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Article ; Online: Challenges in the Practice of Sexual Medicine in the Time of COVID-19 in Spain.

Torremade, Jose / Martínez-Salamanca, Juan Ignacio

2020 Volume 17, Issue 7, Page(s) 1220–1221

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Spain ; Telemedicine ; Urology
Keywords	covid19
Language	English
Publishing date	2020-05-23
Publishing country	Netherlands
Document type	Journal Article ; Comment
ZDB-ID	2251959-2
ISSN	1743-6109 ; 1743-6095
ISSN (online)	1743-6109
ISSN	1743-6095
DOI	10.1016/j.jsxm.2020.05.012
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Article ; Online: Experiencia inicial en el tratamiento microquirúrgico del varicocele: análisis comparativo con la varicocelectomía macroquirúrgica convencional.

Fernández-Concha Schwalb, Jaime J / Torremadé Barreda, José / Suárez Novo, José Francisco / Picola Brau, Natalia / Vigués Julia, Francisco

Revista internacional de andrologia

2020 Volume 19, Issue 2, Page(s) 88–92

Abstract: Introduction: Varicocele is the most common cause of male infertility and the standard treatment is varicocelectomy. Having recently started performing microsurgical varicocelectomy (MV) in our centre, the objective of this study is to determine the ... ...

Title translation	Initial experience in microsurgical treatment of varicocele: Comparative analysis with conventional macrosurgical varicocelectomy.
Abstract	Introduction: Varicocele is the most common cause of male infertility and the standard treatment is varicocelectomy. Having recently started performing microsurgical varicocelectomy (MV) in our centre, the objective of this study is to determine the differences in clinical outcomes and laboratory findings between MV and the conventional varicocelectomy (CV). Material and methods: This is a comparative study between MV and CV in our centre between 01/2013 and 12/2016. We included patients with clinical varicocele and altered seminal parameters. We analyzed the following variables: age, laterality, grade of varicocele, testicular volume, surgical technique used, seminogram parameters prior to and after surgery and recurrence. Results: Between 01/2013 and 12/2016 46 varicocelectomies were performed in our centre, excluding from the study 12 patients due to lack of follow-up. Of the remaining 34, 19 (55.9%) underwent CV and 15 (44.1%) MV. There were no significant differences between the baseline characteristics of both groups. The preoperative sperm count was 30.1±35.6 10 Conclusions: Despite the learning curve with MV, we obtained improvements in seminal analysis similar to those with CV. Even though not statistically significant, there was a tendency to less recurrence in the MV group, consistent with what is already described in medical literature.
MeSH term(s)	Humans ; Infertility, Male/etiology ; Infertility, Male/surgery ; Male ; Microsurgery/methods ; Postoperative Period ; Sperm Count ; Sperm Motility ; Spermatic Cord ; Treatment Outcome ; Varicocele/complications ; Varicocele/surgery ; Vascular Surgical Procedures/adverse effects
Language	Spanish
Publishing date	2020-01-22
Publishing country	Spain
Document type	Comparative Study ; Journal Article
ISSN	1698-0409
ISSN (online)	1698-0409
DOI	10.1016/j.androl.2019.10.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Challenges in the Practice of Sexual Medicine in the Time of COVID-19 in Spain

Torremade, Jose / Martínez-Salamanca, Juan Ignacio

J Sex Med

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #342787
Database	COVID19

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Article ; Online: Challenges in the Practice of Sexual Medicine in the Time of COVID-19 in Spain

Torremade, Jose / Martínez-Salamanca, Juan Ignacio

The Journal of Sexual Medicine

2020 Volume 17, Issue 7, Page(s) 1220–1221

Keywords	Obstetrics and Gynaecology ; Urology ; Reproductive Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	2251959-2
ISSN	1743-6109 ; 1743-6095
ISSN (online)	1743-6109
ISSN	1743-6095
DOI	10.1016/j.jsxm.2020.05.012
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of the Administration of 25(OH) Vitamin D3 in an Experimental Model of Chronic Kidney Disease in Animals Null for 1-Alpha-Hydroxylase.

