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  1. Article ; Online: Factors that influence infliximab biosimilar trough levels in the pediatric inflammatory bowel disease population.

    Dipasquale, Valeria / Alibrandi, Angela / Pellegrino, Salvatore / Ramistella, Vincenzo / Romano, Claudio

    Expert review of clinical immunology

    2024  Volume 20, Issue 2, Page(s) 237–244

    Abstract: Background: The pharmacokinetics and pharmacodynamics of biosimilar infliximab (IFX-BioS) in pediatric inflammatory bowel disease (IBD) are poorly investigated. The aim of this study was to investigate factors predicting IFX-BioS trough levels (TLs).: ...

    Abstract Background: The pharmacokinetics and pharmacodynamics of biosimilar infliximab (IFX-BioS) in pediatric inflammatory bowel disease (IBD) are poorly investigated. The aim of this study was to investigate factors predicting IFX-BioS trough levels (TLs).
    Research design and methods: IBD children with an indication to start IFX-BioS were included in this prospective observational study (January 2021-June 2022). TLs were measured at the 4
    Results: A total of 110 TLs in 55 children were included. The multivariate linear regression model at the 4
    Conclusions: This study discovered some predictors for IFX-BioS TLs in IBD children. Knowledge of predictive factors could help physicians choose the best dosing regimen.
    MeSH term(s) Female ; Humans ; Child ; Infliximab ; Biosimilar Pharmaceuticals/therapeutic use ; Gastrointestinal Agents/therapeutic use ; Gastrointestinal Agents/pharmacokinetics ; Drug Monitoring ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/diagnosis ; Colitis, Ulcerative/drug therapy
    Chemical Substances Infliximab (B72HH48FLU) ; Biosimilar Pharmaceuticals ; Gastrointestinal Agents
    Language English
    Publishing date 2024-01-21
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1080/1744666X.2023.2284226
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6661: Show issues Location:
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  2. Article ; Online: Nutrition in Pediatric Gastroenterology.

    Romano, Claudio / Dipasquale, Valeria

    Nutrients

    2021  Volume 13, Issue 6

    Abstract: Nutrition and intestinal function are strictly interrelated [ ... ]. ...

    Abstract Nutrition and intestinal function are strictly interrelated [...].
    Language English
    Publishing date 2021-06-08
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu13061965
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  3. Article ; Online: Genes vs environment in inflammatory bowel disease: an update.

    Dipasquale, Valeria / Romano, Claudio

    Expert review of clinical immunology

    2022  Volume 18, Issue 10, Page(s) 1005–1013

    Abstract: Introduction: Inflammatory bowel diseases (IBDs) are known to be caused by a combination of genetic and environmental factors that vary in their influence on the development of the disease. Environmental exposures seem to influence IBD susceptibility, ... ...

    Abstract Introduction: Inflammatory bowel diseases (IBDs) are known to be caused by a combination of genetic and environmental factors that vary in their influence on the development of the disease. Environmental exposures seem to influence IBD susceptibility, whereas genetic background is thought to modulate the impact of the environment on disease course and phenotype.
    Areas covered: A broad review of the involvement of genes and the environment in IBD pathogenesis was performed, and information regarding the main genetic and environmental factors - categorized into lifestyle factors, drugs, diet, and microbes - was updated. Monogenic very early onset IBD (VEO-IBD) was also discussed.
    Expert opinion: In the upcoming years, better understanding of gene-environment interactions will contribute to the possibility of a better prediction of disease course, response to therapy, and therapy-related adverse events with the final goal of personalized and more efficient patient management.
    MeSH term(s) Age of Onset ; Disease Progression ; Gene-Environment Interaction ; Genetic Predisposition to Disease ; Humans ; Inflammatory Bowel Diseases/genetics ; Inflammatory Bowel Diseases/therapy ; Phenotype
    Language English
    Publishing date 2022-08-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1080/1744666X.2022.2108407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6661: Show issues Location:
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  4. Article: Biosimilars in Pediatric Inflammatory Bowel Diseases: A Systematic Review and Real Life-Based Evidence.

    Dipasquale, Valeria / Cicala, Giuseppe / Spina, Edoardo / Romano, Claudio

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 846151

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-03-17
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.846151
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  5. Article: A Systematic Review to Manage Avoidant/Restrictive Food Intake Disorders in Pediatric Gastroenterological Practice.

    Cucinotta, Ugo / Romano, Claudio / Dipasquale, Valeria

    Healthcare (Basel, Switzerland)

    2023  Volume 11, Issue 16

    Abstract: Avoidant/Restrictive food intake disorder (ARFID) is a feeding disorder characterized by persistent difficulty eating, such as limited choices of preferred foods, avoidance or restriction of certain foods or food groups, and negative emotions related to ... ...

