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Article ; Online: A New Piece to Help Solve the Interstitial Lung Disease Diagnostic Puzzle.

Cosgrove, Gregory P / Lasky, Joseph A

American journal of respiratory and critical care medicine

2020 Volume 203, Issue 2, Page(s) 158–160

MeSH term(s)	Humans ; Idiopathic Pulmonary Fibrosis ; Lung Diseases, Interstitial/diagnosis ; Tomography, X-Ray Computed
Language	English
Publishing date	2020-11-23
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202008-3189ED
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Article ; Online: Interstitial lung abnormalities in rheumatoid arthritis are common and important.

Fischer, Aryeh / Cosgrove, Gregory P

Chest

2014 Volume 146, Issue 1, Page(s) 8–10

MeSH term(s)	Adult ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/epidemiology ; Female ; Global Health ; Humans ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/diagnostic imaging ; Lung Diseases, Interstitial/epidemiology ; Male ; Morbidity/trends ; Survival Rate/trends ; Tomography, X-Ray Computed
Language	English
Publishing date	2014-07
Publishing country	United States
Document type	Editorial
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1378/chest.14-0030
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Article ; Online: Barriers to timely diagnosis of interstitial lung disease in the real world: the INTENSITY survey.

Cosgrove, Gregory P / Bianchi, Pauline / Danese, Sherry / Lederer, David J

BMC pulmonary medicine

2018 Volume 18, Issue 1, Page(s) 9

Abstract: Background: The diagnosis of idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases (ILD) presents significant clinical challenges. To gain insights regarding the diagnostic experience of patients with ILD and to identify potential ... ...

Abstract	Background: The diagnosis of idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases (ILD) presents significant clinical challenges. To gain insights regarding the diagnostic experience of patients with ILD and to identify potential barriers to a timely and accurate diagnosis, we developed an online questionnaire and conducted a national survey of adults with a self-reported diagnosis of ILD. Methods: A pre-specified total of 600 subjects were recruited to participate in a 40-question online survey. E-mail invitations containing a link to the survey were sent to 16 427 registered members of the Pulmonary Fibrosis Foundation. Additionally, an open invitation was posted on an online forum for patients and caregivers ( www.inspire.com ). The recruitment and screening period was closed once the pre-defined target number of respondents was reached. Eligible participants were adult U.S. residents with a diagnosis of IPF or a non-IPF ILD. Results: A total of 600 eligible respondents met the eligibility criteria and completed the survey. Of these, 55% reported ≥ 1 misdiagnosis and 38% reported ≥ 2 misdiagnoses prior to the current diagnosis. The most common misdiagnoses were asthma (13.5%), pneumonia (13.0%), and bronchitis (12.3%). The median time from symptom onset to current diagnosis was 7 months (range, 0-252 months), with 43% of respondents reporting a delay of ≥ 1 year and 19% reporting a delay of ≥ 3 years. Sixty-one percent of respondents underwent at least one invasive diagnostic procedure. Conclusions: While a minority of patients with ILD will experience an appropriate and expedient diagnosis, the more typical diagnostic experience for individuals with ILD is characterized by considerable delays, frequent misdiagnosis, exposure to costly and invasive diagnostic procedures, and substantial use of healthcare resources. These findings suggest a need for physician education, development of clinical practice recommendations, and improved diagnostic tools aimed at improving diagnostic accuracy in patients with ILD.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Asthma/diagnosis ; Bronchitis/diagnosis ; Delayed Diagnosis/psychology ; Delayed Diagnosis/statistics & numerical data ; Diagnostic Errors/psychology ; Diagnostic Errors/statistics & numerical data ; Diagnostic Techniques, Respiratory System/statistics & numerical data ; Female ; Health Care Surveys ; Humans ; Idiopathic Pulmonary Fibrosis/diagnosis ; Male ; Middle Aged ; Pneumonia/diagnosis ; Quality of Life ; Time Factors ; Young Adult
Language	English
Publishing date	2018-01-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-017-0560-x
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Article ; Online: Essential Components of an Interstitial Lung Disease Clinic: Results From a Delphi Survey and Patient Focus Group Analysis.

Graney, Bridget A / He, Christophe / Marll, Michael / Matson, Scott / Bianchi, Pauline / Cosgrove, Gregory P / Lee, Joyce S

Chest

2020 Volume 159, Issue 4, Page(s) 1517–1530

Abstract: Background: Management of patients with interstitial lung disease (ILD) requires subspecialized, comprehensive, multidisciplinary care. The Pulmonary Fibrosis Foundation established the Care Center Network (CCN) in 2013 with identified criteria to ... ...

