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  1. Article: The great need to overcome osimertinib resistance in advanced non-small cell lung cancer: from combination strategies to fourth-generation tyrosine kinase inhibitors.

    Bronte, Giuseppe / Belloni, Alessia / Calabrò, Luana / Crinò, Lucio

    Frontiers in oncology

    2024  Volume 13, Page(s) 1308460

    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1308460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The future of mesothelioma treatment: time to shift gear.

    Maio, Michele / Calabrò, Luana

    The Lancet. Respiratory medicine

    2019  Volume 7, Issue 7, Page(s) 554–555

    MeSH term(s) Cisplatin ; Double-Blind Method ; Humans ; Indoles ; Mesothelioma ; Pemetrexed
    Chemical Substances Indoles ; Pemetrexed (04Q9AIZ7NO) ; nintedanib (G6HRD2P839) ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2019-05-15
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(19)30171-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7041: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Immune Checkpoint Inhibitors in "Special" NSCLC Populations: A Viable Approach?

    Bronte, Giuseppe / Cosi, Donato Michele / Magri, Chiara / Frassoldati, Antonio / Crinò, Lucio / Calabrò, Luana

    International journal of molecular sciences

    2023  Volume 24, Issue 16

    Abstract: Over the last decade, the therapeutic scenario for advanced non-small-cell lung cancer (NSCLC) has undergone a major paradigm shift. Immune checkpoint inhibitors (ICIs) have shown a meaningful clinical and survival improvement in different settings of ... ...

    Abstract Over the last decade, the therapeutic scenario for advanced non-small-cell lung cancer (NSCLC) has undergone a major paradigm shift. Immune checkpoint inhibitors (ICIs) have shown a meaningful clinical and survival improvement in different settings of the disease. However, the real benefit of this therapeutic approach remains controversial in selected NSCLC subsets, such as those of the elderly with active brain metastases or oncogene-addicted mutations. This is mainly due to the exclusion or underrepresentation of these patient subpopulations in most pivotal phase III studies; this precludes the generalization of ICI efficacy in this context. Moreover, no predictive biomarkers of ICI response exist that can help with patient selection for this therapeutic approach. Here, we critically summarize the current state of ICI efficacy in the most common "special" NSCLC subpopulations.
    MeSH term(s) Aged ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Lung Neoplasms/drug therapy ; Brain Neoplasms ; Patient Selection
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2023-08-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241612622
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  4. Article: The Role of Innovation Technology in the Rehabilitation of Patients Affected by Huntington's Disease: A Scoping Review.

    Maggio, Maria Grazia / Billeri, Luana / Cardile, Davide / Quartarone, Angelo / Calabrò, Rocco Salvatore

    Biomedicines

    2023  Volume 12, Issue 1

    Abstract: Huntington's disease is an autosomal dominant neurodegenerative disease caused by the repetition of cytosine, adenine, and guanine trinucleotides on the short arm of chromosome 4p16.3 within the Huntingtin gene. In this study, we aim to examine and map ... ...

    Abstract Huntington's disease is an autosomal dominant neurodegenerative disease caused by the repetition of cytosine, adenine, and guanine trinucleotides on the short arm of chromosome 4p16.3 within the Huntingtin gene. In this study, we aim to examine and map the existing evidence on the use of innovations in the rehabilitation of Huntington's disease. A scoping review was conducted on innovative rehabilitative treatments performed on patients with Huntington's disease. A search was performed on PubMed, Embase, Web of Science, and Cochrane databases to screen references of included studies and review articles for additional citations. Of an initial 1117 articles, only 20 met the search criteria. These findings showed that available evidence is still limited and that studies generally had small sample sizes and a high risk of bias. Regarding cognitive rehabilitation, it has emerged that VR- and PC-based methods as well as NIBS techniques are feasible and may have promising effects in individuals with Huntington's disease. On the other hand, scarce evidence was found for cognitive and motor training that might have a slight impact on overall cognitive function in individuals with Huntington's disease. Data show that further investigation is needed to explore the effects of innovative rehabilitation tools on cognition, especially considering that cognitive and psychiatric symptoms can precede the onset of motor symptoms by many years.
    Language English
    Publishing date 2023-12-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12010039
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  5. Article ; Online: Correction to: Gambling and internet addiction: a pilot study among a population of italian healthcare workers.

    Lupo, Roberto / Vitale, Elsa / Carriero, Maria Chiara / Calabrò, Antonino / Imperiale, Chiara / Ercolani, Maurizio / Filippini, Aurelio / Santoro, Pietro / Carvello, Maicol / Rizzo, Emanuele / Artioli, Giovanna / Conte, Luana

    Journal of gambling studies

    2024  

    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2016895-0
    ISSN 1573-3602 ; 1050-5350
    ISSN (online) 1573-3602
    ISSN 1050-5350
    DOI 10.1007/s10899-024-10289-4
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  6. Article ; Online: Immunotherapy of mesothelioma: the evolving change of a long-standing therapeutic dream.

