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  1. Article ; Online: Histone Methyltransferase

    Qin, Lei / Gong, Xin / Nong, Jieying / Tang, Xianyu / Cui, Kan / Zhao, Yan / Xia, Shitou

    Journal of fungi (Basel, Switzerland)

    2024  Volume 10, Issue 4

    Abstract: Histone post-translational modification is one of the main mechanisms of epigenetic regulation, which plays a crucial role in the control of gene expression and various biological processes. However, whether or not it affects fungal virulence ... ...

    Abstract Histone post-translational modification is one of the main mechanisms of epigenetic regulation, which plays a crucial role in the control of gene expression and various biological processes. However, whether or not it affects fungal virulence in
    Language English
    Publishing date 2024-04-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof10040271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mask-related adverse skin reactions in orientals during COVID-19: Prevalence, social-psychological impacts and risk factors for acne exacerbation.

    Lujia, Chen / Hanlong, Zheng / Hui, Shao / Jieying, Tang / Jianmin, Yang / Weiwei, Li

    Journal of cosmetic dermatology

    2023  Volume 22, Issue 2, Page(s) 370–377

    Abstract: Background: COVID-19 pandemic has caused mask-related skin problems on health-care professions, yet very few studies have investigated the prevalence in oriental general population.: Objective: To investigate the prevalence of mask-related adverse ... ...

    Abstract Background: COVID-19 pandemic has caused mask-related skin problems on health-care professions, yet very few studies have investigated the prevalence in oriental general population.
    Objective: To investigate the prevalence of mask-related adverse skin reactions in Orientals, to explore psychological influence, to identify risk factors for mask-related acne exacerbation.
    Methods: We performed a survey through social media. Participant demographics, skin condition before and after COVID-19, and the influence of adverse skin on social-psychological conditions were collected. We compared characteristics between individuals with or without acne exacerbation, and we performed a logistic regression to identify risk factors.
    Results: Six hundred and six participants (62.3%) responded the survey and 23.3% complained their facial acnes become exacerbated since COVID-19. The social-psychological impact of acnes is more prevalent in women. Risk factors for mask-related acne exacerbation were occupation as health-care workers (OR = 1.861, p = 0.027), prolonged wearing of N95 masks (OR = 3.167, p = 0.001), and touching of acnes (OR = 2.65, p = 0.002). Sex, pre-existed acnes, and prolonged wearing time per day are also associated with acne exacerbation.
    Conclusions: Mask-related adverse skin reactions are common in Orientals, and could lead to negative social-psychological effects.
    MeSH term(s) Humans ; Female ; Prevalence ; Pandemics ; COVID-19/epidemiology ; Acne Vulgaris/epidemiology ; Risk Factors
    Language English
    Publishing date 2023-01-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.15593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6539: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Early changes of bone metabolites and lymphocyte subsets may participate in osteoporosis onset: a preliminary study of a postmenopausal osteoporosis mouse model.

    Wang, Sizhu / Qiu, Yuyou / Tang, Cuisong / Tang, Huan / Liu, Jinchuan / Chen, Jieying / Zhang, Lin / Tang, Guangyu

    Frontiers in endocrinology

    2024  Volume 15, Page(s) 1323647

    Abstract: Purpose: Metabolic and immune changes in the early stages of osteoporosis are not well understood. This study aimed to explore the changes in bone metabolites and bone marrow lymphocyte subsets and their relationship during the osteoporosis onset.: ... ...

    Abstract Purpose: Metabolic and immune changes in the early stages of osteoporosis are not well understood. This study aimed to explore the changes in bone metabolites and bone marrow lymphocyte subsets and their relationship during the osteoporosis onset.
    Methods: We established OVX and Sham mouse models. After 5, 15, and 40 days, five mice in each group were sacrificed. Humeri were analyzed by microCT. The bone marrow cells of the left femur and tibia were collected for flow cytometry analysis. The right femur and tibia were analyzed by LC-MS/MS for metabolomics analysis.
    Results: Bone microarchitecture was significantly deteriorated 15 days after OVX surgery. Analysis of bone metabolomics showed that obvious metabolite changes had happened since 5 days after surgery. Lipid metabolism was significant at the early stage of the osteoporosis. The proportion of immature B cells was increased, whereas the proportion of mature B cells was decreased in the OVX group. Metabolites were significantly correlated with the proportion of lymphocyte subsets at the early stage of the osteoporosis.
    Conclusion: Lipid metabolism was significant at the early stage of the osteoporosis. Bone metabolites may influence bone formation by interfering with bone marrow lymphocyte subsets.
    MeSH term(s) Humans ; Female ; Mice ; Animals ; Osteoporosis, Postmenopausal/etiology ; Osteoporosis, Postmenopausal/metabolism ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Osteoporosis/etiology ; Osteoporosis/metabolism ; Disease Models, Animal ; Lymphocyte Subsets/metabolism
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2024.1323647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Bone marrow fatty acids affect osteoblastic differentiation through miR-92b-3p in the early stages of postmenopausal osteoporosis.