Torremadé, Noelia / Bozic, Milica / Goltzman, David / Fernandez, Elvira / Valdivielso, José M

PloS one

2017 Volume 12, Issue 1, Page(s) e0170654

Abstract: The final step in vitamin D activation is catalyzed by 1-alpha-hydroxylase (CYP27B1). Chronic kidney disease (CKD) is characterized by low levels of both 25(OH)D3 and 1,25(OH)2D3 provoking secondary hyperparathyroidism (2HPT). Therefore, treatments with ... ...

Abstract	The final step in vitamin D activation is catalyzed by 1-alpha-hydroxylase (CYP27B1). Chronic kidney disease (CKD) is characterized by low levels of both 25(OH)D3 and 1,25(OH)2D3 provoking secondary hyperparathyroidism (2HPT). Therefore, treatments with active or native vitamin D compounds are common in CKD to restore 25(OH)D3 levels and also to decrease PTH. This study evaluates the dose of 25(OH)D3 that restores parathyroid hormone (PTH) and calcium levels in a model of CKD in CYP27B1-/- mice. Furthermore, we compare the safety and efficacy of the same dose in CYP27B1+/+ animals. The dose needed to decrease PTH levels in CYP27B1-/- mice with CKD was 50 ng/g. That dose restored blood calcium levels without modifying phosphate levels, and increased the expression of genes responsible for calcium absorption (TRPV5 and calbindinD- 28K in the kidney, TRPV6 and calbindinD-9k in the intestine). The same dose of 25(OH)D3 did not modify PTH in CYP27B1+/+ animals with CKD. Blood calcium remained normal, while phosphate increased significantly. Blood levels of 25(OH)D3 in CYP27B1-/- mice were extremely high compared to those in CYP27B1+/+ animals. CYP27B1+/+ animals with CKD showed increases in TRPV5, TRPV6, calbindinD-28K and calbindinD-9K, which were not further elevated with the treatment. Furthermore, CYP27B1+/+ animals displayed an increase in vascular calcification. We conclude that the dose of 25(OH)D3 effective in decreasing PTH levels in CYP27B1-/- mice with CKD, has a potentially toxic effect in CYP27B1+/+ animals with CKD.
MeSH term(s)	25-Hydroxyvitamin D3 1-alpha-Hydroxylase/deficiency ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase/physiology ; Animals ; Blotting, Western ; Calcifediol/therapeutic use ; Calcium/blood ; Disease Models, Animal ; Kidney/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Parathyroid Hormone/blood ; Real-Time Polymerase Chain Reaction ; Renal Insufficiency, Chronic/drug therapy
Chemical Substances	Parathyroid Hormone ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase (EC 1.14.13.13) ; Calcifediol (P6YZ13C99Q) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0170654
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Article ; Online: Effects of the Administration of 25(OH) Vitamin D3 in an Experimental Model of Chronic Kidney Disease in Animals Null for 1-Alpha-Hydroxylase.

Noelia Torremadé / Milica Bozic / David Goltzman / Elvira Fernandez / José M Valdivielso

PLoS ONE, Vol 12, Iss 1, p e

2017 Volume 0170654

Abstract	The final step in vitamin D activation is catalyzed by 1-alpha-hydroxylase (CYP27B1). Chronic kidney disease (CKD) is characterized by low levels of both 25(OH)D3 and 1,25(OH)2D3 provoking secondary hyperparathyroidism (2HPT). Therefore, treatments with active or native vitamin D compounds are common in CKD to restore 25(OH)D3 levels and also to decrease PTH. This study evaluates the dose of 25(OH)D3 that restores parathyroid hormone (PTH) and calcium levels in a model of CKD in CYP27B1-/- mice. Furthermore, we compare the safety and efficacy of the same dose in CYP27B1+/+ animals. The dose needed to decrease PTH levels in CYP27B1-/- mice with CKD was 50 ng/g. That dose restored blood calcium levels without modifying phosphate levels, and increased the expression of genes responsible for calcium absorption (TRPV5 and calbindinD- 28K in the kidney, TRPV6 and calbindinD-9k in the intestine). The same dose of 25(OH)D3 did not modify PTH in CYP27B1+/+ animals with CKD. Blood calcium remained normal, while phosphate increased significantly. Blood levels of 25(OH)D3 in CYP27B1-/- mice were extremely high compared to those in CYP27B1+/+ animals. CYP27B1+/+ animals with CKD showed increases in TRPV5, TRPV6, calbindinD-28K and calbindinD-9K, which were not further elevated with the treatment. Furthermore, CYP27B1+/+ animals displayed an increase in vascular calcification. We conclude that the dose of 25(OH)D3 effective in decreasing PTH levels in CYP27B1-/- mice with CKD, has a potentially toxic effect in CYP27B1+/+ animals with CKD.
Keywords	Medicine ; R ; Science ; Q
Subject code	630
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Multicenter Prospective Study of Grafting With Collagen Fleece TachoSil in Patients With Peyronie's Disease.