    Abstract Avoidant/Restrictive food intake disorder (ARFID) is a feeding disorder characterized by persistent difficulty eating, such as limited choices of preferred foods, avoidance or restriction of certain foods or food groups, and negative emotions related to eating or meals. Although ARFID mainly affects children, it can also occur in adolescents and adults. ARFID can have serious physical and mental health consequences, including stunted growth, nutritional deficiencies, anxiety, and other psychiatric comorbidities. Despite its increasing importance, ARFID is relatively underrecognized and undertreated in clinical practice. Treatment consists of a multidisciplinary approach involving pediatric gastroenterologists, nutritionists, neuropsychiatrists, and psychologists. However, there are several gaps in the therapeutic approach for this condition, mainly due to the lack of interventional trials and the methodological variability of existing studies. Few studies have explored the nutritional management of ARFID, and no standardized guidelines exist to date. We performed a systematic literature review to describe the different nutritional interventions for children and adolescents diagnosed with ARFID and to assess their efficacy and tolerability. We identified seven retrospective cohort studies where patients with various eating and feeding disorders, including ARFID, underwent nutritional rehabilitation in hospital settings. In all studies, similar outcomes emerged in terms of efficacy and tolerability. According to our findings, the oral route should be the preferred way to start the refeeding protocol, and the enteral route should be generally considered a last resort for non-compliant patients or in cases of clinical instability. The initial caloric intake may be adapted to the initial nutritional status, but more aggressive refeeding regimens appear to be well tolerated and not associated with an increased risk of clinical refeeding syndrome (RS). In severely malnourished patients, however, phosphorus or magnesium supplementation may be considered to prevent the risk of electrolyte imbalance, or RS.
    Language English
    Publishing date 2023-08-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare11162245
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  6. Article: Gastrointestinal and nutritional care in pediatric neuromuscular disorders.

    Dipasquale, Valeria / Morello, Rossella / Romano, Claudio

    World journal of clinical pediatrics

    2023  Volume 12, Issue 4, Page(s) 197–204

    Abstract: Neuromuscular diseases (NMDs) affect the development and growth of the neuromuscular system in children. The pathology can occur anywhere along the neuromuscular pathway, from the brain to the nerves to the muscle fibers. These diseases have a profound ... ...

    Abstract Neuromuscular diseases (NMDs) affect the development and growth of the neuromuscular system in children. The pathology can occur anywhere along the neuromuscular pathway, from the brain to the nerves to the muscle fibers. These diseases have a profound impact on the quality of life not only of children but also of their families. The predominant manifestation in NMDs is hypotonia, which leads to muscle weakness and fatigue, reduced mobility, and decreased physical performance. However, multiple organ systems can be affected, with resulting orthopedic, cardiac, infectious, respiratory, and nutritional problems. Children with NMD present an increased risk for several dietary and feeding difficulties because of their neuromuscular diagnosis, presentation, and severity. These problems include chronic gastrointestinal issues (constipation, dysphagia, gastroesophageal reflux, and diarrhea), dysphagia, malnutrition, and body composition alterations. As a result, compared to the overall pediatric population, infants and children with NMD are more likely to be malnourished, ranging from failure to thrive to overweight or obesity. Disease-specific guidelines vary in level of detail and recommendations for dietary management. Overall, nutritional data available are sparse, with the exception of Duchenne muscular dystrophy, spinal muscular atrophy, and congenital muscular dystrophy. The purpose of this review is to describe the spectrum of nutritional challenges in children with NMD and to summarize the main dietary and gastrointestinal recommendations for each neuromuscular disorder to provide guidance for daily clinical practice.
    Language English
    Publishing date 2023-09-09
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2219-2808
    ISSN 2219-2808
    DOI 10.5409/wjcp.v12.i4.197
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  7. Article ; Online: Disease phenotype and outcomes of very early-onset inflammatory bowel disease.

    Dipasquale, Valeria / Lo Presti, Giovanna / Romano, Claudio

    European journal of internal medicine

    2022  Volume 102, Page(s) 138–139

    MeSH term(s) Age of Onset ; Colitis, Ulcerative ; Humans ; Inflammatory Bowel Diseases ; Phenotype
    Language English
    Publishing date 2022-05-06
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2022.05.001
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    Zs.A 2608: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article: A Narrative Review on Efficacy and Safety of Proton Pump Inhibitors in Children.