    Wang, Sizhu / Tang, Cuisong / Chen, Jieying / Tang, Huan / Zhang, Lin / Tang, Guangyu

    Heliyon

    2023  Volume 9, Issue 6, Page(s) e16513

    Abstract: Osteoporosis is partially caused by dysfunctions in the commitment, differentiation or survival of osteoblasts. Bone marrow fatty acids affect bone resorption and formation. In this study, we aimed to explore the role of fatty acids in the early stages ... ...

    Abstract Osteoporosis is partially caused by dysfunctions in the commitment, differentiation or survival of osteoblasts. Bone marrow fatty acids affect bone resorption and formation. In this study, we aimed to explore the role of fatty acids in the early stages of postmenopausal osteoporosis and determine whether they influence osteogenic differentiation through microRNAs. A quantitative analysis of bone marrow fatty acids early after ovariectomy or sham surgery in a rat osteoporotic model was performed using gas chromatography/mass spectrometry. The results showed that palmitoleate was significantly decreased on postoperative day 3 while both pentadecanoate and palmitoleate were significantly decreased on postoperative day 5 in rats in the ovariectomized group compared with those in the sham group. Palmitoleate promotes osteogenic differentiation, whereas pentadecanoate inhibits this process. Palmitoleate levels were higher than those of pentadecanoate; therefore, the early overall effect of significant bone marrow fatty acid changes was a decrease in osteogenic differentiation. We also found that miR-92b-3p inhibited osteoblastogenesis via the miR-92b-3p/phosphatase and tensin homolog regulatory axis. Palmitoleate, pentadecanoate, and palmitate influenced the osteoblastogenesis of MC3T3-E1 cells through miR-92b-3p. Taken together, we propose that miR-92b-3p mediates the effect of bone marrow fatty acids on osteoblast differentiation in the early stages of osteoporosis. These findings may provide molecular insights for the treatment of osteoporosis.
    Language English
    Publishing date 2023-05-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e16513
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Stratification of axillary lymph node metastasis risk with breast magnetic resonance imaging in breast cancer.

    Chen, Jieying / Su, Xiaolian / Xu, Tingting / Luo, Qifeng / Zhang, Lin / Tang, Guangyu

    Future oncology (London, England)

    2022  

    Abstract: Aims: ...

    Abstract Aims:
    Language English
    Publishing date 2022-02-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2274956-1
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2021-1559
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6478: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Bone marrow fatty acids affect osteoblastic differentiation through miR-92b-3p in the early stages of postmenopausal osteoporosis

    Wang, Sizhu / Tang, Cuisong / Chen, Jieying / Tang, Huan / Zhang, Lin / Tang, Guangyu

    Heliyon. 2023 May 22, p.e16513-

    2023  

    Abstract: Osteoporosis is partially caused by dysfunctions in the commitment, differentiation or survival of osteoblasts. Bone marrow fatty acids affect bone resorption and formation. In this study, we aimed to explore the role of fatty acids in the early stages ... ...

    Abstract Osteoporosis is partially caused by dysfunctions in the commitment, differentiation or survival of osteoblasts. Bone marrow fatty acids affect bone resorption and formation. In this study, we aimed to explore the role of fatty acids in the early stages of postmenopausal osteoporosis and determine whether they influence osteogenic differentiation through microRNAs. A quantitative analysis of bone marrow fatty acids early after ovariectomy or sham surgery in a rat osteoporotic model was performed using gas chromatography/mass spectrometry. The results showed that palmitoleate was significantly decreased on postoperative day 3 while both pentadecanoate and palmitoleate were significantly decreased on postoperative day 5 in rats in the ovariectomized group compared with those in the sham group. Palmitoleate promotes osteogenic differentiation, whereas pentadecanoate inhibits this process. Palmitoleate levels were higher than those of pentadecanoate; therefore, the early overall effect of significant bone marrow fatty acid changes was a decrease in osteogenic differentiation. We also found that miR-92b-3p inhibited osteoblastogenesis via the miR-92b-3p/phosphatase and tensin homolog regulatory axis. Palmitoleate, pentadecanoate, and palmitate influenced the osteoblastogenesis of MC3T3-E1 cells through miR-92b-3p. Taken together, we propose that miR-92b-3p mediates the effect of bone marrow fatty acids on osteoblast differentiation in the early stages of osteoporosis. These findings may provide molecular insights for the treatment of osteoporosis.
    Keywords bone formation ; bone marrow ; bone resorption ; fatty acids ; gas chromatography ; mass spectrometry ; microRNA ; models ; osteoblasts ; osteoporosis ; ovariectomy ; palmitates ; postmenopause ; quantitative analysis ; rats ; Osteoblast ; Lipids ; Fatty acid ; Gas chromatography/mass spectrometry
    Language English
    Dates of publication 2023-0522
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version ; Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e16513
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: PIM-1 kinase: a potential biomarker of triple-negative breast cancer.