Fernández-Pascual, Esaú / Manfredi, Celeste / Torremadé, Jose / Ibarra, François Peinado / Geli, Joaquim Sarquella / Romero-Otero, Javier / García-Baquero, Rodrigo / Poblador, Agustín Fraile / Barbará, Mariano Roselló / Campos-Juanatey, Félix / Rojo, Alejandra Egui / Iribarren, Ignacio Moncada / Rodríguez, Joaquín Carballido / Martínez-Salamanca, Juan Ignacio

The journal of sexual medicine

2020 Volume 17, Issue 11, Page(s) 2279–2286

Abstract: Background: A xenograft consisting of equine collagen coated with human fibrinogen and thrombin (TachoSil; Baxter, CA) has recently been introduced in grafting procedures for Peyronie's disease (PD).: Aim: To describe the results of a multicenter ... ...

Abstract	Background: A xenograft consisting of equine collagen coated with human fibrinogen and thrombin (TachoSil; Baxter, CA) has recently been introduced in grafting procedures for Peyronie's disease (PD). Aim: To describe the results of a multicenter prospective registry on patients with PD undergoing plaque incision or and grafting (PIG) or plaque excision and grafting (PEG) with collagen fleece TachoSil, to evaluate the efficacy and safety of this procedure. Methods: A prospective non-controlled multicenter study of patients with PD was performed between May 2016 and March 2018. Patients from 10 centers with stable PD for at least 3 months, difficulties in sexual intercourse, normal erectile function with or without pharmacological treatment, curvature >45°, and/or penile shortening and/or complex deformities were included. All patients underwent PIG/PEG with collagen fleece TachoSil. Outcomes: The main outcome measure of this study were penile curvature correction (intraoperative), penile shortening (intraoperative), erectile function with the 5-item version of the International Index of Erectile Function (IIEF-5) and the Erection Hardness Score, subjective patient outcomes with non-validated questionnaires, and complications. Results: A total of 52 patients were enrolled in the study. The mean (SD) preoperative penile curvature was 72.8° (17.0). PIG was the preferred technique (80.8%). Intraoperatively, complete curvature correction was achieved in 92.3%, and no significant penile shortening was recorded in 80.8% of subjects. Subjective penile shortening was reported in 83.3% of patients at 6 months. No objective measurement of penile curvature and length was recorded during follow-up. No statistically significant difference from the baseline was found in IIEF-5 and Erection Hardness Score at 3 or at 6 months, although 16.7% of men experienced a worsening of IIEF-5 scores and 14.3% required de novo phosphodiesterase type 5 inhibitor use. 6 months after surgery, 78.5% of men were satisfied with intervention. Swelling and ecchymosis/hematoma were the most common perioperative complications (40.4%). 2 cases (3.8%) of wound infection were recorded. At 6 months, 35.7% of patients reported mild penile hypesthesia. Clinical implications: Our results confirm the high success rate of grafting with TachoSil, and the surgeon perceived low percentage of penile shortening. Strength & limitations: This is the first multicentre study on patients with PD undergoing grafting with TachoSil without concomitant placement of penile prosthesis. The main limitations are the short follow-up and the relatively small sample size. Conclusion: Grafting with TachoSil after PIG/PEG in patients with PD is an effective and safe procedure. Among the main advantages of this technique, there are ease of use of the graft and reduced operative time. Fernández-Pascual E, Manfredi C, Torremadé J, et al. Multicenter Prospective Study of Grafting With Collagen Fleece TachoSil in Patients With Peyronie's Disease. J Sex Med 2020;17:2279-2286.
MeSH term(s)	Animals ; Collagen ; Drug Combinations ; Fibrinogen/therapeutic use ; Horses ; Humans ; Male ; Patient Satisfaction ; Penile Induration/surgery ; Penis ; Prospective Studies ; Thrombin ; Treatment Outcome
Chemical Substances	Drug Combinations ; TachoSil ; Fibrinogen (9001-32-5) ; Collagen (9007-34-5) ; Thrombin (EC 3.4.21.5)
Keywords	covid19
Language	English
Publishing date	2020-08-20
Publishing country	Netherlands
Document type	Journal Article ; Multicenter Study
ZDB-ID	2251959-2
ISSN	1743-6109 ; 1743-6095
ISSN (online)	1743-6109
ISSN	1743-6095
DOI	10.1016/j.jsxm.2020.07.079
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Article: Andrología y cáncer de pene. Recomendaciones durante la pandemia COVID-19.

