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  1. Article ; Online: Enantioselective Synthesis of Dihydropyrazoles by Palladium/Xu-Phos-Catalyzed Alleneamination of β,γ-Unsaturated Hydrazones with Propargylic Acetates.

    Zhang, Shuting / Wu, Shuaijie / Wang, Qiang / Xu, Shiji / Han, Ying / Yan, Chao-Guo / Zhang, Junliang / Wang, Lei

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 20, Page(s) e202300309

    Abstract: ... enantioselectivities. The chiral sulfinamide phosphine ligand Xu-5 exhibits highly efficient stereoselective control ...

    Abstract The palladium-catalyzed asymmetric carboamination reaction is one of the most significant transformations in organic chemistry. Herein, we report the first palladium-catalyzed asymmetric alleneamination of β,γ-unsaturated hydrazones with propargylic acetates. This protocol enables the efficient installation of various multisubstituted allene groups onto dihydropyrazoles in good yields with excellent enantioselectivities. The chiral sulfinamide phosphine ligand Xu-5 exhibits highly efficient stereoselective control in this protocol. The salient features of this reaction include the readily available starting materials, a broad substrate scope, an easy scale-up, mild reaction conditions and versatile transformations.
    Language English
    Publishing date 2023-04-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202300309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Mechanism of Xu Li's Experiential Prescription for the Treatment of EGFR-Positive NSCLC.

    Xu, Bin / Zhang, Haitao / Wang, Yuchao / Huang, Shuran / Xu, Li

    Evidence-based complementary and alternative medicine : eCAM

    2020  Volume 2020, Page(s) 8787153

    Abstract: ... the human health. Xu Li's experiential prescription (XLEP) can treat the NSCLC. However, whether XLEP can regulate ...

    Abstract The non-small-cell lung cancer (NSCLC) is the most common lung cancer which seriously threatens the human health. Xu Li's experiential prescription (XLEP) can treat the NSCLC. However, whether XLEP can regulate the autophagy in the EGFR-positive NSCLC still remains unknown. We found that the cellular activity of drug-resistant cells and sensitive cells were all decreased in the TCM group and TCM + Gef group. The expression of autophagy-associated proteins (mTOR and Beclin1-Vps34) in drug-resistant cells was decreased in the TCM group, while the expression of autophagy-associated proteins in sensitive cells was all decreased in the TCM + Gef group. The ratio of M1/M2 macrophages was increased when IL-4-induced RAW264.7 was treated with TCM. TCM treatment promoted the expression of CCL2 and CCL3 while it downregulated the CCL22 level among A549, H1975, and PC9 cells. The expression of TNF-
    Language English
    Publishing date 2020-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2020/8787153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Xiao-Xu-Ming

    Wang, Yue-Hua / Yang, Ying-Lin / Cheng, Xiao / Zhang, Jun / Li, Wan / Du, Guan-Hua

    Neural regeneration research

    2018  Volume 14, Issue 3, Page(s) 470–479

    Abstract: Xiao-Xu-Ming decoction has been widely used to treat stroke and sequelae of stroke. We have ... previously shown that the active fractions of Xiao-Xu-Ming decoction attenuate cerebral ischemic injury ... However, the global protein profile and signaling conduction pathways regulated by Xiao-Xu-Ming decoction are still ...

    Abstract Xiao-Xu-Ming decoction has been widely used to treat stroke and sequelae of stroke. We have previously shown that the active fractions of Xiao-Xu-Ming decoction attenuate cerebral ischemic injury. However, the global protein profile and signaling conduction pathways regulated by Xiao-Xu-Ming decoction are still unclear. This study established a two-vessel occlusion rat model by bilateral common carotid artery occlusion. Rats were intragastrically administered 50 or 150 mg/kg Xiao-Xu-Ming decoction for 4 consecutive weeks. Learning and memory abilities were measured with Morris water maze. Motor ability was detected with prehensile test. Coordination ability was examined using the inclined screen test. Neuronal plasticity was observed by immunofluorescent staining. Differentially expressed proteins of rat hippocampus were analyzed by label-free quantitative proteomics. Real time-polymerase chain reaction and western blot assay were used to identify the changes in proteins. Results showed that Xiao-Xu-Ming decoction dramatically alleviated learning and memory deficits, and motor and coordination dysfunction, and increased the expression of microtubule-associated protein 2. Xiao-Xu-Ming decoction extract remarkably decreased 13 upregulated proteins and increased 39 downregulated proteins. The regulated proteins were mainly involved in oxidation reduction process, intracellular signaling cascade process, and protein catabolic process. The signaling pathways were mainly involved in ubiquitin mediated proteolysis and the phosphatidylinositol signaling system. Furthermore, there was an interaction among Rab2a, Ptpn1, Ppm1e, Cdk18, Gorasp2, Eps15, Capza2, Syngap1 and Mt-nd1. Protein analyses confirmed the changes in expression of MT-ND1. The current findings provide new insights into the molecular mechanisms of Xiao-Xu-Ming decoction extract's effects on chronic cerebral hypoperfusion.
    Language English
    Publishing date 2018-12-14
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.245471
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Application of the new 'XU-line' in the dynamic ultrasonographic evaluation of the spatial displacement of anterior cervical tissues for airway management: protocol for a prospective observational study.

