country	United States
Document type	Comparative Study ; Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2727
ISSN (online)	1935-2735
ISSN	1935-2727
DOI	10.1371/journal.pntd.0007147
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Article ; Online: Nephroprotective effect of Rudgea viburnoides (Cham.) Benth leaves on gentamicin-induced nephrotoxicity in rats.

Moreira Galdino, Pablinny / Nunes Alexandre, Layse / Fernanda Pacheco, Lílian / de Souza Lino Junior, Ruy / de Paula, José Realino / Rodrigues Pedrino, Gustavo / Henrique Xavier, Carlos / Maria Ferreira, Patrícia

Journal of ethnopharmacology

2017 Volume 201, Page(s) 100–107

Abstract: Relevance: Rudgea viburnoides, popularly known as "congonha-de-bugre" or "erva de bugre", is used in folk medicine as hypotensive, blood depurative, anti-rheumatic, diuretic and in the treatment of kidney and bladder pain.: Aim: Based on the ... ...

Abstract	Relevance: Rudgea viburnoides, popularly known as "congonha-de-bugre" or "erva de bugre", is used in folk medicine as hypotensive, blood depurative, anti-rheumatic, diuretic and in the treatment of kidney and bladder pain. Aim: Based on the popularly acclaimed nephron-protective effect of R. viburnoides, we investigated, using rats, the protective effect of this plant extract on gentamicin-induced kidney injury. Material and methods: Urinary volume, water and food intakes were assessed in adult male Wistar rats (naive or gentamicin-induced model of nephrotoxicity) treated with R. viburnoides extract. Also blood and kidney samples were collected for further laboratory and histological analyses. Results: R. viburnoides leaves extract improved renal function. It also improved the renal function impairments caused by gentamicin-induced nephrotoxicity, as revealed by glomerular filtration rate, urine output and proteinuria. Conclusion: R. viburnoides exert renoprotective effect, which may support its popular use for renal diseases treatment.
MeSH term(s)	Acute Kidney Injury/blood ; Acute Kidney Injury/drug therapy ; Acute Kidney Injury/pathology ; Acute Kidney Injury/physiopathology ; Animals ; Anti-Bacterial Agents ; Creatinine/blood ; Gentamicins ; Glomerular Filtration Rate/drug effects ; Kidney/drug effects ; Kidney/pathology ; Kidney/physiology ; Male ; Phytotherapy ; Plant Extracts/therapeutic use ; Plant Leaves ; Potassium/blood ; Protective Agents/therapeutic use ; Rats ; Rats, Wistar ; Rubiaceae ; Sodium/blood
Chemical Substances	Anti-Bacterial Agents ; Gentamicins ; Plant Extracts ; Protective Agents ; Sodium (9NEZ333N27) ; Creatinine (AYI8EX34EU) ; Potassium (RWP5GA015D)
Language	English
Publishing date	2017-04-06
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2017.02.035
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Zs.A 1494: Show issues

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Article ; Online: Análise da Qualidade de Vida, Capacidade para o Trabalho e Nível de Estresse em Trabalhadores da Construção Civil

Hernani Camilo Valinote / Lilian Fernanda Pacheco / Fabiana Pavan Viana / Cibelle Kayenne Martins Roberto Formiga

Revista Brasileira de Ciências Ambientais, Iss 32, Pp 115-

2014 Volume 126

Abstract: Analisou-se o perfil epidemiológico, fatores de riscos envolvidos na atividade e QV do trabalhador da construção civil. Pesquisa de delineamento transversal, de caráter epidemiológico, com 71 trabalhadores. Foram aplicados: Questionário Epidemiológico, ... ...

Abstract	Analisou-se o perfil epidemiológico, fatores de riscos envolvidos na atividade e QV do trabalhador da construção civil. Pesquisa de delineamento transversal, de caráter epidemiológico, com 71 trabalhadores. Foram aplicados: Questionário Epidemiológico, Critério de Classificação Econômica da ABEP, Questionário de Qualidade de Vida, Perfil do ambiente e condições de trabalho, Índice de Capacidade para o Trabalho, Questionário de Sintomas Osteomusculares e Job Stress Scale. Os resultados foram analisados descritivamente e correlacionados. Houve uma predominância de trabalhadores pardos, média de 36 anos, primeiro grau de escolaridade, sedentários, classe econômica “C”, receberam treinamento, possuíam boa percepção de QV e saúde, boa capacidade para o trabalho e baixo índice de estresse. As variáveis revelaram que a idade está relacionada com a qualidade de vida, capacidade para o trabalho e nível de estresse. Conclui-se que quanto melhor o ambiente e as condições de trabalho melhor será a QV e menor a percepção do estresse.
Keywords	construção civil ; qualidade de vida ; capacidade para o trabalho ; estresse ; Environmental sciences ; GE1-350
Language	English
Publishing date	2014-06-01T00:00:00Z
Publisher	Associação Brasileira de Engenharia Sanitária e Ambiental
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Quantitative polymerase chain reaction in paucibacillary leprosy diagnosis

Raquel R Barbieri / Fernanda S N Manta / Suelen J M Moreira / Anna M Sales / José A C Nery / Lilian P R Nascimento / Mariana A Hacker / Antônio G Pacheco / Alice M Machado / Euzenir M Sarno / Milton O Moraes

PLoS Neglected Tropical Diseases, Vol 13, Iss 3, p e

A follow-up study.

2019 Volume 0007147

Abstract: OBJECTIVE:The diagnosis of paucibacillary (PB) leprosy cases remains a challenge because of the absence of a confirmatory laboratory method. While quantitative polymerase chain reaction (qPCR) has been shown to provide reliable sensitivity and ... ...

Abstract	OBJECTIVE:The diagnosis of paucibacillary (PB) leprosy cases remains a challenge because of the absence of a confirmatory laboratory method. While quantitative polymerase chain reaction (qPCR) has been shown to provide reliable sensitivity and specificity in PB diagnoses, a thorough investigation of its efficacy in clinical practice has not yet been published. The present study evaluated patients with suspected leprosy skin lesions by using qPCR to identify PB individuals in the Leprosy Outpatient clinic at the Oswaldo Cruz Foundation in Rio de Janeiro, Brazil. METHODS:One hundred seventy-two suspected PB cases were included in the study. The patients were evaluated by a dermatologist at three different times. The clinical dermato-neurological examination and collected samples were performed on the first visit. On the second visit, the results of the histopathological analysis and PCR assay (DNA-based Mycobacterium leprae qPCR-targeting 16S gene) results were analyzed, and a decision regarding multi-drug therapy was made. A year later, the patients were re-examined, and the consensus diagnosis was established. RESULTS:In 58% (100/172) of cases, a conclusive diagnosis via histopathological analysis was not possible; however, 30% (30/100) of these cases had a positive PCR. One hundred ten patients (110/172) attended the third visit. The analysis showed that while the sensitivity of the histopathological test was very low (35%), a qPCR alone was more effective for identifying leprosy, with 57% sensitivity. CONCLUSION:The use of qPCR in suspected PB cases with an inconclusive histology improved the sensitivity of leprosy diagnoses.
Keywords	Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270
Subject code	610
Language	English
Publishing date	2019-03-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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