Fraile, Agustín / Moncada Iribarren, Ignacio / Chantada Abal, Venancio / Fernández-Pascual, Esaú / Romero Otero, Javier / Alonso-Isa, Manuel / Lledó, Enrique / Egui-Rojo, Alejandra / García-Baquero, Rodrigo / Torremadé, Jose / Sarquella, Joaquim / Fes Ascanio, Enrique / Cruz, Natalio / Martínez-Jabaloyas, José Mª / Luján, Saturnino / García Cruz, Eduardo / Martínez-Salamanca, Juan Ignacio

Archivos espanoles de urologia

2020 Volume 73, Issue 5, Page(s) 395–404

Abstract: Purpose: The COVID-19 pandemic which has affected Spain since the beginning of 2020 compels us to determine recomendations for the practice of Andrology in present times.: Materials and methods: A web search is carried out in English and Spanish and ... ...

Title translation	Andrology and penile cancer. Recommendations during COVID-19 pandemia.
Abstract	Purpose: The COVID-19 pandemic which has affected Spain since the beginning of 2020 compels us to determine recomendations for the practice of Andrology in present times. Materials and methods: A web search is carried out in English and Spanish and a joint proposal is defined by experts in Andrology from different regions of Spain. Results: Most diagnostic and therapeutic procedures in Andrology can be safey postponed during the COVID-19 pandemic. Online consultations and outpatient surgeries must be encouraged. Andrologic emergencies and penile cancer management should be considered high priority, and should be diagnosed and treated promptly even in the most severe phases of the pandemic.
MeSH term(s)	Andrology ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Male ; Pandemics ; Penile Neoplasms/diagnosis ; Penile Neoplasms/therapy ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Spain
Keywords	covid19
Language	Spanish
Publishing date	2020-06-15
Publishing country	Spain
Document type	Journal Article
ZDB-ID	211673-x
ISSN	0004-0614
ISSN	0004-0614
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Article ; Online: Vascular Calcification Induced by Chronic Kidney Disease Is Mediated by an Increase of 1α-Hydroxylase Expression in Vascular Smooth Muscle Cells.

Torremadé, Noelia / Bozic, Milica / Panizo, Sara / Barrio-Vazquez, Sara / Fernandez-Martín, Jose L / Encinas, Mario / Goltzman, David / Arcidiacono, Maria V / Fernandez, Elvira / Valdivielso, José M

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

2016 Volume 31, Issue 10, Page(s) 1865–1876

Abstract: Vascular calcification (VC) is a complication of chronic kidney disease that predicts morbidity and mortality. Uremic serum promotes VC, but the mechanism involved is unknown. A role for 1,25(OH) ...

