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  1. Article ; Online: Behind the Scenes Heroes: The COVID-19 Vaccine Data and Safety Monitoring Board.

    Corey, Lawrence

    The Journal of infectious diseases

    2021  Volume 224, Issue 12, Page(s) 1993–1994

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Clinical Trials Data Monitoring Committees ; Humans ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-06-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiab267
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 445: Show issues

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  2. Book ; Conference proceedings: Recommendations for short course therapies in herpes genitalis and herpes labialis

    Corey, Lawrence

    recommendations from the IHMF Management Strategies Workshop held on 12 - 13 June 2006 and ratified at the 13th annual meeting of the IHMF on 27 - 29 October 2006

    (Herpes ; 14, Suppl. 1)

    2007  

    Event/congress International Herpes Management Forum
    Author's details suppl. ed.: Lawrence Corey
    Series title Herpes ; 14, Suppl. 1
    Collection
    Language English
    Size 18A S. : graph. Darst.
    Publisher Cambridge Medical Publ
    Publishing place Worthing
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT015248844
    Database Catalogue ZB MED Medicine, Health

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    Zs A 5737 -14,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  3. Book ; Conference proceedings: Global epidemiology of genital herpes and the interaction of herpes simplex virus with HIV

    Corey, Lawrence

    recommendations from the IHMF Management Strategies Workshop held on 25 - 26 September 2002 [in San Diego, September 2002 and Seattle, May 2003] and ratified at the 10th annual meeting og the IHMF, Paris, France, 28 February - 2 March 2003

    (Herpes ; 11, Suppl. 1)

    2004  

    Event/congress International Herpes Management Forum
    Author's details suppl. ed.: Lawrence Corey
    Series title Herpes ; 11, Suppl. 1
    Collection
    Language English
    Size 45A S. : graph. Darst.
    Publisher Cambridge Medical Publ
    Publishing place Worthing
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT014004284
    Database Catalogue ZB MED Medicine, Health

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    Zs A 5737 -11,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  4. Book ; Conference proceedings: Strategies for interrupting the transmission of genital and neonatal HSV infection

    Corey, Lawrence

    recommendations from the IHMF Management Strategies Workshop held on 25 - 26 September 2002 and ratified at the 10th annual meeting of the IHMF, Paris, France, 28 February - 2 March 2003

    (Herpes ; 11, Suppl. 3)

    2004  

    Event/congress International Herpes Management Forum
    Author's details suppl. ed.: Larence Corey
    Series title Herpes ; 11, Suppl. 3
    Collection
    Language English
    Size S. 129A - 186A : Ill., graph. Darst.
    Publisher Cambridge Medical Publ
    Publishing place Worthing
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT014133338
    Database Catalogue ZB MED Medicine, Health

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    Zs A 5737 -11,Suppl.3- not available for loan Zeitschriften-Lesesaal

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  5. Article ; Online: The path to find an HIV vaccine.

    Gray, Glenda E / Corey, Lawrence

    Journal of the International AIDS Society

    2021  Volume 24, Issue 5, Page(s) e25749

    Language English
    Publishing date 2021-05-18
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2467110-1
    ISSN 1758-2652 ; 1758-2652
    ISSN (online) 1758-2652
    ISSN 1758-2652
    DOI 10.1002/jia2.25749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Accelerating clinical trial development in vaccinology: COVID-19 and beyond.

    Corey, Lawrence / Miner, Maurine D

    Current opinion in immunology

    2022  Volume 76, Page(s) 102206

    Abstract: The remarkable success of the US government-backed COVID-19 vaccine development in 2020 offers several lessons on how to effectively foster rapid vaccine discovery and development. Conceptually, the formation of a public-private partnership that included ...

    Abstract The remarkable success of the US government-backed COVID-19 vaccine development in 2020 offers several lessons on how to effectively foster rapid vaccine discovery and development. Conceptually, the formation of a public-private partnership that included innovative government and academic involvement at all levels of the program was instrumental in promulgating and overseeing the effort. Decades of NIH-sponsored research on vaccine backbones, immunogen design, and clinical trial operations enabled evaluation of vaccine candidates within months of pathogen discovery. Operation Warp Speed fostered industry participation, permitted accelerated movement from preclinical/early phase to efficacy trials, and developed structured clinical trial testing that allowed independent assessment of, yet reasonable comparison between, each vaccine platform by harmonizing protocols, endpoints, laboratories, and statistical analytical criteria for efficacy. This coordinated effort by the US government, pharmaceutical companies, regulators, and academic research institutions resulted in the streamlined, safe, and transparent development and deployment of multiple COVID-19 vaccines in under a year. Lessons learned from this collaborative endeavor should be used to advance additional vaccines of public health importance.
    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Vaccines ; Vaccinology
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2022-04-20
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2022.102206
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2773: Show issues Location:
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    Zs.MG 13: Show issues

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  7. Article: Novel engineered chimeric engulfment receptors trigger T cell effector functions against SIV-infected CD4+ T cells.

    Corey, Daniel / Haeseleer, Francoise / Hou, Joe / Corey, Lawrence

    Molecular therapy. Methods & clinical development

    2022  Volume 28, Page(s) 1–10

    Abstract: Adoptive therapy with genetically engineered T cells offers potential for infectious disease treatment in immunocompromised persons. HIV/simian immunodeficiency virus (SIV)-infected cells express phosphatidylserine (PS) early post infection. We tested ... ...