Abstract	Background: Management of patients with interstitial lung disease (ILD) requires subspecialized, comprehensive, multidisciplinary care. The Pulmonary Fibrosis Foundation established the Care Center Network (CCN) in 2013 with identified criteria to become a designated CCN site. Despite these criteria, the essential components of an ILD clinic remain unknown. Research questions: How are ILD clinics within the CCN structured? What are the essential components of an ILD clinic according to ILD physician experts, patients, and caregivers? Study design and methods: This study had three components. First, all 68 CCN sites were surveyed to determine the characteristics of their current ILD clinics. Second, an online, three-round modified Delphi survey was conducted between October and December 2019 with 48 ILD experts participating in total. Items for round 1 were generated using expert interviews. During rounds 1 and 2, experts rated the importance of each item on a 5-point Likert scale. The a priori threshold for consensus was more than 75% of experts rating an item as important or very important. In round 3, experts graded items that met consensus and ranked items deemed essential for an ILD clinic. Third, ILD patient and caregiver focus groups were conducted and analyzed for content to determine their perspectives of an ideal ILD clinic. Results: Forty items across four categories (members, infrastructure, resources, and multidisciplinary conference) achieved consensus as essential to an ILD clinic. Patient and caregiver focus groups identified three major themes: comprehensive, patient-centered medical care; expanded access to care; and comprehensive support for living and coping with ILD. Interpretation: The essential components of an ILD clinic are well-aligned between physician experts and patients. Future research can use these findings to evaluate the impact of these components on patient outcomes and to inform best practices for ILD clinics throughout the world.
MeSH term(s)	Ambulatory Care Facilities/organization & administration ; Colorado ; Delphi Technique ; Focus Groups ; Humans ; Lung Diseases, Interstitial/therapy ; Models, Organizational ; United States
Keywords	covid19
Language	English
Publishing date	2020-10-05
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2020.09.256
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Article ; Online: Interstitial lung disease: the initial approach.

Alhamad, Esam H / Cosgrove, Gregory P

The Medical clinics of North America

2011 Volume 95, Issue 6, Page(s) 1071–1093

Abstract: In the last decade, significant progress has been made toward a better understanding of interstitial lung disease (ILD). A valuable tool for the clinician is high-resolution computed tomography, which aids in narrowing the differential diagnosis in ... ...

Abstract	In the last decade, significant progress has been made toward a better understanding of interstitial lung disease (ILD). A valuable tool for the clinician is high-resolution computed tomography, which aids in narrowing the differential diagnosis in patients with ILD and obviates the need for surgical lung biopsy when a usual interstitial pneumonia pattern is present. Clinicians evaluating and caring for patients with ILD need to recognize associated comorbidities. Substantial evidence shows that implementation of a multidisciplinary approach provides a high standard of care for patients, leading to improvements in the accuracy of clinical diagnosis that can significantly affect patient outcome.
MeSH term(s)	Bronchiectasis/complications ; Bronchiectasis/diagnostic imaging ; Bronchoscopy ; Connective Tissue Diseases/complications ; Diagnosis, Differential ; Environmental Exposure ; Humans ; Lung/diagnostic imaging ; Lung Diseases, Interstitial/classification ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/diagnosis ; Lung Diseases, Interstitial/diagnostic imaging ; Lung Diseases, Interstitial/etiology ; Medical History Taking ; Occupational Exposure ; Physical Examination ; Sarcoidosis, Pulmonary/complications ; Sarcoidosis, Pulmonary/diagnostic imaging ; Tomography, X-Ray Computed
Language	English
Publishing date	2011-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	215710-x
ISSN	1557-9859 ; 0025-7125
ISSN (online)	1557-9859
ISSN	0025-7125
DOI	10.1016/j.mcna.2011.08.008
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Article ; Online: Early survival following in utero myocardial infarction.

Cosgrove, Peter / Modi, Shan / Lawson, Karla / Hancock-Friesen, Camille / Johnson, Gregory

Cardiology in the young

2018 Volume 28, Issue 10, Page(s) 1079–1087

Abstract: ... our own case. Presentation within the first 12 hours was associated with mortality (OR 3.90, p=0.004 ...

Abstract	Intrauterine myocardial infarction is a rare and frequently fatal diagnosis. It has been presented in the literature only as case reports and short series. We present a case report of a coronary occlusive intrauterine myocardial infarction and survival and present a systematic review of the literature. This is the first summative description of current data on intrauterine and perinatal myocardial infarction. We performed the systematic review based on the guidelines established by the PRISMA statement. Our population of intrauterine and perinatal myocardial infarction included published cases who presented as a live birth within the first 28 postnatal days, and had a diagnosis of myocardial infarction. We conducted descriptive statistics and regression analysis on short-term mortality as the primary outcome. After applying exclusion criteria we described 84 individual cases of myocardial infarction from 63 full-text articles including our own case. Presentation within the first 12 hours was associated with mortality (OR 3.90, p=0.004). Treatment modalities were varied and inconsistently recorded. The aetiologies and comorbidities are varied in our systematic review. We would have a low threshold to perform viral testing, consider anticoagulation early and coronary imaging if feasible. The use of extracorporeal membranous oxygenation may serve as a bridge to cardiac recovery.
MeSH term(s)	Adult ; Cardiac Catheterization ; Coronary Angiography ; Diagnosis, Differential ; Echocardiography/methods ; Electrocardiography ; Female ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/physiopathology ; Humans ; Infant, Newborn ; Magnetic Resonance Imaging, Cine/methods ; Male ; Myocardial Infarction/diagnosis ; Myocardial Infarction/embryology ; Myocardial Infarction/physiopathology ; Pregnancy ; Stroke Volume/physiology ; Ultrasonography, Prenatal/methods
Language	English
Publishing date	2018-07-23
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1078466-4
ISSN	1467-1107 ; 1047-9511
ISSN (online)	1467-1107
ISSN	1047-9511
DOI	10.1017/S1047951118001105
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Article ; Online: Network and matrix analysis of the respiratory disease interactome.