Abstract	Vascular calcification (VC) is a complication of chronic kidney disease that predicts morbidity and mortality. Uremic serum promotes VC, but the mechanism involved is unknown. A role for 1,25(OH)
MeSH term(s)	25-Hydroxyvitamin D3 1-alpha-Hydroxylase/biosynthesis ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase/genetics ; Animals ; Female ; Gene Expression Regulation, Enzymologic ; Humans ; Male ; Mice ; Mice, Knockout ; Muscle, Smooth, Vascular/enzymology ; Muscle, Smooth, Vascular/pathology ; Myocytes, Smooth Muscle/enzymology ; Myocytes, Smooth Muscle/pathology ; Rats ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/enzymology ; Renal Insufficiency, Chronic/genetics ; Renal Insufficiency, Chronic/pathology ; Vascular Calcification/enzymology ; Vascular Calcification/etiology ; Vascular Calcification/genetics ; Vascular Calcification/pathology
Chemical Substances	25-Hydroxyvitamin D3 1-alpha-Hydroxylase (EC 1.14.13.13) ; CYP27B1 protein, human (EC 1.14.15.18)
Language	English
Publishing date	2016-05-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	632783-7
ISSN	1523-4681 ; 0884-0431
ISSN (online)	1523-4681
ISSN	0884-0431
DOI	10.1002/jbmr.2852
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Article: Multicenter Prospective Study of Grafting With Collagen Fleece TachoSil in Patients With Peyronie's Disease

J. sex. med

Abstract: BACKGROUND: A xenograft consisting of equine collagen coated with human fibrinogen and thrombin (TachoSil; Baxter, CA) has recently been introduced in grafting procedures for Peyronie's disease (PD). AIM: To describe the results of a multicenter ... ...

Abstract	BACKGROUND: A xenograft consisting of equine collagen coated with human fibrinogen and thrombin (TachoSil; Baxter, CA) has recently been introduced in grafting procedures for Peyronie's disease (PD). AIM: To describe the results of a multicenter prospective registry on patients with PD undergoing plaque incision or and grafting (PIG) or plaque excision and grafting (PEG) with collagen fleece TachoSil, to evaluate the efficacy and safety of this procedure. METHODS: A prospective non-controlled multicenter study of patients with PD was performed between May 2016 and March 2018. Patients from 10 centers with stable PD for at least 3 months, difficulties in sexual intercourse, normal erectile function with or without pharmacological treatment, curvature >45°, and/or penile shortening and/or complex deformities were included. All patients underwent PIG/PEG with collagen fleece TachoSil. OUTCOMES: The main outcome measure of this study were penile curvature correction (intraoperative), penile shortening (intraoperative), erectile function with the 5-item version of the International Index of Erectile Function (IIEF-5) and the Erection Hardness Score, subjective patient outcomes with non-validated questionnaires, and complications. RESULTS: A total of 52 patients were enrolled in the study. The mean (SD) preoperative penile curvature was 72.8° (17.0). PIG was the preferred technique (80.8%). Intraoperatively, complete curvature correction was achieved in 92.3%, and no significant penile shortening was recorded in 80.8% of subjects. Subjective penile shortening was reported in 83.3% of patients at 6 months. No objective measurement of penile curvature and length was recorded during follow-up. No statistically significant difference from the baseline was found in IIEF-5 and Erection Hardness Score at 3 or at 6 months, although 16.7% of men experienced a worsening of IIEF-5 scores and 14.3% required de novo phosphodiesterase type 5 inhibitor use. 6 months after surgery, 78.5% of men were satisfied with intervention. Swelling and ecchymosis/hematoma were the most common perioperative complications (40.4%). 2 cases (3.8%) of wound infection were recorded. At 6 months, 35.7% of patients reported mild penile hypesthesia. CLINICAL IMPLICATIONS: Our results confirm the high success rate of grafting with TachoSil, and the surgeon perceived low percentage of penile shortening. STRENGTH & LIMITATIONS: This is the first multicentre study on patients with PD undergoing grafting with TachoSil without concomitant placement of penile prosthesis. The main limitations are the short follow-up and the relatively small sample size. CONCLUSION: Grafting with TachoSil after PIG/PEG in patients with PD is an effective and safe procedure. Among the main advantages of this technique, there are ease of use of the graft and reduced operative time. Fernández-Pascual E, Manfredi C, Torremadé J, et al. Multicenter Prospective Study of Grafting With Collagen Fleece TachoSil in Patients With Peyronie's Disease. J Sex Med 2020;XX:XXX-XXX.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32830078
Database	COVID19

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