    Abstract Adoptive therapy with genetically engineered T cells offers potential for infectious disease treatment in immunocompromised persons. HIV/simian immunodeficiency virus (SIV)-infected cells express phosphatidylserine (PS) early post infection. We tested whether chimeric engulfment receptor (CER) T cells designed to recognize PS-expressing cells could eliminate SIV-infected cells. Lentiviral CER constructs composed of the extracellular domain of T cell immunoglobulin and mucin domain containing 4 (TIM-4), the PS receptor, and engulfment signaling domains were transduced into primary rhesus macaque (RM) T cells. We measured PS binding and T cell engulfment of RM CD4+ T cells infected with SIV expressing GFP and
    Language English
    Publishing date 2022-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2872938-9
    ISSN 2329-0501 ; 2329-0501
    ISSN (online) 2329-0501
    ISSN 2329-0501
    DOI 10.1016/j.omtm.2022.11.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Expanding Efforts and Support to Respond to the HIV and COVID-19 Intersecting Pandemics.

    Corey, Lawrence / Corbett-Detig, Russell / Beyrer, Chris

    JAMA

    2022  Volume 327, Issue 13, Page(s) 1227–1228

    MeSH term(s) COVID-19/epidemiology ; COVID-19/therapy ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; Humans ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2022-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2022.3517
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.88: Show issues Location:
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  9. Article ; Online: Serum concentration of antigen-specific IgG can substantially bias interpretation of antibody-dependent phagocytosis assay readout.

    St Germain, Russell / Bossard, Emily L / Corey, Lawrence / Sholukh, Anton M

    iScience

    2023  Volume 26, Issue 9, Page(s) 107527

    Abstract: Because virus neutralization cannot solely explain vaccine-induced, antibody-mediated protection, antibody effector functions are being considered as a potential correlate of protection (CoP). However, measuring effector functions at a fixed serum ... ...

    Abstract Because virus neutralization cannot solely explain vaccine-induced, antibody-mediated protection, antibody effector functions are being considered as a potential correlate of protection (CoP). However, measuring effector functions at a fixed serum dilution for high throughput purposes makes it difficult to distinguish between the effect of serum antibody concentration and antibody properties such as epitopes, subclass, and glycosylation. To address this issue, we evaluated antibody-dependent cellular phagocytosis (ADCP) assay against SARS-CoV-2 spike. Adjustment of serum samples to the same concentration of antigen-specific IgG prior to the ADCP assay revealed concentration-independent differences in ADCP after mRNA vaccination in subjects with and without prior SARS-CoV-2 infection not detectable in assay performed with fixed serum dilution. Phagocytosis measured at different concentrations of spike-specific IgG strongly correlated with the area under the curve (AUC) indicating that ADCP assay can be performed at a standardized antibody concentration for the high throughput necessary for vaccine trial analyses.
    Language English
    Publishing date 2023-08-03
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.107527
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Naturally occurring histological findings and Alzheimer's-like pathology in the brain of aging African green monkeys (Chlorocebus sabaeus).

    Corey, Tatiana M / Illanes, Oscar / Lawrence, Matthew / Perez, Sylvia E / Liddie, Shervin / Callanan, John J

    The Journal of comparative neurology

    2023  Volume 531, Issue 13, Page(s) 1276–1298

    Abstract: Nonhuman primates (NHPs) are important to study the pathophysiology of neurodegenerative disease and evaluate therapies targeting the central nervous system (CNS). Understanding the age-associated incidence of natural CNS pathology in a given NHP species ...

    Abstract Nonhuman primates (NHPs) are important to study the pathophysiology of neurodegenerative disease and evaluate therapies targeting the central nervous system (CNS). Understanding the age-associated incidence of natural CNS pathology in a given NHP species is critical to assess the safety of potential treatments for neurodegenerative disorders like Alzheimer's disease (AD). We describe background and age-related neuropathology in the St. Kitts African green monkey (AGM), a recognized translational model for neurodegenerative research, additionally defining the age progression of AD-associated neuropathology in this species. Seventy-one AGM brains were examined, representing age groups of 3-6 years (n = 20), 7-9 years (n = 20), 10-15 years (n = 20), and >15 years (n = 11). A subset of brains (n = 31) was assessed immunohistochemically for AD-related pathology, including expressions of Aβ, tau, and GFAP. Age-related microscopic findings included hemosiderosis, spheroid formation, neuronal lipofuscinosis and neuromelanosis, white matter and neuropil vacuolation, astrocytosis, and focal microgliosis. Non-age-related findings included perivascular ceroid-laden macrophages, meningeal melanosis, and vascular mineralization. Immunohistochemistry revealed 4G8-immunopositive Aβ plaques and vascular deposits in the prefrontal, frontal, cingulate, and temporal cortices of nine animals over 15 years of age, with associated increase in GFAP expression. In 12 animals, 11 over the age of 10 years, phosphorylated tau CP13-immunoreactive neurons, neuropil, and oligodendrocyte-like cells were seen in the prefrontal, frontal, cingulate, orbital, temporal, and entorhinal cortices as well as the hippocampus; no neurofibrillary tangles were observed. AD-related pathology showed an age-related development in cognitive-associated areas in the AGM, highlighting the value of the AGM as a natural model for these neurodegenerative diseases.
    MeSH term(s) Animals ; Chlorocebus aethiops ; Alzheimer Disease/pathology ; tau Proteins/metabolism ; Amyloid beta-Peptides ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Brain/metabolism ; Aging/pathology
    Chemical Substances tau Proteins ; Amyloid beta-Peptides
    Language English
    Publishing date 2023-06-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3086-7
    ISSN 1096-9861 ; 0021-9967 ; 0092-7317
    ISSN (online) 1096-9861
    ISSN 0021-9967 ; 0092-7317
    DOI 10.1002/cne.25494
    Database MEDical Literature Analysis and Retrieval System OnLINE

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