    Dipasquale, Valeria / Cicala, Giuseppe / Spina, Edoardo / Romano, Claudio

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 839972

    Abstract: Proton pump inhibitors (PPIs) are among the most prescribed drugs worldwide and include omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole. Their use in pediatrics is approved for children older than 1 year, for the short-term ... ...

    Abstract Proton pump inhibitors (PPIs) are among the most prescribed drugs worldwide and include omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole. Their use in pediatrics is approved for children older than 1 year, for the short-term treatment of symptomatic gastroesophageal reflux disease (GERD), healing of erosive esophagitis, treatment of peptic ulcer disease, and eradication of
    Language English
    Publishing date 2022-02-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.839972
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  9. Article ; Online: Randomised controlled trial of melatonin for paediatric functional abdominal pain disorders.

    Dipasquale, Valeria / Palermo, Lisa / Barbalace, Andrea / Tumminello, Giampaolo / Romano, Claudio

    Journal of paediatrics and child health

    2023  Volume 59, Issue 3, Page(s) 458–463

    Abstract: Aim: Melatonin seems to have a positive impact on the brain-gut axis and many direct and indirect effects on the gastrointestinal tract. This trial aimed at assessing the efficacy of melatonin combined with Lactobacillus Rhamnosus GG given in the ... ...

    Abstract Aim: Melatonin seems to have a positive impact on the brain-gut axis and many direct and indirect effects on the gastrointestinal tract. This trial aimed at assessing the efficacy of melatonin combined with Lactobacillus Rhamnosus GG given in the treatment of paediatric patients with functional abdominal pain disorders.
    Methods: Forty-two patients aged 4-18 years old who fulfilled the Rome IV Diagnostic Criteria for functional abdominal pain disorders were enrolled. Melatonin 3 or 5 mg in combination with Lactobacillus Rhamnosus GG (group 1, n = 22) or a placebo in combination with Lactobacillus Rhamnosus GG (control group, n = 20) were taken in the evening for a period of 4 weeks. The study duration was 12 weeks. The primary study endpoint was represented by clinical improvement at week 12 - defined as at least a 50% reduction in mean abdominal pain index (API) from baseline to week 12.
    Results: The mean API was reduced by more than 50% between T0 and T2 in the group of children treated with melatonin. However, the difference in the distributions of the variations of the scores between the two groups was not significant between T0 and T2 (P = 0.082), while it was significant between T0 and T1 (P = 0.001). Similar results were obtained by analysing the API variables 'weekly frequency of pain' (item 1) and 'perceived intensity of pain' (item 4) individually.
    Conclusions: This is the first study to investigate the role of the combination of melatonin and Lactobacillus Rhamnosus GG in the treatment of children with functional abdominal pain disorders. Melatonin combined with Lactobacillus Rhamnosus GG can be considered a therapeutic option for these conditions in children.
    MeSH term(s) Humans ; Child ; Child, Preschool ; Adolescent ; Melatonin/therapeutic use ; Abdominal Pain/drug therapy ; Lacticaseibacillus rhamnosus ; Gastrointestinal Tract ; Probiotics/therapeutic use ; Double-Blind Method ; Treatment Outcome
    Chemical Substances Melatonin (JL5DK93RCL)
    Language English
    Publishing date 2023-01-09
    Publishing country Australia
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/jpc.16323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Biosimilars in Pediatric IBD: Updated Considerations for Disease Management.

    Dipasquale, Valeria / Cucinotta, Ugo / Romano, Claudio

    Biologics : targets & therapy

    2022  Volume 16, Page(s) 57–66

    Abstract: Biologic drugs have significantly modified the pharmacological management of several chronic conditions, including inflammatory bowel diseases (IBD). By contrast, in the last two decades, biologics have been associated with increased direct medical costs. ...

    Abstract Biologic drugs have significantly modified the pharmacological management of several chronic conditions, including inflammatory bowel diseases (IBD). By contrast, in the last two decades, biologics have been associated with increased direct medical costs. As patents for the reference drugs have expired, the development and commercialization of biosimilars through abbreviated licensing pathways represented an affordable alternative in patients fulfilling the indication for biologics. A growing body of evidence, first in adults and then in the pediatric age group too, has provided reassuring data in terms of efficacy and safety of biosimilars both in naïve patients and in those previously on reference drugs who had to switch to the biosimilar. This review summarizes the currently available evidence for biosimilar use in IBD, with a focus on pediatric IBD. The most common practical approaches to biosimilar use in the pediatric clinical settings are also discussed.
    Language English
    Publishing date 2022-06-13
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2415708-9
    ISSN 1177-5491 ; 1177-5475
    ISSN (online) 1177-5491
    ISSN 1177-5475
    DOI 10.2147/BTT.S367032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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