    Calabrò, Luana / Bronte, Giuseppe / Grosso, Federica / Cerbone, Luigi / Delmonte, Angelo / Nicolini, Fabio / Mazza, Massimiliano / Di Giacomo, Anna Maria / Covre, Alessia / Lofiego, Maria Fortunata / Crinò, Lucio / Maio, Michele

    Frontiers in immunology

    2024  Volume 14, Page(s) 1333661

    Abstract: Pleural mesothelioma (PM) is an aggressive and rare disease, characterized by a very poor prognosis. For almost two decades, the world standard treatment regimen for unresectable PM has consisted of a platinum-based drug plus pemetrexed, leading to an ... ...

    Abstract Pleural mesothelioma (PM) is an aggressive and rare disease, characterized by a very poor prognosis. For almost two decades, the world standard treatment regimen for unresectable PM has consisted of a platinum-based drug plus pemetrexed, leading to an overall survival of approximately 12 months. The dramatic therapeutic scenario of PM has recently changed with the entry into the clinic of immune checkpoint inhibition, which has proven to be an effective approach to improve the survival of PM patients. The aim of the present review is to provide a comprehensive overview of the most promising immunotherapeutic-based strategies currently under investigation for advanced PM.
    MeSH term(s) Humans ; Mesothelioma/drug therapy ; Mesothelioma, Malignant ; Immunotherapy ; Pleural Neoplasms ; Pemetrexed
    Chemical Substances Pemetrexed (04Q9AIZ7NO)
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1333661
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  7. Article ; Online: COVID and Lung Cancer.

    Calabrò, Luana / Rossi, Giulia / Covre, Alessia / Morra, Aldo / Maio, Michele

    Current oncology reports

    2021  Volume 23, Issue 11, Page(s) 134

    Abstract: Purpose of review: Since the past year, the fast spread of coronavirus disease 2019 (COVID-19) has represented a global health threat, especially for cancer patients, that has required an urgent reorganization of clinical activities. Here, we will ... ...

    Abstract Purpose of review: Since the past year, the fast spread of coronavirus disease 2019 (COVID-19) has represented a global health threat, especially for cancer patients, that has required an urgent reorganization of clinical activities. Here, we will critically revise the profound impact that the pandemic has generated in lung cancer patients, as well the most significant challenges that oncologists have to face to maintain the highest possible standards in the management of lung cancer patients in the pandemic era.
    Recent findings: Evidences suggested a higher susceptibility and mortality of lung cancer patients due to COVID-19. The hard management of this patient population has been also due to the potential cross interference of anti-tumor drugs on SARS-Cov-2 infection and to the differential diagnosis between COVID-19 pneumonitis and drug-related pneumonitis. COVID-19 pandemic has generated a profound reshaping of oncological activities and the development of recommendations by the oncology scientific community to prioritize anti-tumor treatments for lung cancer patients.
    MeSH term(s) Antineoplastic Agents/pharmacology ; COVID-19/complications ; COVID-19/mortality ; COVID-19 Vaccines ; Comorbidity ; Diagnosis, Differential ; Humans ; Lung Neoplasms/complications ; Lung Neoplasms/mortality ; Medical Oncology/methods ; Pandemics ; Pneumonia/diagnosis ; Risk Factors ; SARS-CoV-2 ; Tomography, X-Ray Computed
    Chemical Substances Antineoplastic Agents ; COVID-19 Vaccines
    Language English
    Publishing date 2021-10-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057359-5
    ISSN 1534-6269 ; 1523-3790
    ISSN (online) 1534-6269
    ISSN 1523-3790
    DOI 10.1007/s11912-021-01125-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5521: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Toward Improving Functional Recovery in AIDS-associated Progressive Multifocal Leukoencephalopathy: A Single Case Pilot Study on a Novel Neuromodulation Approach.

    Naro, Antonino / Billeri, Luana / Lauria, Paola / Manuli, Alfredo / Calabrò, Rocco Salvatore

    Innovations in clinical neuroscience

    2022  Volume 19, Issue 1-3, Page(s) 15–18

    Abstract: Patients with progressive multifocal leukoencephalopathy (PML) in the context of human immunodeficiency virus-acquired immunodeficiency syndrome (HIV-AIDS) show a partial improvement following rehabilitation; however, this improvement is rapidly lost if ... ...