    Chen, Jieying / Tang, Guangyu

    OncoTargets and therapy

    2019  Volume 12, Page(s) 6267–6273

    Abstract: Triple-negative breast cancer is associated with a poor prognosis, and effective biomarkers for targeted diagnosis and treatment are lacking. The tumorigenicity of the provirus integration site for Moloney murine leukemia virus 1 ( ...

    Abstract Triple-negative breast cancer is associated with a poor prognosis, and effective biomarkers for targeted diagnosis and treatment are lacking. The tumorigenicity of the provirus integration site for Moloney murine leukemia virus 1 (
    Language English
    Publishing date 2019-08-08
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2495130-4
    ISSN 1178-6930
    ISSN 1178-6930
    DOI 10.2147/OTT.S212752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Discovery of Novel Hybrids of Edaravone and 6-phenyl-4,5-dihydropyridazin-3(2H)-one with Antiplatelet Aggregation and Neuroprotection for Ischemic Stroke Treatment.

    Li, Yi / He, Jieying / Luo, Bilan / Yu, Qinyang / Cai, Ting / Li, Yong / Fan, Lingling / Zhou, Xunrong / Tang, Lei

    Chemistry & biodiversity

    2024  , Page(s) e202400110

    Abstract: Drugs with anti-platelet aggregation and neuroprotection are of great significance for the treatment of ischemic stroke. A series of edaravone and 6-phenyl-4,5-dihydropyridazin-3(2H)-one hybrids were designed and synthesized. Among them, 6g showed the ... ...

    Abstract Drugs with anti-platelet aggregation and neuroprotection are of great significance for the treatment of ischemic stroke. A series of edaravone and 6-phenyl-4,5-dihydropyridazin-3(2H)-one hybrids were designed and synthesized. Among them, 6g showed the most effective cytoprotective effect against oxygen-glucose deprivation/reoxygenation-induced damage in BV2 cells and an excellent inhibitory effect on platelet aggregation induced by adenosine diphosphate and arachidonic acid. Additionally, 6g could prevent thrombosis caused by ferric chloride in rats and pose a lower risk of causing bleeding compared with aspirin. It provides better protection against ischemia/reperfusion injury in rats compared with edaravone and alleviates the oxidative stress related to cerebral ischemia/reperfusion by increasing the GSH and SOD levels and decreasing the MDA concentration. Finally, molecular docking results showed that 6g probably acts on PDE3 A and plays an anti-platelet aggregation effect. Overall, 6g could be a potential candidate compound for the treatment of ischemic stroke.
    Language English
    Publishing date 2024-02-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202400110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Ss

    Qin, Lei / Nong, Jieying / Cui, Kan / Tang, Xianyu / Gong, Xin / Xia, Yunong / Xu, Yan / Qiu, Yilan / Li, Xin / Xia, Shitou

    International journal of molecular sciences

    2023  Volume 24, Issue 16

    Abstract: Sclerotinia ... ...

    Abstract Sclerotinia sclerotiorum
    MeSH term(s) Virulence/genetics ; Ascomycota/genetics ; Gene Silencing ; High-Throughput Nucleotide Sequencing
    Language English
    Publishing date 2023-08-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241612610
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Therapeutic efficacy of acupuncture point stimulation for stomach cancer pain: a systematic review and meta-analysis.

    Zhou, Xuancheng / Zhang, Jieying / Jiang, Lai / Zhang, Shengke / Gu, Yuheng / Tang, Jingyi / Pu, Tong / Quan, Xiaomin / Chi, Hao / Huang, Shangke

    Frontiers in neurology

    2024  Volume 15, Page(s) 1334657

    Abstract: Purpose: In recent years, traditional Chinese medicine has received widespread attention in the field of cancer pain treatment. This meta-analysis is the first to evaluate the effectiveness and safety of acupuncture point stimulation in the treatment of ...

    Abstract Purpose: In recent years, traditional Chinese medicine has received widespread attention in the field of cancer pain treatment. This meta-analysis is the first to evaluate the effectiveness and safety of acupuncture point stimulation in the treatment of stomach cancer pain.
    Methods: For this systematic review and meta-analysis, we searched PubMed, Web of Science, Cochrane Library, Embase, WANFANG, China National Knowledge Infrastructure (CNKI), and Chinese Journal of Science and Technology (VIP) databases as well as forward and backward citations to studies published between database creation to July 27, 2023. All randomized controlled trials (RCTs) on acupuncture point stimulation for the treatment of patients with stomach cancer pain were included without language restrictions. We assessed all outcome indicators of the included trials. The evidence from the randomized controlled trials was synthesized as the standardized mean difference (SMD) of symptom change. The quality of the evidence was assessed using the Cochrane Risk of Bias tool. This study is registered on PROSPERO under the number CRD42023457341.
    Results: Eleven RCTs were included. The study included 768 patients, split into 2 groups: acupuncture point stimulation treatment group (
    Systematic review registration: https://clinicaltrials.gov/, identifier CRD42023457341.
    Language English
    Publishing date 2024-04-04
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2024.1334657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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