Garcia, Benjamin / Datta, Gargi / Cosgrove, Gregory P / Strong, Michael

BMC systems biology

2014 Volume 8, Page(s) 34

Abstract: Background: Although respiratory diseases exhibit in a wide array of clinical manifestations, certain respiratory diseases may share related genetic mechanisms or may be influenced by similar chemical stimuli. Here we explore and infer relationships ... ...

Abstract	Background: Although respiratory diseases exhibit in a wide array of clinical manifestations, certain respiratory diseases may share related genetic mechanisms or may be influenced by similar chemical stimuli. Here we explore and infer relationships among genes, diseases, and chemicals using network and matrix based clustering methods. Results: In order to better understand and elucidate these shared genetic mechanisms and chemical relationships we analyzed a comprehensive collection of gene, disease, and chemical relationships pertinent to respiratory disease, using network and matrix based analysis approaches. Our methods enabled us to analyze relationships and make biological inferences among over 200 different respiratory and related diseases, involving thousands of gene-chemical-disease relationships. Conclusions: The resulting networks provided insight into shared mechanisms of respiratory disease and in some cases suggest novel targets or repurposed drug strategies.
MeSH term(s)	Cluster Analysis ; Computational Biology ; Respiratory Tract Diseases/genetics ; Respiratory Tract Diseases/metabolism ; Systems Biology/methods
Language	English
Publishing date	2014-03-22
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2265490-2
ISSN	1752-0509 ; 1752-0509
ISSN (online)	1752-0509
ISSN	1752-0509
DOI	10.1186/1752-0509-8-34
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Article ; Online: Dyspnea in a 43-year-old woman with polycystic kidney disease.

Li, Howard Y / Cosgrove, Gregory P / Swigris, Jeffrey J

Chest

2009 Volume 135, Issue 1, Page(s) 238–243

MeSH term(s)	Adult ; Dyspnea/etiology ; Female ; Humans ; Polycystic Kidney Diseases/complications ; Polycystic Kidney Diseases/diagnosis ; Polycystic Kidney Diseases/genetics ; TRPP Cation Channels/genetics ; Tuberous Sclerosis Complex 2 Protein ; Tumor Suppressor Proteins/genetics
Chemical Substances	TRPP Cation Channels ; Tuberous Sclerosis Complex 2 Protein ; Tumor Suppressor Proteins ; polycystic kidney disease 1 protein
Language	English
Publishing date	2009-01-08
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1378/chest.08-1223
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Article ; Online: The Fibrosis Across Organs Symposium: A Roadmap for Future Research Priorities.

Roman, Jesse / Barnes, Teresa R / Kervitsky, Dolly J / Cosgrove, Gregory P / Doherty, Dennis E / Tager, Andrew M / Richeldi, Luca / White, Eric S / Brenner, David A / Schnapp, Lynn M / Hewitson, Timothy D / Jugdutt, Bodh I / McKinsey, Timothy A / Tosi, John D / Crane, Stephen / Brown, Kevin K

The American journal of the medical sciences

2019 Volume 357, Issue 5, Page(s) 405–410

MeSH term(s)	Colorado ; Congresses as Topic ; Fibrosis/etiology ; Fibrosis/pathology ; Fibrosis/physiopathology ; Research Design
Language	English
Publishing date	2019-04-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	82078-7
ISSN	1538-2990 ; 0002-9629
ISSN (online)	1538-2990
ISSN	0002-9629
DOI	10.1016/j.amjms.2019.02.014
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Article: Matrix metalloproteinase-7 expression in fibrosing lung disease: restoring the balance.

Cosgrove, Gregory P / du Bois, Roland M

Chest

2008 Volume 133, Issue 5, Page(s) 1058–1060

MeSH term(s)	Animals ; Biomarkers/metabolism ; Bronchoalveolar Lavage Fluid/chemistry ; Cell Proliferation ; Humans ; Lung/enzymology ; Lung/pathology ; Matrix Metalloproteinase 7/biosynthesis ; Mice ; Prognosis ; Pulmonary Fibrosis/enzymology ; Pulmonary Fibrosis/pathology ; Severity of Illness Index
Chemical Substances	Biomarkers ; Matrix Metalloproteinase 7 (EC 3.4.24.23)
Language	English
Publishing date	2008-05
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1378/chest.07-2882
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