    Abstract Patients with progressive multifocal leukoencephalopathy (PML) in the context of human immunodeficiency virus-acquired immunodeficiency syndrome (HIV-AIDS) show a partial improvement following rehabilitation; however, this improvement is rapidly lost if the patient is not provided with intensive rehabilitation. A 42-year-old patient affected by HIV-AIDS had a clinical worsening within a few months following PML onset, despite being treated with antiretroviral drugs and conventional rehabilitation. He developed severe paraparesis and significant dependency in the activities of daily life. A first cycle of intensive rehabilitation provided the patient with some significant functional outcomes, although he experienced a worsening of the clinical condition after two months of rest, before admission to our rehabilitation unit. We thus sought to evaluate the effects of intensive robot-aided gait training (RAGT) coupled with transcranial direct current stimulation (tDCS). The patient significantly improved when provided with intensive RAGT coupled with tDCS (as per 10-meter Walk Test [10MWT] and 6-minute Walk Test [6MWT]), and the improvement was maintained at three-month follow-up. As this advanced approach was feasible, safe, and potentially effective, this case suggests that patients with PML-HIV require prolonged multidisciplinary rehabilitation treatment. We can speculate that individuals with PML should also be treated with innovative technology to improve their functional outcomes and therefore quality of life.
    Language English
    Publishing date 2022-03-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2675366-2
    ISSN 2158-8341 ; 2158-8333
    ISSN (online) 2158-8341
    ISSN 2158-8333
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  9. Article: When Two Is Better Than One: A Pilot Study on Transcranial Magnetic Stimulation Plus Muscle Vibration in Treating Chronic Pelvic Pain in Women.

    Calabrò, Rocco Salvatore / Billeri, Luana / Porcari, Bruno / Pignolo, Loris / Naro, Antonino

    Brain sciences

    2022  Volume 12, Issue 3

    Abstract: Chronic pelvic pain syndrome (CPPS) affects about 4-16% of adult women, and about one-third of them require medical assistance due to severe symptoms. Repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA) has been ... ...

    Abstract Chronic pelvic pain syndrome (CPPS) affects about 4-16% of adult women, and about one-third of them require medical assistance due to severe symptoms. Repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA) has been shown to manage pain in refractory CPPS. Focal muscle vibration (FMV) has also been reported to relieve pelvic pain. The objective of this study was to assess the feasibility and effect of rTMS coupled with FMV to reduce pain in seven adult women with refractory CPPS. This pilot, open-labeled, prospective trial examined treatment by 5 Hz rTMS over SMA and 150 Hz FMV over the perineum, suprapubic, and sacrococcygeal areas, with one daily session for five consecutive days for three weeks. We assessed tolerance and subjective pain changes (as per visual analog scale, VAS) until one month post-treatment, with a primary endpoint at day 7. No patients experienced serious adverse effects or a significant increase in pain. Six out of seven patients experienced a VAS improvement of at least 10% at T7; three of these individuals experienced a VAS improvement of more than 30%. Overall, we found a significant VAS reduction of 15 points (95% CI 8.4-21.6) at T7 (t = 6.3,
    Language English
    Publishing date 2022-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci12030396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The prognostic effects of circulating myeloid-derived suppressor cells in non-small cell lung cancer: systematic review and meta-analysis.

    Bronte, Giuseppe / Calabrò, Luana / Olivieri, Fabiola / Procopio, Antonio Domenico / Crinò, Lucio

    Clinical and experimental medicine

    2022  Volume 23, Issue 5, Page(s) 1551–1561

    Abstract: Immunotherapy is the main standard treatment for non-small cell lung cancer (NSCLC) patients. Immune suppressive cells in tumor microenvironment can counteract its efficacy. Myeloid-derived suppressor cells (MDSCs) include two major subsets: ... ...

    Abstract Immunotherapy is the main standard treatment for non-small cell lung cancer (NSCLC) patients. Immune suppressive cells in tumor microenvironment can counteract its efficacy. Myeloid-derived suppressor cells (MDSCs) include two major subsets: polymorphonuclear (PMN-MDSCs) and monocytic (M-MDSCs). Many studies explored the prognostic impact of these cell populations in NSCLC patients. The aim of this systematic review is to select studies for a meta-analysis, which compares prognosis between patients with high vs low circulating MDSC levels. We collected hazard ratios (HRs) and relative 95% confidence intervals (CIs) in terms of progression-free survival (PFS) or recurrence-free survival (RFS), and overall survival (OS). Among 139 studies retrieved from literature search, 14 eligible studies (905 NSCLC patients) met inclusion criteria. Low circulating MDSC levels favor a better PFS/RFS (HR = 1.84; 95% CI = 1.28-2.65) and OS (HR = 1.78; 95% CI = 1.29-2.46). The subgroup analysis based on MDSC subtypes (total-, PMN-, and M-MDSCs) obtained a statistical significance only for M-MDSCs, both in terms of PFS/RFS (HR = 2.67; 95% CI = 2.04-3.50) and OS (HR = 2.10; 95% CI = 1.61-2.75). NSCLC patients bearing high M-MDSC levels in peripheral blood experience a worse prognosis than those with low levels, both in terms of PFS/RFS and OS. This finding suggests that detecting and targeting this MDSC subset could help to improve NSCLC treatment efficacy.
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/pathology ; Myeloid-Derived Suppressor Cells/pathology ; Prognosis ; Lung Neoplasms/pathology ; Proportional Hazards Models ; Tumor Microenvironment
    Language English
    Publishing date 2022-11-19
    Publishing country Italy
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2053018-3
    ISSN 1591-9528 ; 1591-8890
    ISSN (online) 1591-9528
    ISSN 1591-8890
    DOI 10.1007/s10238-022-00946-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5481: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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