    Wang, Yujie / Mao, Mingfeng / Zhou, Yang / Shi, Wanrui / Xu, Mao

    BMJ open

    2022  Volume 12, Issue 6, Page(s) e058896

    Abstract: ... of the cervical soft tissue for airway assessment. This study will use the new 'XU-line' in the dynamic ... will be recruited. The parallel trunk reference line through the mentum is defined as the XU-line, and ... the spatial displacement of the anterior cervical soft tissue relative to the XU-line at six anatomical levels ...

    Abstract Introduction: Patients with cervical spondylosis have a high incidence of difficult airway, and unpredicted difficult intubation may be life-threatening. Traditional predictors and imaging data may suggest a difficult airway, but these data have limited predictive value, with low sensitivity and specificity. Ultrasonography is a non-irradiating, reproducible, inexpensive and simple tool that provides good imaging of the cervical soft tissue for airway assessment. This study will use the new 'XU-line' in the dynamic ultrasonographic airway evaluation of the spatial displacement of the anterior cervical tissues to determine whether preoperative ultrasonographic assessment of the neck anatomy can predict difficult airway.
    Methods and analysis: This prospective, observational study will be conducted in a single centre. Four hundred and eleven patients scheduled for anterior cervical decompression and fusion under general anaesthesia will be recruited. The parallel trunk reference line through the mentum is defined as the XU-line, and the spatial displacement of the anterior cervical soft tissue relative to the XU-line at six anatomical levels in the transverse plane and two distances in the sagittal plane will be measured on ultrasonography with the patient in the supine position and the sniff position. The spatial displacement distances of soft tissue structures relative to the XU-line will be compared between the 'easy intubation' and 'difficult intubation' groups (in accordance with the Cormack-Lehane classification). Receiver operating characteristic curves will be used to determine the sensitivity and specificity of the 'difficulty prediction capability' of each ultrasonographic and physical measurement. Multiple logistic regression analysis will be performed to determine the independent predictors of difficult intubation.
    Ethics and dissemination: Ethical approval for this study has been obtained from the Peking University Third Hospital Medical Science Research Ethics Committee. The results of this study will be disseminated via a peer-reviewed publication and national and international conferences and workshops.
    Trial registration number: ChiCTR2000034446.
    MeSH term(s) Anesthesia, General/methods ; Humans ; Intubation, Intratracheal/methods ; Neck/anatomy & histology ; Neck/diagnostic imaging ; Observational Studies as Topic ; Prospective Studies ; Spondylosis/surgery
    Language English
    Publishing date 2022-06-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2021-058896
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The clinical efficacy of Zuqing Xu "Wuduling" powder for snake injury on the swelling of the affected limb bitten by Agkistrodon

    Ye, Jingjing / Qian, Wei / Chen, Ninggang / Hu, Zhikai / Ye, Shu / Li, Mei / Zhang, Lian / Wang, Hui / Lu, Yanwu

    Biotechnology & genetic engineering reviews

    2023  , Page(s) 1–18

    Abstract: To determine the clinical efficacy of Zuqing Xu 'Wuduling' powder for snake injury on the swelling ...

    Abstract To determine the clinical efficacy of Zuqing Xu 'Wuduling' powder for snake injury on the swelling of the affected limb bitten by
    Language English
    Publishing date 2023-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 49457-4
    ISSN 2046-5556 ; 0264-8725
    ISSN (online) 2046-5556
    ISSN 0264-8725
    DOI 10.1080/02648725.2023.2191085
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    In stock of ZB MED Cologne/Königswinter

    Se 1012: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Mechanistic study on the side arm effect in a palladium/Xu-Phos-catalyzed enantioselective alkoxyalkenylation of γ-hydroxyalkenes.

    Zhu, Shuai / Ye, Zihao / Chen, Ming-Jie / Wang, Lei / Wang, Yu-Zhuo / Zhang, Ke-Nan / Li, Wen-Bo / Ding, Han-Ming / Li, Zhiming / Zhang, Junliang

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 7611

    Abstract: ... identified Xu-Phos (Xu8 and Xu9) with a suitable side-arm adjacent to the PCy ...

    Abstract Recently, the asymmetric bifunctionalization of alkenes has received much attention. However, the development of enantioselective alkoxyalkenylation has posed a considerable challenge and has lagged largely behind. Herein, we report a new palladium-catalyzed enantioselective alkoxyalkenylation reaction, using a range of primary, secondary, and tertiary γ-hydroxy-alkenes with alkenyl halides. By employing newly identified Xu-Phos (Xu8 and Xu9) with a suitable side-arm adjacent to the PCy
    Language English
    Publishing date 2023-11-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-43202-5
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  7. Article: Corrigendum: Detecting key functional components group and speculating the potential mechanism of Xiao-Xu-Ming decoction in treating stroke.

    Chen, Yu-Peng / Wang, Ke-Xin / Cai, Jie-Qi / Li, Yi / Yu, Hai-Lang / Wu, Qi / Meng, Wei / Wang, Han-Duo / Yin, Chuan-Hui / Wu, Jie / Huang, Mian-Bo / Li, Rong / Guan, Dao-Gang

    Frontiers in cell and developmental biology

    2023  Volume 10, Page(s) 1107236

    Abstract: This corrects the article DOI: 10.3389/fcell.2022.753425.]. ...

    Abstract [This corrects the article DOI: 10.3389/fcell.2022.753425.].
    Language English
    Publishing date 2023-01-20
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.1107236
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  8. Article ; Online: Pd/Xu-Phos-catalyzed asymmetric elimination of fully substituted enol triflates into axially chiral trisubstituted allenes.

    Han, Jie / Liu, Siyuan / Wang, Huanan / Wang, Jie / Qian, Hui / Li, Zhiming / Ma, Shengming / Zhang, Junliang

    Science advances

    2023  Volume 9, Issue 11, Page(s) eadg1002

    Abstract: The β-H elimination, as one of the most important elementary reactions in transition metal chemistry, is a key step in quenching the carbon-palladium bond for the Heck reaction. However, the β-H elimination of the alkenyl palladium species leading to ... ...

    Abstract The β-H elimination, as one of the most important elementary reactions in transition metal chemistry, is a key step in quenching the carbon-palladium bond for the Heck reaction. However, the β-H elimination of the alkenyl palladium species leading to allene is an energetically unfavored process, and therefore, it has been a long-standing challenge in control of this process via enantioselective manner. We developed a concise and efficient methodology to construct trisubstituted chiral allenes from stereodefined fully substituted enol triflates by the enantioselective β
    Language English
    Publishing date 2023-03-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adg1002
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  9. Article: Differences of airborne and mural microorganisms in a 1,500-year-old Xu Xianxiu's Tomb, Taiyuan, China.

    Liu, Jiangyun / Wu, Fasi / Xiang, Ting / Ma, Wenxia / He, Dongpeng / Zhang, Qi / Wang, Wanfu / Duan, Yulong / Tian, Tian / Feng, Huyuan

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1253461

    Abstract: ... mural painting samples, were collected from different sites of Xu Xianxiu's Tomb and analyzed using ...

    Abstract Background: Microbial colonization represents one of the main threats to the conservation of subterranean cultural heritage sites. Recently, the microbial colonization on murals in tombs has gradually attracted attention.
    Methods: In this study, a total of 33 samples, including 27 aerosol samples and 6 mural painting samples, were collected from different sites of Xu Xianxiu's Tomb and analyzed using culture-dependent methods. We compared the diversities of culturable bacteria and fungi isolated from the air and murals and explored the potential impacts of microorganisms on the biodeterioration of the murals.
    Results: Phylogenetic analyses revealed that the culturable bacteria belonged to Bacillus, Microbacterium, Lysobacter and Arthrobacter. And the most of fungal belonged to the Penicillium, Cladosporium and Aspergillus genera. The composition and structure of airborne bacteria and fungi outside the tomb were both significantly different from that inside the tomb. The variation trends of airborne bacterial and fungal concentrations at different sampling sites were remarkably similar. Bacillus frigoritolerans, Bacillus halotolerans, Bacillus safensis, Exiguobacterium mexicanum, Microbacterium trichothecenolyticum, and Micrococcus yunnanensis were bacterial species commonly isolated from both the mural and air environments. Fungal species commonly isolated from aerosol samples and mural painting samples were Alternaria alternata, Cladosporium cladosporioides, Penicillium brevicompactum, and Peyronellaea glomerata. The prediction of the ecological functions of the bacteria revealed that chemoheterotrophy or aerobic_chemoheterotrophy accounted for substantial relative proportions in all sample types.
    Conclusion: These results suggest that the aerosol circulation between the inside and outside environments of the tomb was weak and that the outside environment had yet to have an impact on the air microbial community inside the tomb. Selective colonization of microorganisms, which is mediated by interaction between microorganisms and special microenvironmental factors, is an important reason for the biodeterioration of murals.
    Language English
    Publishing date 2023-10-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1253461
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  10. Article: Palladium/Xu-Phos-catalyzed asymmetric carboamination towards isoxazolidines and pyrrolidines.

    Wang, Yuzhuo / Wang, Lei / Chen, Mingjie / Tu, Youshao / Liu, Yu / Zhang, Junliang

    Chemical science

    2021  Volume 12, Issue 23, Page(s) 8241–8245

    Abstract: An efficient palladium-catalyzed enantioselective carboamination reaction ... ...

    Abstract An efficient palladium-catalyzed enantioselective carboamination reaction of
    Language English
    Publishing date 2021-05-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d1sc01337h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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